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Eomestm1Rob
Targeted Allele Detail
Summary
Symbol: Eomestm1Rob
Name: eomesodermin; targeted mutation 1, Elizabeth J Robertson
MGI ID: MGI:3774027
Synonyms: EomesCA, Tbr2/EomesCA
Gene: Eomes  Location: Chr9:118307259-118315176 bp, + strand  Genetic Position: Chr9, 70.21 cM, cytoband F3
Alliance: Eomestm1Rob page
Eomestm1Rob/Eomestm2.1Rob Edil3Tg(Sox2-cre)1Amc/0 embryos fail to form the mesoderm cell layer and are blocked in gastrulation

Show the 1 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:131055
Parent Cell Line:  CCE/EK.CCE (ES Cell)
Strain of Origin:  129S/SvEv-Gpi1c
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA floxed neo cassette was inserted into intron 5-6 and additional loxP site was inserted into intron 1-2. This resulted in the floxing of exons 2 through 5. Transient Cre expression was used to removed the neo cassette. (J:131055)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 10 assay results
1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation: 7 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Eomes Mutation:  41 strains or lines available
References
Original:  J:131055 Arnold SJ, et al., Pivotal roles for eomesodermin during axis formation, epithelium-to-mesenchyme transition and endoderm specification in the mouse. Development. 2008 Feb;135(3):501-11
All:  16 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory