Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Eomestm1Rob mutation
(0 available);
any
Eomes mutation
(41 available)
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normal phenotype
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• animals are recovered in normal numbers at weaning; mice are fertile and show no overt abnormalities
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Edil3Tg(Sox2-cre)1Amc mutation
(5 available);
any
Edil3 mutation
(42 available)
Eomestm1.1Rob mutation
(0 available);
any
Eomes mutation
(41 available)
Eomestm1Rob mutation
(0 available);
any
Eomes mutation
(41 available)
Gt(ROSA)26Sortm1Sor mutation
(8 available);
any
Gt(ROSA)26Sor mutation
(942 available)
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embryo
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• specification of the definitive endoderm is disrupted
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• visceral endoderm fails to displace proximally at E7.5
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Eomestm1.1Rob mutation
(0 available);
any
Eomes mutation
(41 available)
Eomestm1Rob mutation
(0 available);
any
Eomes mutation
(41 available)
Tg(T-cre)1Lwd mutation
(1 available)
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embryo
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• Mendelian numbers of conditionally null embryos are recovered around E6.5
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mortality/aging
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• severely affected embryos are not recovered
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embryo
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• embryos with anterior axis truncations are recovered at low frequency
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Eomestm1Rob mutation
(0 available);
any
Eomes mutation
(41 available)
Sox1tm1(cre)Take mutation
(1 available);
any
Sox1 mutation
(13 available)
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behavior/neurological
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• increased exploratory behavior in the open field test
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• enhanced aggressiveness upon handling
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• male mutants mutilated or killed pups
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• significantly reduced grip strength
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nervous system
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• enhanced cell death in the dentate migration stream
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• fraction of callosal axons are misrouted
• the typical input-related patterning in Barrel cortex was strongly diminished
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• significant decrease of nonventricular surface proliferation during cortical development
• expression of subventricular zone (SVZ) markers were reduced indicating about 25% decrease of proliferating cells in the mutant SVZ throughout development
• neurogenesis in the dentate gyrus was completely absent
• nerurogenesis in th subependymal zone of adult mutants appeared normal
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• despite normal body weight, mutant brains showed a markedly reduced brain size
• the size of the cortex and the olfactory bulbs was markedly reduced at birth
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• the contralateral projecting fibers from olfactory nuclei and temporal lobes which forms the anterior commissure were absent
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• the infrapyramidal blade did not develop
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• cortical layers II-IV thickness is reduced
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• the mitral cell layer in the olfactory bulb is absent
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cellular
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• enhanced cell death in the dentate migration stream
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• fraction of callosal axons are misrouted
• the typical input-related patterning in Barrel cortex was strongly diminished
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• significant decrease of nonventricular surface proliferation during cortical development
• expression of subventricular zone (SVZ) markers were reduced indicating about 25% decrease of proliferating cells in the mutant SVZ throughout development
• neurogenesis in the dentate gyrus was completely absent
• nerurogenesis in th subependymal zone of adult mutants appeared normal
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Edil3Tg(Sox2-cre)1Amc mutation
(5 available);
any
Edil3 mutation
(42 available)
Eomestm1Rob mutation
(0 available);
any
Eomes mutation
(41 available)
Eomestm2.1Rob mutation
(0 available);
any
Eomes mutation
(41 available)
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Eomestm1Rob/Eomestm2.1Rob Edil3Tg(Sox2-cre)1Amc/0 embryos fail to form the mesoderm cell layer and are blocked in gastrulation
embryo
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• mice are blocked in gastrulation
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• epiblast cells fails to undergo the epithelial to mesenchyme transition and to form a distinctive mesodermal cell layer unlike in wild-type mice
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• unlike in wild-type mice, the primitive streak is populated by nascent mesoderm
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Edil3Tg(Sox2-cre)1Amc mutation
(5 available);
any
Edil3 mutation
(42 available)
Eomestm1.1Rob mutation
(0 available);
any
Eomes mutation
(41 available)
Eomestm1Rob mutation
(0 available);
any
Eomes mutation
(41 available)
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embryo
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• by late headfold stages, embryos have multiple cystic epiblast invaginations and completely lack a discrete mesoderm layer
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• at E7.5, there is complete absence of mesodermal cells between the visceral endoderm and the epiblast
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• mutant embryos display abnormal thickening of the primitive streak at E7.0, resulting in an abnormal embryo shape
• there is accumulation of cells with mesenchymal morphology in the primitive streak
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