Nf1Mhdadsk9/Nf1+
C3HeB/FeJ-Nf1Mhdadsk9/Ieg
|
abnormal tongue morphology |
J:81301
|
|
increased ear pigmentation |
J:81301
|
|
increased foot pad pigmentation |
J:81301
|
|
increased tail pigmentation |
J:81301
|
Nf1Mhdadsk9/Nf1+
involves: C3HeB/FeJ * C57BL/6
|
abnormal seminiferous tubule epithelium morphology |
J:269534
|
|
abnormal Sertoli cell barrier morphology |
J:269534
|
|
abnormal spermatid morphology |
J:269534
|
|
abnormal spermatogenesis |
J:269534
|
|
abnormal spermiation |
J:269534
|
|
decreased Leydig cell number |
J:269534
|
|
decreased litter size |
J:269534
|
|
enlarged sperm head |
J:269534
|
|
enlarged testis |
J:269534
|
|
increased sperm number |
J:269534
|
|
reduced male fertility |
J:269534
|
|
seminiferous tubule degeneration |
J:269534
|
Nf1Mhdadsk9/Nf1Mhdadsk9
involves: C3HeB/FeJ * C57BL/6J
|
prenatal lethality, complete penetrance |
J:81301
|
Nf1tm1.1Kest/Nf1tm1.1Kest
involves: 129S4/SvJaeSor * C57BL/6 * C57BL/6NTac
|
embryonic lethality during organogenesis, complete penetrance |
J:234172
|
|
pericardial effusion |
J:234172
|
Nf1tm1.1Kest/Nf1tm1c(KOMP)Wtsi
Tg(Dhh-cre)1Mejr/0
involves: 129S4/SvJaeSor * C57BL/6 * C57BL/6N * C57BL/6NTac * FVB/N
|
abnormal somatic nervous system morphology |
J:234172
|
|
abnormal spinal nerve morphology |
J:234172
|
|
dehydration |
J:234172
|
|
dermatitis |
J:234172
|
|
hindlimb paralysis |
J:234172
|
|
increased neurofibroma incidence |
J:234172
|
|
lethargy |
J:234172
|
|
weight loss |
J:234172
|
Nf1tm1a(KOMP)Wtsi/Nf1+
B6Dnk;B6Brd;B6N-Tyrc-Brd Nf1tm1a(KOMP)Wtsi/Wtsi
|
abnormal hair cycle anagen phase |
J:232539
|
Nf1tm1a(KOMP)Wtsi/Nf1+
B6JTyr;B6N-Nf1tm1a(KOMP)Wtsi/Wtsi
|
decreased circulating alanine transaminase level |
J:175295
|
|
decreased circulating aspartate transaminase level |
J:175295
|
|
decreased lactate dehydrogenase level |
J:175295
|
|
increased body weight |
J:165965
|
Nf1tm1a(KOMP)Wtsi/Nf1tm1a(KOMP)Wtsi
B6JTyr;B6N-Nf1tm1a(KOMP)Wtsi/Wtsi
|
preweaning lethality, complete penetrance |
J:211773
|
Nf1tm1c(KOMP)Wtsi/Nf1tm1c(KOMP)Wtsi
Tg(Dhh-cre)1Mejr/0
involves: 129S4/SvJaeSor * C57BL/6 * C57BL/6N * FVB/N
|
abnormal somatic nervous system morphology |
J:234172
|
|
abnormal spinal nerve morphology |
J:234172
|
|
dehydration |
J:234172
|
|
dermatitis |
J:234172
|
|
hindlimb paralysis |
J:234172
|
|
increased neurofibroma incidence |
J:234172
|
|
lethargy |
J:234172
|
|
weight loss |
J:234172
|
Nf1tm1Cbr/Nf1+
involves: 129S1/Sv * C57BL/6
|
normal
neoplasm |
J:68489
|
Nf1tm1Cbr/Nf1tm1Cbr
involves: 129S1/Sv * C57BL/6
|
abnormal discrimination learning |
J:68489
|
|
abnormal spatial learning |
J:68489
|
|
impaired coordination |
J:68489
|
|
normal
neoplasm |
J:68489
|
|
normal
nervous system phenotype |
J:68489
|
Nf1tm1d(KOMP)Wtsi/Nf1tm1d(KOMP)Wtsi
involves: 129S4/SvJaeSor * C57BL/6 * C57BL/6N * FVB/N
|
embryonic lethality during organogenesis, complete penetrance |
J:234172
|
Nf1tm1d(KOMP)Wtsi/Nf1tm2.1Kest
involves: 129S4/SvJaeSor * C57BL/6 * C57BL/6N * FVB/N
|
no abnormal phenotype detected |
J:234172
|
Nf1tm1Fcr/Nf1+
Tg(GFAP-cre)#Gtm/0
involves: 129S/SvEv * 129S4/SvJae * C57BL/6 * CBA
|
abnormal neuron proliferation |
J:176586
|
|
abnormal optic nerve morphology |
J:176586
|
|
increased glioma incidence |
J:176586
|
|
increased optic chiasm size |
J:176586
|
Nf1tm1Fcr/Nf1tm1.1Par
involves: 129S/SvEv * 129S1/Sv * 129S2/SvPas * 129X1/SvJ
|
decreased eye pigmentation |
J:68558
|
|
edema |
J:68558
|
|
embryonic lethality during organogenesis, complete penetrance |
J:68558
|
|
enlarged heart |
J:68558
|
|
hemorrhage |
J:68558
|
|
microphthalmia |
J:68558
|
Nf1tm1Fcr/Nf1tm1Fcr
either: (involves: 129S/SvEv) or (involves: 129S/SvEv * C57BL/6J)
|
abnormal atrioventricular cushion morphology |
J:18048
|
|
abnormal fetal atrioventricular canal morphology |
J:18048
|
|
abnormal heart development |
J:18048
|
|
abnormal heart valve morphology |
J:18048
|
|
abnormal lymphatic vessel morphology |
J:18048
|
|
abnormal metanephros morphology |
J:18048
|
|
abnormal mitral valve cusp morphology |
J:18048
|
|
abnormal muscle morphology |
J:18048
|
|
abnormal vein morphology |
J:18048
|
|
blood vessel congestion |
J:18048
|
|
decreased renal glomerulus number |
J:18048
|
|
delayed hepatic development |
J:18048
|
|
delayed kidney development |
J:18048
|
|
delayed muscle development |
J:18048
|
|
disorganized myocardium |
J:18048
|
|
edema |
J:18048
|
|
enlarged chest |
J:18048
|
|
exencephaly |
J:18048
|
|
focal hepatic necrosis |
J:18048
|
|
globular heart |
J:18048
|
|
heart hypoplasia |
J:18048
|
|
increased atrioventricular cushion size |
J:18048
|
|
lethality throughout fetal growth and development, complete penetrance |
J:18048
|
|
liver hemorrhage |
J:18048
|
|
liver hypoplasia |
J:18048
|
|
megacephaly |
J:18048
|
|
microphthalmia |
J:18048
|
|
pale liver |
J:18048
|
|
paravertebral ganglia hyperplasia |
J:18048
|
|
pericardial effusion |
J:18048
|
|
persistent truncus arteriosus |
J:18048
|
|
pleural effusion |
J:18048
|
|
prevertebral ganglia hyperplasia |
J:18048
|
|
skeletal muscle hypoplasia |
J:18048
|
|
ventricular septal defect |
J:18048
|
Nf1tm1Fcr/Nf1tm1Fcr
involves: 129S/SvEv
|
abnormal enzyme/coenzyme activity |
J:114455
|
|
embryonic lethality during organogenesis, complete penetrance |
J:114455
|
Nf1tm1Fcr/Nf1tm1Par
Pax3tm1(cre)Joe/Pax3+
involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ
|
abnormal somatic sensory system morphology |
J:114455
|
|
adrenal medulla hyperplasia |
J:114455
|
|
neonatal lethality, complete penetrance |
J:114455
|
Nf1tm1Fcr/Nf1tm1Par
Tg(Tek-cre)1Ywa/0
involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL
|
abnormal spleen morphology |
J:114455
|
|
absent spleen germinal center |
J:114455
|
|
enlarged spleen |
J:114455
|
|
spleen fibrosis |
J:114455
|
Nf1tm1Par/Nf1+
Tg(Fabp7-cre,-lacZ)3Gtm/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
|
abnormal astrocyte morphology |
J:139866
|
Nf1tm1Par/Nf1tm1Fcr
Tg(GFAP-cre)#Gtm/0
involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
|
abnormal astrocyte morphology |
J:165209
|
|
abnormal astrocyte physiology |
J:165209
|
|
abnormal microglial cell morphology |
J:165209
|
|
abnormal myelination |
J:165209
|
|
abnormal optic chiasm morphology |
J:165209
|
|
abnormal optic nerve morphology |
J:165209
|
|
axon degeneration |
J:165209
|
|
hypermyelination |
J:165209
|
|
increased glioma incidence |
J:165209
|
|
retina ganglion cell degeneration |
J:165209
|
Nf1tm1Par/Nf1tm1Par
involves: 129S1/Sv * 129X1/SvJ
|
abnormal astrocyte physiology |
J:176586
|
Nf1tm1Par/Nf1tm1Par
H2az2Tg(Wnt1-cre)11Rth/H2az2+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
|
abnormal adrenal cortex morphology |
J:80323
|
|
abnormal adrenal gland morphology |
J:80323
|
|
abnormal adrenergic chromaffin cell morphology |
J:80323
|
|
abnormal sympathetic ganglion morphology |
J:80323
|
|
normal
cardiovascular system phenotype |
J:80323
|
|
decreased body size |
J:80323
|
|
enlarged adrenal glands |
J:80323
|
|
increased ganglioneuroma incidence |
J:80323
|
|
increased gangliosarcoma incidence |
J:80323
|
|
increased pheochromocytoma incidence |
J:80323
|
|
increased tumor incidence |
J:80323
|
|
respiratory failure |
J:80323
|
|
thin adrenal cortex |
J:80323
|
Nf1tm1Par/Nf1tm1Par
Tg(Fabp7-cre,-lacZ)3Gtm/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
|
abnormal astrocyte morphology |
J:139866
|
|
abnormal behavior |
J:139866
|
|
abnormal brain development |
J:139866
|
|
abnormal CNS glial cell morphology |
J:139866
|
|
abnormal dendrite morphology |
J:139866
|
|
abnormal hippocampus morphology |
J:139866
|
|
abnormal hormone level |
J:138868
|
|
abnormal hypothalamus physiology |
J:138868
|
|
abnormal nervous system physiology |
J:139866
|
|
abnormal neuronal precursor proliferation |
J:139866
|
|
abnormal pituitary gland development |
J:138868
|
|
abnormal pituitary gland morphology |
J:138868
|
|
abnormal pituitary gland physiology |
J:138868
|
|
abnormal secondary somatosensory cortex morphology |
J:139866
|
|
abnormal voluntary movement |
J:139866
|
|
decreased body weight |
J:138868,
J:139866
|
|
decreased circulating growth hormone level |
J:138868
|
|
increased oligodendrocyte number |
J:139866
|
|
normal
nervous system phenotype |
J:139866
|
|
postnatal growth retardation |
J:138868,
J:139866
|
|
postnatal lethality, incomplete penetrance |
J:139866
|
|
premature death |
J:139866
|
|
small adenohypophysis |
J:138868
|
|
small pituitary gland |
J:138868
|
Nf1tm1Par/Nf1tm1Par
Tg(Gfap-cre)77.6Mvs/0
involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6NHsd
|
normal
neoplasm |
J:154673
|
Nf1tm1Par/Nf1tm1Par
Tg(Mpz-cre)94Imeg/0
involves: 129S1/Sv * 129X1/SvJ
|
abnormal adrenal cortex morphology |
J:80323
|
|
abnormal adrenal gland morphology |
J:80323
|
|
abnormal adrenergic chromaffin cell morphology |
J:80323
|
|
abnormal sympathetic ganglion morphology |
J:80323
|
|
normal
cardiovascular system phenotype |
J:80323
|
|
decreased body size |
J:80323
|
|
enlarged adrenal glands |
J:80323
|
|
increased ganglioneuroma incidence |
J:80323
|
|
increased gangliosarcoma incidence |
J:80323
|
|
increased pheochromocytoma incidence |
J:80323
|
|
increased tumor incidence |
J:80323
|
|
respiratory failure |
J:80323
|
|
thin adrenal cortex |
J:80323
|
Nf1tm1Par/Nf1tm1Par
Tg(Mx1-cre)1Cgn/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
|
abnormal bone marrow cell morphology/development |
J:90973
|
|
abnormal common myeloid progenitor cell morphology |
J:90973
|
|
abnormal definitive hematopoiesis |
J:90973
|
|
abnormal gait |
J:90973
|
|
abnormal hematopoietic cell number |
J:90973
|
|
abnormal myeloid leukocyte morphology |
J:90973
|
|
abnormal myelopoiesis |
J:90973
|
|
abnormal spleen morphology |
J:90973
|
|
disheveled coat |
J:90973
|
|
enlarged spleen |
J:90973
|
|
hunched posture |
J:90973
|
|
increased granulocyte number |
J:90973
|
|
increased leukocyte cell number |
J:90973
|
|
increased lymphocyte cell number |
J:90973
|
|
increased monocyte cell number |
J:90973
|
|
increased neutrophil cell number |
J:90973
|
|
premature death |
J:90973
|
Nf1tm1Par/Nf1tm1Par
Tg(Pax3-cre)1Joe/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL
|
abnormal adrenal cortex morphology |
J:80323
|
|
abnormal adrenal gland morphology |
J:80323
|
|
abnormal adrenergic chromaffin cell morphology |
J:80323
|
|
abnormal sympathetic ganglion morphology |
J:80323
|
|
normal
cardiovascular system phenotype |
J:80323
|
|
decreased body size |
J:80323
|
|
enlarged adrenal glands |
J:80323
|
|
increased ganglioneuroma incidence |
J:80323
|
|
increased gangliosarcoma incidence |
J:80323
|
|
increased pheochromocytoma incidence |
J:80323
|
|
increased tumor incidence |
J:80323
|
|
respiratory failure |
J:80323
|
|
thin adrenal cortex |
J:80323
|
Nf1tm1Par/Nf1tm1Par
Tg(Prrx1-cre)1Cjt/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * C57BL/6N * SJL/J
|
abnormal bone healing |
J:193350
|
|
abnormal cartilage morphology |
J:193350
|
|
abnormal endochondral bone ossification |
J:193350
|
|
abnormal osteoblast cell number |
J:193350
|
|
abnormal osteoid morphology |
J:193350
|
|
decreased bone mineral density |
J:193350
|
|
fragile skeleton |
J:193350
|
|
increased compact bone volume |
J:193350
|
|
increased osteoclast cell number |
J:193350
|
|
increased osteoid thickness |
J:193350
|
Nf1tm1Par/Nf1tm1Par
Tg(Prrx1-cre)1Cjt/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL/J
|
abnormal muscle development |
J:173779
|
|
abnormal muscle fiber morphology |
J:173779
|
|
abnormal muscle morphology |
J:173779
|
|
abnormal muscle physiology |
J:173779
|
|
abnormal myoblast differentiation |
J:173779
|
|
abnormal myogenesis |
J:173779
|
|
decreased body weight |
J:173779
|
|
decreased muscle weight |
J:173779
|
|
decreased skeletal muscle fiber number |
J:173779
|
|
decreased skeletal muscle mass |
J:173779
|
|
increased myoblast proliferation |
J:173779
|
|
short limbs |
J:173779
|
|
skeletal muscle fibrosis |
J:173779
|
Nf1tm1Par/Nf1tm1Par
Tg(Syn1-cre)671Jxm/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
|
abnormal cerebral cortex morphology |
J:68558
|
|
abnormal learning/memory/conditioning |
J:68558
|
|
astrocytosis |
J:68558
|
|
decreased body weight |
J:68558
|
|
decreased forebrain size |
J:68558
|
|
normal
neoplasm |
J:68558
|
|
postnatal growth retardation |
J:68558
|
|
thin cerebral cortex |
J:68558
|
Nf1tm1Par/Nf1tm1Par
Tg(Tek-cre)1Ywa/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL
|
double outlet right ventricle |
J:80323
|
|
increased atrioventricular cushion size |
J:80323
|
|
pericardial effusion |
J:80323
|
|
thin myocardium |
J:80323
|
|
thin myocardium compact layer |
J:80323
|
|
ventricular septal defect |
J:80323
|
Nf1tm1Par/Nf1tm1Tyj
H2az2Tg(Wnt1-cre)11Rth/H2az2+
involves: 129/Sv * C57BL/6 * CBA
|
abnormal neural crest cell morphology |
J:131914
|
Nf1tm1Par/Nf1tm1Tyj
Tg(Mpz-cre)1Brn/0
involves: 129/Sv * FVB/N
|
increased neurofibroma incidence |
J:131914
|
|
normal
nervous system phenotype |
J:131914
|
Nf1tm1Par/Nf1tm1Tyj
Tg(Postn-cre)1Sjc/0
involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ
|
abnormal neural crest cell morphology |
J:131914
|
|
normal
neoplasm |
J:131914
|
|
premature death |
J:131914
|
Nf1tm1Tyj/Nf1+
involves: 129S2/SvPas
|
abnormal mast cell physiology |
J:142439
|
|
increased mast cell degranulation |
J:142439
|
Nf1tm1Tyj/Nf1+
involves: 129S2/SvPas * C57BL/6
|
increased adrenal gland tumor incidence |
J:18542
|
|
increased fibrosarcoma incidence |
J:18542
|
|
increased hepatoma incidence |
J:18542
|
|
increased leukemia incidence |
J:18542
|
|
increased lung adenocarcinoma incidence |
J:18542
|
|
increased lymphoma incidence |
J:18542
|
|
increased neurofibrosarcoma incidence |
J:18542
|
|
increased pheochromocytoma incidence |
J:18542
|
|
increased tumor incidence |
J:18542
|
Nf1tm1Tyj/Nf1+
involves: 129S2/SvPas * C57BL/6J
|
abnormal spatial learning |
J:38703
|
Nf1tm1Tyj/Nf1tm1Tyj
involves: 129S2/SvPas
|
abnormal neural crest cell morphology |
J:131914
|
Nf1tm1Tyj/Nf1tm1Tyj
involves: 129S2/SvPas * C57BL/6
|
abnormal myocardium layer morphology |
J:18542
|
|
distended pericardium |
J:18542
|
|
double outlet right ventricle |
J:18542
|
|
embryonic lethality during organogenesis, complete penetrance |
J:18542
|
|
hydrops fetalis |
J:18542
|
|
pallor |
J:18542
|
Nf1tm1Tyj/Nf1tm2Tyj
chimera involves: 129S2/SvPas
|
abnormal muscle morphology |
J:58876
|
|
increased neurofibroma incidence |
J:58876
|
|
no abnormal phenotype detected |
J:58876
|
|
postnatal lethality, complete penetrance |
J:58876
|
Nf1tm2.1Kest/Nf1tm2.1Kest
involves: 129S4/SvJaeSor * C57BL/6 * C57BL/6NTac
|
no abnormal phenotype detected |
J:234172
|
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