Nf1^tm2Tyj
Targeted Allele Detail

Summary

• Symbol: Nf1^tm2Tyj
• Name: neurofibromin 1; targeted mutation 2, Tyler Jacks
• MGI ID: MGI:1926954
• Synonyms: Nf1^-
• Gene: Nf1 Location: Chr11:79230519-79472438 bp, + strand Genetic Position: Chr11, 46.74 cM, cytoband B4-5
• Alliance: Nf1^tm2Tyj page

Mutation origin

• Mouse Generated: Earliest citation of chimera generation: J:58876
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A hygromycin resistance cassette replaced the first 42 codons of exon 31, the exon 31 splice acceptor site, and approximately 2 kb of intron 30. This allele is identical to Nf1^tm1Tyj except that a hygromycin cassette was used instead of a neomycin cassette. This targeting event occurred in ES cells already containing the Nf1^tm1Tyj allelle. (J:58876)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Nf1^tm2Tyj

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nf1 Mutation: 157 strains or lines available

References

• Original: J:58876 Cichowski K, et al., Mouse models of tumor development in neurofibromatosis type 1. Science. 1999 Dec 10;286(5447):2172-6
• All: 1 reference(s)