All Phenotypes Nf1<tm2Tyj> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Nf1^tm2Tyj
targeted mutation 2, Tyler Jacks
MGI:1926954

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Nf1^tm1Tyj/Nf1^tm2Tyj	chimera involves: 129S2/SvPas	MGI:5313434

Allelic Composition	Nf1^tm1Tyj/Nf1^tm2Tyj
Genetic Background	chimera involves: 129S2/SvPas

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nf1^tm1Tyj mutation (3 available); any Nf1 mutation (157 available)
Nf1^tm2Tyj mutation (0 available); any Nf1 mutation (157 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:58876 )

• mice exhibiting a high degree of chimerism are all dead by one month of age

muscle

abnormal muscle morphology ( J:58876 )

• mice exhibiting a moderate degree of chimerism exhibit muscle dysplasia

normal phenotype

no abnormal phenotype detected ( J:58876 )

• mice exhibiting a low degree of chimerism exhibit normal pathology

neoplasm

increased neurofibroma incidence ( J:58876 )

• mice exhibiting a moderate degree of chimerism exhibit an increased incidence of neurofibromas; plexiform neurofibromas only, no dermal neurofibromas

nervous system

increased neurofibroma incidence ( J:58876 )

• mice exhibiting a moderate degree of chimerism exhibit an increased incidence of neurofibromas; plexiform neurofibromas only, no dermal neurofibromas

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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