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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Chat
choline O-acetyltransferase
MGI:88392
35 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
\Aplp2tm1Dbo/\Aplp2tm1Dbo
\Apptm1.1Zhe/\Apptm1.1Zhe
\Chattm2(cre)Lowl/\Chat+
involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6J 		abnormal neuromuscular synapse morphology J:152457
\Brsk2tm2.1Jrs/\Brsk2tm2.1Jrs
\Chattm1(cre)Lowl/\Chat+
involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ 		normal nervous system phenotype J:201695
\Chattm2(cre)Lowl/\Chat+
\Mecp2tm2Bird/Y
involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J 		abnormal respiration J:241788
apnea J:241788
normal behavior/neurological phenotype J:241788
normal cardiovascular system phenotype J:241788
normal homeostasis/metabolism phenotype J:241788
\Chattm2(cre)Lowl/\Chat+
\Gt(ROSA)26Sortm9(CAG-tdTomato)Hze/\Gt(ROSA)26Sor+
\Sema6aGt(KST069)Byg/\Sema6aGt(KST069)Byg
involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6NCr 		abnormal inhibitory postsynaptic currents J:202884
\Chattm2(cre)Lowl/\Chat+
\Mapttm3(Sema3e)Arbr/\Mapttm3(Sema3e)Arbr
involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 		abnormal motor neuron innervation pattern J:149553
normal behavior/neurological phenotype J:149553
\Chattm2(cre)Lowl/\Chat+
\Plxna2tm1a(EUCOMM)Wtsi/\Plxna2tm1Hfu
involves: 129S6/SvEvTac * C57BL/6N * CBA/JNCrlj 		abnormal amacrine cell morphology J:202884
abnormal dendrite morphology J:202884
abnormal retina inner plexiform layer morphology J:202884
\Chattm2(cre)Lowl/\Chat+
\Mapttm2(FUS)Neas/\Mapt+
B6.129-Mapttm2(FUS)Neas Chattm2(cre)Lowl 		abnormal neuromuscular synapse morphology J:232167
motor neuron degeneration J:232167
\Chattm2(cre)Lowl/\Chat+
\Mapttm3(FUS)Neas/\Mapt+
B6.129-Mapttm3(FUS)Neas Chattm2(cre)Lowl 		abnormal neuromuscular synapse morphology J:232167
motor neuron degeneration J:232167
\Chattm2(cre)Lowl/\Chat+
\Cpeb2tm1.1Yshu/\Cpeb2tm1.1Yshu
involves: C57BL/6 * C57BL/6J * C57BL/6NJ * SJL/J 		abnormal breathing pattern J:237513
abnormal whole-body plethysmography J:237513
apnea J:237513
decreased pulmonary respiratory rate J:237513
increased acetylcholine level J:237513
increased airway responsiveness J:237513
increased brain choline acetyltransferase activity J:237513
\Chattm2(cre)Lowl/\Chat+
\Stmn2em2Jmi/\Stmn2em2Jmi
involves: 129S6/SvEvTac * C57BL/6J * C57BL/6N 		abnormal neuromuscular synapse morphology J:337175
abnormal neuron morphology J:337175
decreased grip strength J:337175
preweaning lethality, incomplete penetrance J:337175
\Fustm1a(EUCOMM)Wtsi/\Fustm1c(EUCOMM)Wtsi
\Chattm2(cre)Lowl/\Chat+
involves: 129S6/SvEvTac * C3H * C57BL/6 * C57BL/6N 		normal nervous system phenotype J:232167
\Mc4rtm1Lowl/\Mc4rtm1Lowl
\Chattm1(cre)Lowl/\Chat+
involves: 129S4/SvJae * 129S6/SvEvTac 		hypertension J:193452
increased circulating insulin level J:193452
\Mc4rtm2Lowl/\Mc4rtm2Lowl
\Chattm1(cre)Lowl/\Chat+
\Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/\Gt(ROSA)26Sor+
involves: 129S6/SvEvTac * C57BL/6NCr 		abnormal nervous system electrophysiology J:193452
normal nervous system phenotype J:193452
\Mecp2tm1Jae/Y
\Chattm2(cre)Lowl/\Chat+
involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6 * C57BL/6J 		abnormal heartbeat J:241788
normal behavior/neurological phenotype J:241788
decreased body temperature J:241788
decreased heart rate J:241788
increased heart rate variability J:241788
increased response of heart to induced stress J:241788
premature death J:241788
prolonged QT interval J:241788
normal respiratory system phenotype J:241788
ventricular premature beat J:241788
ventricular tachycardia J:241788
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory