Stmn2^em2Jmi
Endonuclease-mediated Allele Detail

Summary

• Symbol: Stmn2^em2Jmi
• Name: stathmin-like 2; endonuclease-mediated mutation 2, Jeffrey Milbrandt
• MGI ID: MGI:7494070
• Synonyms: Stmn2^fl
• Gene: Stmn2 Location: Chr3:8574587-8626664 bp, + strand Genetic Position: Chr3, 2.15 cM
• Alliance: Stmn2^em2Jmi page

Mutation origin

• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Endonuclease-mediated (Conditional ready)
• Mutation: Insertion
• CRISPR/Cas9 genome editing technology was used to generate loxP site insertions flanking exon 3. (J:337175)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Stmn2 Mutation: 41 strains or lines available

References

• Original: J:337175 Krus KL, et al., Loss of Stathmin-2, a hallmark of TDP-43-associated ALS, causes motor neuropathy. Cell Rep. 2022 Jun 28;39(13):111001
• All: 1 reference(s)