App^tm1.1Zhe
Targeted Allele Detail

Summary

• Symbol: App^tm1.1Zhe
• Name: amyloid beta precursor protein; targeted mutation 1.1, Hui Zheng
• MGI ID: MGI:4359011
• Gene: App Location: Chr16:84751236-84972187 bp, - strand Genetic Position: Chr16, 46.92 cM, cytoband C3-qter
• Alliance: App^tm1.1Zhe page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:152457
• Parent Cell Line: AB2.2 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Exon 3 was floxed. The floxed neo cassette inserted into intron 2 was removed by germ line, cre mediated recombination. (J:152457)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any App Mutation: 89 strains or lines available

References

• Original: J:152457 Wang Z, et al., Presynaptic and postsynaptic interaction of the amyloid precursor protein promotes peripheral and central synaptogenesis. J Neurosci. 2009 Sep 2;29(35):10788-801
• All: 4 reference(s)