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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Ncstn
nicastrin
MGI:1891700
57 phenotypes from 7 alleles in 9 genetic backgrounds
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Allelic Composition
Genetic Background
Annotated Term Reference
Ncstntm1.1Akli/Ncstntm1.1Akli
Tg(Mx1-cre)1Cgn/0
involves: 129 * C57BL/6 * CBA * SJL
abnormal definitive hematopoiesis J:172442
abnormal hematopoietic stem cell morphology J:172442
abnormal spleen morphology J:172442
enlarged spleen J:172442
increased hematopoietic stem cell number J:172442
increased leukemia incidence J:172442
increased leukocyte cell number J:172442
increased monocyte cell number J:172442
increased spleen red pulp amount J:172442
premature death J:172442
Ncstntm1.1Akli/Ncstntm1.1Akli
Tg(Upk2-cre,-EGFP)#Akli/0
involves: 129
hydronephrosis J:227748
increased urinary bladder carcinoma incidence J:227748
ureter obstruction J:227748
Ncstntm1.1Akli/Ncstntm1.1Akli
Tg(VAV1-cre)1Graf/0
involves: 129
abnormal splenocyte physiology J:196407
enlarged spleen J:196407
premature death J:196407
Ncstntm1.1Akli/Ncstntm1.1Akli
Tg(VAV1-cre)1Graf/0
involves: 129 * C57BL/6 * SJL
abnormal definitive hematopoiesis J:172442
abnormal hematopoietic stem cell morphology J:172442
abnormal spleen morphology J:172442
enlarged spleen J:172442
increased hematopoietic stem cell number J:172442
increased leukemia incidence J:172442
increased leukocyte cell number J:172442
increased monocyte cell number J:172442
increased spleen red pulp amount J:172442
premature death J:172442
Ncstntm1.1Sud/Ncstntm1.1Sud
Olig1tm1(cre)Rth/Olig1+
involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ
abnormal coat appearance J:234705
decreased myelin sheath thickness J:234705
decreased prepulse inhibition J:234705
dysmyelination J:234705
hyperactivity J:234705
increased exploration in new environment J:234705
increased grooming behavior J:234705
increased stereotypic behavior J:234705
skin lesions J:234705
Ncstntm1.1Sud/Ncstntm1.1Sud
Tg(Camk2a-cre)1Shn/0
B6.Cg-Ncstntm1.1Sud Tg(Camk2a-cre)1Shn
abnormal dendrite morphology J:149506
abnormal spatial learning J:149506
astrocytosis J:149506
normal behavior/neurological phenotype J:149506
decreased CNS synapse formation J:149506
gliosis J:149506
impaired contextual conditioning behavior J:149506
impaired spatial working memory J:149506
increased neuron apoptosis J:149506
loss of cortex neurons J:149506
normal nervous system phenotype J:149506
thin cerebral cortex J:149506
Ncstntm1.2Sud/Ncstntm1.2Sud
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL
embryonic lethality, complete penetrance J:149506
Ncstntm1Jli/Ncstntm1Jli
involves: 129S5/SvEvBrd * C57BL/6
abnormal somite development J:85205
embryonic lethality, complete penetrance J:85205
Ncstntm1Pcw/Ncstntm1Pcw
involves: 129X1/SvJ * C57BL/6
abnormal cell physiology J:83376
abnormal heart development J:83376
abnormal neural tube morphology J:83376
abnormal vitelline vasculature morphology J:83376
caudal body truncation J:83376
distended pericardium J:83376
embryonic growth retardation J:83376
embryonic lethality during organogenesis, complete penetrance J:83376
failure of heart looping J:83376
failure of somite differentiation J:83376
kinked neural tube J:83376
small heart J:83376
Ncstntm1Rroz/Ncstntm1Rroz
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
abnormal first pharyngeal arch morphology J:108976
abnormal neural crest morphology J:108976
abnormal optic vesicle formation J:108976
abnormal rostral-caudal body axis extension J:108976
abnormal somite development J:108976
abnormal vitelline vasculature morphology J:108976
decreased embryo size J:108976
embryonic lethality during organogenesis, complete penetrance J:108976
increased apoptosis J:108976
increased embryonic neuroepithelium apoptosis J:108976
kinked neural tube J:108976
Ncstntm1Sud/Ncstntm1Sud
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
no abnormal phenotype detected J:149506

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/16/2024
MGI 6.23
The Jackson Laboratory