Ncstn^tm1Jli
Targeted Allele Detail

Summary

• Symbol: Ncstn^tm1Jli
• Name: nicastrin; targeted mutation 1, Jinhe Li
• MGI ID: MGI:2675667
• Synonyms: Nicastrin^-
• Gene: Ncstn Location: Chr1:171893580-171910356 bp, - strand Genetic Position: Chr1, 79.54 cM
• Alliance: Ncstn^tm1Jli page

Abnormally segmented somite pairs in Ncstn^tm1Jli/Ncstn^tm1Jli mice

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:85205
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S5/SvEvBrd

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Beginning 3 nucleotides upstream of the translation initiation codon, 1530 bases were replaced with an IRESlacZ/MC1neo cassette. This replaced genomic sequence starting in exon 1 and extending through part of intron 2, deleting the first 63 amino acids of the protein product. (J:85205)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ncstn Mutation: 36 strains or lines available

References

• Original: J:85205 Li J, et al., Positive and negative regulation of the gamma-secretase activity by nicastrin in a murine model. J Biol Chem. 2003 Aug 29;278(35):33445-9
• All: 1 reference(s)