Dnmt3a Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Dnmt3a
DNA methyltransferase 3A
MGI:1261827

33 phenotypes from 8 alleles in 7 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Alpl^tm1(cre)Nagy/Alpl⁺ Dnmt3a^tm3.1Enl/Dnmt3a^tm3.2Enl involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ	azoospermia	J:91108
	decreased testis weight	J:91108
	female infertility	J:91108
	male infertility	J:91108
Dnmt3a^tm1.1Jae/Dnmt3a^tm1.1Jae involves: 129S4/SvJae * C57BL/6	decreased body size	J:121563
	postnatal lethality, complete penetrance	J:121563
Dnmt3a^{tm1a(KOMP)Wtsi}/Dnmt3a^{tm1a(KOMP)Wtsi} C57BL/6N-Dnmt3a^{tm1a(KOMP)Wtsi}/Wtsi	increased grip strength	J:211773
Dnmt3a^{tm1b(KOMP)Wtsi}/Dnmt3a⁺ C57BL/6N-Dnmt3a^{tm1b(KOMP)Wtsi}/J	abnormal bone structure	J:211773
	convulsive seizures	J:211773
	decreased circulating cholesterol level	J:211773
	decreased circulating glucose level	J:211773
	decreased circulating HDL cholesterol level	J:211773
	decreased lean body mass	J:211773
	increased total body fat amount	J:211773
Dnmt3a^{tm1b(KOMP)Wtsi}/Dnmt3a^{tm1b(KOMP)Wtsi} C57BL/6N-Dnmt3a^{tm1b(KOMP)Wtsi}/J	abnormal embryo size	J:211773
	preweaning lethality, incomplete penetrance	J:211773
Dnmt3a^tm1Enl/Dnmt3a^tm1Enl involves: 129S4/SvJae * C57BL/6	postnatal growth retardation	J:58298
Dnmt3a^tm1Enl/Dnmt3a^tm1Enl involves: 129S4/SvJae * C57BL/6	premature death	J:58298
Dnmt3a^tm1Jae/Dnmt3a^tm1Jae Tg(Nes-cre)1Atp/0 involves: 129S4/SvJae * C57BL/6 * FVB/N	abnormal gait	J:121563
	abnormal neuromuscular synapse morphology	J:121563
	decreased body weight	J:121563
	decreased exploration in new environment	J:121563
	decreased grip strength	J:121563
	decreased locomotor activity	J:121563
	decreased motor neuron number	J:121563
	normal homeostasis/metabolism phenotype	J:121563
	impaired coordination	J:121563
	normal muscle phenotype	J:121563
	normal nervous system phenotype	J:121563
	premature death	J:121563
Dnmt3a^tm1Trow/Dnmt3a⁺ Tg(Mx1-cre)1Cgn/0 B6.Cg-Dnmt3a^tm1Trow Tg(Mx1-cre)1Cgn	abnormal bone marrow hematopoietic cell morphology	J:272803
	abnormal multipotent stem cell morphology	J:272803
	increased common myeloid progenitor cell number	J:272803
	increased hematopoietic stem cell number	J:272803
Dnmt3a^tm3.2Enl/Dnmt3a^tm3.2Enl involves: 129S4/SvJae	postnatal growth retardation	J:91108
Dnmt3a^tm3.2Enl/Dnmt3a^tm3.2Enl involves: 129S4/SvJae	premature death	J:91108

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/23/2024 MGI 6.23