About   Help   FAQ
Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Dnmt3a
DNA methyltransferase 3A
MGI:1261827
81 phenotypes from 11 alleles in 10 genetic backgrounds
Export: Excel File
Allelic Composition
Genetic Background		 Annotated Term Reference
Alpltm1(cre)Nagy/Alpl+
Dnmt3atm3.1Enl/Dnmt3atm3.2Enl
involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ 		azoospermia J:91108
decreased testis weight J:91108
female infertility J:91108
male infertility J:91108
Dnmt3aem1Hsas/Dnmt3a+
C57BL/6J-Dnmt3aem1Hsas 		abnormal imprinting J:349016
prenatal lethality, incomplete penetrance J:349016
Dnmt3aem1Hsas/Dnmt3aem1Hsas
C57BL/6J-Dnmt3aem1Hsas 		abnormal DNA methylation during gametogenesis J:347433, J:349016
abnormal imprinting J:347433, J:349016
abnormal parturition J:349016
abnormal pregnancy J:349016
prenatal lethality, incomplete penetrance J:349016
Dnmt3aem1Hwg/Dnmt3a+
B6.Cg-Dnmt3aem1Hwg 		abnormal brain morphology J:348795
abnormal brain white matter morphology J:348795
abnormal cranium morphology J:348795
abnormal response to novel object J:348795
abnormal skeleton physiology J:348991
normal behavior/neurological phenotype J:348795
decreased bone stiffness J:348991
decreased brain size J:348795
decreased femur compact bone thickness J:348991
decreased femur maximal load J:348991
decreased femur yield load J:348991
decreased vocalization J:348795
increased body fat mass J:348795
increased length of long bones J:348795
increased long bone epiphyseal plate size J:348991
increased susceptibility to diet-induced obesity J:348795
long tibia J:348991
obese J:348795
thin cerebral cortex J:348795
Dnmt3atm1.1Jae/Dnmt3atm1.1Jae
involves: 129S4/SvJae * C57BL/6 		decreased body size J:121563
postnatal lethality, complete penetrance J:121563
Dnmt3atm1.1Rlvn/Dnmt3a+
B6(C)-Dnmt3atm1.1Rlvn 		abnormal associative learning J:348795
abnormal bone marrow adipose tissue morphology J:348991
abnormal bone marrow cavity morphology J:348991
abnormal brain morphology J:348795
abnormal brain ventricle morphology J:348795
abnormal cranium morphology J:321204
abnormal motor capabilities/coordination/movement J:321204
abnormal response to novel object J:348795
abnormal social/conspecific interaction behavior J:348795
abnormal tibia morphology J:348991
normal behavior/neurological phenotype J:321204
decreased body weight J:348991
decreased brain size J:348795
decreased femur compact bone thickness J:348991
decreased food intake J:321204
decreased lean body mass J:348991
decreased respiratory quotient J:321204
decreased vertical activity J:321204
decreased vocalization J:348795
dystocia J:321204
enhanced contextual conditioning behavior J:321204
enhanced cued conditioning behavior J:321204
normal homeostasis/metabolism phenotype J:321204
hypoactivity J:321204
increased acute myeloid leukemia incidence J:321204
increased body height J:321204
increased body size J:321204
increased body weight J:321204, J:348991
increased classified tumor incidence J:321204
increased leukemia incidence J:321204
increased long bone epiphyseal plate size J:348991
increased stereotypic behavior J:321204
increased susceptibility to diet-induced obesity J:321204
increased total body fat amount J:321204
large mandible J:321204
long femur J:321204
long tibia J:348991
obese J:321204
thin cerebral cortex J:348795
Dnmt3atm1.1Rlvn/Dnmt3atm1.1Rlvn
B6(C)-Dnmt3atm1.1Rlvn 		decreased birth body size J:321204
postnatal lethality, complete penetrance J:321204
Dnmt3atm1a(KOMP)Wtsi/Dnmt3atm1a(KOMP)Wtsi
C57BL/6N-Dnmt3atm1a(KOMP)Wtsi/Wtsi 		increased grip strength J:211773
Dnmt3atm1b(KOMP)Wtsi/Dnmt3a+
C57BL/6N-Dnmt3atm1b(KOMP)Wtsi/J 		abnormal bone structure J:211773
convulsive seizures J:211773
decreased circulating cholesterol level J:211773
decreased circulating glucose level J:211773
decreased circulating HDL cholesterol level J:211773
decreased exploration in new environment J:211773
decreased lean body mass J:211773
increased total body fat amount J:211773
Dnmt3atm1b(KOMP)Wtsi/Dnmt3atm1b(KOMP)Wtsi
C57BL/6N-Dnmt3atm1b(KOMP)Wtsi/J 		abnormal embryo size J:211773
preweaning lethality, incomplete penetrance J:211773
Dnmt3atm1Enl/Dnmt3atm1Enl
involves: 129S4/SvJae * C57BL/6 		postnatal growth retardation J:58298
premature death J:58298
Dnmt3atm1Jae/Dnmt3atm1Jae
Tg(Nes-cre)1Atp/0
involves: 129S4/SvJae * C57BL/6 * FVB/N 		abnormal gait J:121563
abnormal neuromuscular synapse morphology J:121563
decreased body weight J:121563
decreased exploration in new environment J:121563
decreased grip strength J:121563
decreased locomotor activity J:121563
decreased motor neuron number J:121563
normal homeostasis/metabolism phenotype J:121563
impaired coordination J:121563
normal muscle phenotype J:121563
normal nervous system phenotype J:121563
premature death J:121563
Dnmt3atm1Trow/Dnmt3a+
Tg(Mx1-cre)1Cgn/0
B6.Cg-Dnmt3atm1Trow Tg(Mx1-cre)1Cgn 		abnormal bone marrow hematopoietic cell morphology J:272803
abnormal multipotent stem cell morphology J:272803
increased common myeloid progenitor cell number J:272803
increased hematopoietic stem cell number J:272803
Dnmt3atm3.2Enl/Dnmt3atm3.2Enl
involves: 129S4/SvJae 		postnatal growth retardation J:91108
premature death J:91108
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory