Dnmt3a^tm1Jae
Targeted Allele Detail

Summary

• Symbol: Dnmt3a^tm1Jae
• Name: DNA methyltransferase 3A; targeted mutation 1, Rudolf Jaenisch
• MGI ID: MGI:3711072
• Synonyms: Dnmt3a^2lox, Dnmt3a^F
• Gene: Dnmt3a Location: Chr12:3856007-3964443 bp, + strand Genetic Position: Chr12, 1.99 cM, cytoband A2-A3
• Alliance: Dnmt3a^tm1Jae page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:121563
• Parent Cell Line: v6.5 (ES Cell)
• Strain of Origin: (C57BL/6 x 129S4/SvJae)F1

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: An FRT-flanked neomycin resistance gene was inserted into intron 17 and loxP sites were inserted into introns 17 and 20. The neo was removed via flp recombinase expression. (J:121563)

Expression

In Mice Carrying this Mutation:	104036 assay results 2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	1 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Dnmt3a^tm1Jae

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Dnmt3a Mutation: 138 strains or lines available

References

• Original: J:121563 Nguyen S, et al., Ablation of de novo DNA methyltransferase Dnmt3a in the nervous system leads to neuromuscular defects and shortened lifespan. Dev Dyn. 2007 Jun;236(6):1663-76
• All: 20 reference(s)