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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Sox17
SRY (sex determining region Y)-box 17
MGI:107543
68 phenotypes from 8 alleles in 17 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Sox17SHIVA/Sox17+
either: C57BL/6-Sox17SHIVA or (involves: C57BL/6 * C3H/HeN) 		abnormal enzyme/coenzyme level J:219119
abnormal lipid metabolism J:219119
abnormal metabolism J:219119
abnormal peroxisome morphology J:219119
decreased birth body size J:219119
decreased circulating HDL cholesterol level J:219119
decreased circulating ketone body level J:219119
decreased fasting circulating glucose level J:219119
decreased liver triglyceride level J:219119
ovary atrophy J:219119
reduced female fertility J:219119
Sox17tm1.1Nat/Sox17tm1.1Nat
involves: 129 * C57BL/6 * SJL 		no abnormal phenotype detected J:101977
Sox17tm1Jaw/Sox17tm1Jaw
Tg(Foxa3-cre)1Khk/0
involves: 129S6/SvEvTac * C57BL/6 * DBA 		abnormal bile duct development J:151981
abnormal common bile duct morphology J:151981
absent gallbladder J:151981
Sox17tm1Jaw/Sox17tm1Jaw
Tg(Pdx1-cre)6Tuv/0
involves: 129S6/SvEvTac * FVB/N 		abnormal bile duct development J:151981
Sox17tm1Jaw/Sox17tm1Sjm
Tg(Foxa3-cre)1Khk/0
involves: 129 * C57BL/6 * DBA 		abnormal bile duct development J:151981
Sox17tm1Jaw/Sox17tm1Sjm
Tg(Pdx1-cre)6Tuv/0
involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * FVB/N 		abnormal bile duct development J:151981
absent gallbladder J:151981
Sox17tm1Sjm/Sox17tm1Sjm
BKa.129-Sox17tm1Sjm 		abnormal embryo turning J:123050
abnormal embryonic hematopoiesis J:123050
abnormal rostral-caudal axis patterning J:123050
decreased hematopoietic stem cell number J:123050
embryonic growth retardation J:123050
embryonic lethality during organogenesis, complete penetrance J:123050
liver hypoplasia J:123050
Sox17tm1Sjm/Sox17tm1Sjm
involves: 129S1/Sv * 129X1/SvJ 		abnormal bile duct development J:151981
absent pancreas J:151981
Sox17tm1Sjm/Sox17tm2Sjm
Tg(Mx1-cre)1Cgn/0
involves: 129/Sv * C3H * C57BL/6 * C57BL/Ka * CBA 		decreased bone marrow cell number J:123050
decreased hematopoietic stem cell number J:123050
decreased leukocyte cell number J:123050
postnatal lethality, complete penetrance J:123050
spleen hypoplasia J:123050
thrombocytopenia J:123050
thymus hypoplasia J:123050
Sox17tm1Sjm/Sox17tm2Sjm
Tg(Tek-cre)12Flv/0
involves: 129S1/Sv * 129X1/SvJ * C3H * C57BL/6 * C57BL/Ka 		abnormal embryonic hematopoiesis J:123050
embryonic growth retardation J:123050
embryonic lethality during organogenesis, complete penetrance J:123050
Sox17tm1Ysk/Sox17+
B6.129S1-Sox17tm1Ysk 		abnormal bile duct development J:194071
abnormal extrahepatic bile duct morphology J:194071
abnormal gallbladder epithelium morphology J:194071, J:241569
abnormal gallbladder morphology J:194071, J:241569
abnormal gallbladder physiology J:241569
abnormal gallbladder smooth muscle morphology J:241569
abnormal hepatocyte morphology J:194071
abnormal liver development J:194071
abnormal liver lobule morphology J:194071
biliary atresia J:241569
cholestasis J:194071, J:241569
decreased liver weight J:194071
extrahepatic cholestasis J:194071
gallbladder inflammation J:241569
increased bile salt level J:194071
increased circulating alanine transaminase level J:194071
increased circulating alkaline phosphatase level J:194071
liver inflammation J:194071
neonatal lethality, incomplete penetrance J:241569
perinatal lethality, incomplete penetrance J:194071
small gallbladder J:241569
Sox17tm1Ysk/Sox17+
involves: 129S1/Sv * C57BL/6 		abnormal extrahepatic bile duct morphology J:194071
abnormal gallbladder morphology J:194071
liver inflammation J:194071
Sox17tm1Ysk/Sox17tm1Ysk
involves: 129S1/Sv 		abnormal endoderm development J:75946
abnormal foregut morphology J:75946
abnormal hindgut morphology J:75946
abnormal midgut morphology J:75946
abnormal rostral-caudal axis patterning J:75946
embryonic lethality during organogenesis, complete penetrance J:75946
failure of initiation of embryo turning J:75946
thin endoderm J:75946
Sox17tm2.1(icre)Heli/Sox17tm2.1(icre)Heli
involves: 129S6/SvEvTac * C57BL/6 * SJL 		no abnormal phenotype detected J:155991
Sox17tm2Sjm/Sox17+
Tg(Pdx1-cre)6Tuv/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N 		abnormal cystic duct morphology J:241569
abnormal gallbladder epithelium morphology J:241569
abnormal gallbladder size J:241569
abnormal liver morphology J:241569
biliary atresia J:241569
cholestasis J:241569
liver inflammation J:241569
Sox17tm2Sjm/Sox17tm2Sjm
Tg(Cdh5-cre/ERT2)1Rha/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J 		abnormal abdominal aorta morphology J:234137
abnormal artery morphology J:234137
abnormal blood vessel endothelium morphology J:234137
abnormal thoracic aorta morphology J:234137
abnormal vascular smooth muscle morphology J:234137
aneurysm J:234137
aortic dissection J:234137
decreased endothelial cell proliferation J:234137
hemorrhage J:234137
increased vascular permeability J:234137
Sox17tm3.1Heli/Sox17tm3.1Heli
B6.Cg-Sox17tm3.1Heli 		no abnormal phenotype detected J:185482
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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04/23/2024
MGI 6.23 		The Jackson Laboratory