Sox17^SHIVA
Chemically induced Allele Detail

Summary

• Symbol: Sox17^SHIVA
• Name: SRY (sex determining region Y)-box 17; Seric and Hepatic Impaired VAnin
• MGI ID: MGI:5751535
• Gene: Sox17 Location: Chr1:4561154-4567577 bp, - strand Genetic Position: Chr1, 1.65 cM
• Alliance: Sox17^SHIVA page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: ENU mutagenesis induced a T to G substitution leading to a Met72 to Arg change in the DNA binding region of the alpha 1 helix of the HMG domain of Sox17. qRT-PCR and immunoprecipitation confirmed protein expression in adult liver. (J:219119)
• Inheritance: Dominant

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sox17 Mutation: 28 strains or lines available

References

• Original: J:219119 Rommelaere S, et al., Sox17 regulates liver lipid metabolism and adaptation to fasting. PLoS One. 2014;9(8):e104925
• All: 3 reference(s)