Sox17tm2.1(icre)Heli
Targeted Allele Detail
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Symbol: |
Sox17tm2.1(icre)Heli |
Name: |
SRY (sex determining region Y)-box 17; targeted mutation 2.1, Heiko Lickert |
MGI ID: |
MGI:4418897 |
Synonyms: |
Sox17- 2Aicre, Sox172A-iCre, Sox17-2A-iCre, Sox172A-iCredeltaneo, Sox17tm2.1(icre)Lic |
Gene: |
Sox17 Location: Chr1:4561154-4567577 bp, - strand Genetic Position: Chr1, 1.65 cM
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Alliance: |
Sox17tm2.1(icre)Heli page
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Allele Type: |
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Targeted (Recombinase) |
Mutations: |
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Insertion, Intragenic deletion
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Sox17tm2.1(icre)Heli expression driven by
1 gene
Knock-in expression driven by:
Organism |
Driver Gene |
Note |
mouse |
Sox17 (MGI:107543) |
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Mutation details: The Sox17 translational stop codon in exon 5 was replaced by a T2A (Thosea asigna virus, TaV) self-cleaving peptide followed by the improved Cre (iCre) for the efficient and equimolar translation of Sox17 and icre. Sox17 and icre are postranslationally cleaved by a 2A-mediated ribosome-skipping mechanism. The FRT-flanked neo selection cassette was subsequently deleted in the germline by FLP-mediated recombination.
(J:155991)
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Generation of the Sox17tm2.1(icre)Heli allele |
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Activity: |
Tissue activity of this recombinase allele
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Driver:
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Sox17
(mouse)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Sox17 Mutation: |
28 strains or lines available
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Original: |
J:155991 Engert S, et al., Sox17-2A-iCre: a knock-in mouse line expressing Cre recombinase in endoderm and vascular endothelial cells. Genesis. 2009 Sep;47(9):603-10 |
All: |
17 reference(s) |
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