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Irf8 Gene Detail
Summary
  • Symbol
    Irf8
  • Name
    interferon regulatory factor 8
  • Synonyms
    ICSBP, Icsbp1, IRF-8, Myls
  • Feature Type
    protein coding gene
  • IDs
    MGI:96395
    NCBI Gene: 15900
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
  • Regulated by
    Rr174, Rr172, Rr173 ... (4 regulatory regions)
Location &
Maps
more
  • Sequence Map
    Chr8:121463097-121483433 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 70.05 cM
  • Mapping Data
    13 experiments
Strain
Comparison
more
  • SNPs within 2kb
    562 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96395
 protein coding gene Chr8:121463097-121483433 (+)
129S1/SvImJ MGP_129S1SvImJ_G0034206
 protein coding gene Chr8:124187579-124209006 (+)
A/J MGP_AJ_G0034186
 protein coding gene Chr8:119026234-119046564 (+)
AKR/J MGP_AKRJ_G0034113
 protein coding gene Chr8:122496932-122517268 (+)
BALB/cJ MGP_BALBcJ_G0034180
 protein coding gene Chr8:119242237-119263173 (+)
C3H/HeJ MGP_C3HHeJ_G0033891
 protein coding gene Chr8:123228482-123248652 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034700
 protein coding gene Chr8:128318723-128340680 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031642
 protein coding gene Chr8:111894739-111914837 (+)
CAST/EiJ MGP_CASTEiJ_G0033218
 protein coding gene Chr8:123223585-123243898 (+)
CBA/J MGP_CBAJ_G0033864
 protein coding gene Chr8:133009714-133032226 (+)
DBA/2J MGP_DBA2J_G0034020
 protein coding gene Chr8:118241777-118262004 (+)
FVB/NJ MGP_FVBNJ_G0033963
 protein coding gene Chr8:117318585-117339278 (+)
LP/J MGP_LPJ_G0034109
 protein coding gene Chr8:124308760-124330546 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0034010
 protein coding gene Chr8:135361623-135382973 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034718
 protein coding gene Chr8:122668459-122690095 (+)
PWK/PhJ MGP_PWKPhJ_G0032920
 protein coding gene Chr8:118026211-118046775 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032760
 protein coding gene Chr8:121372637-121398386 (+)
WSB/EiJ MGP_WSBEiJ_G0033334
 protein coding gene Chr8:123405259-123427167 (+)



Homology
more
  • Human Ortholog
    IRF8, interferon regulatory factor 8
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    IRF8, interferon regulatory factor 8
  • Synonyms
    H-ICSBP, ICSBP, ICSBP1, IMD32A, IMD32B, IRF-8
  • Links
    NCBI Gene ID: 3394
    UniProt: Q02556

  • Chr Location
    16q24.1; chr16:85899116-85922609 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Irf8 mouse models; 5 with human IRF8 associations

Human Disease Mouse Models
      
IDs
 View 4 models
      
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    53 phenotypes from 7 alleles in 9 genetic backgrounds
    18 phenotypes from multigenic genotypes
    217 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a targeted null mutation exhibit increased incidence of viral infections, shortened life span, deregulated hematopoiesis, and hematological neoplasias. Heterozygotes show similar, but milder, phenotypes.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    97
  • GO References
    19
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    927
  • Tissues
    174
  • cDNA Data
    95
  • Literature Summary
    15
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 15900 NCBI Gene Model | MGI Sequence Detail 20337 C57BL/6J ±  kb
    transcript NM_001301811 RefSeq | MGI Sequence Detail 3391 ZRU/MplStud  
    polypeptide P23611 UniProt | EBI | MGI Sequence Detail 424 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 101
      Genomic 3
      cDNA 95
      Primer pair 3

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-11151, MGI:2142648, MGI:3574547
    References
    more
    • Summaries
      All 323
      Developmental Gene Expression 15
      Diseases 2
      Gene Ontology 19
      Phenotypes 217
    • Earliest
      J:17559 Driggers PH, et al., An interferon gamma-regulated protein that binds the interferon-inducible enhancer element of major histocompatibility complex class I genes. Proc Natl Acad Sci U S A. 1990 May;87(10):3743-7
    • Latest
      J:372692 Chen J, et al., C/EBPalpha activates Irf8 expression in myeloid progenitors at the +56-kb enhancer to initiate cDC1 development. Sci Immunol. 2025 May 16;10(107):eadt5899
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/30/2025
    MGI 6.24     		The Jackson Laboratory