Rr173 Other Genome Feature Detail

Summary

• Symbol
  Rr173
• Name
  regulatory region 173
• Synonyms
  E-box, Irf8 +41

• Feature Type
  enhancer
• IDs
  MGI:6863878
• Regulates expression of
  Irf8, Gm39266 (2 regulated genes)

Location &
Maps

• Sequence Map
  Chr8:121503787-121504483 bp

  From MGI annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI
• J:279982 Fig.S6b coordinates chr8:120777048-120777744 (GRCm38) chr8:121503787-121504483 (GRCm39)

• Genetic Map
  Chromosome 8, Syntenic

Strain
Comparison

• SNPs within 2kb
  120 from dbSNP Build 142

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  5 phenotype references
  

• All Mutations and Alleles
  1
• Endonuclease-mediated
  1
• Find Mice (IMSR)
  0 strains or lines available

References

• Summaries
  All 7

  Phenotypes 5
• Earliest
  J:279982 Durai V, et al., Cryptic activation of an Irf8 enhancer governs cDC1 fate specification. Nat Immunol. 2019 Sep;20(9):1161-1173
• Latest
  J:372692 Chen J, et al., C/EBPalpha activates Irf8 expression in myeloid progenitors at the +56-kb enhancer to initiate cDC1 development. Sci Immunol. 2025 May 16;10(107):eadt5899

Rr173 regulates expression of:

Feature	Feature Type	Location	Reference
Irf8, interferon regulatory factor 8	protein coding gene	Chr8:121463097-121483433 (+)	J:279982
Gm39266, predicted gene, 39266	lncRNA gene	Chr8:121494202-121495865 (-)	J:355425