Rr172 Other Genome Feature Detail

Summary

• Symbol
  Rr172
• Name
  regulatory region 172
• Synonyms
  AICE, Irf8 +32

• Feature Type
  enhancer
• IDs
  MGI:6863877
• Alliance
  genome feature page
• Regulates expression of
  Irf8 (1 regulated gene)

Location &
Maps

• Sequence Map
  Chr8:121495079-121495626 bp

  From MGI annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI
• chr8:121495079-121495626 (GRCm39)

• Genetic Map
  Chromosome 8, Syntenic

Strain
Comparison

• SNPs within 2kb
  122 from dbSNP Build 142

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  6 phenotypes from multigenic genotypes
  24 phenotype references
  

• All Mutations and Alleles
  2
• Endonuclease-mediated
  2
• Find Mice (IMSR)
  0 strains or lines available

References

• Summaries
  All 26

  Phenotypes 24
• Earliest
  J:279982 Durai V, et al., Cryptic activation of an Irf8 enhancer governs cDC1 fate specification. Nat Immunol. 2019 Sep;20(9):1161-1173
• Latest
  J:386580 Lobb TA, et al., Type I interferon restricts mRNA vaccine efficacy through suppression of antigen uptake in cDCs. NPJ Vaccines. 2026 Jan 5;11(1):41

Rr172 regulates expression of:

Feature	Feature Type	Location	Reference
Irf8, interferon regulatory factor 8	protein coding gene	Chr8:121463097-121483433 (+)	J:279982