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Atf4 Gene Detail
Summary
  • Symbol
    Atf4
  • Name
    activating transcription factor 4
  • Synonyms
    Atf-4, C/ATF, CREB2, TAXREB67
  • Feature Type
    protein coding gene
  • IDs
    MGI:88096
    NCBI Gene: 11911
  • Alliance
    genome feature page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:80139385-80141742 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 37.85 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    134 from dbSNP Build 142
  • Strain Annotations
    19
  • PCR
    1
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88096
 protein coding gene Chr15:80139385-80141746 (+)
129S1/SvImJ ENSMUSG00200052579
 protein coding gene Chr15:77242204-77244561 (+)
A/J ENSMUSG00195043720
 protein coding gene Chr15:77187527-77189884 (+)
AKR/J ENSMUSG00220045317
 protein coding gene Chr15:77230649-77233006 (+)
BALB/cJ ENSMUSG00180052458
 protein coding gene Chr15:77064587-77066944 (+)
C3H/HeJ ENSMUSG00175040245
 protein coding gene Chr15:77375687-77378044 (+)
C57BL/6NJ ENSMUSG00215052020
 protein coding gene Chr15:77149979-77152336 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020037
 protein coding gene Chr15:74276069-74278432 (+)
CAST/EiJ ENSTCUG00005046950
 protein coding gene Chr15:76676306-76678661 (+)
CBA/J ENSMUSG00210047297
 protein coding gene Chr15:77150828-77153185 (+)
DBA/2J ENSMUSG00185049309
 protein coding gene Chr15:77160633-77162990 (+)
FVB/NJ ENSMUSG00205022830
 protein coding gene Chr15:76888077-76890434 (+)
JF1/MsJ ENSUMUG00000054045
 protein coding gene Chr15:76737976-76740333 (+)
LP/J ENSMUSG00230051442
 protein coding gene Chr15:80490583-80492940 (+)
NOD/ShiLtJ ENSMUSG00190037175
 protein coding gene Chr15:77167875-77170232 (+)
NZO/HlLtJ ENSMUSG00225049300
 protein coding gene Chr15:80826730-80829087 (+)
PWK/PhJ ENSLUMG00010038447
 protein coding gene Chr15:76958622-76960979 (+)
SPRET/EiJ ENSMSPG00010047771
 protein coding gene Chr15:78623682-78626048 (+)
WSB/EiJ ENSIUOG00005038510
 protein coding gene Chr15:77234150-77236507 (+)



Homology
more
  • Human Ortholog
    ATF4, activating transcription factor 4
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ATF4, activating transcription factor 4
  • Synonyms
    CREB-2, CREB2, TAXREB67, TXREB
  • Links
    NCBI Gene ID: 468
    UniProt: P18848

  • Chr Location
    22q13.1; chr22:39519695-39522690 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human ATF4 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    69 phenotypes from 12 alleles in 12 genetic backgrounds
    23 phenotypes from multigenic genotypes
    4 images
    150 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for one knock-out allele exhibit postnatal lethality, abnormal lens development, and reduced male fertility. Mice homozygous for a different knock-out allele exhibit abnormal pancreatic and skeletal development, glucose homeostasis, and insulin homeostasis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    208
  • GO References
    41
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    995
  • Tissues
    265
  • cDNA Data
    341
  • Literature Summary
    104
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000042406 Ensembl Gene Model | MGI Sequence Detail 2358 C57BL/6J ±  kb
    transcript ENSMUST00000109605 Ensembl | MGI Sequence Detail 1725 Not Applicable  
    polypeptide ENSMUSP00000105234 Ensembl | MGI Sequence Detail 349 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 356
      cDNA 342
      Primer pair 13
      Other 1
      Antibodies 12

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-1444, MGD-MRK-1445
    References
    more
    • Summaries
      All 425
      Developmental Gene Expression 104
      Diseases 1
      Gene Ontology 41
      Phenotypes 150
    • Earliest
      J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
    • Latest
      J:391329 Duan CH, et al., Loss of Echs1 in neural stem and progenitor cells impairs neurogenesis via ER stress activation and lipid metabolic reprogramming. Nat Commun. 2026 Jul 1;17(1)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory