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Piezo1 Gene Detail
Summary
  • Symbol
    Piezo1
  • Name
    piezo-type mechanosensitive ion channel component 1
  • Synonyms
    Fam38a, Piezo1
  • Feature Type
    protein coding gene
  • IDs
    MGI:3603204
    NCBI Gene: 234839
  • Alliance
    genome feature page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:123208437-123278068 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 71.31 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    2043 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3603204
 protein coding gene Chr8:123208437-123278068 (-)
129S1/SvImJ ENSMUSG00200042042
 protein coding gene Chr8:117539685-117609320 (-)
A/J ENSMUSG00195024159
 protein coding gene Chr8:117829729-117899588 (-)
AKR/J ENSMUSG00220037807
 protein coding gene Chr8:118020897-118090756 (-)
BALB/cJ ENSMUSG00180026531
 protein coding gene Chr8:117875771-117945633 (-)
C3H/HeJ ENSMUSG00175027516
 protein coding gene Chr8:117932642-118002501 (-)
C57BL/6NJ ENSMUSG00215027387
 protein coding gene Chr8:117514414-117584048 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031665
 protein coding gene Chr8:113641274-113714746 (-)
CAST/EiJ ENSTCUG00005032743
 protein coding gene Chr8:117260960-117331101 (-)
CBA/J ENSMUSG00210030772
 protein coding gene Chr8:117866885-117936515 (-)
DBA/2J ENSMUSG00185032348
 protein coding gene Chr8:123971806-124041437 (-)
FVB/NJ ENSMUSG00205031484
 protein coding gene Chr8:116833066-116902689 (-)
JF1/MsJ ENSUMUG00000012853
 protein coding gene Chr8:126272267-126341288 (-)
LP/J ENSMUSG00230027512
 protein coding gene Chr8:127591131-127660766 (-)
NOD/ShiLtJ ENSMUSG00190017185
 protein coding gene Chr8:117967396-118037014 (-)
NZO/HlLtJ ENSMUSG00225041888
 protein coding gene Chr8:130972279-131041933 (-)
PWK/PhJ ENSLUMG00010032971
 protein coding gene Chr8:117677049-117746069 (-)
SPRET/EiJ ENSMSPG00010033977
 protein coding gene Chr8:119868095-119938168 (-)
WSB/EiJ ENSIUOG00005029685
 protein coding gene Chr8:118661440-118731030 (-)



Homology
more
  • Human Ortholog
    PIEZO1, piezo type mechanosensitive ion channel component 1 (Er blood group)
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PIEZO1, piezo type mechanosensitive ion channel component 1 (Er blood group)
  • Synonyms
    DHS, ER, FAM38A, LMPH3, LMPHM6, Mib
  • Links
    NCBI Gene ID: 9780
    UniProt: Q92508

  • Chr Location
    16q24.3; chr16:88715338-88785251 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Piezo1 mouse models; 2 with human PIEZO1 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    54 phenotypes from 7 alleles in 7 genetic backgrounds
    3 images
    161 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Most mice homozygous for a gene trapped allele die at midgestation, exhibiting embryonic growth retardation, pericardial effusion, and vascular remodeling defects in the yolk sac and the embryo proper. The p.S1612A phosphorylation blocking allele affects blood pressure and exercise endurance.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    52
  • GO References
    19
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    759
  • Tissues
    85
  • cDNA Data
    9
  • Literature Summary
    18
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 234839 NCBI Gene Model | MGI Sequence Detail 69632 C57BL/6J ±  kb
    transcript NM_001357349 RefSeq | MGI Sequence Detail 8219 C57BL/6  
    polypeptide E2JF22 UniProt | EBI | MGI Sequence Detail 2547 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 14
      cDNA 9
      Primer pair 5
      Antibodies 3

      Microarray probesets 4
    References
    more
    • Summaries
      All 247
      Developmental Gene Expression 18
      Diseases 1
      Gene Ontology 19
      Phenotypes 161
    • Earliest
      J:86589 McClive PJ, et al., Subtractive hybridisation screen identifies sexually dimorphic gene expression in the embryonic mouse gonad. Genesis. 2003 Oct;37(2):84-90
    • Latest
      J:391377 Nakazawa Y, et al., Verification of the expression of Piezo1 and Piezo2 ion channels in the mouse lens during the embryonic, postnatal and adult growth. Exp Eye Res. 2026 Aug 21;:111208
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory