Sequence Detail

ID/Version

E2JF22 (UniProt | EBI)

Last sequence update: 2010-11-30
Last annotation update: 2024-03-27

Sequence description from provider

RecName: Full=Piezo-type mechanosensitive ion channel component 1;AltName: Full=Protein FAM38A;

Provider

SWISS-PROT

Sequence

Polypeptide 2547 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Piezo1	piezo-type mechanosensitive ion channel component 1	41	100	3	40

Sequence references in MGI

J:143718 Trost M, et al., The phagosomal proteome in interferon-gamma-activated macrophages. Immunity. 2009 Jan;30(1):143-54
J:164433 Coste B, et al., Piezo1 and Piezo2 are essential components of distinct mechanically activated cation channels. Science. 2010 Oct 1;330(6000):55-60
J:197533 Andolfo I, et al., Multiple clinical forms of dehydrated hereditary stomatocytosis arise from mutations in PIEZO1. Blood. 2013 May 9;121(19):3925-35, S1-12
J:212179 Ranade SS, et al., Piezo1, a mechanically activated ion channel, is required for vascular development in mice. Proc Natl Acad Sci U S A. 2014 Jul 15;111(28):10347-52
J:213170 Poole K, et al., Tuning Piezo ion channels to detect molecular-scale movements relevant for fine touch. Nat Commun. 2014;5:3520
J:217082 Li J, et al., Piezo1 integration of vascular architecture with physiological force. Nature. 2014 Nov 13;515(7526):279-82
J:217259 Peyronnet R, et al., Piezo1-dependent stretch-activated channels are inhibited by Polycystin-2 in renal tubular epithelial cells. EMBO Rep. 2013 Dec;14(12):1143-8
J:245270 Coste B, et al., Piezo proteins are pore-forming subunits of mechanically activated channels. Nature. 2012 Feb 19;483(7388):176-81
J:247395 Ge J, et al., Architecture of the mammalian mechanosensitive Piezo1 channel. Nature. 2015 Nov 05;527(7576):64-9
J:262981 Tsuchiya M, et al., Cell surface flip-flop of phosphatidylserine is critical for PIEZO1-mediated myotube formation. Nat Commun. 2018 May 24;9(1):2049
J:273541 Saotome K, et al., Structure of the mechanically activated ion channel Piezo1. Nature. 2018 Feb 22;554(7693):481-486
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:332299 Vaisey G, et al., Piezo1 as a force-through-membrane sensor in red blood cells. Elife. 2022 Dec 14;11