Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes VPS11
  • Mouse genes Vps11
  • Rat genes Vps11
  • Zfish genes vps11
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Vps11

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	VPS11	IPI	UniProtKB:O15400	Human	PMID:11382755
Molecular Function	GO:0005515	protein binding	VPS11	IPI	UniProtKB:Q63615	Human	PMID:11382755
Molecular Function	GO:0005515	protein binding	VPS11	IPI	UniProtKB:Q9H269	Human	PMID:11382755
Molecular Function	GO:0005515	protein binding	VPS11	IPI	UniProtKB:Q9P253	Human	PMID:11382755
Molecular Function	GO:0005515	protein binding	VPS11	IPI	UniProtKB:P26038	Human	PMID:21148287
Molecular Function	GO:0005515	protein binding	VPS11	IPI	UniProtKB:P35241	Human	PMID:21148287
Molecular Function	GO:0005515	protein binding	VPS11	IPI	UniProtKB:P35226	Human	PMID:22493164
Molecular Function	GO:0005515	protein binding	VPS11	IPI	UniProtKB:Q9H269	Human	PMID:23901104
Molecular Function	GO:0005515	protein binding	VPS11	IPI	UniProtKB:Q9P253	Human	PMID:23901104
Molecular Function	GO:0005515	protein binding	VPS11	IPI	UniProtKB:Q8WUH2	Human	PMID:25266290
Molecular Function	GO:0005515	protein binding	VPS11	IPI	UniProtKB:P60410	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	VPS11	IPI	UniProtKB:P49754	Human	PMID:25500191
Molecular Function	GO:0005515	protein binding	VPS11	IPI	UniProtKB:Q8WUH2	Human	PMID:26496610
Molecular Function	GO:0005515	protein binding	VPS11	IPI	UniProtKB:Q96AX1	Human	PMID:26496610
Molecular Function	GO:0005515	protein binding	VPS11	IPI	UniProtKB:Q9H269	Human	PMID:26496610
Molecular Function	GO:0005515	protein binding	VPS11	IPI	UniProtKB:Q9P253	Human	PMID:26496610
Molecular Function	GO:0005515	protein binding	VPS11	IPI	UniProtKB:Q9Y4G2	Human	PMID:28325809
Molecular Function	GO:0005515	protein binding	VPS11	IPI	UniProtKB:Q8WUH2	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	VPS11	IPI	UniProtKB:Q96JC1-2	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	VPS11	IPI	UniProtKB:Q9P253	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	VPS11	IPI	UniProtKB:Q96AX1	Human	PMID:29778605
Molecular Function	GO:0005515	protein binding	VPS11	IPI	UniProtKB:P60410	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	VPS11	IPI	UniProtKB:Q96JC1-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	VPS11	IPI	UniProtKB:O14901	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	VPS11	IPI	UniProtKB:O75190-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	VPS11	IPI	UniProtKB:P01112	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	VPS11	IPI	UniProtKB:P05067	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	VPS11	IPI	UniProtKB:P06396	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	VPS11	IPI	UniProtKB:P08670	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	VPS11	IPI	UniProtKB:P16284	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	VPS11	IPI	UniProtKB:P22607	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	VPS11	IPI	UniProtKB:P28329-3	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	VPS11	IPI	UniProtKB:P61086	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	VPS11	IPI	UniProtKB:Q7Z699	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	VPS11	IPI	UniProtKB:Q9Y649	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	VPS11	IPI	UniProtKB:P49754	Human	PMID:33422265
Molecular Function	GO:0005515	protein binding	Vps11	IPI	UniProtKB:Q9H9C1	Mouse	MGI:MGI:4441246|PMID:19109425
Molecular Function	GO:0005515	protein binding	Vps11	IPI	PR:Q8R307	Mouse	PMID:14668490
Molecular Function	GO:0019904	protein domain specific binding	VPS11	IPI	UniProtKB:P15311	Human	PMID:21148287
Molecular Function	GO:0019905	syntaxin binding	VPS11	IDA		Human	PMID:11382755
Molecular Function	GO:0061630	ubiquitin protein ligase activity	VPS11	IMP		Human	PMID:31015428
Cellular Component	GO:0005884	actin filament	Vps11	IDA		Mouse	PMID:14668490
Cellular Component	GO:0030123	AP-3 adaptor complex	Vps11	IDA		Mouse	MGI:MGI:5645203|PMID:21411634
Cellular Component	GO:0033263	CORVET complex	Vps11	IDA		Mouse	MGI:MGI:5645189|PMID:25266290
Cellular Component	GO:0005769	early endosome	VPS11	IDA		Human	PMID:21148287
Cellular Component	GO:0005769	early endosome	Vps11	IDA		Mouse	PMID:14668490
Cellular Component	GO:0030139	endocytic vesicle	VPS11	IDA		Human	PMID:20682791
Cellular Component	GO:0005768	endosome	VPS11	IDA		Human	PMID:20682791
Cellular Component	GO:0030897	HOPS complex	VPS11	IDA		Human	PMID:19109425
Cellular Component	GO:0030897	HOPS complex	VPS11	IDA		Human	PMID:23901104
Cellular Component	GO:0005770	late endosome	VPS11	IDA		Human	PMID:21148287
Cellular Component	GO:0005770	late endosome	VPS11	IDA		Human	PMID:11382755
Cellular Component	GO:0005765	lysosomal membrane	VPS11	HDA		Human	PMID:17897319
Cellular Component	GO:0005764	lysosome	VPS11	IDA		Human	PMID:21148287
Cellular Component	GO:0005764	lysosome	VPS11	IDA		Human	PMID:11382755
Cellular Component	GO:0005764	lysosome	VPS11	IDA		Human	PMID:21802320
Cellular Component	GO:0048786	presynaptic active zone	Vps11	IDA		Mouse	PMID:17027648
Cellular Component	GO:0048786	presynaptic active zone	Vps11	IPI		Mouse	PMID:17027648
Biological Process	GO:0034058	endosomal vesicle fusion	VPS11	IMP		Human	PMID:21148287
Biological Process	GO:0008333	endosome to lysosome transport	VPS11	IMP		Human	PMID:25783203
Biological Process	GO:0001889	liver development	vps11	IMP	ZFIN:ZDB-GENO-120301-9	Zfish	PMID:21330665
Biological Process	GO:1902362	melanocyte apoptotic process	vps11	IMP	ZFIN:ZDB-GENO-110802-3	Zfish	PMID:23724125
Biological Process	GO:0030318	melanocyte differentiation	vps11	IMP	ZFIN:ZDB-GENO-120301-9	Zfish	PMID:21330665
Biological Process	GO:0030318	melanocyte differentiation	vps11	IMP	ZFIN:ZDB-MRPHLNO-120223-1	Zfish	PMID:21330665
Biological Process	GO:0010507	negative regulation of autophagy	vps11	IMP	ZFIN:ZDB-GENO-110802-3	Zfish	PMID:23724125
Biological Process	GO:0033147	negative regulation of intracellular estrogen receptor signaling pathway	VPS11	IGI	UniProtKB:Q9P253	Human	PMID:31015428
Biological Process	GO:0003407	neural retina development	vps11	IMP	ZFIN:ZDB-GENO-120301-9	Zfish	PMID:21330665
Biological Process	GO:0060036	notochord cell vacuolation	vps11	IMP	ZFIN:ZDB-GENO-130409-4	Zfish	PMID:23460678
Biological Process	GO:2000643	positive regulation of early endosome to late endosome transport	VPS11	IMP		Human	PMID:21148287
Biological Process	GO:0045732	positive regulation of protein catabolic process	VPS11	IMP		Human	PMID:21148287
Biological Process	GO:1903955	positive regulation of protein targeting to mitochondrion	VPS11	HMP		Human	PMID:24270810
Biological Process	GO:0016567	protein ubiquitination	VPS11	IMP		Human	PMID:31015428
Biological Process	GO:1902115	regulation of organelle assembly	VPS11	IMP		Human	PMID:21148287
Biological Process	GO:0031647	regulation of protein stability	VPS11	HMP		Human	PMID:24270810
Biological Process	GO:0003406	retinal pigment epithelium development	vps11	IMP	ZFIN:ZDB-GENO-120301-9	Zfish	PMID:21330665
Biological Process	GO:0048794	swim bladder development	vps11	IMP	ZFIN:ZDB-GENO-120301-9	Zfish	PMID:21330665
Biological Process	GO:1901998	toxin transport	Vps11	IMP		Mouse	PMID:23716698

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern