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Vps11 Gene Detail
Summary
  • Symbol
    Vps11
  • Name
    VPS11, CORVET/HOPS core subunit
  • Synonyms
    1200011A11Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1918982
    NCBI Gene: 71732
  • Gene Overview
    MyGene.info: VPS11
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:44347881-44361672 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 24.84 cM, cytoband B
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    83 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1918982
protein coding gene Chr9:44347749-44361672 (-)
129S1/SvImJ MGP_129S1SvImJ_G0034704
protein coding gene Chr9:42834777-42852708 (-)
A/J MGP_AJ_G0034685
protein coding gene Chr9:41643570-41657046 (-)
AKR/J MGP_AKRJ_G0034611
protein coding gene Chr9:42502173-42519723 (-)
BALB/cJ MGP_BALBcJ_G0034676
protein coding gene Chr9:41390226-41403624 (-)
C3H/HeJ MGP_C3HHeJ_G0034387
protein coding gene Chr9:42962602-42976431 (-)
C57BL/6NJ MGP_C57BL6NJ_G0035197
protein coding gene Chr9:44106383-44122333 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032112
protein coding gene Chr9:41221882-41237271 (-)
CAST/EiJ MGP_CASTEiJ_G0033709
protein coding gene Chr9:42804657-42819489 (-)
CBA/J MGP_CBAJ_G0034359
protein coding gene Chr9:45709653-45723117 (-)
DBA/2J MGP_DBA2J_G0034518
protein coding gene Chr9:41546266-41559743 (-)
FVB/NJ MGP_FVBNJ_G0034459
protein coding gene Chr9:40800393-40813923 (-)
LP/J MGP_LPJ_G0034599
protein coding gene Chr9:43133764-43148161 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0034503
protein coding gene Chr9:47560000-47575252 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0035218
protein coding gene Chr9:42403898-42417305 (-)
PWK/PhJ MGP_PWKPhJ_G0033415
protein coding gene Chr9:41415465-41429515 (-)
SPRET/EiJ MGP_SPRETEiJ_G0033249
protein coding gene Chr9:42723588-42737416 (-)
WSB/EiJ MGP_WSBEiJ_G0033822
protein coding gene Chr9:42444229-42457692 (-)



Homology
more
  • Human Ortholog
    VPS11, VPS11, CORVET/HOPS core subunit
  • Vertebrate Orthologs
    10
  • Human Ortholog
    VPS11, VPS11, CORVET/HOPS core subunit
    Orthology source: HomoloGene, HGNC
  • Synonyms
    END1, HLD12, hVPS11, PEP5, RNF108
  • Links
    NCBI Gene ID: 55823
    neXtProt AC: NX_Q9H270
    UniProt: Q9H270

  • Chr Location
    11q23.3; chr11:119067752-119081978 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human VPS11 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 71732 NCBI Gene Model | MGI Sequence Detail 13792 C57BL/6J ±  kb
transcript NM_027889 RefSeq | MGI Sequence Detail 3536 Not Specified  
polypeptide Q91W86 UniProt | EBI | MGI Sequence Detail 941 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    7 Sequences
  • InterPro Domains
    IPR016024 Armadillo-type fold
    IPR000547 Clathrin, heavy chain/VPS, 7-fold repeat
    IPR011990 Tetratricopeptide-like helical domain superfamily
    IPR016528 Vacuolar protein sorting-associated protein 11
    IPR024763 Vacuolar protein sorting protein 11, C-terminal
    IPR036322 WD40-repeat-containing domain superfamily
    IPR015943 WD40/YVTN repeat-like-containing domain superfamily
    IPR013083 Zinc finger, RING/FYVE/PHD-type
    IPR001841 Zinc finger, RING-type
Molecular
Reagents
less
  • All nucleic 89
    cDNA 89

    Microarray probesets 6
References
more
  • Summaries
    All 37
    Gene Ontology 11
    Phenotypes 6
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:222663 Perini ED, et al., Mammalian CORVET is required for fusion and conversion of distinct early endosome subpopulations. Traffic. 2014 Dec;15(12):1366-89

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory