Gene Ontology Classifications

Symbol
Name
ID

Vps11
VPS11, CORVET/HOPS core subunit
MGI:1918982

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Automated description from the Alliance of Genome Resources (Release 7.0.0)

Predicted to enable several functions, including protein-macromolecule adaptor activity; syntaxin binding activity; and ubiquitin protein ligase activity. Predicted to be involved in several processes, including negative regulation of intracellular estrogen receptor signaling pathway; positive regulation of early endosome to late endosome transport; and vesicle organization. Predicted to act upstream of or within autophagy and protein transport. Located in actin filament and early endosome. Part of AP-3 adaptor complex and CORVET complex. Is active in presynaptic active zone. Human ortholog(s) of this gene implicated in dystonia and hypomyelinating leukodystrophy 12. Orthologous to human VPS11 (VPS11 core subunit of CORVET and HOPS complexes).

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Aspect

Category

Evidence

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP: Inferred from experiment
HMP: Inferred from high throughput mutant phenotype
HGI: Inferred from high throughput genetic interaction
HDA: Inferred from high throughput direct assay
HEP: Inferred from high throughput expression pattern
IDA: Inferred from direct assay
IEP: Inferred from expression pattern
IGI: Inferred from genetic interaction
IMP: Inferred from mutant phenotype
IPI: Inferred from physical interaction

Homology:

IAS: Inferred from ancestral sequence
IBA: Inferred from biological aspect of ancestor
IBD: Inferred from biological aspect of descendant
IKR: Inferred from key residues
IMR: Inferred from missing residues
IRD: Inferred from rapid divergence
ISA: Inferred from sequence alignment
ISM: Inferred from sequence model
ISO: Inferred from sequence orthology
ISS: Inferred from sequence or structural similarity

Automated:

IEA: Inferred from electronic annotation
RCA: Reviewed computational analysis

Other:

IC: Inferred by curator
NAS: Non-traceable author statement
ND: No biological data available
TAS: Traceable author statement

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Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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