About   Help   FAQ
Gene Ontology Browser
Term Detail
GO term:actin filament
Synonym: microfilament
GO id:GO:0005884
Definition:A filamentous structure formed of a two-stranded helical polymer of the protein actin and associated proteins. Actin filaments are a major component of the contractile apparatus of skeletal muscle and the microfilaments of the cytoskeleton of eukaryotic cells. The filaments, comprising polymerized globular actin molecules, appear as flexible structures with a diameter of 5-9 nm. They are organized into a variety of linear bundles, two-dimensional networks, and three dimensional gels. In the cytoskeleton they are most highly concentrated in the cortex of the cell just beneath the plasma membrane.
Number of paths to term: 30

is-adenotes an 'is-a' relationship
part-ofdenotes a 'part-of' relationship
regulatesdenotes a 'regulates' relationship
positively-regulatesdenotes a 'positively-regulates' relationship
negatively-regulatesdenotes a 'negatively-regulates' relationship


obsolete Gene_Ontology
        is-acellular_component
                is-acell
                        part-ofcell part
                                is-aintracellular
                                        part-ofintracellular part
                                                is-aintracellular organelle
                                                        is-aintracellular non-membrane-bounded organelle
                                                                is-acytoskeleton
                                                                        is-aactin cytoskeleton
                                                                                part-ofactin filament [GO:0005884] (99 genes, 108 annotations)
                                                                                        is-aactin filament of cell cortex of cell tip
                                                                                        is-aactomyosin contractile ring actin filament
                                                                                        is-aactomyosin, actin portion
                                                                                        part-offilamentous actin
                                                                                part-ofactin filament bundle +
                                                                                part-ofactin fusion focus
                                                                                part-ofactin rod +
                                                                                part-ofactomyosin +
                                                                                part-ofArp2/3 protein complex
                                                                                part-ofcortical actin cytoskeleton +
                                                                                part-ofdynactin complex +
                                                                                part-ofF-actin capping protein complex +
                                                                                part-ofmyosin complex +
                                                                                part-ofpodosome
                                                                                is-apostsynaptic actin cytoskeleton +
                                                                                part-ofstriated muscle thin filament +


obsolete Gene_Ontology
        is-acellular_component
                is-acell
                        part-ofcell part
                                is-aintracellular
                                        part-ofintracellular part
                                                is-aintracellular organelle
                                                        is-aintracellular non-membrane-bounded organelle
                                                                is-acytoskeleton
                                                                        part-ofcytoskeletal part
                                                                                is-apolymeric cytoskeletal fiber
                                                                                        is-aactin filament [GO:0005884] (99 genes, 108 annotations)
                                                                                                is-aactin filament of cell cortex of cell tip
                                                                                                is-aactomyosin contractile ring actin filament
                                                                                                is-aactomyosin, actin portion
                                                                                                part-offilamentous actin
                                                                                        is-aintermediate filament +
                                                                                        is-amicrotubule +
                                                                                        is-aouter dense fiber


obsolete Gene_Ontology
        is-acellular_component
                is-acell
                        part-ofcell part
                                is-aintracellular
                                        part-ofintracellular part
                                                is-aintracellular organelle
                                                        is-aintracellular non-membrane-bounded organelle
                                                                is-acytoskeleton
                                                                        part-ofpolymeric cytoskeletal fiber
                                                                                is-aactin filament [GO:0005884] (99 genes, 108 annotations)
                                                                                        is-aactin filament of cell cortex of cell tip
                                                                                        is-aactomyosin contractile ring actin filament
                                                                                        is-aactomyosin, actin portion
                                                                                        part-offilamentous actin
                                                                                is-aintermediate filament +
                                                                                is-amicrotubule +
                                                                                is-aouter dense fiber


obsolete Gene_Ontology
        is-acellular_component
                is-acell
                        part-ofcell part
                                is-aintracellular
                                        part-ofintracellular part
                                                is-aintracellular organelle
                                                        part-ofintracellular organelle part
                                                                is-acytoskeletal part
                                                                        is-apolymeric cytoskeletal fiber
                                                                                is-aactin filament [GO:0005884] (99 genes, 108 annotations)
                                                                                        is-aactin filament of cell cortex of cell tip
                                                                                        is-aactomyosin contractile ring actin filament
                                                                                        is-aactomyosin, actin portion
                                                                                        part-offilamentous actin
                                                                                is-aintermediate filament +
                                                                                is-amicrotubule +
                                                                                is-aouter dense fiber


obsolete Gene_Ontology
        is-acellular_component
                is-acell
                        part-ofcell part
                                is-aintracellular
                                        part-ofintracellular part
                                                is-aintracellular organelle part
                                                        is-acytoskeletal part
                                                                is-apolymeric cytoskeletal fiber
                                                                        is-aactin filament [GO:0005884] (99 genes, 108 annotations)
                                                                                is-aactin filament of cell cortex of cell tip
                                                                                is-aactomyosin contractile ring actin filament
                                                                                is-aactomyosin, actin portion
                                                                                part-offilamentous actin
                                                                        is-aintermediate filament +
                                                                        is-amicrotubule +
                                                                        is-aouter dense fiber


obsolete Gene_Ontology
        is-acellular_component
                is-acell
                        part-ofcell part
                                is-aintracellular part
                                        is-aintracellular organelle
                                                is-aintracellular non-membrane-bounded organelle
                                                        is-acytoskeleton
                                                                is-aactin cytoskeleton
                                                                        part-ofactin filament [GO:0005884] (99 genes, 108 annotations)
                                                                                is-aactin filament of cell cortex of cell tip
                                                                                is-aactomyosin contractile ring actin filament
                                                                                is-aactomyosin, actin portion
                                                                                part-offilamentous actin
                                                                        part-ofactin filament bundle +
                                                                        part-ofactin fusion focus
                                                                        part-ofactin rod +
                                                                        part-ofactomyosin +
                                                                        part-ofArp2/3 protein complex
                                                                        part-ofcortical actin cytoskeleton +
                                                                        part-ofdynactin complex +
                                                                        part-ofF-actin capping protein complex +
                                                                        part-ofmyosin complex +
                                                                        part-ofpodosome
                                                                        is-apostsynaptic actin cytoskeleton +
                                                                        part-ofstriated muscle thin filament +


obsolete Gene_Ontology
        is-acellular_component
                is-acell
                        part-ofcell part
                                is-aintracellular part
                                        is-aintracellular organelle
                                                is-aintracellular non-membrane-bounded organelle
                                                        is-acytoskeleton
                                                                part-ofcytoskeletal part
                                                                        is-apolymeric cytoskeletal fiber
                                                                                is-aactin filament [GO:0005884] (99 genes, 108 annotations)
                                                                                        is-aactin filament of cell cortex of cell tip
                                                                                        is-aactomyosin contractile ring actin filament
                                                                                        is-aactomyosin, actin portion
                                                                                        part-offilamentous actin
                                                                                is-aintermediate filament +
                                                                                is-amicrotubule +
                                                                                is-aouter dense fiber


obsolete Gene_Ontology
        is-acellular_component
                is-acell
                        part-ofcell part
                                is-aintracellular part
                                        is-aintracellular organelle
                                                is-aintracellular non-membrane-bounded organelle
                                                        is-acytoskeleton
                                                                part-ofpolymeric cytoskeletal fiber
                                                                        is-aactin filament [GO:0005884] (99 genes, 108 annotations)
                                                                                is-aactin filament of cell cortex of cell tip
                                                                                is-aactomyosin contractile ring actin filament
                                                                                is-aactomyosin, actin portion
                                                                                part-offilamentous actin
                                                                        is-aintermediate filament +
                                                                        is-amicrotubule +
                                                                        is-aouter dense fiber


obsolete Gene_Ontology
        is-acellular_component
                is-acell
                        part-ofcell part
                                is-aintracellular part
                                        is-aintracellular organelle
                                                part-ofintracellular organelle part
                                                        is-acytoskeletal part
                                                                is-apolymeric cytoskeletal fiber
                                                                        is-aactin filament [GO:0005884] (99 genes, 108 annotations)
                                                                                is-aactin filament of cell cortex of cell tip
                                                                                is-aactomyosin contractile ring actin filament
                                                                                is-aactomyosin, actin portion
                                                                                part-offilamentous actin
                                                                        is-aintermediate filament +
                                                                        is-amicrotubule +
                                                                        is-aouter dense fiber


obsolete Gene_Ontology
        is-acellular_component
                is-acell
                        part-ofcell part
                                is-aintracellular part
                                        is-aintracellular organelle part
                                                is-acytoskeletal part
                                                        is-apolymeric cytoskeletal fiber
                                                                is-aactin filament [GO:0005884] (99 genes, 108 annotations)
                                                                        is-aactin filament of cell cortex of cell tip
                                                                        is-aactomyosin contractile ring actin filament
                                                                        is-aactomyosin, actin portion
                                                                        part-offilamentous actin
                                                                is-aintermediate filament +
                                                                is-amicrotubule +
                                                                is-aouter dense fiber


obsolete Gene_Ontology
        is-acellular_component
                is-acell part
                        is-aintracellular
                                part-ofintracellular part
                                        is-aintracellular organelle
                                                is-aintracellular non-membrane-bounded organelle
                                                        is-acytoskeleton
                                                                is-aactin cytoskeleton
                                                                        part-ofactin filament [GO:0005884] (99 genes, 108 annotations)
                                                                                is-aactin filament of cell cortex of cell tip
                                                                                is-aactomyosin contractile ring actin filament
                                                                                is-aactomyosin, actin portion
                                                                                part-offilamentous actin
                                                                        part-ofactin filament bundle +
                                                                        part-ofactin fusion focus
                                                                        part-ofactin rod +
                                                                        part-ofactomyosin +
                                                                        part-ofArp2/3 protein complex
                                                                        part-ofcortical actin cytoskeleton +
                                                                        part-ofdynactin complex +
                                                                        part-ofF-actin capping protein complex +
                                                                        part-ofmyosin complex +
                                                                        part-ofpodosome
                                                                        is-apostsynaptic actin cytoskeleton +
                                                                        part-ofstriated muscle thin filament +


obsolete Gene_Ontology
        is-acellular_component
                is-acell part
                        is-aintracellular
                                part-ofintracellular part
                                        is-aintracellular organelle
                                                is-aintracellular non-membrane-bounded organelle
                                                        is-acytoskeleton
                                                                part-ofcytoskeletal part
                                                                        is-apolymeric cytoskeletal fiber
                                                                                is-aactin filament [GO:0005884] (99 genes, 108 annotations)
                                                                                        is-aactin filament of cell cortex of cell tip
                                                                                        is-aactomyosin contractile ring actin filament
                                                                                        is-aactomyosin, actin portion
                                                                                        part-offilamentous actin
                                                                                is-aintermediate filament +
                                                                                is-amicrotubule +
                                                                                is-aouter dense fiber


obsolete Gene_Ontology
        is-acellular_component
                is-acell part
                        is-aintracellular
                                part-ofintracellular part
                                        is-aintracellular organelle
                                                is-aintracellular non-membrane-bounded organelle
                                                        is-acytoskeleton
                                                                part-ofpolymeric cytoskeletal fiber
                                                                        is-aactin filament [GO:0005884] (99 genes, 108 annotations)
                                                                                is-aactin filament of cell cortex of cell tip
                                                                                is-aactomyosin contractile ring actin filament
                                                                                is-aactomyosin, actin portion
                                                                                part-offilamentous actin
                                                                        is-aintermediate filament +
                                                                        is-amicrotubule +
                                                                        is-aouter dense fiber


obsolete Gene_Ontology
        is-acellular_component
                is-acell part
                        is-aintracellular
                                part-ofintracellular part
                                        is-aintracellular organelle
                                                part-ofintracellular organelle part
                                                        is-acytoskeletal part
                                                                is-apolymeric cytoskeletal fiber
                                                                        is-aactin filament [GO:0005884] (99 genes, 108 annotations)
                                                                                is-aactin filament of cell cortex of cell tip
                                                                                is-aactomyosin contractile ring actin filament
                                                                                is-aactomyosin, actin portion
                                                                                part-offilamentous actin
                                                                        is-aintermediate filament +
                                                                        is-amicrotubule +
                                                                        is-aouter dense fiber


obsolete Gene_Ontology
        is-acellular_component
                is-acell part
                        is-aintracellular
                                part-ofintracellular part
                                        is-aintracellular organelle part
                                                is-acytoskeletal part
                                                        is-apolymeric cytoskeletal fiber
                                                                is-aactin filament [GO:0005884] (99 genes, 108 annotations)
                                                                        is-aactin filament of cell cortex of cell tip
                                                                        is-aactomyosin contractile ring actin filament
                                                                        is-aactomyosin, actin portion
                                                                        part-offilamentous actin
                                                                is-aintermediate filament +
                                                                is-amicrotubule +
                                                                is-aouter dense fiber


obsolete Gene_Ontology
        is-acellular_component
                is-acell part
                        is-aintracellular part
                                is-aintracellular organelle
                                        is-aintracellular non-membrane-bounded organelle
                                                is-acytoskeleton
                                                        is-aactin cytoskeleton
                                                                part-ofactin filament [GO:0005884] (99 genes, 108 annotations)
                                                                        is-aactin filament of cell cortex of cell tip
                                                                        is-aactomyosin contractile ring actin filament
                                                                        is-aactomyosin, actin portion
                                                                        part-offilamentous actin
                                                                part-ofactin filament bundle +
                                                                part-ofactin fusion focus
                                                                part-ofactin rod +
                                                                part-ofactomyosin +
                                                                part-ofArp2/3 protein complex
                                                                part-ofcortical actin cytoskeleton +
                                                                part-ofdynactin complex +
                                                                part-ofF-actin capping protein complex +
                                                                part-ofmyosin complex +
                                                                part-ofpodosome
                                                                is-apostsynaptic actin cytoskeleton +
                                                                part-ofstriated muscle thin filament +


obsolete Gene_Ontology
        is-acellular_component
                is-acell part
                        is-aintracellular part
                                is-aintracellular organelle
                                        is-aintracellular non-membrane-bounded organelle
                                                is-acytoskeleton
                                                        part-ofcytoskeletal part
                                                                is-apolymeric cytoskeletal fiber
                                                                        is-aactin filament [GO:0005884] (99 genes, 108 annotations)
                                                                                is-aactin filament of cell cortex of cell tip
                                                                                is-aactomyosin contractile ring actin filament
                                                                                is-aactomyosin, actin portion
                                                                                part-offilamentous actin
                                                                        is-aintermediate filament +
                                                                        is-amicrotubule +
                                                                        is-aouter dense fiber


obsolete Gene_Ontology
        is-acellular_component
                is-acell part
                        is-aintracellular part
                                is-aintracellular organelle
                                        is-aintracellular non-membrane-bounded organelle
                                                is-acytoskeleton
                                                        part-ofpolymeric cytoskeletal fiber
                                                                is-aactin filament [GO:0005884] (99 genes, 108 annotations)
                                                                        is-aactin filament of cell cortex of cell tip
                                                                        is-aactomyosin contractile ring actin filament
                                                                        is-aactomyosin, actin portion
                                                                        part-offilamentous actin
                                                                is-aintermediate filament +
                                                                is-amicrotubule +
                                                                is-aouter dense fiber


obsolete Gene_Ontology
        is-acellular_component
                is-acell part
                        is-aintracellular part
                                is-aintracellular organelle
                                        part-ofintracellular organelle part
                                                is-acytoskeletal part
                                                        is-apolymeric cytoskeletal fiber
                                                                is-aactin filament [GO:0005884] (99 genes, 108 annotations)
                                                                        is-aactin filament of cell cortex of cell tip
                                                                        is-aactomyosin contractile ring actin filament
                                                                        is-aactomyosin, actin portion
                                                                        part-offilamentous actin
                                                                is-aintermediate filament +
                                                                is-amicrotubule +
                                                                is-aouter dense fiber


obsolete Gene_Ontology
        is-acellular_component
                is-acell part
                        is-aintracellular part
                                is-aintracellular organelle part
                                        is-acytoskeletal part
                                                is-apolymeric cytoskeletal fiber
                                                        is-aactin filament [GO:0005884] (99 genes, 108 annotations)
                                                                is-aactin filament of cell cortex of cell tip
                                                                is-aactomyosin contractile ring actin filament
                                                                is-aactomyosin, actin portion
                                                                part-offilamentous actin
                                                        is-aintermediate filament +
                                                        is-amicrotubule +
                                                        is-aouter dense fiber


obsolete Gene_Ontology
        is-acellular_component
                is-aorganelle
                        is-aintracellular organelle
                                is-aintracellular non-membrane-bounded organelle
                                        is-acytoskeleton
                                                is-aactin cytoskeleton
                                                        part-ofactin filament [GO:0005884] (99 genes, 108 annotations)
                                                                is-aactin filament of cell cortex of cell tip
                                                                is-aactomyosin contractile ring actin filament
                                                                is-aactomyosin, actin portion
                                                                part-offilamentous actin
                                                        part-ofactin filament bundle +
                                                        part-ofactin fusion focus
                                                        part-ofactin rod +
                                                        part-ofactomyosin +
                                                        part-ofArp2/3 protein complex
                                                        part-ofcortical actin cytoskeleton +
                                                        part-ofdynactin complex +
                                                        part-ofF-actin capping protein complex +
                                                        part-ofmyosin complex +
                                                        part-ofpodosome
                                                        is-apostsynaptic actin cytoskeleton +
                                                        part-ofstriated muscle thin filament +


obsolete Gene_Ontology
        is-acellular_component
                is-aorganelle
                        is-aintracellular organelle
                                is-aintracellular non-membrane-bounded organelle
                                        is-acytoskeleton
                                                part-ofcytoskeletal part
                                                        is-apolymeric cytoskeletal fiber
                                                                is-aactin filament [GO:0005884] (99 genes, 108 annotations)
                                                                        is-aactin filament of cell cortex of cell tip
                                                                        is-aactomyosin contractile ring actin filament
                                                                        is-aactomyosin, actin portion
                                                                        part-offilamentous actin
                                                                is-aintermediate filament +
                                                                is-amicrotubule +
                                                                is-aouter dense fiber


obsolete Gene_Ontology
        is-acellular_component
                is-aorganelle
                        is-aintracellular organelle
                                is-aintracellular non-membrane-bounded organelle
                                        is-acytoskeleton
                                                part-ofpolymeric cytoskeletal fiber
                                                        is-aactin filament [GO:0005884] (99 genes, 108 annotations)
                                                                is-aactin filament of cell cortex of cell tip
                                                                is-aactomyosin contractile ring actin filament
                                                                is-aactomyosin, actin portion
                                                                part-offilamentous actin
                                                        is-aintermediate filament +
                                                        is-amicrotubule +
                                                        is-aouter dense fiber


obsolete Gene_Ontology
        is-acellular_component
                is-aorganelle
                        is-aintracellular organelle
                                part-ofintracellular organelle part
                                        is-acytoskeletal part
                                                is-apolymeric cytoskeletal fiber
                                                        is-aactin filament [GO:0005884] (99 genes, 108 annotations)
                                                                is-aactin filament of cell cortex of cell tip
                                                                is-aactomyosin contractile ring actin filament
                                                                is-aactomyosin, actin portion
                                                                part-offilamentous actin
                                                        is-aintermediate filament +
                                                        is-amicrotubule +
                                                        is-aouter dense fiber


obsolete Gene_Ontology
        is-acellular_component
                is-aorganelle
                        is-anon-membrane-bounded organelle
                                is-aintracellular non-membrane-bounded organelle
                                        is-acytoskeleton
                                                is-aactin cytoskeleton
                                                        part-ofactin filament [GO:0005884] (99 genes, 108 annotations)
                                                                is-aactin filament of cell cortex of cell tip
                                                                is-aactomyosin contractile ring actin filament
                                                                is-aactomyosin, actin portion
                                                                part-offilamentous actin
                                                        part-ofactin filament bundle +
                                                        part-ofactin fusion focus
                                                        part-ofactin rod +
                                                        part-ofactomyosin +
                                                        part-ofArp2/3 protein complex
                                                        part-ofcortical actin cytoskeleton +
                                                        part-ofdynactin complex +
                                                        part-ofF-actin capping protein complex +
                                                        part-ofmyosin complex +
                                                        part-ofpodosome
                                                        is-apostsynaptic actin cytoskeleton +
                                                        part-ofstriated muscle thin filament +


obsolete Gene_Ontology
        is-acellular_component
                is-aorganelle
                        is-anon-membrane-bounded organelle
                                is-aintracellular non-membrane-bounded organelle
                                        is-acytoskeleton
                                                part-ofcytoskeletal part
                                                        is-apolymeric cytoskeletal fiber
                                                                is-aactin filament [GO:0005884] (99 genes, 108 annotations)
                                                                        is-aactin filament of cell cortex of cell tip
                                                                        is-aactomyosin contractile ring actin filament
                                                                        is-aactomyosin, actin portion
                                                                        part-offilamentous actin
                                                                is-aintermediate filament +
                                                                is-amicrotubule +
                                                                is-aouter dense fiber


obsolete Gene_Ontology
        is-acellular_component
                is-aorganelle
                        is-anon-membrane-bounded organelle
                                is-aintracellular non-membrane-bounded organelle
                                        is-acytoskeleton
                                                part-ofpolymeric cytoskeletal fiber
                                                        is-aactin filament [GO:0005884] (99 genes, 108 annotations)
                                                                is-aactin filament of cell cortex of cell tip
                                                                is-aactomyosin contractile ring actin filament
                                                                is-aactomyosin, actin portion
                                                                part-offilamentous actin
                                                        is-aintermediate filament +
                                                        is-amicrotubule +
                                                        is-aouter dense fiber


obsolete Gene_Ontology
        is-acellular_component
                is-aorganelle
                        part-oforganelle part
                                is-aintracellular organelle part
                                        is-acytoskeletal part
                                                is-apolymeric cytoskeletal fiber
                                                        is-aactin filament [GO:0005884] (99 genes, 108 annotations)
                                                                is-aactin filament of cell cortex of cell tip
                                                                is-aactomyosin contractile ring actin filament
                                                                is-aactomyosin, actin portion
                                                                part-offilamentous actin
                                                        is-aintermediate filament +
                                                        is-amicrotubule +
                                                        is-aouter dense fiber


obsolete Gene_Ontology
        is-acellular_component
                is-aorganelle part
                        is-aintracellular organelle part
                                is-acytoskeletal part
                                        is-apolymeric cytoskeletal fiber
                                                is-aactin filament [GO:0005884] (99 genes, 108 annotations)
                                                        is-aactin filament of cell cortex of cell tip
                                                        is-aactomyosin contractile ring actin filament
                                                        is-aactomyosin, actin portion
                                                        part-offilamentous actin
                                                is-aintermediate filament +
                                                is-amicrotubule +
                                                is-aouter dense fiber


obsolete Gene_Ontology
        is-acellular_component
                is-asupramolecular fiber
                        is-apolymeric cytoskeletal fiber
                                is-aactin filament [GO:0005884] (99 genes, 108 annotations)
                                        is-aactin filament of cell cortex of cell tip
                                        is-aactomyosin contractile ring actin filament
                                        is-aactomyosin, actin portion
                                        part-offilamentous actin
                                is-aintermediate filament +
                                is-amicrotubule +
                                is-aouter dense fiber


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/23/2016
MGI 6.05
The Jackson Laboratory