Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes TLR7
  • Mouse genes Tlr7
  • Rat genes Tlr7
  • Zfish genes tlr7
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Tlr7

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003725	double-stranded RNA binding	TLR7	IDA		Human	PMID:16111635
Molecular Function	GO:0005515	protein binding	TLR7	IPI	UniProtKB:Q9H1C4	Human	PMID:33432245
Molecular Function	GO:0005515	protein binding	Tlr7	IPI	UniProtKB:Q8VCW4	Mouse	MGI:MGI:4457250|PMID:17452530
Molecular Function	GO:0005515	protein binding	Tlr7	IPI	UniProtKB:P58242	Mouse	MGI:MGI:5689225|PMID:26095358
Molecular Function	GO:0005515	protein binding	Tlr7	IPI	UniProtKB:P22366	Mouse	MGI:MGI:5775261|PMID:25848864
Molecular Function	GO:0003727	single-stranded RNA binding	TLR7	IMP		Human	PMID:35477763
Molecular Function	GO:0003727	single-stranded RNA binding	Tlr7	IMP		Mouse	MGI:MGI:3042321|PMID:14976262
Molecular Function	GO:0035197	siRNA binding	Tlr7	IMP		Mouse	MGI:MGI:3574266|PMID:15723075
Cellular Component	GO:0005737	cytoplasm	TLR7	IDA		Human	PMID:19740627
Cellular Component	GO:0032009	early phagosome	Tlr7	IDA		Mouse	MGI:MGI:3776596|PMID:18305481
Cellular Component	GO:0005783	endoplasmic reticulum	Tlr7	IDA		Mouse	MGI:MGI:3776596|PMID:18305481
Cellular Component	GO:0005768	endosome	Tlr7	IDA		Mouse	MGI:MGI:3776596|PMID:18305481
Cellular Component	GO:0005764	lysosome	Tlr7	IDA		Mouse	MGI:MGI:3776596|PMID:18305481
Cellular Component	GO:0005886	plasma membrane	TLR7	IDA		Human	PMID:19740627
Cellular Component	GO:0043235	receptor complex	TLR7	IDA		Human	PMID:23382219
Biological Process	GO:0071260	cellular response to mechanical stimulus	TLR7	IEP		Human	PMID:19593445
Biological Process	GO:0098586	cellular response to virus	Tlr7	IMP		Mouse	PMID:18802055
Biological Process	GO:0051607	defense response to virus	TLR7	IMP		Human	PMID:16188996
Biological Process	GO:0051607	defense response to virus	TLR7	IEP		Human	PMID:32634389
Biological Process	GO:0051607	defense response to virus	Tlr7	IMP		Mouse	MGI:MGI:3042320|PMID:14976261
Biological Process	GO:0007249	I-kappaB kinase/NF-kappaB signaling	TLR7	IMP		Human	PMID:35477763
Biological Process	GO:0007252	I-kappaB phosphorylation	TLR7	IDA		Human	PMID:19740627
Biological Process	GO:0045087	innate immune response	TLR7	IMP		Human	PMID:35477763
Biological Process	GO:0032635	interleukin-6 production	Tlr7	IDA		Mouse	PMID:18261938
Biological Process	GO:0007254	JNK cascade	Tlr7	IMP		Mouse	PMID:18802055
Biological Process	GO:0010934	macrophage cytokine production	Tlr7	IDA		Mouse	PMID:18261938
Biological Process	GO:0000165	MAPK cascade	Tlr7	IMP		Mouse	PMID:18802055
Biological Process	GO:0032722	positive regulation of chemokine production	TLR7	IDA		Human	PMID:19740627
Biological Process	GO:0032727	positive regulation of interferon-alpha production	TLR7	IDA		Human	PMID:16286015
Biological Process	GO:0032727	positive regulation of interferon-alpha production	Tlr7	IMP		Mouse	MGI:MGI:3042320|PMID:14976261
Biological Process	GO:0032728	positive regulation of interferon-beta production	TLR7	IDA		Human	PMID:16286015
Biological Process	GO:0032755	positive regulation of interleukin-6 production	Tlr7	IDA		Mouse	PMID:18261938
Biological Process	GO:0032757	positive regulation of interleukin-8 production	TLR7	IMP		Human	PMID:16188996
Biological Process	GO:0032757	positive regulation of interleukin-8 production	TLR7	IDA		Human	PMID:19740627
Biological Process	GO:0060907	positive regulation of macrophage cytokine production	Tlr7	IDA		Mouse	PMID:18261938
Biological Process	GO:1901224	positive regulation of NIK/NF-kappaB signaling	TLR7	IDA		Human	PMID:19740627
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Tlr7	IGI	MGI:MGI:2156367	Mouse	PMID:18802055
Biological Process	GO:0032729	positive regulation of type II interferon production	TLR7	IDA		Human	PMID:16286015
Biological Process	GO:0001932	regulation of protein phosphorylation	Tlr7	IGI	MGI:MGI:2176887	Mouse	PMID:24740015
Biological Process	GO:0070305	response to cGMP	TLR7	IMP		Human	PMID:35477763
Biological Process	GO:0034154	toll-like receptor 7 signaling pathway	Tlr7	IMP		Mouse	MGI:MGI:3042320|PMID:14976261

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern