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Gene Ontology Browser
Term Detail
GO term:I-kappaB phosphorylation
Synonym: IkappaB phosphorylation
Synonym: IKB phosphorylation
Synonym: inhibitor of kappaB phosphorylation
Synonym: inhibitor of NF-kappaB phosphorylation
GO id:GO:0007252
Definition:The process of introducing a phosphate group into an inhibitor of kappa B (I-kappaB) protein. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing bound NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription.
Number of paths to term: 19

is-adenotes an 'is-a' relationship
part-ofdenotes a 'part-of' relationship
regulatesdenotes a 'regulates' relationship
positively-regulatesdenotes a 'positively-regulates' relationship
negatively-regulatesdenotes a 'negatively-regulates' relationship


Gene_Ontology
        is-abiological_process
                is-abiological regulation
                        is-aregulation of biological process
                                is-aregulation of cellular process
                                        is-asignal transduction
                                                is-aintracellular signal transduction
                                                        is-aI-kappaB kinase/NF-kappaB signaling
                                                                part-ofI-kappaB phosphorylation [GO:0007252] (12 genes, 15 annotations)
                                                                negatively-regulatesnegative regulation of I-kappaB kinase/NF-kappaB signaling +
                                                                part-ofNF-kappaB import into nucleus +
                                                                positively-regulatespositive regulation of I-kappaB kinase/NF-kappaB signaling +
                                                                regulatesregulation of I-kappaB kinase/NF-kappaB signaling +
                                                                part-ofrelease of cytoplasmic sequestered NF-kappaB


Gene_Ontology
        is-abiological_process
                is-acellular process
                        is-acellular metabolic process
                                is-acellular macromolecule metabolic process
                                        is-acellular protein metabolic process
                                                is-acellular protein modification process
                                                        is-aprotein phosphorylation
                                                                is-aactin phosphorylation +
                                                                is-acommon-partner SMAD protein phosphorylation
                                                                is-aDNA damage induced protein phosphorylation
                                                                is-ahistone phosphorylation +
                                                                is-aI-kappaB phosphorylation [GO:0007252] (12 genes, 15 annotations)
                                                                is-ainhibitory G-protein coupled receptor phosphorylation
                                                                is-aJUN phosphorylation
                                                                negatively-regulatesnegative regulation of protein phosphorylation +
                                                                is-apathway-restricted SMAD protein phosphorylation +
                                                                is-apeptidyl-arginine phosphorylation
                                                                is-apeptidyl-aspartic acid phosphorylation +
                                                                is-apeptidyl-cysteine phosphorylation +
                                                                is-apeptidyl-histidine phosphorylation +
                                                                is-apeptidyl-serine phosphorylation +
                                                                is-apeptidyl-threonine phosphorylation +
                                                                is-apeptidyl-tyrosine phosphorylation +
                                                                is-aphosphorylation of RNA polymerase II C-terminal domain +
                                                                positively-regulatespositive regulation of protein phosphorylation +
                                                                is-aprotein autophosphorylation +
                                                                is-aprotein phosphorylation involved in cellular protein catabolic process
                                                                regulatesregulation of protein phosphorylation +
                                                                is-aregulation of translational initiation by eIF2 alpha phosphorylation +


Gene_Ontology
        is-abiological_process
                is-acellular process
                        is-acellular metabolic process
                                is-aphosphorus metabolic process
                                        is-aphosphate-containing compound metabolic process
                                                is-aphosphorylation
                                                        is-aprotein phosphorylation
                                                                is-aactin phosphorylation +
                                                                is-acommon-partner SMAD protein phosphorylation
                                                                is-aDNA damage induced protein phosphorylation
                                                                is-ahistone phosphorylation +
                                                                is-aI-kappaB phosphorylation [GO:0007252] (12 genes, 15 annotations)
                                                                is-ainhibitory G-protein coupled receptor phosphorylation
                                                                is-aJUN phosphorylation
                                                                negatively-regulatesnegative regulation of protein phosphorylation +
                                                                is-apathway-restricted SMAD protein phosphorylation +
                                                                is-apeptidyl-arginine phosphorylation
                                                                is-apeptidyl-aspartic acid phosphorylation +
                                                                is-apeptidyl-cysteine phosphorylation +
                                                                is-apeptidyl-histidine phosphorylation +
                                                                is-apeptidyl-serine phosphorylation +
                                                                is-apeptidyl-threonine phosphorylation +
                                                                is-apeptidyl-tyrosine phosphorylation +
                                                                is-aphosphorylation of RNA polymerase II C-terminal domain +
                                                                positively-regulatespositive regulation of protein phosphorylation +
                                                                is-aprotein autophosphorylation +
                                                                is-aprotein phosphorylation involved in cellular protein catabolic process
                                                                regulatesregulation of protein phosphorylation +
                                                                is-aregulation of translational initiation by eIF2 alpha phosphorylation +


Gene_Ontology
        is-abiological_process
                is-acellular process
                        is-acellular response to stimulus
                                is-asignal transduction
                                        is-aintracellular signal transduction
                                                is-aI-kappaB kinase/NF-kappaB signaling
                                                        part-ofI-kappaB phosphorylation [GO:0007252] (12 genes, 15 annotations)
                                                        negatively-regulatesnegative regulation of I-kappaB kinase/NF-kappaB signaling +
                                                        part-ofNF-kappaB import into nucleus +
                                                        positively-regulatespositive regulation of I-kappaB kinase/NF-kappaB signaling +
                                                        regulatesregulation of I-kappaB kinase/NF-kappaB signaling +
                                                        part-ofrelease of cytoplasmic sequestered NF-kappaB


Gene_Ontology
        is-abiological_process
                is-acellular process
                        regulatesregulation of cellular process
                                is-asignal transduction
                                        is-aintracellular signal transduction
                                                is-aI-kappaB kinase/NF-kappaB signaling
                                                        part-ofI-kappaB phosphorylation [GO:0007252] (12 genes, 15 annotations)
                                                        negatively-regulatesnegative regulation of I-kappaB kinase/NF-kappaB signaling +
                                                        part-ofNF-kappaB import into nucleus +
                                                        positively-regulatespositive regulation of I-kappaB kinase/NF-kappaB signaling +
                                                        regulatesregulation of I-kappaB kinase/NF-kappaB signaling +
                                                        part-ofrelease of cytoplasmic sequestered NF-kappaB


Gene_Ontology
        is-abiological_process
                is-acellular process
                        is-asingle-organism cellular process
                                is-acell communication
                                        part-ofsignal transduction
                                                is-aintracellular signal transduction
                                                        is-aI-kappaB kinase/NF-kappaB signaling
                                                                part-ofI-kappaB phosphorylation [GO:0007252] (12 genes, 15 annotations)
                                                                negatively-regulatesnegative regulation of I-kappaB kinase/NF-kappaB signaling +
                                                                part-ofNF-kappaB import into nucleus +
                                                                positively-regulatespositive regulation of I-kappaB kinase/NF-kappaB signaling +
                                                                regulatesregulation of I-kappaB kinase/NF-kappaB signaling +
                                                                part-ofrelease of cytoplasmic sequestered NF-kappaB


Gene_Ontology
        is-abiological_process
                is-ametabolic process
                        is-acellular metabolic process
                                is-acellular macromolecule metabolic process
                                        is-acellular protein metabolic process
                                                is-acellular protein modification process
                                                        is-aprotein phosphorylation
                                                                is-aactin phosphorylation +
                                                                is-acommon-partner SMAD protein phosphorylation
                                                                is-aDNA damage induced protein phosphorylation
                                                                is-ahistone phosphorylation +
                                                                is-aI-kappaB phosphorylation [GO:0007252] (12 genes, 15 annotations)
                                                                is-ainhibitory G-protein coupled receptor phosphorylation
                                                                is-aJUN phosphorylation
                                                                negatively-regulatesnegative regulation of protein phosphorylation +
                                                                is-apathway-restricted SMAD protein phosphorylation +
                                                                is-apeptidyl-arginine phosphorylation
                                                                is-apeptidyl-aspartic acid phosphorylation +
                                                                is-apeptidyl-cysteine phosphorylation +
                                                                is-apeptidyl-histidine phosphorylation +
                                                                is-apeptidyl-serine phosphorylation +
                                                                is-apeptidyl-threonine phosphorylation +
                                                                is-apeptidyl-tyrosine phosphorylation +
                                                                is-aphosphorylation of RNA polymerase II C-terminal domain +
                                                                positively-regulatespositive regulation of protein phosphorylation +
                                                                is-aprotein autophosphorylation +
                                                                is-aprotein phosphorylation involved in cellular protein catabolic process
                                                                regulatesregulation of protein phosphorylation +
                                                                is-aregulation of translational initiation by eIF2 alpha phosphorylation +


Gene_Ontology
        is-abiological_process
                is-ametabolic process
                        is-acellular metabolic process
                                is-aphosphorus metabolic process
                                        is-aphosphate-containing compound metabolic process
                                                is-aphosphorylation
                                                        is-aprotein phosphorylation
                                                                is-aactin phosphorylation +
                                                                is-acommon-partner SMAD protein phosphorylation
                                                                is-aDNA damage induced protein phosphorylation
                                                                is-ahistone phosphorylation +
                                                                is-aI-kappaB phosphorylation [GO:0007252] (12 genes, 15 annotations)
                                                                is-ainhibitory G-protein coupled receptor phosphorylation
                                                                is-aJUN phosphorylation
                                                                negatively-regulatesnegative regulation of protein phosphorylation +
                                                                is-apathway-restricted SMAD protein phosphorylation +
                                                                is-apeptidyl-arginine phosphorylation
                                                                is-apeptidyl-aspartic acid phosphorylation +
                                                                is-apeptidyl-cysteine phosphorylation +
                                                                is-apeptidyl-histidine phosphorylation +
                                                                is-apeptidyl-serine phosphorylation +
                                                                is-apeptidyl-threonine phosphorylation +
                                                                is-apeptidyl-tyrosine phosphorylation +
                                                                is-aphosphorylation of RNA polymerase II C-terminal domain +
                                                                positively-regulatespositive regulation of protein phosphorylation +
                                                                is-aprotein autophosphorylation +
                                                                is-aprotein phosphorylation involved in cellular protein catabolic process
                                                                regulatesregulation of protein phosphorylation +
                                                                is-aregulation of translational initiation by eIF2 alpha phosphorylation +


Gene_Ontology
        is-abiological_process
                is-ametabolic process
                        is-aorganic substance metabolic process
                                is-amacromolecule metabolic process
                                        is-acellular macromolecule metabolic process
                                                is-acellular protein metabolic process
                                                        is-acellular protein modification process
                                                                is-aprotein phosphorylation
                                                                        is-aactin phosphorylation +
                                                                        is-acommon-partner SMAD protein phosphorylation
                                                                        is-aDNA damage induced protein phosphorylation
                                                                        is-ahistone phosphorylation +
                                                                        is-aI-kappaB phosphorylation [GO:0007252] (12 genes, 15 annotations)
                                                                        is-ainhibitory G-protein coupled receptor phosphorylation
                                                                        is-aJUN phosphorylation
                                                                        negatively-regulatesnegative regulation of protein phosphorylation +
                                                                        is-apathway-restricted SMAD protein phosphorylation +
                                                                        is-apeptidyl-arginine phosphorylation
                                                                        is-apeptidyl-aspartic acid phosphorylation +
                                                                        is-apeptidyl-cysteine phosphorylation +
                                                                        is-apeptidyl-histidine phosphorylation +
                                                                        is-apeptidyl-serine phosphorylation +
                                                                        is-apeptidyl-threonine phosphorylation +
                                                                        is-apeptidyl-tyrosine phosphorylation +
                                                                        is-aphosphorylation of RNA polymerase II C-terminal domain +
                                                                        positively-regulatespositive regulation of protein phosphorylation +
                                                                        is-aprotein autophosphorylation +
                                                                        is-aprotein phosphorylation involved in cellular protein catabolic process
                                                                        regulatesregulation of protein phosphorylation +
                                                                        is-aregulation of translational initiation by eIF2 alpha phosphorylation +


Gene_Ontology
        is-abiological_process
                is-ametabolic process
                        is-aorganic substance metabolic process
                                is-amacromolecule metabolic process
                                        is-amacromolecule modification
                                                is-aprotein modification process
                                                        is-acellular protein modification process
                                                                is-aprotein phosphorylation
                                                                        is-aactin phosphorylation +
                                                                        is-acommon-partner SMAD protein phosphorylation
                                                                        is-aDNA damage induced protein phosphorylation
                                                                        is-ahistone phosphorylation +
                                                                        is-aI-kappaB phosphorylation [GO:0007252] (12 genes, 15 annotations)
                                                                        is-ainhibitory G-protein coupled receptor phosphorylation
                                                                        is-aJUN phosphorylation
                                                                        negatively-regulatesnegative regulation of protein phosphorylation +
                                                                        is-apathway-restricted SMAD protein phosphorylation +
                                                                        is-apeptidyl-arginine phosphorylation
                                                                        is-apeptidyl-aspartic acid phosphorylation +
                                                                        is-apeptidyl-cysteine phosphorylation +
                                                                        is-apeptidyl-histidine phosphorylation +
                                                                        is-apeptidyl-serine phosphorylation +
                                                                        is-apeptidyl-threonine phosphorylation +
                                                                        is-apeptidyl-tyrosine phosphorylation +
                                                                        is-aphosphorylation of RNA polymerase II C-terminal domain +
                                                                        positively-regulatespositive regulation of protein phosphorylation +
                                                                        is-aprotein autophosphorylation +
                                                                        is-aprotein phosphorylation involved in cellular protein catabolic process
                                                                        regulatesregulation of protein phosphorylation +
                                                                        is-aregulation of translational initiation by eIF2 alpha phosphorylation +


Gene_Ontology
        is-abiological_process
                is-ametabolic process
                        is-aorganic substance metabolic process
                                is-amacromolecule metabolic process
                                        is-aprotein metabolic process
                                                is-acellular protein metabolic process
                                                        is-acellular protein modification process
                                                                is-aprotein phosphorylation
                                                                        is-aactin phosphorylation +
                                                                        is-acommon-partner SMAD protein phosphorylation
                                                                        is-aDNA damage induced protein phosphorylation
                                                                        is-ahistone phosphorylation +
                                                                        is-aI-kappaB phosphorylation [GO:0007252] (12 genes, 15 annotations)
                                                                        is-ainhibitory G-protein coupled receptor phosphorylation
                                                                        is-aJUN phosphorylation
                                                                        negatively-regulatesnegative regulation of protein phosphorylation +
                                                                        is-apathway-restricted SMAD protein phosphorylation +
                                                                        is-apeptidyl-arginine phosphorylation
                                                                        is-apeptidyl-aspartic acid phosphorylation +
                                                                        is-apeptidyl-cysteine phosphorylation +
                                                                        is-apeptidyl-histidine phosphorylation +
                                                                        is-apeptidyl-serine phosphorylation +
                                                                        is-apeptidyl-threonine phosphorylation +
                                                                        is-apeptidyl-tyrosine phosphorylation +
                                                                        is-aphosphorylation of RNA polymerase II C-terminal domain +
                                                                        positively-regulatespositive regulation of protein phosphorylation +
                                                                        is-aprotein autophosphorylation +
                                                                        is-aprotein phosphorylation involved in cellular protein catabolic process
                                                                        regulatesregulation of protein phosphorylation +
                                                                        is-aregulation of translational initiation by eIF2 alpha phosphorylation +


Gene_Ontology
        is-abiological_process
                is-ametabolic process
                        is-aorganic substance metabolic process
                                is-amacromolecule metabolic process
                                        is-aprotein metabolic process
                                                is-aprotein modification process
                                                        is-acellular protein modification process
                                                                is-aprotein phosphorylation
                                                                        is-aactin phosphorylation +
                                                                        is-acommon-partner SMAD protein phosphorylation
                                                                        is-aDNA damage induced protein phosphorylation
                                                                        is-ahistone phosphorylation +
                                                                        is-aI-kappaB phosphorylation [GO:0007252] (12 genes, 15 annotations)
                                                                        is-ainhibitory G-protein coupled receptor phosphorylation
                                                                        is-aJUN phosphorylation
                                                                        negatively-regulatesnegative regulation of protein phosphorylation +
                                                                        is-apathway-restricted SMAD protein phosphorylation +
                                                                        is-apeptidyl-arginine phosphorylation
                                                                        is-apeptidyl-aspartic acid phosphorylation +
                                                                        is-apeptidyl-cysteine phosphorylation +
                                                                        is-apeptidyl-histidine phosphorylation +
                                                                        is-apeptidyl-serine phosphorylation +
                                                                        is-apeptidyl-threonine phosphorylation +
                                                                        is-apeptidyl-tyrosine phosphorylation +
                                                                        is-aphosphorylation of RNA polymerase II C-terminal domain +
                                                                        positively-regulatespositive regulation of protein phosphorylation +
                                                                        is-aprotein autophosphorylation +
                                                                        is-aprotein phosphorylation involved in cellular protein catabolic process
                                                                        regulatesregulation of protein phosphorylation +
                                                                        is-aregulation of translational initiation by eIF2 alpha phosphorylation +


Gene_Ontology
        is-abiological_process
                is-ametabolic process
                        is-aprimary metabolic process
                                is-aprotein metabolic process
                                        is-acellular protein metabolic process
                                                is-acellular protein modification process
                                                        is-aprotein phosphorylation
                                                                is-aactin phosphorylation +
                                                                is-acommon-partner SMAD protein phosphorylation
                                                                is-aDNA damage induced protein phosphorylation
                                                                is-ahistone phosphorylation +
                                                                is-aI-kappaB phosphorylation [GO:0007252] (12 genes, 15 annotations)
                                                                is-ainhibitory G-protein coupled receptor phosphorylation
                                                                is-aJUN phosphorylation
                                                                negatively-regulatesnegative regulation of protein phosphorylation +
                                                                is-apathway-restricted SMAD protein phosphorylation +
                                                                is-apeptidyl-arginine phosphorylation
                                                                is-apeptidyl-aspartic acid phosphorylation +
                                                                is-apeptidyl-cysteine phosphorylation +
                                                                is-apeptidyl-histidine phosphorylation +
                                                                is-apeptidyl-serine phosphorylation +
                                                                is-apeptidyl-threonine phosphorylation +
                                                                is-apeptidyl-tyrosine phosphorylation +
                                                                is-aphosphorylation of RNA polymerase II C-terminal domain +
                                                                positively-regulatespositive regulation of protein phosphorylation +
                                                                is-aprotein autophosphorylation +
                                                                is-aprotein phosphorylation involved in cellular protein catabolic process
                                                                regulatesregulation of protein phosphorylation +
                                                                is-aregulation of translational initiation by eIF2 alpha phosphorylation +


Gene_Ontology
        is-abiological_process
                is-ametabolic process
                        is-aprimary metabolic process
                                is-aprotein metabolic process
                                        is-aprotein modification process
                                                is-acellular protein modification process
                                                        is-aprotein phosphorylation
                                                                is-aactin phosphorylation +
                                                                is-acommon-partner SMAD protein phosphorylation
                                                                is-aDNA damage induced protein phosphorylation
                                                                is-ahistone phosphorylation +
                                                                is-aI-kappaB phosphorylation [GO:0007252] (12 genes, 15 annotations)
                                                                is-ainhibitory G-protein coupled receptor phosphorylation
                                                                is-aJUN phosphorylation
                                                                negatively-regulatesnegative regulation of protein phosphorylation +
                                                                is-apathway-restricted SMAD protein phosphorylation +
                                                                is-apeptidyl-arginine phosphorylation
                                                                is-apeptidyl-aspartic acid phosphorylation +
                                                                is-apeptidyl-cysteine phosphorylation +
                                                                is-apeptidyl-histidine phosphorylation +
                                                                is-apeptidyl-serine phosphorylation +
                                                                is-apeptidyl-threonine phosphorylation +
                                                                is-apeptidyl-tyrosine phosphorylation +
                                                                is-aphosphorylation of RNA polymerase II C-terminal domain +
                                                                positively-regulatespositive regulation of protein phosphorylation +
                                                                is-aprotein autophosphorylation +
                                                                is-aprotein phosphorylation involved in cellular protein catabolic process
                                                                regulatesregulation of protein phosphorylation +
                                                                is-aregulation of translational initiation by eIF2 alpha phosphorylation +


Gene_Ontology
        is-abiological_process
                regulatesregulation of biological process
                        is-aregulation of cellular process
                                is-asignal transduction
                                        is-aintracellular signal transduction
                                                is-aI-kappaB kinase/NF-kappaB signaling
                                                        part-ofI-kappaB phosphorylation [GO:0007252] (12 genes, 15 annotations)
                                                        negatively-regulatesnegative regulation of I-kappaB kinase/NF-kappaB signaling +
                                                        part-ofNF-kappaB import into nucleus +
                                                        positively-regulatespositive regulation of I-kappaB kinase/NF-kappaB signaling +
                                                        regulatesregulation of I-kappaB kinase/NF-kappaB signaling +
                                                        part-ofrelease of cytoplasmic sequestered NF-kappaB


Gene_Ontology
        is-abiological_process
                is-aresponse to stimulus
                        is-acellular response to stimulus
                                is-asignal transduction
                                        is-aintracellular signal transduction
                                                is-aI-kappaB kinase/NF-kappaB signaling
                                                        part-ofI-kappaB phosphorylation [GO:0007252] (12 genes, 15 annotations)
                                                        negatively-regulatesnegative regulation of I-kappaB kinase/NF-kappaB signaling +
                                                        part-ofNF-kappaB import into nucleus +
                                                        positively-regulatespositive regulation of I-kappaB kinase/NF-kappaB signaling +
                                                        regulatesregulation of I-kappaB kinase/NF-kappaB signaling +
                                                        part-ofrelease of cytoplasmic sequestered NF-kappaB


Gene_Ontology
        is-abiological_process
                is-asignaling
                        is-asingle organism signaling
                                part-ofsignal transduction
                                        is-aintracellular signal transduction
                                                is-aI-kappaB kinase/NF-kappaB signaling
                                                        part-ofI-kappaB phosphorylation [GO:0007252] (12 genes, 15 annotations)
                                                        negatively-regulatesnegative regulation of I-kappaB kinase/NF-kappaB signaling +
                                                        part-ofNF-kappaB import into nucleus +
                                                        positively-regulatespositive regulation of I-kappaB kinase/NF-kappaB signaling +
                                                        regulatesregulation of I-kappaB kinase/NF-kappaB signaling +
                                                        part-ofrelease of cytoplasmic sequestered NF-kappaB


Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle organism signaling
                                part-ofsignal transduction
                                        is-aintracellular signal transduction
                                                is-aI-kappaB kinase/NF-kappaB signaling
                                                        part-ofI-kappaB phosphorylation [GO:0007252] (12 genes, 15 annotations)
                                                        negatively-regulatesnegative regulation of I-kappaB kinase/NF-kappaB signaling +
                                                        part-ofNF-kappaB import into nucleus +
                                                        positively-regulatespositive regulation of I-kappaB kinase/NF-kappaB signaling +
                                                        regulatesregulation of I-kappaB kinase/NF-kappaB signaling +
                                                        part-ofrelease of cytoplasmic sequestered NF-kappaB


Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle-organism cellular process
                                is-acell communication
                                        part-ofsignal transduction
                                                is-aintracellular signal transduction
                                                        is-aI-kappaB kinase/NF-kappaB signaling
                                                                part-ofI-kappaB phosphorylation [GO:0007252] (12 genes, 15 annotations)
                                                                negatively-regulatesnegative regulation of I-kappaB kinase/NF-kappaB signaling +
                                                                part-ofNF-kappaB import into nucleus +
                                                                positively-regulatespositive regulation of I-kappaB kinase/NF-kappaB signaling +
                                                                regulatesregulation of I-kappaB kinase/NF-kappaB signaling +
                                                                part-ofrelease of cytoplasmic sequestered NF-kappaB


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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory