| GO term: | I-kappaB phosphorylation |
| Synonym: | IkappaB phosphorylation |
| Synonym: | IKB phosphorylation |
| Synonym: | inhibitor of kappaB phosphorylation |
| Synonym: | inhibitor of NF-kappaB phosphorylation |
| GO id: | GO:0007252 |
| Definition: | The process of introducing a phosphate group into an inhibitor of kappa B (I-kappaB) protein. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing bound NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription. |
| Number of paths to term: | 20 |
denotes an 'is-a' relationship
denotes a 'part-of' relationship
denotes a 'regulates' relationship
denotes a 'positively-regulates' relationship
denotes a 'negatively-regulates' relationship
biological_processbiological regulationregulation of biological processregulation of cellular processsignal transductionintracellular signal transductionintracellular protein kinase cascadeI-kappaB kinase/NF-kappaB cascadeI-kappaB phosphorylation [GO:0007252] (12 genes, 15 annotations)negative regulation of I-kappaB kinase/NF-kappaB cascade +NF-kappaB import into nucleus +positive regulation of I-kappaB kinase/NF-kappaB cascade +regulation of I-kappaB kinase/NF-kappaB cascade +release of cytoplasmic sequestered NF-kappaBbiological_processcellular processcellular metabolic processcellular macromolecule metabolic processcellular protein metabolic processcellular protein modification processprotein phosphorylationactin phosphorylation +common-partner SMAD protein phosphorylationDNA damage induced protein phosphorylationhistone phosphorylation +I-kappaB phosphorylation [GO:0007252] (12 genes, 15 annotations)inhibitory G-protein coupled receptor phosphorylationJUN phosphorylationnegative regulation of protein phosphorylation +pathway-restricted SMAD protein phosphorylation +peptidyl-arginine phosphorylationpeptidyl-aspartic acid phosphorylation +peptidyl-cysteine phosphorylation +peptidyl-histidine phosphorylation +peptidyl-serine phosphorylation +peptidyl-threonine phosphorylation +peptidyl-tyrosine phosphorylation +phosphorylation of RNA polymerase II C-terminal domain +positive regulation of protein phosphorylation +protein autophosphorylation +protein phosphorylation involved in cellular protein catabolic processregulation of protein phosphorylation +regulation of translational initiation by eIF2 alpha phosphorylation +biological_processcellular processcellular metabolic processphosphorus metabolic processphosphate-containing compound metabolic processphosphorylationprotein phosphorylationactin phosphorylation +common-partner SMAD protein phosphorylationDNA damage induced protein phosphorylationhistone phosphorylation +I-kappaB phosphorylation [GO:0007252] (12 genes, 15 annotations)inhibitory G-protein coupled receptor phosphorylationJUN phosphorylationnegative regulation of protein phosphorylation +pathway-restricted SMAD protein phosphorylation +peptidyl-arginine phosphorylationpeptidyl-aspartic acid phosphorylation +peptidyl-cysteine phosphorylation +peptidyl-histidine phosphorylation +peptidyl-serine phosphorylation +peptidyl-threonine phosphorylation +peptidyl-tyrosine phosphorylation +phosphorylation of RNA polymerase II C-terminal domain +positive regulation of protein phosphorylation +protein autophosphorylation +protein phosphorylation involved in cellular protein catabolic processregulation of protein phosphorylation +regulation of translational initiation by eIF2 alpha phosphorylation +biological_processcellular processregulation of cellular processsignal transductionintracellular signal transductionintracellular protein kinase cascadeI-kappaB kinase/NF-kappaB cascadeI-kappaB phosphorylation [GO:0007252] (12 genes, 15 annotations)negative regulation of I-kappaB kinase/NF-kappaB cascade +NF-kappaB import into nucleus +positive regulation of I-kappaB kinase/NF-kappaB cascade +regulation of I-kappaB kinase/NF-kappaB cascade +release of cytoplasmic sequestered NF-kappaBbiological_processcellular processsingle-organism cellular processcell communicationsignal transductionintracellular signal transductionintracellular protein kinase cascadeI-kappaB kinase/NF-kappaB cascadeI-kappaB phosphorylation [GO:0007252] (12 genes, 15 annotations)negative regulation of I-kappaB kinase/NF-kappaB cascade +NF-kappaB import into nucleus +positive regulation of I-kappaB kinase/NF-kappaB cascade +regulation of I-kappaB kinase/NF-kappaB cascade +release of cytoplasmic sequestered NF-kappaBbiological_processcellular processsingle-organism cellular processcellular response to stimulussignal transductionintracellular signal transductionintracellular protein kinase cascadeI-kappaB kinase/NF-kappaB cascadeI-kappaB phosphorylation [GO:0007252] (12 genes, 15 annotations)negative regulation of I-kappaB kinase/NF-kappaB cascade +NF-kappaB import into nucleus +positive regulation of I-kappaB kinase/NF-kappaB cascade +regulation of I-kappaB kinase/NF-kappaB cascade +release of cytoplasmic sequestered NF-kappaBbiological_processmetabolic processcellular metabolic processcellular macromolecule metabolic processcellular protein metabolic processcellular protein modification processprotein phosphorylationactin phosphorylation +common-partner SMAD protein phosphorylationDNA damage induced protein phosphorylationhistone phosphorylation +I-kappaB phosphorylation [GO:0007252] (12 genes, 15 annotations)inhibitory G-protein coupled receptor phosphorylationJUN phosphorylationnegative regulation of protein phosphorylation +pathway-restricted SMAD protein phosphorylation +peptidyl-arginine phosphorylationpeptidyl-aspartic acid phosphorylation +peptidyl-cysteine phosphorylation +peptidyl-histidine phosphorylation +peptidyl-serine phosphorylation +peptidyl-threonine phosphorylation +peptidyl-tyrosine phosphorylation +phosphorylation of RNA polymerase II C-terminal domain +positive regulation of protein phosphorylation +protein autophosphorylation +protein phosphorylation involved in cellular protein catabolic processregulation of protein phosphorylation +regulation of translational initiation by eIF2 alpha phosphorylation +biological_processmetabolic processcellular metabolic processphosphorus metabolic processphosphate-containing compound metabolic processphosphorylationprotein phosphorylationactin phosphorylation +common-partner SMAD protein phosphorylationDNA damage induced protein phosphorylationhistone phosphorylation +I-kappaB phosphorylation [GO:0007252] (12 genes, 15 annotations)inhibitory G-protein coupled receptor phosphorylationJUN phosphorylationnegative regulation of protein phosphorylation +pathway-restricted SMAD protein phosphorylation +peptidyl-arginine phosphorylationpeptidyl-aspartic acid phosphorylation +peptidyl-cysteine phosphorylation +peptidyl-histidine phosphorylation +peptidyl-serine phosphorylation +peptidyl-threonine phosphorylation +peptidyl-tyrosine phosphorylation +phosphorylation of RNA polymerase II C-terminal domain +positive regulation of protein phosphorylation +protein autophosphorylation +protein phosphorylation involved in cellular protein catabolic processregulation of protein phosphorylation +regulation of translational initiation by eIF2 alpha phosphorylation +biological_processmetabolic processorganic substance metabolic processmacromolecule metabolic processcellular macromolecule metabolic processcellular protein metabolic processcellular protein modification processprotein phosphorylationactin phosphorylation +common-partner SMAD protein phosphorylationDNA damage induced protein phosphorylationhistone phosphorylation +I-kappaB phosphorylation [GO:0007252] (12 genes, 15 annotations)inhibitory G-protein coupled receptor phosphorylationJUN phosphorylationnegative regulation of protein phosphorylation +pathway-restricted SMAD protein phosphorylation +peptidyl-arginine phosphorylationpeptidyl-aspartic acid phosphorylation +peptidyl-cysteine phosphorylation +peptidyl-histidine phosphorylation +peptidyl-serine phosphorylation +peptidyl-threonine phosphorylation +peptidyl-tyrosine phosphorylation +phosphorylation of RNA polymerase II C-terminal domain +positive regulation of protein phosphorylation +protein autophosphorylation +protein phosphorylation involved in cellular protein catabolic processregulation of protein phosphorylation +regulation of translational initiation by eIF2 alpha phosphorylation +biological_processmetabolic processorganic substance metabolic processmacromolecule metabolic processmacromolecule modificationprotein modification processcellular protein modification processprotein phosphorylationactin phosphorylation +common-partner SMAD protein phosphorylationDNA damage induced protein phosphorylationhistone phosphorylation +I-kappaB phosphorylation [GO:0007252] (12 genes, 15 annotations)inhibitory G-protein coupled receptor phosphorylationJUN phosphorylationnegative regulation of protein phosphorylation +pathway-restricted SMAD protein phosphorylation +peptidyl-arginine phosphorylationpeptidyl-aspartic acid phosphorylation +peptidyl-cysteine phosphorylation +peptidyl-histidine phosphorylation +peptidyl-serine phosphorylation +peptidyl-threonine phosphorylation +peptidyl-tyrosine phosphorylation +phosphorylation of RNA polymerase II C-terminal domain +positive regulation of protein phosphorylation +protein autophosphorylation +protein phosphorylation involved in cellular protein catabolic processregulation of protein phosphorylation +regulation of translational initiation by eIF2 alpha phosphorylation +biological_processmetabolic processorganic substance metabolic processmacromolecule metabolic processprotein metabolic processcellular protein metabolic processcellular protein modification processprotein phosphorylationactin phosphorylation +common-partner SMAD protein phosphorylationDNA damage induced protein phosphorylationhistone phosphorylation +I-kappaB phosphorylation [GO:0007252] (12 genes, 15 annotations)inhibitory G-protein coupled receptor phosphorylationJUN phosphorylationnegative regulation of protein phosphorylation +pathway-restricted SMAD protein phosphorylation +peptidyl-arginine phosphorylationpeptidyl-aspartic acid phosphorylation +peptidyl-cysteine phosphorylation +peptidyl-histidine phosphorylation +peptidyl-serine phosphorylation +peptidyl-threonine phosphorylation +peptidyl-tyrosine phosphorylation +phosphorylation of RNA polymerase II C-terminal domain +positive regulation of protein phosphorylation +protein autophosphorylation +protein phosphorylation involved in cellular protein catabolic processregulation of protein phosphorylation +regulation of translational initiation by eIF2 alpha phosphorylation +biological_processmetabolic processorganic substance metabolic processmacromolecule metabolic processprotein metabolic processprotein modification processcellular protein modification processprotein phosphorylationactin phosphorylation +common-partner SMAD protein phosphorylationDNA damage induced protein phosphorylationhistone phosphorylation +I-kappaB phosphorylation [GO:0007252] (12 genes, 15 annotations)inhibitory G-protein coupled receptor phosphorylationJUN phosphorylationnegative regulation of protein phosphorylation +pathway-restricted SMAD protein phosphorylation +peptidyl-arginine phosphorylationpeptidyl-aspartic acid phosphorylation +peptidyl-cysteine phosphorylation +peptidyl-histidine phosphorylation +peptidyl-serine phosphorylation +peptidyl-threonine phosphorylation +peptidyl-tyrosine phosphorylation +phosphorylation of RNA polymerase II C-terminal domain +positive regulation of protein phosphorylation +protein autophosphorylation +protein phosphorylation involved in cellular protein catabolic processregulation of protein phosphorylation +regulation of translational initiation by eIF2 alpha phosphorylation +biological_processmetabolic processprimary metabolic processprotein metabolic processcellular protein metabolic processcellular protein modification processprotein phosphorylationactin phosphorylation +common-partner SMAD protein phosphorylationDNA damage induced protein phosphorylationhistone phosphorylation +I-kappaB phosphorylation [GO:0007252] (12 genes, 15 annotations)inhibitory G-protein coupled receptor phosphorylationJUN phosphorylationnegative regulation of protein phosphorylation +pathway-restricted SMAD protein phosphorylation +peptidyl-arginine phosphorylationpeptidyl-aspartic acid phosphorylation +peptidyl-cysteine phosphorylation +peptidyl-histidine phosphorylation +peptidyl-serine phosphorylation +peptidyl-threonine phosphorylation +peptidyl-tyrosine phosphorylation +phosphorylation of RNA polymerase II C-terminal domain +positive regulation of protein phosphorylation +protein autophosphorylation +protein phosphorylation involved in cellular protein catabolic processregulation of protein phosphorylation +regulation of translational initiation by eIF2 alpha phosphorylation +biological_processmetabolic processprimary metabolic processprotein metabolic processprotein modification processcellular protein modification processprotein phosphorylationactin phosphorylation +common-partner SMAD protein phosphorylationDNA damage induced protein phosphorylationhistone phosphorylation +I-kappaB phosphorylation [GO:0007252] (12 genes, 15 annotations)inhibitory G-protein coupled receptor phosphorylationJUN phosphorylationnegative regulation of protein phosphorylation +pathway-restricted SMAD protein phosphorylation +peptidyl-arginine phosphorylationpeptidyl-aspartic acid phosphorylation +peptidyl-cysteine phosphorylation +peptidyl-histidine phosphorylation +peptidyl-serine phosphorylation +peptidyl-threonine phosphorylation +peptidyl-tyrosine phosphorylation +phosphorylation of RNA polymerase II C-terminal domain +positive regulation of protein phosphorylation +protein autophosphorylation +protein phosphorylation involved in cellular protein catabolic processregulation of protein phosphorylation +regulation of translational initiation by eIF2 alpha phosphorylation +biological_processregulation of biological processregulation of cellular processsignal transductionintracellular signal transductionintracellular protein kinase cascadeI-kappaB kinase/NF-kappaB cascadeI-kappaB phosphorylation [GO:0007252] (12 genes, 15 annotations)negative regulation of I-kappaB kinase/NF-kappaB cascade +NF-kappaB import into nucleus +positive regulation of I-kappaB kinase/NF-kappaB cascade +regulation of I-kappaB kinase/NF-kappaB cascade +release of cytoplasmic sequestered NF-kappaBbiological_processresponse to stimuluscellular response to stimulussignal transductionintracellular signal transductionintracellular protein kinase cascadeI-kappaB kinase/NF-kappaB cascadeI-kappaB phosphorylation [GO:0007252] (12 genes, 15 annotations)negative regulation of I-kappaB kinase/NF-kappaB cascade +NF-kappaB import into nucleus +positive regulation of I-kappaB kinase/NF-kappaB cascade +regulation of I-kappaB kinase/NF-kappaB cascade +release of cytoplasmic sequestered NF-kappaBbiological_processsignalingsingle organism signalingsignal transductionintracellular signal transductionintracellular protein kinase cascadeI-kappaB kinase/NF-kappaB cascadeI-kappaB phosphorylation [GO:0007252] (12 genes, 15 annotations)negative regulation of I-kappaB kinase/NF-kappaB cascade +NF-kappaB import into nucleus +positive regulation of I-kappaB kinase/NF-kappaB cascade +regulation of I-kappaB kinase/NF-kappaB cascade +release of cytoplasmic sequestered NF-kappaBbiological_processsingle-organism processsingle organism signalingsignal transductionintracellular signal transductionintracellular protein kinase cascadeI-kappaB kinase/NF-kappaB cascadeI-kappaB phosphorylation [GO:0007252] (12 genes, 15 annotations)negative regulation of I-kappaB kinase/NF-kappaB cascade +NF-kappaB import into nucleus +positive regulation of I-kappaB kinase/NF-kappaB cascade +regulation of I-kappaB kinase/NF-kappaB cascade +release of cytoplasmic sequestered NF-kappaBbiological_processsingle-organism processsingle-organism cellular processcell communicationsignal transductionintracellular signal transductionintracellular protein kinase cascadeI-kappaB kinase/NF-kappaB cascadeI-kappaB phosphorylation [GO:0007252] (12 genes, 15 annotations)negative regulation of I-kappaB kinase/NF-kappaB cascade +NF-kappaB import into nucleus +positive regulation of I-kappaB kinase/NF-kappaB cascade +regulation of I-kappaB kinase/NF-kappaB cascade +release of cytoplasmic sequestered NF-kappaBbiological_processsingle-organism processsingle-organism cellular processcellular response to stimulussignal transductionintracellular signal transductionintracellular protein kinase cascadeI-kappaB kinase/NF-kappaB cascadeI-kappaB phosphorylation [GO:0007252] (12 genes, 15 annotations)negative regulation of I-kappaB kinase/NF-kappaB cascade +NF-kappaB import into nucleus +positive regulation of I-kappaB kinase/NF-kappaB cascade +regulation of I-kappaB kinase/NF-kappaB cascade +release of cytoplasmic sequestered NF-kappaBMouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc |
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last database update 06/05/2013 MGI 5.13 |
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