Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Sry

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes SRY
- Mouse genes Sry
- Rat genes Sry
- Zfish genes sox32
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Sry

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003677	DNA binding	SRY	IDA		Human	PMID:1425584
Molecular Function	GO:0003677	DNA binding	SRY	IDA		Human	PMID:8265659
Molecular Function	GO:0003677	DNA binding	Sry	IDA		Mouse	PMID:8625802
Molecular Function	GO:0003677	DNA binding	sox32	IDA		Zfish	PMID:14723850
Molecular Function	GO:0008301	DNA binding, bending	Sry	IDA		Mouse	MGI:MGI:3690807\|PMID:7774816
Molecular Function	GO:0003700	DNA-binding transcription factor activity	sox32	IGI	ZFIN:ZDB-GENE-980526-485	Zfish	PMID:14723850
Molecular Function	GO:0003700	DNA-binding transcription factor activity	sox32	IDA		Zfish	PMID:14723850
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	SRY	IDA		Human	PMID:21412441
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	Sry	IDA		Mouse	PMID:22344693
Molecular Function	GO:0140297	DNA-binding transcription factor binding	SRY	IPI	UniProtKB:F1LMV3	Human	PMID:16582099
Molecular Function	GO:0140297	DNA-binding transcription factor binding	SRY	IPI	UniProtKB:P05554	Human	PMID:16582099
Molecular Function	GO:0140297	DNA-binding transcription factor binding	SRY	IPI	UniProtKB:P08047	Human	PMID:16582099
Molecular Function	GO:0140297	DNA-binding transcription factor binding	SRY	IPI	UniProtKB:P17325	Human	PMID:16582099
Molecular Function	GO:0140297	DNA-binding transcription factor binding	SRY	IPI	UniProtKB:P31361	Human	PMID:16582099
Molecular Function	GO:0140297	DNA-binding transcription factor binding	SRY	IPI	UniProtKB:P43120	Human	PMID:16582099
Molecular Function	GO:0140297	DNA-binding transcription factor binding	SRY	IPI	UniProtKB:P51514	Human	PMID:16582099
Molecular Function	GO:0140297	DNA-binding transcription factor binding	SRY	IPI	UniProtKB:P51774	Human	PMID:16582099
Molecular Function	GO:0140297	DNA-binding transcription factor binding	SRY	IPI	UniProtKB:P70396	Human	PMID:16582099
Molecular Function	GO:0140297	DNA-binding transcription factor binding	SRY	IPI	UniProtKB:Q6J1H4	Human	PMID:16582099
Molecular Function	GO:0140297	DNA-binding transcription factor binding	SRY	IPI	UniProtKB:Q9EQW6	Human	PMID:16582099
Molecular Function	GO:0019899	enzyme binding	Sry	IPI	RGD:1551988	Rat	PMID:16904257\|RGD:1598774
Molecular Function	GO:0005515	protein binding	SRY	IPI	UniProtKB:Q15599	Human	PMID:16166090
Molecular Function	GO:0005515	protein binding	SRY	IPI	UniProtKB:Q15599	Human	PMID:9054412
Molecular Function	GO:0005515	protein binding	Sry	IPI	UniProtKB:Q15599	Mouse	MGI:MGI:3610770\|PMID:16166090
Molecular Function	GO:0005515	protein binding	Sry	IPI	PR:Q8BTB4	Mouse	PMID:15469996
Molecular Function	GO:0005515	protein binding	Sry	IPI	PR:Q9JHL1	Mouse	PMID:10410901
Molecular Function	GO:0005515	protein binding	Sry	IPI	PR:P20263	Mouse	PMID:22344693
Molecular Function	GO:0005515	protein binding	Sry	IPI	MGI:MGI:1916455	Mouse	PMID:19850934
Molecular Function	GO:0046982	protein heterodimerization activity	sox32	IPI	ZFIN:ZDB-GENE-010108-1	Zfish	PMID:23364327
Molecular Function	GO:0046982	protein heterodimerization activity	sox32	IPI	ZFIN:ZDB-GENE-980526-485	Zfish	PMID:23364327
Molecular Function	GO:0043565	sequence-specific DNA binding	Sry	IMP		Rat	PMID:15464265\|RGD:1598776
Cellular Component	GO:0005737	cytoplasm	Sry	IDA		Rat	PMID:16488877\|RGD:1598769
Cellular Component	GO:0005634	nucleus	SRY	IDA		Human	PMID:21412441
Cellular Component	GO:0005634	nucleus	SRY	IDA		Human	PMID:28030592
Cellular Component	GO:0005634	nucleus	Sry	IDA		Mouse	PMID:15469996
Cellular Component	GO:0005634	nucleus	Sry	IDA		Mouse	PMID:16185683
Cellular Component	GO:0005634	nucleus	Sry	IDA		Mouse	PMID:22514746
Cellular Component	GO:0005634	nucleus	Sry	IDA		Rat	PMID:16488877\|RGD:1598769
Cellular Component	GO:0005667	transcription regulator complex	Sry	IDA		Mouse	PMID:22344693
Biological Process	GO:0043534	blood vessel endothelial cell migration	sox32	IMP	ZFIN:ZDB-MRPHLNO-050818-2	Zfish	PMID:21726513
Biological Process	GO:0042074	cell migration involved in gastrulation	sox32	IMP	ZFIN:ZDB-MRPHLNO-051216-6	Zfish	PMID:18291651
Biological Process	GO:0060216	definitive hemopoiesis	sox32	IMP	ZFIN:ZDB-MRPHLNO-050818-2	Zfish	PMID:21726513
Biological Process	GO:0007368	determination of left/right symmetry	sox32	IMP	ZFIN:ZDB-GENO-980202-572	Zfish	PMID:12571098
Biological Process	GO:0035050	embryonic heart tube development	sox32	IMP	ZFIN:ZDB-GENO-980202-572	Zfish	PMID:10491254
Biological Process	GO:0003262	endocardial progenitor cell migration to the midline involved in heart field formation	sox32	IMP	ZFIN:ZDB-MRPHLNO-051216-6	Zfish	PMID:22119054
Biological Process	GO:0007492	endoderm development	sox32	IMP	ZFIN:ZDB-MRPHLNO-051216-6	Zfish	PMID:11410529
Biological Process	GO:0007492	endoderm development	sox32	IMP	ZFIN:ZDB-MRPHLNO-051216-6	Zfish	PMID:18291651
Biological Process	GO:0001706	endoderm formation	sox32	IMP		Zfish	PMID:11410530
Biological Process	GO:0001706	endoderm formation	sox32	IMP	ZFIN:ZDB-MRPHLNO-050818-2	Zfish	PMID:16452093
Biological Process	GO:0001706	endoderm formation	sox32	IMP		Zfish	PMID:16198294
Biological Process	GO:0001706	endoderm formation	sox32	IDA		Zfish	PMID:16672336
Biological Process	GO:0001706	endoderm formation	sox32	IMP	ZFIN:ZDB-GENO-980202-572	Zfish	PMID:10545242
Biological Process	GO:0001706	endoderm formation	sox32	IMP	ZFIN:ZDB-GENO-980202-572	Zfish	PMID:27122171
Biological Process	GO:0007493	endodermal cell fate determination	sox32	IMP		Zfish	PMID:11807021
Biological Process	GO:0001885	endothelial cell development	sox32	IMP	ZFIN:ZDB-GENO-120127-9	Zfish	PMID:19747827
Biological Process	GO:0003007	heart morphogenesis	sox32	IMP	ZFIN:ZDB-GENO-980202-572	Zfish	PMID:9007249
Biological Process	GO:0035701	hematopoietic stem cell migration	sox32	IMP	ZFIN:ZDB-MRPHLNO-050818-2	Zfish	PMID:21726513
Biological Process	GO:0001889	liver development	sox32	IMP	ZFIN:ZDB-GENO-120406-1	Zfish	PMID:22313811
Biological Process	GO:0001889	liver development	sox32	IGI	ZFIN:ZDB-GENO-130807-3	Zfish	PMID:22313811
Biological Process	GO:0001946	lymphangiogenesis	sox32	IMP	ZFIN:ZDB-GENO-120402-6	Zfish	PMID:25992545
Biological Process	GO:0001946	lymphangiogenesis	sox32	IMP	ZFIN:ZDB-MRPHLNO-080814-2	Zfish	PMID:25992545
Biological Process	GO:0008584	male gonad development	Sry	IDA		Mouse	MGI:MGI:6471836\|PMID:33004521
Biological Process	GO:0008584	male gonad development	Sry	IDA		Mouse	PMID:19457926
Biological Process	GO:0030238	male sex determination	Sry	IDA		Mouse	MGI:MGI:6471836\|PMID:33004521
Biological Process	GO:0030238	male sex determination	Sry	IGI	MGI:MGI:104723	Mouse	PMID:16700629
Biological Process	GO:0030238	male sex determination	Sry	IGI	MGI:MGI:98371	Mouse	PMID:16700629
Biological Process	GO:0030238	male sex determination	Sry	IGI	MGI:MGI:1352460	Mouse	PMID:15879091
Biological Process	GO:0030238	male sex determination	Sry	IEP		Rat	PMID:8430080\|RGD:1598778
Biological Process	GO:0007498	mesoderm development	sox32	IDA		Zfish	PMID:17026981
Biological Process	GO:0010629	negative regulation of gene expression	Sry	IDA		Mouse	PMID:11869290
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Sry	IGI	MGI:MGI:98660	Mouse	PMID:19850934
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	SRY	IDA		Human	PMID:21412441
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	sox32	IGI	ZFIN:ZDB-GENE-980526-485	Zfish	PMID:14723850
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	sox32	IDA		Zfish	PMID:14723850
Biological Process	GO:0010628	positive regulation of gene expression	SRY	IDA		Human	PMID:24681825
Biological Process	GO:2000020	positive regulation of male gonad development	SRY	IDA		Human	PMID:21412441
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Sry	IDA		Rat	PMID:15464265\|RGD:1598776
Biological Process	GO:0061035	regulation of cartilage development	sox32	IMP	ZFIN:ZDB-GENO-980202-572	Zfish	PMID:27122171
Biological Process	GO:0061035	regulation of cartilage development	sox32	IGI	ZFIN:ZDB-GENO-120220-6,ZFIN:ZDB-GENO-980202-572	Zfish	PMID:22185793
Biological Process	GO:0061035	regulation of cartilage development	sox32	IMP	ZFIN:ZDB-GENO-980202-572	Zfish	PMID:22185793
Biological Process	GO:0042663	regulation of endodermal cell fate specification	sox32	IGI	ZFIN:ZDB-GENE-030813-1	Zfish	PMID:23364327
Biological Process	GO:0042663	regulation of endodermal cell fate specification	sox32	IDA		Zfish	PMID:23364327
Biological Process	GO:0042663	regulation of endodermal cell fate specification	sox32	IGI	ZFIN:ZDB-GENE-010108-1	Zfish	PMID:23364327
Biological Process	GO:0042663	regulation of endodermal cell fate specification	sox32	IGI	ZFIN:ZDB-GENE-980526-485	Zfish	PMID:23364327
Biological Process	GO:0042663	regulation of endodermal cell fate specification	sox32	IGI	ZFIN:ZDB-GENE-010108-1,ZFIN:ZDB-GENE-980526-485	Zfish	PMID:23364327
Biological Process	GO:0042663	regulation of endodermal cell fate specification	sox32	IGI	ZFIN:ZDB-GENE-010108-2	Zfish	PMID:23364327
Biological Process	GO:0010468	regulation of gene expression	sox32	IMP		Zfish	PMID:11410530
Biological Process	GO:0007530	sex determination	Sry	IDA		Mouse	MGI:MGI:6471836\|PMID:33004521
Biological Process	GO:0007530	sex determination	Sry	IGI	MGI:MGI:1352460	Mouse	PMID:9486644

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/23/2024 MGI 6.23

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.