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Sry Gene Detail
Summary
  • Symbol
    Sry
  • Name
    sex determining region of Chr Y
  • Synonyms
    Tdf, Tdy
  • Feature Type
    protein coding gene
  • IDs
    MGI:98660
    NCBI Gene: 21674
  • Gene Overview
    MyGene.info: SRY
  • Alliance
Location &
Maps
more
  • Sequence Map
    ChrY:2662471-2663658 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome Y, cytoband p
  • Mapping Data
    10 experiments
Strain
Comparison
more
  • Strain Annotations
    1
  • PCR
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98660
protein coding gene ChrY:2662471-2663658 (-)
129S1/SvImJ no annotation
A/J no annotation
AKR/J no annotation
BALB/cJ no annotation
C3H/HeJ no annotation
C57BL/6NJ no annotation
CAROLI/EiJ no annotation
CAST/EiJ no annotation
CBA/J no annotation
DBA/2J no annotation
FVB/NJ no annotation
LP/J no annotation
NOD/ShiLtJ no annotation
NZO/HlLtJ no annotation
PWK/PhJ no annotation
SPRET/EiJ no annotation
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    SRY, sex determining region Y
  • Human Ortholog
    SRY, sex determining region Y
    Orthology source: HGNC
  • Synonyms
    SRXX1, SRXY1, TDF, TDY
  • Links
    NCBI Gene ID: 6736
    neXtProt AC: NX_Q05066
    UniProt: Q05066

  • Chr Location
    Yp11.2; chrY:2786855-2787741 (-)  GRCh38.p7

  • HCOP
    human homology predictions: SRY
  • Gene Tree
    Sry
Human Diseases
more
  • Diseases
    2 with human SRY associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    15 phenotypes from 11 alleles in 10 genetic backgrounds
    14 phenotypes from multigenic genotypes
    1 images
    64 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Variations in expression of alleles on specific backgrounds result in partial and/or complete male to female sex reversal. Deletion of alleles results in XY females.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 21674 NCBI Gene Model | MGI Sequence Detail 1188 C57BL/6J ±  kb
    transcript NM_011564 RefSeq | MGI Sequence Detail 1188 129  
    polypeptide Q05738 UniProt | EBI | MGI Sequence Detail 395 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • InterPro Domains
      IPR009071 High mobility group box domain
      IPR036910 High mobility group box domain superfamily
      IPR017253 Transcription factor SRY
    Molecular
    Reagents
    less
    • All nucleic 94
      Genomic 44
      cDNA 19
      Primer pair 28
      Other 3

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-14604, MGD-MRK-14983, MGD-MRK-14986
    References
    more
    • Summaries
      All 265
      Developmental Gene Expression 90
      Gene Ontology 17
      Phenotypes 64
    • Earliest
      J:6802 Eicher EM, et al., Mus poschiavinus Y chromosome in the C57BL/6J murine genome causes sex reversal. Science. 1982 Aug 6;217(4559):535-7
    • Latest
      J:263354 Gonen N, et al., Sex reversal following deletion of a single distal enhancer of Sox9. Science. 2018 Jun 29;360(6396):1469-1473

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/13/2018
    MGI 6.13
    The Jackson Laboratory