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Sry Gene Detail
Summary
  • Symbol
    Sry
  • Name
    sex determining region of Chr Y
  • Synonyms
    Tdf, Tdy
  • Feature Type
    protein coding gene
  • IDs
    MGI:98660
    NCBI Gene: 21674
Location & Maps
more
  • Genetic Map
    Chromosome Y, cytoband p
  • Mapping Data
    10 experiments
Homology
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  • Gene Tree
    Sry
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    15 phenotypes from 11 alleles in 10 genetic backgrounds
    14 phenotypes from multigenic genotypes
    54 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    31
  • Endonuclease-mediated
    1
  • Spontaneous
    6
  • Targeted
    5
  • Transgenic
    19
  • Genomic Mutations
    2 involving Sry
  • Incidental Mutations
Variations in expression of alleles on specific backgrounds result in partial and/or complete male to female sex reversal. Deletion of alleles results in XY females.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000045384 VEGA Gene Model | MGI Sequence Detail 1188 C57BL/6J ±  kb
transcript OTTMUST00000119113 VEGA | MGI Sequence Detail 1188 Not Applicable  
polypeptide OTTMUSP00000066370 VEGA | MGI Sequence Detail 395 Not Applicable  
For the selected sequence
Polymorphisms
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  • PCR
  • RFLP
Protein
Information
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  • UniProt
    3 Sequences
  • InterPro Domains
    IPR009071 High mobility group box domain
    IPR017253 Transcription factor SRY
Molecular
Reagents
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  • All nucleic 88
    Genomic 44
    cDNA 18
    Primer pair 24
    Other 2

    Microarray probesets 5
Other
Accession IDs
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MGD-MRK-14604, MGD-MRK-14983, MGD-MRK-14986
References
more
  • Summaries
    All 227
    Developmental Gene Expression 80
    Gene Ontology 15
    Phenotypes 54
  • Earliest
    J:6802 Eicher EM, et al., Mus poschiavinus Y chromosome in the C57BL/6J murine genome causes sex reversal. Science. 1982 Aug 6;217(4559):535-7
  • Latest
    J:229445 Yamauchi Y, et al., Two genes substitute for the mouse Y chromosome for spermatogenesis and reproduction. Science. 2016 Jan 29;351(6272):514-6

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory