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Sry
Gene Detail
 Symbol
Name
ID
Sry
sex determining region of Chr Y
MGI:98660
Synonyms Tdf, Tdy
Feature Type protein coding gene
Genetic Map
Chromosome Y
cytoband p

Mapping data(10)
Sequence Map
ChrY:2662471-2663658 bp, - strand
From VEGA annotation of GRCm38

  1188 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
Gene Tree: Sry
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Endonuclease-mediated(1) Spontaneous(4)
Incidental mutations (data from Mutagenetix )
 
Variations in expression of alleles on specific backgrounds result in partial and/or complete male to female sex reversal. Deletion of alleles results in XY females.
 
Gene Ontology
(GO)
classifications
All GO classifications: (23 annotations)
Process cell differentiation, male gonad development, ...
Component cytoplasm, nuclear transcription factor complex, ...
Function calmodulin binding, DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (73 records)
Data Summary: Results (689)    Tissues (104)    Images (82)
Theiler Stages: 4, 5, 11, 13, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 28
Assay TypeResults
Immunohistochemistry 59
RNA in situ 35
Northern blot 10
Western blot 21
RT-PCR 514
RNase protection 50
cDNA source data(17)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(88) Genomic(44) cDNA(18) Primer pair(24) Other(2)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000045384 (Evidence)
Ensembl Gene ModelENSMUSG00000069036 (Evidence)
Entrez Gene21674 (Evidence)
UniGene377114
DFCITC1591618, TC1599123, TC1606600
DoTSDT.110950175, DT.91598473
NIA Mouse Gene IndexU124267
Consensus CDS ProjectCCDS30545.1
International Mouse Knockout Project StatusSry
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000045384 VEGA Gene Model | MGI Sequence Detail 1188 C57BL/6J ±  kb
transcript OTTMUST00000119113 VEGA | MGI Sequence Detail 1188 Not Applicable 
polypeptide OTTMUSP00000066370 VEGA | MGI Sequence Detail 395 Not Applicable 

For the selected sequences
All sequences(57) RefSeq(2) UniProt(3)
Polymorphisms All PCR and RFLP(4) : PCR(2) RFLP(2) SNPs within 2kb(0 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR009071 High mobility group (HMG) box domain
Protein Ontology PR:000015643 sex-determining region Y protein
References (Earliest) J:6802 Eicher EM, et al., Mus poschiavinus Y chromosome in the C57BL/6J murine genome causes sex reversal. Science. 1982 Aug 6;217(4559):535-7
(Latest) J:211622 DeFalco T, et al., Yolk-sac-derived macrophages regulate fetal testis vascularization and morphogenesis. Proc Natl Acad Sci U S A. 2014 Jun 10;111(23):E2384-93
All references(221)
Other
accession IDs
MGD-MRK-14604, MGD-MRK-14983, MGD-MRK-14986

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/16/2014
MGI 5.19
The Jackson Laboratory