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Sry Gene Detail
Summary
  • Symbol
    Sry
  • Name
    sex determining region of Chr Y
  • Synonyms
    Tdf, Tdy
  • Feature Type
    protein coding gene
  • IDs
    MGI:98660
    NCBI Gene: 21674
  • Gene Overview
    MyGene.info: SRY
  • Alliance
Location & Maps
more
  • Genetic Map
    Chromosome Y, cytoband p
  • Mapping Data
    10 experiments
Homology
more
  • Human Ortholog
    SRY, sex determining region Y
  • Human Ortholog
    SRY, sex determining region Y
    Orthology source: HGNC
  • Synonyms
    SRXX1, SRXY1, TDF, TDY
  • Links
    NCBI Gene ID: 6736
    neXtProt AC: NX_Q05066
    UniProt: Q05066

  • Chr Location
    Yp11.2; chrY:2786855-2787741 (-)  GRCh38.p7

  • HCOP
    human homology predictions: SRY
  • Gene Tree
    Sry
Human Diseases
more
  • Diseases
    2 with human SRY associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    15 phenotypes from 11 alleles in 10 genetic backgrounds
    14 phenotypes from multigenic genotypes
    1 images
    63 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Variations in expression of alleles on specific backgrounds result in partial and/or complete male to female sex reversal. Deletion of alleles results in XY females.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000045384 VEGA Gene Model | MGI Sequence Detail 1188 C57BL/6J ±  kb
    transcript OTTMUST00000119113 VEGA | MGI Sequence Detail 1188 Not Applicable  
    polypeptide OTTMUSP00000066370 VEGA | MGI Sequence Detail 395 Not Applicable  
    For the selected sequence
    Polymorphisms
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    • PCR
    • RFLP
    Protein
    Information
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    • UniProt
      3 Sequences
    • InterPro Domains
      IPR009071 High mobility group box domain
      IPR036910 High mobility group box domain superfamily
      IPR017253 Transcription factor SRY
    Molecular
    Reagents
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    • All nucleic 92
      Genomic 44
      cDNA 18
      Primer pair 27
      Other 3

      Microarray probesets 5
    Other
    Accession IDs
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    MGD-MRK-14604, MGD-MRK-14983, MGD-MRK-14986
    References
    more
    • Summaries
      All 259
      Developmental Gene Expression 88
      Gene Ontology 15
      Phenotypes 63
    • Earliest
      J:6802 Eicher EM, et al., Mus poschiavinus Y chromosome in the C57BL/6J murine genome causes sex reversal. Science. 1982 Aug 6;217(4559):535-7
    • Latest
      J:255730 Jimenez-Badillo SE, et al., Catsper1 promoter is bidirectional and regulates the expression of a novel lncRNA. Sci Rep. 2017 Oct 17;7(1):13351

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    05/15/2018
    MGI 6.12
    The Jackson Laboratory