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Sry
Gene Detail
 Symbol
Name
ID
Sry
sex determining region of Chr Y
MGI:98660
Synonyms Tdf, Tdy
Feature Type protein coding gene
Genetic Map
Chromosome Y
cytoband p

Mapping data(10)
Sequence Map
ChrY:2662471-2663658 bp, - strand
From NCBI annotation of GRCm38

  1188 bp   ±  kb flank

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Mouse Genome Browser
Vertebrate
homology
Gene Tree: Sry
Alleles
and
phenotypes
All alleles(7) : Endonuclease-mediated(1) Spontaneous(4)
Incidental mutations (data from Mutagenetix )
 
Variations in expression of alleles on specific backgrounds result in partial and/or complete male to female sex reversal. Deletion of alleles results in XY females.
 
Gene Ontology
(GO)
classifications
All GO classifications: (23 annotations)
Process cell differentiation, male gonad development, ...
Component cytoplasm, nuclear transcription factor complex, ...
Function calmodulin binding, DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (73 records)
Data Summary: Results (690)    Tissues (104)    Images (82)
Theiler Stages: 4, 5, 11, 13, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 28
Assay TypeResults
Immunohistochemistry 59
RNA in situ 35
Northern blot 10
Western blot 21
RT-PCR 514
RNase protection 51
cDNA source data(17)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(88) Genomic(44) cDNA(18) Primer pair(24) Other(2)
Microarray probesets(5)
Other database
links
Ensembl Gene ModelENSMUSG00000069036 (Evidence)
Entrez Gene21674 (Evidence)
UniGene377114
DFCITC1591618, TC1599123, TC1606600
DoTSDT.110950175, DT.91598473
NIA Mouse Gene IndexU124267
Consensus CDS ProjectCCDS30545.1
International Mouse Knockout Project StatusSry
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 21674 NCBI Gene Model | MGI Sequence Detail 1188 C57BL/6J ±  kb
transcript NM_011564 RefSeq | MGI Sequence Detail 1188 129 
polypeptide Q05738 UniProt | EBI | MGI Sequence Detail 395 Not Applicable 

For the selected sequences
All sequences(54) RefSeq(2) UniProt(3)
Polymorphisms All PCR and RFLP(4) : PCR(2) RFLP(2) SNPs within 2kb(0 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR009071 High mobility group (HMG) box domain
Protein Ontology PR:000015643 sex-determining region Y protein
Graphical View of Protein Domain Structure
References (Earliest) J:6802 Eicher EM, et al., Mus poschiavinus Y chromosome in the C57BL/6J murine genome causes sex reversal. Science. 1982 Aug 6;217(4559):535-7
(Latest) J:208433 Vernet N, et al., The expression of Y-linked Zfy2 in XY mouse oocytes leads to frequent meiosis 2 defects, a high incidence of subsequent early cleavage stage arrest and infertility. Development. 2014 Feb;141(4):855-66
All references(219)
Other
accession IDs
MGD-MRK-14604, MGD-MRK-14983, MGD-MRK-14986

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory