Sry
Gene Detail

Symbol Name ID

Sry sex determining region of Chr Y MGI:98660

Synonyms

Tdf, Tdy

Feature Type

protein coding gene

Genetic Map

Chromosome Y
cytoband p

Mapping data(10)

Sequence Map

ChrY:2662471-2663658 bp, - strand From NCBI annotation of GRCm38   1188 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

Gene Tree: Sry

Alleles and phenotypes

All alleles(6) : Spontaneous(4) Other(2)
 

Variations in expression of alleles on specific backgrounds result in partial and/or complete male to female sex reversal. Deletion of alleles results in XY females.

 

Gene Ontology (GO) classifications

All GO classifications: (17 annotations)

Process	cell differentiation, male gonad development, ...
Component	nucleus
Function	calmodulin binding, DNA binding, ...

External Resources: FuncBase

Expression

Literature Summary: (68 records)
Data Summary: Results (522)    Tissues (103)    Images (75)
Theiler Stages: 4, 5, 11, 13, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
Immunohistochemistry	59
RNA in situ	34
Northern blot	10
Western blot	21
RT-PCR	347
RNase protection	51

cDNA source data(17)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(88) Genomic(44) cDNA(18) Primer pair(24) Other(2)
Microarray probesets(5)

Other database links

Ensembl Gene Model	ENSMUSG00000069036 (Evidence)
Entrez Gene	21674 (Evidence)
UniGene	377114
DFCI	TC1591618, TC1599123, TC1606600
DoTS	DT.110950175, DT.91598473
NIA Mouse Gene Index	U124267
Consensus CDS Project	CCDS30545.1
International Mouse Knockout Project Status	Sry

Sequences

Length	Strain/Species
genomic	21674	NCBI Gene Model | MGI Sequence Detail	1188	C57BL/6J
transcript	NM_011564	RefSeq | MGI Sequence Detail	1188	129
polypeptide	Q05738	UniProt | EBI | MGI Sequence Detail	395	Not Applicable

All sequences(54) RefSeq(2) UniProt(3)

Polymorphisms

All PCR and RFLP(4) : PCR(2) RFLP(2) SNPs(0 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR009071	High mobility group, superfamily
Protein Ontology	PR:000015643	sex-determining region Y protein

Graphical View of Protein Domain Structure

References

(Earliest) J:6802 Eicher EM, et al., Mus poschiavinus Y chromosome in the C57BL/6J murine genome causes sex reversal. Science. 1982 Aug 6;217(4559):535-7
(Latest) J:191096 Warr N, et al., Gadd45gamma and Map3k4 interactions regulate mouse testis determination via p38 MAPK-mediated control of Sry expression. Dev Cell. 2012 Nov 13;23(5):1020-31
All references(208)

Other accession IDs

MGD-MRK-14604, MGD-MRK-14983, MGD-MRK-14986