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Sequence Detail
Q05738 (UniProt | EBI) Last sequence update: 2021-02-10
Last annotation update: 2024-01-24
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RecName: Full=Sex-determining region Y protein {ECO:0000303|PubMed:1518820};AltName: Full=Testis-determining factor {ECO:0000250|UniProtKB:Q05066};
Polypeptide 392 aa
For this sequence
Organism mouse
See UniProt | EBI for source
Annotated genes and markers Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.
Type Symbol Name GO Terms Expression
Orthologs Phenotypic
Gene Sry sex determining region of Chr Y 41 202 3 45
Sequence references in MGI J:2258 Gubbay J, et al., Inverted repeat structure of the Sry locus in mice. Proc Natl Acad Sci U S A. 1992 Sep 1;89(17):7953-7
J:10645 Gubbay J, et al., A gene mapping to the sex-determining region of the mouse Y chromosome is a member of a novel family of embryonically expressed genes [see comments]. Nature. 1990 Jul 19;346(6281):245-50
J:17098 Coward P, et al., Polymorphism of a CAG trinucleotide repeat within Sry correlates with B6.YDom sex reversal. Nat Genet. 1994 Mar;6(3):245-50
J:18226 Giese K, et al., Distinct DNA-binding properties of the high mobility group domain of murine and human SRY sex-determining factors. Proc Natl Acad Sci U S A. 1994 Apr 12;91(8):3368-72
J:26101 Hacker A, et al., Expression of Sry, the mouse sex determining gene. Development. 1995 Jun;121(6):1603-14
J:27741 Jeske YW, et al., Expression of a linear Sry transcript in the mouse genital ridge. Nat Genet. 1995 Aug;10(4):480-2
J:49298 Tucker PK, et al., Rapid evolution of the sex determining locus in Old World mice and rats. Nature. 1993 Aug 19;364(6439):715-7
J:73280 Albrecht KH, et al., Evidence that sry is expressed in pre-sertoli cells and sertoli and granulosa cells have a common precursor. Dev Biol. 2001 Dec 1;240(1):92-107
J:74052 Mayer A, et al., Developmental profile of Sry transcripts in mouse brain. Neurogenetics. 2000 Sep;3(1):25-30
J:103823 Thevenet L, et al., NHERF2/SIP-1 interacts with mouse SRY via a different mechanism than human SRY. J Biol Chem. 2005 Nov 18;280(46):38625-30
J:123875 Dewing P, et al., Direct regulation of adult brain function by the male-specific factor SRY. Curr Biol. 2006 Feb 21;16(4):415-20
J:164348 Oh HJ, et al., Sry associates with the heterochromatin protein 1 complex by interacting with a KRAB domain protein. Biol Reprod. 2005 Feb;72(2):407-15
J:297093 Miyawaki S, et al., The mouse Sry locus harbors a cryptic exon that is essential for male sex determination. Science. 2020 Oct 2;370(6512):121-124

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.23
The Jackson Laboratory