Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Serpine1

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes SERPINE1
- Mouse genes Serpine1
- Rat genes Serpine1
- Zfish genes serpine1
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Serpine1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0002020	protease binding	SERPINE1	IPI	UniProtKB:P08246	Human	PMID:12114510
Molecular Function	GO:0002020	protease binding	SERPINE1	IPI	UniProtKB:Q8BIK6	Human	PMID:15853774
Molecular Function	GO:0002020	protease binding	SERPINE1	IPI	UniProtKB:P00750	Human	PMID:2503541
Molecular Function	GO:0002020	protease binding	SERPINE1	IPI	UniProtKB:P00750	Human	PMID:8508955
Molecular Function	GO:0002020	protease binding	SERPINE1	IPI	UniProtKB:P00734	Human	PMID:8626514
Molecular Function	GO:0002020	protease binding	Serpine1	IDA		Rat	PMID:9316343\|RGD:8547951
Molecular Function	GO:0005515	protein binding	SERPINE1	IPI	UniProtKB:P02763	Human	PMID:16272158
Molecular Function	GO:0005515	protein binding	SERPINE1	IPI	UniProtKB:O43765	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SERPINE1	IPI	UniProtKB:Q96EQ0	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SERPINE1	IPI	UniProtKB:Q9UMX0	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SERPINE1	IPI	UniProtKB:Q9UMX0-2	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SERPINE1	IPI	UniProtKB:P62140	Human	PMID:28296156
Molecular Function	GO:0005515	protein binding	SERPINE1	IPI	UniProtKB:O43711	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SERPINE1	IPI	UniProtKB:O43765	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SERPINE1	IPI	UniProtKB:P78337	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SERPINE1	IPI	UniProtKB:Q8NBQ5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SERPINE1	IPI	UniProtKB:Q96EQ0	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SERPINE1	IPI	UniProtKB:Q96Q45-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SERPINE1	IPI	UniProtKB:Q9UHD9	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	Serpine1	IPI	PR:Q5S248	Mouse	PMID:15328353
Molecular Function	GO:0005515	protein binding	Serpine1	IPI	PR:Q9CZD3	Mouse	PMID:8939962
Molecular Function	GO:0004867	serine-type endopeptidase inhibitor activity	SERPINE1	IDA		Human	PMID:1695900
Molecular Function	GO:0004867	serine-type endopeptidase inhibitor activity	SERPINE1	IDA		Human	PMID:8508955
Molecular Function	GO:0004867	serine-type endopeptidase inhibitor activity	Serpine1	IDA		Mouse	PMID:15328353
Molecular Function	GO:0004867	serine-type endopeptidase inhibitor activity	Serpine1	IDA		Rat	PMID:9316343\|RGD:8547951
Molecular Function	GO:0004867	serine-type endopeptidase inhibitor activity	serpine1	IDA		Zfish	PMID:23702291
Molecular Function	GO:0005102	signaling receptor binding	SERPINE1	IPI	UniProtKB:Q07954	Human	PMID:8626514
Cellular Component	GO:0042583	chromaffin granule	Serpine1	IDA		Rat	PMID:21596853\|RGD:8547918
Cellular Component	GO:0062023	collagen-containing extracellular matrix	SERPINE1	HDA		Human	PMID:28327460
Cellular Component	GO:0062023	collagen-containing extracellular matrix	SERPINE1	IDA		Human	PMID:1632457
Cellular Component	GO:0062023	collagen-containing extracellular matrix	SERPINE1	HDA		Human	PMID:23979707
Cellular Component	GO:0005737	cytoplasm	Serpine1	IDA		Rat	PMID:26286041\|RGD:11073724
Cellular Component	GO:0070062	extracellular exosome	SERPINE1	IDA		Human	PMID:21276792
Cellular Component	GO:0005576	extracellular region	SERPINE1	IDA		Human	PMID:9386191
Cellular Component	GO:0005576	extracellular region	Serpine1	IDA		Rat	PMID:10717410\|RGD:8547889
Cellular Component	GO:0005576	extracellular region	Serpine1	IDA		Rat	PMID:17071586\|RGD:1624958
Cellular Component	GO:0005615	extracellular space	SERPINE1	IDA		Human	PMID:1695900
Cellular Component	GO:0005615	extracellular space	SERPINE1	IDA		Human	PMID:18835034
Cellular Component	GO:0005615	extracellular space	Serpine1	HDA		Mouse	MGI:MGI:5640941\|PMID:24006456
Cellular Component	GO:0005615	extracellular space	Serpine1	IDA		Rat	PMID:20083474\|RGD:2316114
Cellular Component	GO:1904090	peptidase inhibitor complex	SERPINE1	IPI		Human	PMID:12808446
Cellular Component	GO:0097180	serine protease inhibitor complex	SERPINE1	IPI		Human	PMID:21199867
Cellular Component	GO:0097180	serine protease inhibitor complex	SERPINE1	IPI		Human	PMID:26324706
Biological Process	GO:0001525	angiogenesis	SERPINE1	IEP		Human	PMID:11866539
Biological Process	GO:0001525	angiogenesis	Serpine1	IMP		Mouse	PMID:21119013
Biological Process	GO:1904045	cellular response to aldosterone	Serpine1	IEP		Rat	PMID:26617694\|RGD:11073721
Biological Process	GO:1904385	cellular response to angiotensin	Serpine1	IEP		Rat	PMID:19051364\|RGD:13208594
Biological Process	GO:0071318	cellular response to ATP	Serpine1	IEP		Rat	PMID:10712415\|RGD:8547950
Biological Process	GO:0071320	cellular response to cAMP	Serpine1	IEP		Rat	PMID:9603932\|RGD:8547856
Biological Process	GO:0071321	cellular response to cGMP	Serpine1	IEP		Rat	PMID:9812917\|RGD:8547931
Biological Process	GO:0071409	cellular response to cycloheximide	Serpine1	IEP		Rat	PMID:9798919\|RGD:8547916
Biological Process	GO:0071549	cellular response to dexamethasone stimulus	Serpine1	IEP		Rat	PMID:1333984\|RGD:8547845
Biological Process	GO:0044344	cellular response to fibroblast growth factor stimulus	Serpine1	IEP		Rat	PMID:10615432\|RGD:8547892
Biological Process	GO:0071372	cellular response to follicle-stimulating hormone stimulus	Serpine1	IEP		Rat	PMID:9716558\|RGD:8547924
Biological Process	GO:0071377	cellular response to glucagon stimulus	Serpine1	IEP		Rat	PMID:17721610\|RGD:8547915
Biological Process	GO:0071333	cellular response to glucose stimulus	Serpine1	IEP		Rat	PMID:15828931\|RGD:13208547
Biological Process	GO:0071333	cellular response to glucose stimulus	Serpine1	IEP		Rat	PMID:23008698\|RGD:8547888
Biological Process	GO:0071258	cellular response to gravity	Serpine1	IEP		Rat	PMID:19574431\|RGD:4144861
Biological Process	GO:0071363	cellular response to growth factor stimulus	Serpine1	IEP		Rat	PMID:17474984\|RGD:2316122
Biological Process	GO:0070301	cellular response to hydrogen peroxide	Serpine1	IEP		Rat	PMID:12409145\|RGD:8547917
Biological Process	GO:0071456	cellular response to hypoxia	Serpine1	IEP		Rat	PMID:10590062\|RGD:8547811
Biological Process	GO:0032869	cellular response to insulin stimulus	Serpine1	IEP		Rat	PMID:10590062\|RGD:8547811
Biological Process	GO:0071347	cellular response to interleukin-1	Serpine1	IDA		Rat	PMID:9420877\|RGD:8547942
Biological Process	GO:1990830	cellular response to leukemia inhibitory factor	Serpine1	IEP		Rat	PMID:2170427\|RGD:11080968
Biological Process	GO:0071222	cellular response to lipopolysaccharide	SERPINE1	IMP		Human	PMID:19916862
Biological Process	GO:0071222	cellular response to lipopolysaccharide	Serpine1	IEP		Rat	PMID:20060032\|RGD:13208812
Biological Process	GO:0071404	cellular response to low-density lipoprotein particle stimulus	Serpine1	IEP		Rat	PMID:11057874\|RGD:8547812
Biological Process	GO:0071260	cellular response to mechanical stimulus	Serpine1	IEP		Rat	PMID:20054150\|RGD:8547898
Biological Process	GO:0071248	cellular response to metal ion	Serpine1	IEP		Rat	PMID:21596853\|RGD:8547918
Biological Process	GO:1990090	cellular response to nerve growth factor stimulus	Serpine1	IEP		Rat	PMID:21596853\|RGD:8547918
Biological Process	GO:0071316	cellular response to nicotine	Serpine1	IEP		Rat	PMID:21596853\|RGD:8547918
Biological Process	GO:0071407	cellular response to organic cyclic compound	Serpine1	IEP		Rat	PMID:15961275\|RGD:8547726
Biological Process	GO:0071407	cellular response to organic cyclic compound	Serpine1	IEP		Rat	PMID:20471392\|RGD:8547860
Biological Process	GO:0036120	cellular response to platelet-derived growth factor stimulus	Serpine1	IEP		Rat	PMID:10615432\|RGD:8547892
Biological Process	GO:0035865	cellular response to potassium ion	Serpine1	IEP		Rat	PMID:21596853\|RGD:8547918
Biological Process	GO:1904639	cellular response to resveratrol	Serpine1	IEP		Rat	PMID:25850408\|RGD:11075079
Biological Process	GO:0071560	cellular response to transforming growth factor beta stimulus	Serpine1	IDA		Mouse	PMID:21829547
Biological Process	GO:0071560	cellular response to transforming growth factor beta stimulus	Serpine1	IEP		Rat	PMID:19247458\|RGD:8547745
Biological Process	GO:0071466	cellular response to xenobiotic stimulus	Serpine1	IDA		Rat	PMID:23378038\|RGD:8547945
Biological Process	GO:0046697	decidualization	Serpine1	IEP		Rat	PMID:8862764\|RGD:8547846
Biological Process	GO:0050829	defense response to Gram-negative bacterium	SERPINE1	IGI	UniProtKB:P22777	Human	PMID:17032919
Biological Process	GO:0050829	defense response to Gram-negative bacterium	Serpine1	IMP		Mouse	MGI:MGI:3830955\|PMID:17032919
Biological Process	GO:0097187	dentinogenesis	SERPINE1	IDA		Human	PMID:27046084
Biological Process	GO:0008585	female gonad development	Serpine1	IDA		Rat	PMID:8527517\|RGD:8547900
Biological Process	GO:0042593	glucose homeostasis	Serpine1	IEP		Rat	PMID:12105191\|RGD:729915
Biological Process	GO:0045576	mast cell activation	Serpine1	IEP		Rat	PMID:15961275\|RGD:8547726
Biological Process	GO:0033629	negative regulation of cell adhesion mediated by integrin	SERPINE1	IDA		Human	PMID:8837777
Biological Process	GO:0030336	negative regulation of cell migration	SERPINE1	IDA		Human	PMID:10902815
Biological Process	GO:0030336	negative regulation of cell migration	Serpine1	IDA		Rat	PMID:15596522\|RGD:8547853
Biological Process	GO:0030336	negative regulation of cell migration	Serpine1	IMP		Rat	PMID:15596522\|RGD:8547853
Biological Process	GO:0010951	negative regulation of endopeptidase activity	SERPINE1	IDA		Human	PMID:1695900
Biological Process	GO:0010951	negative regulation of endopeptidase activity	Serpine1	IDA		Rat	PMID:10717410\|RGD:8547889
Biological Process	GO:2000352	negative regulation of endothelial cell apoptotic process	SERPINE1	IMP		Human	PMID:18835034
Biological Process	GO:1902042	negative regulation of extrinsic apoptotic signaling pathway via death domain receptors	SERPINE1	IMP		Human	PMID:18835034
Biological Process	GO:0051918	negative regulation of fibrinolysis	SERPINE1	IDA		Human	PMID:2503541
Biological Process	GO:0010629	negative regulation of gene expression	Serpine1	IMP		Rat	PMID:22659625\|RGD:8547927
Biological Process	GO:0010757	negative regulation of plasminogen activation	SERPINE1	IMP		Human	PMID:18835034
Biological Process	GO:0010757	negative regulation of plasminogen activation	SERPINE1	IMP		Human	PMID:19855083
Biological Process	GO:0010757	negative regulation of plasminogen activation	SERPINE1	IDA		Human	PMID:8508955
Biological Process	GO:0010757	negative regulation of plasminogen activation	Serpine1	IMP		Mouse	MGI:MGI:4418017\|PMID:19855083
Biological Process	GO:0010757	negative regulation of plasminogen activation	serpine1	IDA		Zfish	PMID:23702291
Biological Process	GO:0014912	negative regulation of smooth muscle cell migration	SERPINE1	IDA		Human	PMID:8837777
Biological Process	GO:2000098	negative regulation of smooth muscle cell-matrix adhesion	SERPINE1	IDA		Human	PMID:8837777
Biological Process	GO:0061044	negative regulation of vascular wound healing	SERPINE1	IGI	UniProtKB:P22777	Human	PMID:9386191
Biological Process	GO:0061044	negative regulation of vascular wound healing	Serpine1	IMP		Mouse	MGI:MGI:1100384\|PMID:9386191
Biological Process	GO:0001890	placenta development	Serpine1	IMP		Mouse	PMID:21119013
Biological Process	GO:0045766	positive regulation of angiogenesis	SERPINE1	IMP		Human	PMID:18835034
Biological Process	GO:0045766	positive regulation of angiogenesis	Serpine1	IMP		Mouse	MGI:MGI:3811928\|PMID:18835034
Biological Process	GO:0045766	positive regulation of angiogenesis	Serpine1	IMP		Mouse	PMID:21119013
Biological Process	GO:0030194	positive regulation of blood coagulation	SERPINE1	IMP		Human	PMID:9207454
Biological Process	GO:0090280	positive regulation of calcium ion import	Serpine1	IMP		Rat	PMID:22659625\|RGD:8547927
Biological Process	GO:0050820	positive regulation of coagulation	Serpine1	IMP		Rat	PMID:18239154\|RGD:2316121
Biological Process	GO:0032967	positive regulation of collagen biosynthetic process	Serpine1	IMP		Rat	PMID:15828931\|RGD:13208547
Biological Process	GO:1905043	positive regulation of epithelium regeneration	Serpine1	IMP		Rat	PMID:17071586\|RGD:1624958
Biological Process	GO:0048146	positive regulation of fibroblast proliferation	Serpine1	IMP		Rat	PMID:22659625\|RGD:8547927
Biological Process	GO:0010628	positive regulation of gene expression	Serpine1	IMP		Rat	PMID:22659625\|RGD:8547927
Biological Process	GO:0050729	positive regulation of inflammatory response	SERPINE1	IGI	UniProtKB:P22777	Human	PMID:17032919
Biological Process	GO:0032757	positive regulation of interleukin-8 production	SERPINE1	IMP		Human	PMID:19916862
Biological Process	GO:0051549	positive regulation of keratinocyte migration	Serpine1	IMP		Rat	PMID:15174100\|RGD:8547947
Biological Process	GO:0035491	positive regulation of leukotriene production involved in inflammatory response	SERPINE1	IMP		Human	PMID:19916862
Biological Process	GO:0090026	positive regulation of monocyte chemotaxis	SERPINE1	IMP		Human	PMID:19916862
Biological Process	GO:1901331	positive regulation of odontoblast differentiation	SERPINE1	IDA		Human	PMID:27046084
Biological Process	GO:0048260	positive regulation of receptor-mediated endocytosis	SERPINE1	IDA		Human	PMID:8626514
Biological Process	GO:0048260	positive regulation of receptor-mediated endocytosis	Serpine1	IMP		Rat	PMID:8626514\|RGD:8554276
Biological Process	GO:0045765	regulation of angiogenesis	Serpine1	IDA		Mouse	PMID:11818362
Biological Process	GO:0042127	regulation of cell population proliferation	Serpine1	IGI	MGI:MGI:88039	Mouse	PMID:18258607
Biological Process	GO:0010469	regulation of signaling receptor activity	SERPINE1	IDA		Human	PMID:8837777
Biological Process	GO:0090399	replicative senescence	SERPINE1	IMP		Human	PMID:16862142
Biological Process	GO:0034097	response to cytokine	Serpine1	IEP		Rat	PMID:20083474\|RGD:2316114
Biological Process	GO:0070849	response to epidermal growth factor	Serpine1	IEP		Rat	PMID:1333984\|RGD:8547845
Biological Process	GO:0043627	response to estrogen	Serpine1	IEP		Rat	PMID:20838740\|RGD:4144853
Biological Process	GO:0055093	response to hyperoxia	Serpine1	IEP		Rat	PMID:19099788\|RGD:4143526
Biological Process	GO:0034616	response to laminar fluid shear stress	Serpine1	IEP		Rat	PMID:16500919\|RGD:8547920
Biological Process	GO:0032496	response to lipopolysaccharide	Serpine1	IEP		Rat	PMID:9569197\|RGD:8547847
Biological Process	GO:0031667	response to nutrient levels	Serpine1	IEP		Rat	PMID:26879937\|RGD:11073685
Biological Process	GO:0000302	response to reactive oxygen species	Serpine1	IEP		Rat	PMID:12719791\|RGD:1580124
Biological Process	GO:0042594	response to starvation	Serpine1	IEP		Rat	PMID:17721610\|RGD:8547915
Biological Process	GO:0071559	response to transforming growth factor beta	Serpine1	IEP		Rat	PMID:16105028\|RGD:8547842
Biological Process	GO:0042246	tissue regeneration	Serpine1	IEP		Rat	PMID:12399226\|RGD:1580125

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/23/2024 MGI 6.23

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.