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Serpine1 Gene Detail
Summary
  • Symbol
    Serpine1
  • Name
    serine (or cysteine) peptidase inhibitor, clade E, member 1
  • Synonyms
    PAI1, PAI-1, Planh1
  • Feature Type
    protein coding gene
  • IDs
    MGI:97608
    NCBI Gene: 18787
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr5:137061504-137072268 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      10765 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 76.16 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    SERPINE1, serpin family E member 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    SERPINE1, serpin family E member 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    PAI, PAI1, PAI-1, PLANH1
  • Links
    NCBI Gene ID: 5054
    neXtProt AC: NX_P05121
    UniProt: P05121

  • Chr Location
    7q22.1; chr7:101127087-101139266 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    44 phenotypes from 3 alleles in 7 genetic backgrounds
    15 phenotypes from multigenic genotypes
    140 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Although mice homozygous for disruptions in this gene display an essentially normal phenotype, a mild blood clotting defect does exist. Mice homozygous for an allele with amino acid substitutions exhibit decreased sensitivity to LPS-induced lethality.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000054456 VEGA Gene Model | MGI Sequence Detail 10765 C57BL/6J ±  kb
    transcript OTTMUST00000135048 VEGA | MGI Sequence Detail 3011 Not Applicable  
    polypeptide OTTMUSP00000071541 VEGA | MGI Sequence Detail 402 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      40 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 30
      Genomic 2
      cDNA 23
      Primer pair 4
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-13344
    References
    more
    • Summaries
      All 258
      Developmental Gene Expression 41
      Gene Ontology 14
      Phenotypes 140
    • Earliest
      J:32471 Prendergast GC, et al., The c-myc-regulated gene mrl encodes plasminogen activator inhibitor 1. Mol Cell Biol. 1990 Mar;10(3):1265-9
    • Latest
      J:261111 Pant A, et al., Plasminogen Activator Inhibitor-1 Reduces Tissue-Type Plasminogen Activator-Dependent Fibrinolysis and Intrahepatic Hemorrhage in Experimental Acetaminophen Overdose. Am J Pathol. 2018 May;188(5):1204-1212

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    05/15/2018
    MGI 6.12
    The Jackson Laboratory