About   Help   FAQ
Serpine1
Gene Detail
Symbol

Name
ID
Serpine1
serine (or cysteine) peptidase inhibitor, clade E, member 1
MGI:97608
Synonyms
PAI1, PAI-1, Planh1
Feature Type
protein coding gene
Genetic Map
Chromosome 5
76.16 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr5:137061504-137072272 bp, - strand
From NCBI annotation of GRCm38

  10769 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:68070  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: serpin
Gene Tree: Serpine1

Human
homologs
Human Homolog SERPINE1, serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
NCBI Gene ID 5054
neXtProt AC  NX_P05121
Human Synonyms  PAI, PAI1, PAI-1, PLANH1
Human Chr (Location)  7q22.1; chr7:101127089-101139266 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human SERPINE1
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Gene trapped(1) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Although mice homozygous for disruptions in this gene display an essentially normal phenotype, a mild blood clotting defect does exist.
 
Interactions
Serpine1 interacts with 250 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (59 annotations)
Process cellular response to drug, cellular response to interleukin-1, ...
Component chromaffin granule, extracellular matrix, ...
Function peptidase inhibitor activity, protease binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (32 records)
Data Summary: Results (84)    Tissues (33)    Images (18)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 5
RNA in situ 26
Northern blot 24
RT-PCR 29
cDNA source data(22)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(29) Genomic(2) cDNA(23) Primer pair(3) Other(1)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000037411 (Evidence)
Entrez Gene18787 (Evidence)
UniGene250422
DFCITC1579525, TC1617185
DoTSDT.101168537, DT.101722102, DT.40158297
NIA Mouse Gene IndexU026838
PDB3LW2
Consensus CDS ProjectCCDS19761.1
International Mouse Knockout Project StatusSerpine1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 18787 NCBI Gene Model | MGI Sequence Detail 10769 C57BL/6J ±  kb
transcript NM_008871 RefSeq | MGI Sequence Detail 3024 Not Specified 
polypeptide P22777 UniProt | EBI | MGI Sequence Detail 402 Not Applicable 

For the selected sequences
All sequences(25) RefSeq(2) UniProt(5)
Polymorphisms
SNPs within 2kb(40 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR023795 Protease inhibitor I4, serpin, conserved site
InterPro IPR023796 Serpin domain
InterPro IPR000215 Serpin family
Protein Ontology PR:000014702 plasminogen activator inhibitor 1
Graphical View of Protein Domain Structure
References
(Earliest) J:32471 Prendergast GC, et al., The c-myc-regulated gene mrl encodes plasminogen activator inhibitor 1. Mol Cell Biol. 1990 Mar;10(3):1265-9
(Latest) J:211073 Eren M, et al., PAI-1-regulated extracellular proteolysis governs senescence and survival in Klotho mice. Proc Natl Acad Sci U S A. 2014 May 13;111(19):7090-5
All references(205)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-13344

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
10/08/2014
MGI 5.20
The Jackson Laboratory