Serpine1
Gene Detail

Symbol Name ID

Serpine1 serine (or cysteine) peptidase inhibitor, clade E, member 1 MGI:97608

Synonyms

PAI1, PAI-1, Planh1

Feature Type

protein coding gene

Genetic Map

Chromosome 5

76.16 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr5:137061504-137072272 bp, - strand From NCBI annotation of GRCm38   10769 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:68070  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 zebrafish

Protein SuperFamily: serpin
Gene Tree: Serpine1

Human homologs

Human Homolog		SERPINE1, serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
NCBI Gene ID		5054
neXtProt AC		NX_P05121
Human Synonyms		PAI, PAI1, PAI-1, PLANH1
Human Chr (Location)		7q22.1; chr7:100770370-100782547 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human SERPINE1

Alleles and phenotypes

All alleles(4) : Targeted(3) Gene trapped(1)
 

Although mice homozygous for disruptions in this gene display an essentially normal phenotype, a mild blood clotting defect does exist.

 

Gene Ontology (GO) classifications

All GO classifications: (44 annotations)

Process	cellular response to chemical stimulus, cellular response to lipopolysaccharide, ...
Component	extracellular matrix, extracellular region, ...
Function	peptidase inhibitor activity, protease binding, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (27 records)
Data Summary: Results (71)    Tissues (31)    Images (17)
Theiler Stages: 1, 2, 3, 4, 9, 11, 13, 15, 17, 19, 20, 21, 22, 23, 28

Assay Type	Results
Immunohistochemistry	5
RNA in situ	26
Northern blot	24
RT-PCR	16

cDNA source data(22)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(28) Genomic(2) cDNA(23) Primer pair(2) Other(1)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000037411 (Evidence)
Entrez Gene	18787 (Evidence)
UniGene	250422
DFCI	TC1579525, TC1617185
DoTS	DT.101168537, DT.101722102, DT.40158297
NIA Mouse Gene Index	U026838
PDB	3LW2
Consensus CDS Project	CCDS19761.1
International Mouse Knockout Project Status	Serpine1

Sequences

Length	Strain/Species
genomic	18787	NCBI Gene Model | MGI Sequence Detail	10769	C57BL/6J
transcript	NM_008871	RefSeq | MGI Sequence Detail	3024	Not Specified
polypeptide	P22777	UniProt | EBI | MGI Sequence Detail	402	Not Applicable

All sequences(26) RefSeq(2) UniProt(6)

Polymorphisms

SNPs(19 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR023795	Protease inhibitor I4, serpin, conserved site
InterPro	IPR023796	Serpin domain
InterPro	IPR000215	Serpin family
Protein Ontology	PR:000014702	plasminogen activator inhibitor 1

Graphical View of Protein Domain Structure

References

(Earliest) J:32471 Prendergast GC, et al., The c-myc-regulated gene mrl encodes plasminogen activator inhibitor 1. Mol Cell Biol. 1990 Mar;10(3):1265-9
(Latest) J:194605 Kenny S, et al., Gastric expression of plasminogen activator inhibitor (PAI)-1 is associated with hyperphagia and obesity in mice. Endocrinology. 2013 Feb;154(2):718-26
All references(189)

Other accession IDs

MGD-MRK-13344