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Serpine1
Gene Detail
Symbol

Name
ID
Serpine1
serine (or cysteine) peptidase inhibitor, clade E, member 1
MGI:97608
Synonyms
PAI1, PAI-1, Planh1
Feature Type
protein coding gene
Genetic Map
Chromosome 5
76.16 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr5:137061504-137072268 bp, - strand
From VEGA annotation of GRCm38

  10765 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:68070  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: SERPINE1
Protein SuperFamily: serpin
Gene Tree: Serpine1

Human
homologs
SERPINE1, serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 5054
neXtProt AC: NX_P05121

Human Synonyms: PAI, PAI1, PAI-1, PLANH1

Human Chr (Location): 7q22.1; chr7:101127089-101139266 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human SERPINE1

Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Gene trapped(1) Targeted(3) Transgenic(2)
Incidental mutations (data from Mutagenetix , APF )
 
Although mice homozygous for disruptions in this gene display an essentially normal phenotype, a mild blood clotting defect does exist.
 
Interactions
Serpine1 interacts with 250 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (61 annotations)
Process cellular response to drug, cellular response to interleukin-1, ...
Component chromaffin granule, extracellular exosome, ...
Function peptidase inhibitor activity, protease binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (34 records)
Data Summary: Results (86)    Tissues (34)    Images (19)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 5
RNA in situ 26
Northern blot 24
RT-PCR 31
cDNA source data(22)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase serpine1    NEW 
Molecular
reagents
All nucleic(30) Genomic(2) cDNA(23) Primer pair(4) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000054456 (Evidence)
Ensembl Gene Model ENSMUSG00000037411 (Evidence)
Entrez Gene 18787 (Evidence)
UniGene 250422
DFCI TC1579525, TC1617185
DoTS DT.101168537, DT.101722102, DT.40158297
NIA Mouse Gene Index U026838
PDB 3LW2
Consensus CDS Project CCDS19761.1
International Mouse Phenotyping Consortium Status Serpine1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000054456 VEGA Gene Model | MGI Sequence Detail 10765 C57BL/6J ±  kb
transcript OTTMUST00000135048 VEGA | MGI Sequence Detail 3011 Not Applicable 
polypeptide OTTMUSP00000071541 VEGA | MGI Sequence Detail 402 Not Applicable 

For the selected sequences
All sequences(29) RefSeq(2) UniProt(5)
Polymorphisms
SNPs within 2kb(40 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR023795 Serpin, conserved site
InterPro IPR023796 Serpin domain
InterPro IPR000215 Serpin family
Protein Ontology PR:000014702 plasminogen activator inhibitor 1
References
(Earliest) J:32471 Prendergast GC, et al., The c-myc-regulated gene mrl encodes plasminogen activator inhibitor 1. Mol Cell Biol. 1990 Mar;10(3):1265-9
(Latest) J:222043 Hijazi N, et al., Endogenous plasminogen activators mediate progressive intracerebral hemorrhage after traumatic brain injury in mice. Blood. 2015 Apr 16;125(16):2558-67
All references(213)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-13344

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory