Symbol
Name
ID

Serpine1
serine (or cysteine) peptidase inhibitor, clade E, member 1
MGI:97608

Phenotype annotations related to homeostasis/metabolism

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes

Pedal edema

Increased LDL cholesterol concentration

Hypercholesterolemia

Hypertriglyceridemia

Elevated circulating C-reactive protein concentration

Elevated circulating amyloid A concentration

Elevated erythrocyte sedimentation rate

Glucose intolerance

Diabetes mellitus

Type II diabetes mellitus

Impaired glucose tolerance

Pleural effusion

Fever

Recurrent fever

Proteinuria

Amyloidosis

Renal amyloidosis

Ascites

Increased circulating free T3

Increased circulating free T4 concentration

Decreased thyroid-stimulating hormone level

Disease(s) Associated with SERPINE1

coronary artery disease

familial mediterranean fever

Graves' disease

Mouse Phenotypes

homeostasis/metabolism phenotype

increased blood urea nitrogen level

hyperglycemia

decreased circulating cholesterol level

decreased circulating interleukin-6 level

increased body temperature

abnormal energy expenditure

increased oxygen consumption

decreased liver triglyceride level

decreased skeletal muscle triglyceride level

abnormal interleukin level

increased urine protein level

abnormal enzyme/coenzyme activity

decreased susceptibility to xenobiotic induced morbidity/mortality

enhanced wound healing

Availability

Mouse Genotype

Serpine1^tm1.1Vlp/Serpine1^tm1.1Vlp

Serpine1^tm1Mlg/Serpine1^tm1Mlg

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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