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Targeted Allele Detail
Symbol: Serpine1tm1Mlg
Name: serine (or cysteine) peptidase inhibitor, clade E, member 1; targeted mutation 1, Richard C Mulligan
MGI ID: MGI:1857287
Synonyms: PAI-1-, Planh1tm1, Serpine1tm1Mg
Gene: Serpine1  Location: Chr5:137090358-137101122 bp, - strand  Genetic Position: Chr5, 76.16 cM
Alliance: Serpine1tm1Mlg page
Germline Transmission:  Earliest citation of germline transmission: J:39819
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA PGK-neomycin resistance cassette replaced all of the Serpine1 coding sequence and part of the promoter region including the transcription initiation site. Northern blot analysis did not detect Serpine1 mRNA in endotoxin-treated homozygous mutant liver. Neither untreated nor endotoxin-treated homozygous mutant kidney produced detectable SERPINE1 immunoreactivity. A monoclonal antibody based immunofunctional assay did not detect protein levels in plasma of endotoxin-treated homozygous mutant mice. (J:39819)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Mice Carrying this Mutation: 29 assay results
In Structures Affected by this Mutation: 11 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 4 strains available      Cell Lines: 0 lines available
Carrying any Serpine1 Mutation:  18 strains or lines available
Original:  J:39819 Carmeliet P, et al., Plasminogen activator inhibitor-1 gene-deficient mice. I. Generation by homologous recombination and characterization. J Clin Invest. 1993 Dec;92(6):2746-55
All:  164 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.22
The Jackson Laboratory