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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Serpine1
serine (or cysteine) peptidase inhibitor, clade E, member 1
MGI:97608
15 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
Apoetm1Unc/Apoetm1Unc
Serpine1tm1Mlg/Serpine1tm1Mlg
B6.129-Serpine1tm1Mlg Apoetm1Unc 		atherosclerotic lesions J:61287
increased circulating cholesterol level J:61287
Apoetm1Unc/Apoetm1Unc
Tg(CMV-Serpine1)1Dgi/0
B6.Cg-Apoetm1Unc Tg(CMV-Serpine1)1Dgi 		atherosclerotic lesions J:61287
increased circulating cholesterol level J:61287
Ldlrtm1Her/Ldlrtm1Her
Serpine1tm1Mlg/Serpine1tm1Mlg
B6.129S-Serpine1tm1Mlg Ldlrtm1Her 		atherosclerotic lesions J:61287
increased circulating cholesterol level J:61287
Ldlrtm1Her/Ldlrtm1Her
Tg(CMV-Serpine1)1Dgi/0
B6.Cg-Ldlrtm1Her Tg(CMV-Serpine1)1Dgi 		atherosclerotic lesions J:61287
increased circulating cholesterol level J:61287
Lepob/Lepob
Serpine1tm1Mlg/Serpine1tm1Mlg
involves: 129S2/SvPas * C57BL/6 		abnormal tumor necrosis factor level J:70695
impaired glucose tolerance J:70695
increased circulating insulin level J:70695
Leprdb/Leprdb
Serpine1tm1Mlg/Serpine1tm1Mlg
involves: 129S2/SvPas * C57BL/6 * C57BLKS/J 		abnormal enzyme/coenzyme activity J:127478
abnormal kidney morphology J:127478
abnormal renal glomerulus morphology J:127478
albuminuria J:127478
decreased body size J:127478
hyperglycemia J:127478
increased blood urea nitrogen level J:127478
obese J:127478
premature death J:127478
Serpinb2tm1Dgi/Serpinb2tm1Dgi
Serpine1tm1Mlg/Serpine1tm1Mlg
involves: 129S1/Sv * 129S2/SvPas * C57BL/6 * DBA/2 		normal homeostasis/metabolism phenotype J:52283
Serpinb2tm2Dgi/Serpinb2tm2Dgi
Serpine1tm1Mlg/Serpine1tm1Mlg
involves: 129S2/SvPas * C57BL/6J * DBA/2J 		normal homeostasis/metabolism phenotype J:52283
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory