Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes SELENOS
  • Mouse genes Selenos
  • Rat genes Selenos
  • Zfish genes selenos
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Selenos

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0016209	antioxidant activity	SELENOS	IDA		Human	PMID:15063746
Molecular Function	GO:0051117	ATPase binding	SELENOS	IPI	UniProtKB:Q01853	Human	PMID:24424410
Molecular Function	GO:0019899	enzyme binding	SELENOS	IPI	UniProtKB:P55072	Human	PMID:15215856
Molecular Function	GO:0005515	protein binding	SELENOS	IPI	UniProtKB:Q01853	Human	PMID:15215856
Molecular Function	GO:0005515	protein binding	SELENOS	IPI	UniProtKB:Q9BUN8	Human	PMID:15215856
Molecular Function	GO:0005515	protein binding	SELENOS	IPI	UniProtKB:Q6Q788	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	Selenos	IPI	UniProtKB:Q9D024	Mouse	MGI:MGI:5605216|PMID:25009997
Molecular Function	GO:0005515	protein binding	Selenos	IPI	UniProtKB:Q8CII8	Mouse	MGI:MGI:4441244|PMID:19164528
Molecular Function	GO:1990381	ubiquitin-specific protease binding	SELENOS	IPI	UniProtKB:P54252	Human	PMID:17000876
Cellular Component	GO:0005881	cytoplasmic microtubule	SELENOS	IDA		Human	PMID:23264731
Cellular Component	GO:0036513	Derlin-1 retrotranslocation complex	SELENOS	IDA		Human	PMID:15215856
Cellular Component	GO:0036502	Derlin-1-VIMP complex	SELENOS	IDA		Human	PMID:15215856
Cellular Component	GO:0005783	endoplasmic reticulum	SELENOS	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005789	endoplasmic reticulum membrane	SELENOS	IDA		Human	PMID:15215856
Cellular Component	GO:0034362	low-density lipoprotein particle	SELENOS	IDA		Human	PMID:17374524
Cellular Component	GO:0034361	very-low-density lipoprotein particle	SELENOS	IDA		Human	PMID:17374524
Biological Process	GO:0045454	cell redox homeostasis	SELENOS	IDA		Human	PMID:15063746
Biological Process	GO:0071222	cellular response to lipopolysaccharide	SELENOS	IMP		Human	PMID:18675776
Biological Process	GO:0034599	cellular response to oxidative stress	SELENOS	IMP		Human	PMID:18675776
Biological Process	GO:0030968	endoplasmic reticulum unfolded protein response	SELENOS	IDA		Human	PMID:15215856
Biological Process	GO:0006983	ER overload response	SELENOS	IDA		Human	PMID:16574427
Biological Process	GO:0006983	ER overload response	SELENOS	IMP		Human	PMID:17210132
Biological Process	GO:0002865	negative regulation of acute inflammatory response to antigenic stimulus	SELENOS	IMP		Human	PMID:18675776
Biological Process	GO:1902236	negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway	SELENOS	IMP		Human	PMID:17210132
Biological Process	GO:0032715	negative regulation of interleukin-6 production	Selenos	IMP		Mouse	MGI:MGI:3773781|PMID:16227999
Biological Process	GO:2000110	negative regulation of macrophage apoptotic process	SELENOS	IMP		Human	PMID:17210132
Biological Process	GO:0051771	negative regulation of nitric-oxide synthase biosynthetic process	SELENOS	IMP		Human	PMID:18675776
Biological Process	GO:0032720	negative regulation of tumor necrosis factor production	Selenos	IMP		Mouse	MGI:MGI:3773781|PMID:16227999
Biological Process	GO:0080164	regulation of nitric oxide metabolic process	SELENOS	IMP		Human	PMID:18675776
Biological Process	GO:0009749	response to glucose	SELENOS	IEP		Human	PMID:12031974
Biological Process	GO:0009749	response to glucose	SELENOS	IEP		Human	PMID:15063746
Biological Process	GO:0051775	response to redox state	SELENOS	IDA		Human	PMID:15063746
Biological Process	GO:0030970	retrograde protein transport, ER to cytosol	SELENOS	IDA		Human	PMID:15215856
Biological Process	GO:0030433	ubiquitin-dependent ERAD pathway	SELENOS	IDA		Human	PMID:15215856

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern