Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes PIK3CB
  • Mouse genes Pik3cb
  • Rat genes Pik3cb
  • Zfish genes pik3cb
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Pik3cb

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0016303	1-phosphatidylinositol-3-kinase activity	Pik3cb	IMP		Mouse	PMID:15834429
Molecular Function	GO:0016303	1-phosphatidylinositol-3-kinase activity	Pik3cb	IMP		Mouse	PMID:16625210
Molecular Function	GO:0016303	1-phosphatidylinositol-3-kinase activity	Pik3cb	IDA		Rat	PMID:11931646|RGD:633612
Molecular Function	GO:0016303	1-phosphatidylinositol-3-kinase activity	Pik3cb	IDA		Rat	PMID:12882977|RGD:4144086
Molecular Function	GO:0043560	insulin receptor substrate binding	Pik3cb	IPI	MGI:MGI:109334	Mouse	PMID:16625210
Molecular Function	GO:0043560	insulin receptor substrate binding	Pik3cb	IPI	PR:P35569	Mouse	PMID:16625210
Molecular Function	GO:0016301	kinase activity	PIK3CB	IDA		Human	PMID:25327288
Molecular Function	GO:0046934	phosphatidylinositol-4,5-bisphosphate 3-kinase activity	PIK3CB	IDA		Human	PMID:12502714
Molecular Function	GO:0005515	protein binding	PIK3CB	IPI	UniProtKB:O00459	Human	PMID:19380743
Molecular Function	GO:0005515	protein binding	PIK3CB	IPI	UniProtKB:P27986	Human	PMID:20713702
Molecular Function	GO:0005515	protein binding	PIK3CB	IPI	UniProtKB:O00459	Human	PMID:22402981
Molecular Function	GO:0005515	protein binding	PIK3CB	IPI	UniProtKB:Q92569	Human	PMID:22402981
Molecular Function	GO:0005515	protein binding	PIK3CB	IPI	UniProtKB:P27986	Human	PMID:25241761
Molecular Function	GO:0005515	protein binding	PIK3CB	IPI	UniProtKB:P0DOE7	Human	PMID:25556234
Molecular Function	GO:0005515	protein binding	PIK3CB	IPI	UniProtKB:Q92569	Human	PMID:25814554
Molecular Function	GO:0005515	protein binding	PIK3CB	IPI	UniProtKB:P27986	Human	PMID:26496610
Molecular Function	GO:0005515	protein binding	PIK3CB	IPI	UniProtKB:P27986-2	Human	PMID:27107012
Molecular Function	GO:0005515	protein binding	PIK3CB	IPI	UniProtKB:O00459	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	PIK3CB	IPI	UniProtKB:Q92569	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	PIK3CB	IPI	UniProtKB:O00459	Human	PMID:32707033
Molecular Function	GO:0005515	protein binding	PIK3CB	IPI	UniProtKB:P27986	Human	PMID:32707033
Molecular Function	GO:0005515	protein binding	PIK3CB	IPI	UniProtKB:P05067	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PIK3CB	IPI	UniProtKB:P27986-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	Pik3cb	IPI	UniProtKB:P26450	Mouse	MGI:MGI:3795660|PMID:18449193
Molecular Function	GO:0005515	protein binding	Pik3cb	IPI	UniProtKB:P26450	Mouse	MGI:MGI:3688344|PMID:15102471
Molecular Function	GO:0106310	protein serine kinase activity	PIK3CB	IDA		Human	PMID:12502714
Cellular Component	GO:0031526	brush border membrane	Pik3cb	IDA		Rat	PMID:11931646|RGD:633612
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	PIK3CB	IDA		Human	GO_REF:0000052
Cellular Component	GO:0030496	midbody	PIK3CB	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005730	nucleolus	PIK3CB	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005654	nucleoplasm	PIK3CB	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	PIK3CB	IDA		Human	PMID:30496354
Cellular Component	GO:0005634	nucleus	Pik3cb	IDA		Mouse	MGI:MGI:6444553|PMID:30496354
Cellular Component	GO:0005942	phosphatidylinositol 3-kinase complex	Pik3cb	IDA		Rat	PMID:12882977|RGD:4144086
Cellular Component	GO:0005943	phosphatidylinositol 3-kinase complex, class IA	PIK3CB	IPI		Human	PMID:20713702
Cellular Component	GO:0005943	phosphatidylinositol 3-kinase complex, class IA	PIK3CB	IPI		Human	PMID:22402981
Biological Process	GO:0060055	angiogenesis involved in wound healing	Pik3cb	IMP	MGI:MGI:3795849	Mouse	PMID:25139353
Biological Process	GO:0040016	embryonic cleavage	Pik3cb	IMP	MGI:MGI:2180703	Mouse	PMID:11919689
Biological Process	GO:0001935	endothelial cell proliferation	Pik3cb	IMP	MGI:MGI:3795849	Mouse	PMID:25139353
Biological Process	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules	Pik3cb	IMP		Mouse	PMID:15834429
Biological Process	GO:0006874	intracellular calcium ion homeostasis	Pik3cb	IMP		Mouse	PMID:15834429
Biological Process	GO:1903298	negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway	Pik3cb	IMP		Mouse	MGI:MGI:6444553|PMID:30496354
Biological Process	GO:0043407	negative regulation of MAP kinase activity	Pik3cb	IMP		Mouse	MGI:MGI:6444553|PMID:30496354
Biological Process	GO:0051898	negative regulation of protein kinase B signaling	PIK3CB	IGI	UniProtKB:P15692	Human	PMID:30496354
Biological Process	GO:0051898	negative regulation of protein kinase B signaling	Pik3cb	IMP		Mouse	MGI:MGI:6444553|PMID:30496354
Biological Process	GO:1903671	negative regulation of sprouting angiogenesis	PIK3CB	IMP		Human	PMID:30496354
Biological Process	GO:1900747	negative regulation of vascular endothelial growth factor signaling pathway	PIK3CB	IGI	UniProtKB:P15692	Human	PMID:30496354
Biological Process	GO:0014065	phosphatidylinositol 3-kinase signaling	PIK3CB	IMP		Human	PMID:18558630
Biological Process	GO:0014065	phosphatidylinositol 3-kinase signaling	PIK3CB	IMP		Human	PMID:25339672
Biological Process	GO:0014065	phosphatidylinositol 3-kinase signaling	PIK3CB	IGI	UniProtKB:P15692	Human	PMID:30496354
Biological Process	GO:0014065	phosphatidylinositol 3-kinase signaling	Pik3cb	IMP		Mouse	MGI:MGI:6444553|PMID:30496354
Biological Process	GO:0014065	phosphatidylinositol 3-kinase signaling	Pik3cb	IGI	UniProtKB:O35904	Mouse	MGI:MGI:4461861|PMID:18558630
Biological Process	GO:0046854	phosphatidylinositol phosphate biosynthetic process	PIK3CB	IDA		Human	PMID:12502714
Biological Process	GO:0046854	phosphatidylinositol phosphate biosynthetic process	Pik3cb	IDA		Rat	PMID:12882977|RGD:4144086
Biological Process	GO:0016310	phosphorylation	PIK3CB	IDA		Human	PMID:25327288
Biological Process	GO:0030168	platelet activation	Pik3cb	IMP		Mouse	PMID:15834429
Biological Process	GO:0010595	positive regulation of endothelial cell migration	PIK3CB	IGI	UniProtKB:O00329	Human	PMID:18558630
Biological Process	GO:0010595	positive regulation of endothelial cell migration	Pik3cb	IGI	UniProtKB:O35904	Mouse	MGI:MGI:4461861|PMID:18558630
Biological Process	GO:0010628	positive regulation of gene expression	PIK3CB	IMP		Human	PMID:25139353
Biological Process	GO:0033031	positive regulation of neutrophil apoptotic process	PIK3CB	IMP		Human	PMID:25339672
Biological Process	GO:0051000	positive regulation of nitric-oxide synthase activity	PIK3CB	IMP		Human	PMID:18558630
Biological Process	GO:0051897	positive regulation of protein kinase B signaling	PIK3CB	IMP		Human	PMID:18558630
Biological Process	GO:0035022	positive regulation of Rac protein signal transduction	PIK3CB	IGI	UniProtKB:O00329	Human	PMID:18558630
Biological Process	GO:0035022	positive regulation of Rac protein signal transduction	Pik3cb	IGI	UniProtKB:O35904	Mouse	MGI:MGI:4461861|PMID:18558630
Biological Process	GO:0001952	regulation of cell-matrix adhesion	PIK3CB	IMP		Human	PMID:25139353
Biological Process	GO:0001952	regulation of cell-matrix adhesion	Pik3cb	IMP		Mouse	PMID:15834429
Biological Process	GO:0002931	response to ischemia	Pik3cb	IMP		Mouse	MGI:MGI:6444553|PMID:30496354
Biological Process	GO:0003376	sphingosine-1-phosphate receptor signaling pathway	PIK3CB	IMP		Human	PMID:18558630
Biological Process	GO:0003376	sphingosine-1-phosphate receptor signaling pathway	Pik3cb	IGI	UniProtKB:O35904	Mouse	MGI:MGI:4461861|PMID:18558630

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern