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Pik3cb
Gene Detail
Symbol

Name
ID
Pik3cb
phosphatidylinositol 3-kinase, catalytic, beta polypeptide
MGI:1922019
Synonyms
1110001J02Rik, p110beta
Feature Type
protein coding gene
Genetic Map
Chromosome 9
51.41 cM, cytoband E4
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr9:99036654-99140621 bp, - strand
From VEGA annotation of GRCm38

  103968 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:21250  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: phosphatidylinositol 3-kinase
Gene Tree: Pik3cb

Human
homologs
Human Homolog PIK3CB, phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
NCBI Gene ID 5291
neXtProt AC  NX_P42338
Human Synonyms  P110BETA, PI3K, PI3KBETA, PIK3C1
Human Chr (Location)  3q22.3; chr3:138652698-138834938 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(118) : Gene trapped(109) Targeted(9)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit 30% fetal lethality, decreased size at birth and postnatally, abnormal glucose homeostasis, and dyslipidemia. Mice homozygous for a different knock-out allele die prior to E8.5
 
Phenotype Images(1)
Interactions
Pik3cb interacts with 270 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (33 annotations)
Process autophagy, cell adhesion, ...
Component brush border membrane, cell, ...
Function 1-phosphatidylinositol-3-kinase activity, 1-phosphatidylinositol-4-phosphate 3-kinase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (10 records)
Data Summary: Results (166)    Tissues (123)    Images (4)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 118
Northern blot 12
RT-PCR 36
cDNA source data(43)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(44) cDNA(43) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000021081 (Evidence)
Ensembl Gene ModelENSMUSG00000032462 (Evidence)
Entrez Gene74769 (Evidence)
UniGene213128
DoTSDT.101718468, DT.87068643, DT.97386104
NIA Mouse Gene IndexU031230
EC2.7.1.153
PDB2Y3A, 4BFR
Consensus CDS ProjectCCDS23432.1
International Mouse Knockout Project StatusPik3cb
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021081 VEGA Gene Model | MGI Sequence Detail 103968 C57BL/6J ±  kb
transcript OTTMUST00000049861 VEGA | MGI Sequence Detail 6478 Not Applicable 
polypeptide OTTMUSP00000023176 VEGA | MGI Sequence Detail 1064 Not Applicable 

For the selected sequences
All sequences(42) RefSeq(4) UniProt(7)
Polymorphisms
SNPs within 2kb(761 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR016024 Armadillo-type fold
InterPro IPR000008 C2 calcium-dependent membrane targeting
InterPro IPR000403 Phosphatidylinositol 3-/4-kinase, catalytic domain
InterPro IPR018936 Phosphatidylinositol 3/4-kinase, conserved site
InterPro IPR003113 Phosphatidylinositol 3-kinase adaptor-binding (PI3K ABD) domain
InterPro IPR002420 Phosphatidylinositol 3-kinase C2 (PI3K C2) domain
InterPro IPR000341 Phosphatidylinositol 3-kinase Ras-binding (PI3K RBD) domain
InterPro IPR015433 Phosphatidylinositol Kinase
InterPro IPR001263 Phosphoinositide 3-kinase, accessory (PIK) domain
InterPro IPR011009 Protein kinase-like domain
Protein Ontology PR:000012720 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:208835 Schmit F, et al., PI3K isoform dependence of PTEN-deficient tumors can be altered by the genetic context. Proc Natl Acad Sci U S A. 2014 Apr 29;111(17):6395-400
All references(95)
Other
accession IDs
MGI:2143049

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory