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Pik3cb Gene Detail
Summary
  • Symbol
    Pik3cb
  • Name
    phosphatidylinositol 3-kinase, catalytic, beta polypeptide
  • Synonyms
    1110001J02Rik, p110beta
  • Feature Type
    protein coding gene
  • IDs
    MGI:1922019
    NCBI Gene: 74769
  • Gene Overview
    MyGene.info: PIK3CB
Location & Maps
more
  • Sequence Map
    Chr9:99036654-99140621 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      103968 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    PIK3CB, phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PIK3CB, phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
    Orthology source: HomoloGene
  • Synonyms
    P110BETA, PI3K, PI3KBETA, PIK3C1
  • Links
    NCBI Gene ID: 5291
    neXtProt AC: NX_P42338

  • Chr Location
    3q22.3; chr3:138652698-138834938 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    34 phenotypes from 9 alleles in 12 genetic backgrounds
    9 phenotypes from multigenic genotypes
    1 images
    45 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    120
  • Chemically induced (other)
    1
  • Gene trapped
    109
  • Targeted
    10
  • Genomic Mutations
    1 involving Pik3cb
  • Incidental Mutations
Mice homozygous for a knock-out allele exhibit 30% fetal lethality, decreased size at birth and postnatally, abnormal glucose homeostasis, and dyslipidemia. Mice homozygous for a different knock-out allele die prior to E8.5
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021081 VEGA Gene Model | MGI Sequence Detail 103968 C57BL/6J ±  kb
transcript OTTMUST00000049861 VEGA | MGI Sequence Detail 6478 Not Applicable  
polypeptide OTTMUSP00000023176 VEGA | MGI Sequence Detail 1064 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    753 from dbSNP Build 142
Protein
Information
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  • UniProt
    7 Sequences
  • Protein Ontology
    PR:000012720 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
  • PDB
  • EC
  • InterPro Domains
    IPR016024 Armadillo-type fold
    IPR000008 C2 domain
    IPR000403 Phosphatidylinositol 3-/4-kinase, catalytic domain
    IPR018936 Phosphatidylinositol 3/4-kinase, conserved site
    IPR003113 Phosphatidylinositol 3-kinase adaptor-binding (PI3K ABD) domain
    IPR002420 Phosphatidylinositol 3-kinase, C2 domain
    IPR000341 Phosphatidylinositol 3-kinase Ras-binding (PI3K RBD) domain
    IPR015433 Phosphatidylinositol Kinase
    IPR001263 Phosphoinositide 3-kinase, accessory (PIK) domain
    IPR011009 Protein kinase-like domain
    IPR029071 Ubiquitin-related domain
Molecular
Reagents
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  • All nucleic 44
    cDNA 43
    Primer pair 1

    Microarray probesets 3
Other
Accession IDs
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MGI:2143049
References
more
  • Summaries
    All 102
    Developmental Gene Expression 11
    Gene Ontology 11
    Phenotypes 45
  • Earliest
    J:214 ALLEN SL, H-2f, a tenth allele at the histocompatibility-2 locus in the mouse as determined by tumor transplantation. Cancer Res. 1955 Jun;15(5):315-9
  • Latest
    J:228366 Gross C, et al., Selective role of the catalytic PI3K subunit p110beta in impaired higher order cognition in fragile X syndrome. Cell Rep. 2015 May 5;11(5):681-8

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/26/2016
MGI 6.03
The Jackson Laboratory