Pik3cb
Gene Detail

Symbol Name ID

Pik3cb phosphatidylinositol 3-kinase, catalytic, beta polypeptide MGI:1922019

Synonyms

1110001J02Rik, p110beta

Feature Type

protein coding gene

Genetic Map

Chromosome 9

51.41 cM, cytoband E4
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr9:99038402-99140621 bp, - strand From VEGA annotation of GRCm38   102220 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Mammalian homology

human; rat; cattle; dog, domestic    (Mammalian Orthology)
Comparative Map (Mouse/Human Pik3cb ± 2 cM)

Protein SuperFamily: phosphatidylinositol 3-kinase
Gene Tree: Pik3cb

Human ortholog

PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta NCBI Gene ID 5291
Human Synonyms: P110BETA, PI3K, PI3KBETA, PIK3C1
Human Chr3:138374231-138478185 bp, - strand Reference GRCh37.p2 Primary Assembly

Alleles and phenotypes

All alleles(118) : Targeted(9) Gene trapped(109)
 

Mice homozygous for a knock-out allele exhibit 30% fetal lethality, decreased size at birth and postnatally, abnormal glucose homeostasis, and dyslipidemia. Mice homozygous for a different knock-out allele die prior to E8.5

 
Phenotype Images(1)

Gene Ontology (GO) classifications

All GO classifications: (31 annotations)

Process	autophagy, cell adhesion, ...
Component	brush border membrane, cytoplasm, ...
Function	1-phosphatidylinositol-3-kinase activity, 1-phosphatidylinositol-4-phosphate 3-kinase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (10 records)
Data Summary: Results (166)    Tissues (123)    Images (4)
Theiler Stages: 2, 3, 10, 18, 22, 23, 25, 28

Assay Type	Results
RNA in situ	118
Northern blot	12
RT-PCR	36

cDNA source data(43)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(44) cDNA(43) Primer pair(1)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000021081 (Evidence)
Ensembl Gene Model	ENSMUSG00000032462 (Evidence)
Entrez Gene	74769 (Evidence)
UniGene	213128
DoTS	DT.101718468, DT.87068643, DT.97386104
NIA Mouse Gene Index	U031230
EC	2.7.1.153
PDB	2Y3A
Consensus CDS Project	CCDS23432.1
International Mouse Knockout Project Status	Pik3cb

Sequences

Length	Strain/Species
genomic	OTTMUSG00000021081	VEGA Gene Model | MGI Sequence Detail	102220	C57BL/6J
transcript	OTTMUST00000049861	VEGA | MGI Sequence Detail	4730	Not Applicable
polypeptide	OTTMUSP00000023176	VEGA | MGI Sequence Detail	1064	Not Applicable

All sequences(37) RefSeq(2) UniProt(6)

Polymorphisms

SNPs(493 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR016024	Armadillo-type fold
InterPro	IPR008973	C2 calcium/lipid-binding domain, CaLB
InterPro	IPR000403	Phosphatidylinositol 3-/4-kinase, catalytic domain
InterPro	IPR018936	Phosphatidylinositol 3/4-kinase, conserved site
InterPro	IPR003113	Phosphatidylinositol 3-kinase adaptor-binding (PI3K ABD) domain
InterPro	IPR002420	Phosphatidylinositol 3-kinase C2 (PI3K C2) domain
InterPro	IPR000341	Phosphatidylinositol 3-kinase Ras-binding (PI3K RBD) domain
InterPro	IPR015433	Phosphatidylinositol Kinase
InterPro	IPR001263	Phosphoinositide 3-kinase, accessory (PIK) domain
InterPro	IPR011009	Protein kinase-like domain
Protein Ontology	PR:000012720	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta isoform

References

(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:191970 Juss JK, et al., Functional redundancy of class I phosphoinositide 3-kinase (PI3K) isoforms in signaling growth factor-mediated human neutrophil survival. PLoS One. 2012;7(9):e45933
All references(89)

Other accession IDs

MGI:2143049