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Pik3cb
Gene Detail
Symbol

Name
ID
Pik3cb
phosphatidylinositol 3-kinase, catalytic, beta polypeptide
MGI:1922019
Synonyms
1110001J02Rik, p110beta
Feature Type
protein coding gene
Genetic Map
Chromosome 9
51.41 cM, cytoband E4
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr9:99036654-99140621 bp, - strand
From VEGA annotation of GRCm38

  103968 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:21250  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: PIK3CB
Protein SuperFamily: phosphatidylinositol 3-kinase
Gene Tree: Pik3cb

Human
homologs
PIK3CB, phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 5291
neXtProt AC: NX_P42338

Human Synonyms: P110BETA, PI3K, PI3KBETA, PIK3C1

Human Chr (Location): 3q22.3; chr3:138652698-138834938 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(119) : Gene trapped(109) Targeted(10)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit 30% fetal lethality, decreased size at birth and postnatally, abnormal glucose homeostasis, and dyslipidemia. Mice homozygous for a different knock-out allele die prior to E8.5
 
Phenotype Images(1)
Interactions
Pik3cb interacts with 269 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (11 records)
Data Summary: Results (166)    Tissues (123)    Images (4)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 118
Northern blot 12
RT-PCR 36
cDNA source data(43)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase pik3cb    NEW 
Molecular
reagents
All nucleic(44) cDNA(43) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000021081 (Evidence)
Ensembl Gene Model ENSMUSG00000032462 (Evidence)
Entrez Gene 74769 (Evidence)
UniGene 213128
DoTS DT.101718468, DT.87068643, DT.97386104
NIA Mouse Gene Index U031230
EC 2.7.1.153
PDB 2Y3A, 4BFR
Consensus CDS Project CCDS23432.1
International Mouse Phenotyping Consortium Status Pik3cb
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021081 VEGA Gene Model | MGI Sequence Detail 103968 C57BL/6J ±  kb
transcript OTTMUST00000049861 VEGA | MGI Sequence Detail 6478 Not Applicable 
polypeptide OTTMUSP00000023176 VEGA | MGI Sequence Detail 1064 Not Applicable 

For the selected sequences
All sequences(46) RefSeq(8) UniProt(7)
Polymorphisms
SNPs within 2kb(761 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR016024 Armadillo-type fold
InterPro IPR000008 C2 domain
InterPro IPR000403 Phosphatidylinositol 3-/4-kinase, catalytic domain
InterPro IPR018936 Phosphatidylinositol 3/4-kinase, conserved site
InterPro IPR003113 Phosphatidylinositol 3-kinase adaptor-binding (PI3K ABD) domain
InterPro IPR002420 Phosphatidylinositol 3-kinase, C2 domain
InterPro IPR000341 Phosphatidylinositol 3-kinase Ras-binding (PI3K RBD) domain
InterPro IPR015433 Phosphatidylinositol Kinase
InterPro IPR001263 Phosphoinositide 3-kinase, accessory (PIK) domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR029071 Ubiquitin-related domain
Protein Ontology PR:000012720 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
References
(Earliest) J:214 ALLEN SL, H-2f, a tenth allele at the histocompatibility-2 locus in the mouse as determined by tumor transplantation. Cancer Res. 1955 Jun;15(5):315-9
(Latest) J:221208 Laurent PA, et al., Platelet PI3Kbeta and GSK3 regulate thrombus stability at a high shear rate. Blood. 2015 Jan 29;125(5):881-8
All references(99)
Other
accession IDs
MGI:2143049

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory