Pik3cb Phenotype Annotations - Multigenic Genotypes

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Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Pik3cb
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
MGI:1922019

9 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Pik3ca^tm1Jjz/Pik3ca^tm1Jjz Pik3cb^tm1Jjz/Pik3cb^tm1Jjz Pten^tm1Hwu/Pten^tm1Hwu Tg(KRT14-cre)#Smr/0 FVB.Cg-Pik3ca^tm1Jjz Pik3cb^tm1Jjz Pten^tm1Hwu Tg(KRT14-cre)#Smr	normal integument phenotype	J:199362
Pik3ca^tm1Nbm/Pik3ca⁺ Pik3cb^tm1Nbm/Pik3cb⁺ involves: 129S6/SvEvTac	impaired glucose tolerance	J:96761
	increased circulating insulin level	J:96761
Pik3cb^tm1.1Ehi/Pik3cb^tm1.1Ehi Tg(MMTVneu)202Mul/0 involves: 129/Sv * 129P2/OlaHsd * BALB/c * C57BL/6J * FVB/N	decreased mammary gland tumor incidence	J:152332
	decreased tumor growth/size	J:152332
Pik3cb^tm1Jjz/Pik3cb^tm1Jjz Pten^tm1Hwu/Pten^tm1Hwu Tg(KRT14-cre)#Smr/0 FVB.Cg-Pik3cb^tm1Jjz Pten^tm1Hwu Tg(KRT14-cre)#Smr	abnormal epidermis suprabasal layer morphology	J:199362
	increased skin hamartoma incidence	J:199362
	skin lesions	J:199362
	thick skin	J:199362

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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