Pik3catm1Nbm
Targeted Allele Detail
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Symbol: |
Pik3catm1Nbm |
Name: |
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha; targeted mutation 1, Robert L Nussbaum |
MGI ID: |
MGI:2180704 |
Synonyms: |
p110alpha-, Pik3cadel |
Gene: |
Pik3ca Location: Chr3:32451203-32520256 bp, + strand Genetic Position: Chr3, 15.7 cM, cytoband B
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Alliance: |
Pik3catm1Nbm page
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Hemorrhage is observed in Pik3catm1Nbm/Pik3catm1Nbm embryos
Show the 2 phenotype image(s) involving this allele.
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Germline Transmission: |
Earliest citation of germline transmission:
J:54237
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Parent Cell Line: |
TC1/TC-1 (ES Cell)
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Strain of Origin: |
129S6/SvEvTac
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Allele Type: |
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Targeted (Null/knockout) |
Mutations: |
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Insertion, Intragenic deletion
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Mutation details: Exon 1 was replaced with a PGK-neo cassette via homologous recombination resulting in deletion of the translation initiation site and the domain required for catalytic activity of the protein.
(J:54237)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Pik3ca Mutation: |
62 strains or lines available
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Original: |
J:54237 Bi L, et al., Proliferative defect and embryonic lethality in mice homozygous for a deletion in the p110alpha subunit of phosphoinositide 3-kinase. J Biol Chem. 1999 Apr 16;274(16):10963-8 |
All: |
5 reference(s) |
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