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Targeted Allele Detail
Symbol: Pik3catm1Jjz
Name: phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha; targeted mutation 1, Jean J Zhao
MGI ID: MGI:3691486
Synonyms: p110alphaflox, p110alpha flox
Gene: Pik3ca  Location: Chr3:32451203-32520256 bp, + strand  Genetic Position: Chr3, 15.7 cM, cytoband B
Alliance: Pik3catm1Jjz page
Germline Transmission:  Earliest citation of germline transmission: J:115274
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation detailsExon 1 was flanked by lox P sites, with an FRT-flanked selection cassette between exon 1 and the downstream loxP site. The selection cassette was subsequently removed from the locus via transient transfection with a FLP recombinase plasmid. (J:115274)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 1 anatomical structures
Tumor Data
List all tumor models in MMHCdb carrying Pik3catm1Jjz
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Pik3ca Mutation:  49 strains or lines available
Original:  J:115274 Zhao JJ, et al., The p110alpha isoform of PI3K is essential for proper growth factor signaling and oncogenic transformation. Proc Natl Acad Sci U S A. 2006 Oct 31;103(44):16296-300
All:  33 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.22
The Jackson Laboratory