| GO term: | sphingosine-1-phosphate signaling pathway |
| Synonym: | S1P-activated GPCR signaling pathway |
| Synonym: | S1P-activated G-protein coupled receptor signaling pathway |
| Synonym: | S1P receptor signaling pathway |
| Synonym: | S1P signaling pathway |
| Synonym: | S1P-stimulated signal transduction pathway |
| Synonym: | sphingolipid signaling pathway |
| Synonym: | sphingolipid signalling pathway |
| GO id: | GO:0003376 |
| Definition: | A series of molecular signals initiated by the sphingolipid sphingosine-1-phosphate (S1P) binding to a receptor on the surface of the cell, and which proceeds with the activated receptor transmitting the signal by promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The pathway ends with regulation of a downstream cellular process, e.g. transcription. |
| Comments | Sphingosine-1-phosphate (S1P) can act both as an extracellular ligand for cell surface G-protein coupled receptors, and as an intracellular second messenger. GO:0003376 describes a pathway where S1P acts as an extracellular ligand. Where S1P acts within the cell to transmit a signal, consider instead 'intracellular signal transduction ; GO:0035556' or 'G-protein signaling, coupled to S1P second messenger (sphingosine kinase activating) ; GO:0001789'. |
| Number of paths to term: | 20 |
denotes an 'is-a' relationship
denotes a 'part-of' relationship
denotes a 'regulates' relationship
denotes a 'positively-regulates' relationship
denotes a 'negatively-regulates' relationship
biological_processbiological regulationregulation of biological processregulation of cellular processsignal transductioncell surface receptor signaling pathwayG-protein coupled receptor signaling pathwayadrenergic receptor signaling pathway +angiotensin-mediated signaling pathway +apelin receptor signaling pathwaybombesin receptor signaling pathwaycannabinoid signaling pathway +complement component C5a signaling pathwaydimeric G-protein coupled receptor signaling pathway +dopamine receptor signaling pathway +endothelin receptor signaling pathway +epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathwayfollicle-stimulating hormone signaling pathwayG-protein coupled acetylcholine receptor signaling pathway +G-protein coupled glutamate receptor signaling pathway +G-protein coupled purinergic receptor signaling pathway +G-protein coupled receptor signaling in absence of ligandG-protein coupled receptor signaling pathway involved in heart process +G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger +G-protein coupled receptor signaling pathway, coupled to S1P second messengergamma-aminobutyric acid signaling pathwayheterotrimeric G-protein complex cycleluteinizing hormone signaling pathway +negative regulation of G-protein coupled receptor protein signaling pathway +neuropeptide signaling pathwayoctopamine or tyramine signaling pathway +opioid receptor signaling pathway +pheromone-dependent signal transduction involved in conjugation with cellular fusion +phospholipase C-activating G-protein coupled receptor signaling pathway +phospholipase C-inhibiting G-protein coupled receptor signaling pathwayphospholipase D-activating G-protein coupled receptor signaling pathwaypositive regulation of G-protein coupled receptor protein signaling pathway +protein kinase C-activating G-protein coupled receptor signaling pathwayregulation of G-protein coupled receptor protein signaling pathway +rhodopsin mediated signaling pathway +serotonin receptor signaling pathway +signal transduction involved in conjugation with mutual genetic exchangesomatostatin receptor signaling pathway +sphingosine-1-phosphate signaling pathway [GO:0003376] (6 genes, 6 annotations)regulation of apoptosis by sphingosine-1-phosphate signaling pathwayregulation of inflammatory response by sphingosine-1-phosphate signaling pathwaytachykinin receptor signaling pathway +thrombin receptor signaling pathway +biological_processbiological regulationregulation of biological processregulation of cellular processsignal transductionsphingolipid mediated signaling pathwaynegative regulation of sphingolipid mediated signaling pathwaypositive regulation of sphingolipid mediated signaling pathwayregulation of sphingolipid mediated signaling pathway +sphingosine-1-phosphate signaling pathway [GO:0003376] (6 genes, 6 annotations)regulation of apoptosis by sphingosine-1-phosphate signaling pathwayregulation of inflammatory response by sphingosine-1-phosphate signaling pathwaybiological_processcellular processregulation of cellular processsignal transductioncell surface receptor signaling pathwayG-protein coupled receptor signaling pathwayadrenergic receptor signaling pathway +angiotensin-mediated signaling pathway +apelin receptor signaling pathwaybombesin receptor signaling pathwaycannabinoid signaling pathway +complement component C5a signaling pathwaydimeric G-protein coupled receptor signaling pathway +dopamine receptor signaling pathway +endothelin receptor signaling pathway +epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathwayfollicle-stimulating hormone signaling pathwayG-protein coupled acetylcholine receptor signaling pathway +G-protein coupled glutamate receptor signaling pathway +G-protein coupled purinergic receptor signaling pathway +G-protein coupled receptor signaling in absence of ligandG-protein coupled receptor signaling pathway involved in heart process +G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger +G-protein coupled receptor signaling pathway, coupled to S1P second messengergamma-aminobutyric acid signaling pathwayheterotrimeric G-protein complex cycleluteinizing hormone signaling pathway +negative regulation of G-protein coupled receptor protein signaling pathway +neuropeptide signaling pathwayoctopamine or tyramine signaling pathway +opioid receptor signaling pathway +pheromone-dependent signal transduction involved in conjugation with cellular fusion +phospholipase C-activating G-protein coupled receptor signaling pathway +phospholipase C-inhibiting G-protein coupled receptor signaling pathwayphospholipase D-activating G-protein coupled receptor signaling pathwaypositive regulation of G-protein coupled receptor protein signaling pathway +protein kinase C-activating G-protein coupled receptor signaling pathwayregulation of G-protein coupled receptor protein signaling pathway +rhodopsin mediated signaling pathway +serotonin receptor signaling pathway +signal transduction involved in conjugation with mutual genetic exchangesomatostatin receptor signaling pathway +sphingosine-1-phosphate signaling pathway [GO:0003376] (6 genes, 6 annotations)regulation of apoptosis by sphingosine-1-phosphate signaling pathwayregulation of inflammatory response by sphingosine-1-phosphate signaling pathwaytachykinin receptor signaling pathway +thrombin receptor signaling pathway +biological_processcellular processregulation of cellular processsignal transductionsphingolipid mediated signaling pathwaynegative regulation of sphingolipid mediated signaling pathwaypositive regulation of sphingolipid mediated signaling pathwayregulation of sphingolipid mediated signaling pathway +sphingosine-1-phosphate signaling pathway [GO:0003376] (6 genes, 6 annotations)regulation of apoptosis by sphingosine-1-phosphate signaling pathwayregulation of inflammatory response by sphingosine-1-phosphate signaling pathwaybiological_processcellular processsingle-organism cellular processcell communicationsignal transductioncell surface receptor signaling pathwayG-protein coupled receptor signaling pathwayadrenergic receptor signaling pathway +angiotensin-mediated signaling pathway +apelin receptor signaling pathwaybombesin receptor signaling pathwaycannabinoid signaling pathway +complement component C5a signaling pathwaydimeric G-protein coupled receptor signaling pathway +dopamine receptor signaling pathway +endothelin receptor signaling pathway +epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathwayfollicle-stimulating hormone signaling pathwayG-protein coupled acetylcholine receptor signaling pathway +G-protein coupled glutamate receptor signaling pathway +G-protein coupled purinergic receptor signaling pathway +G-protein coupled receptor signaling in absence of ligandG-protein coupled receptor signaling pathway involved in heart process +G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger +G-protein coupled receptor signaling pathway, coupled to S1P second messengergamma-aminobutyric acid signaling pathwayheterotrimeric G-protein complex cycleluteinizing hormone signaling pathway +negative regulation of G-protein coupled receptor protein signaling pathway +neuropeptide signaling pathwayoctopamine or tyramine signaling pathway +opioid receptor signaling pathway +pheromone-dependent signal transduction involved in conjugation with cellular fusion +phospholipase C-activating G-protein coupled receptor signaling pathway +phospholipase C-inhibiting G-protein coupled receptor signaling pathwayphospholipase D-activating G-protein coupled receptor signaling pathwaypositive regulation of G-protein coupled receptor protein signaling pathway +protein kinase C-activating G-protein coupled receptor signaling pathwayregulation of G-protein coupled receptor protein signaling pathway +rhodopsin mediated signaling pathway +serotonin receptor signaling pathway +signal transduction involved in conjugation with mutual genetic exchangesomatostatin receptor signaling pathway +sphingosine-1-phosphate signaling pathway [GO:0003376] (6 genes, 6 annotations)regulation of apoptosis by sphingosine-1-phosphate signaling pathwayregulation of inflammatory response by sphingosine-1-phosphate signaling pathwaytachykinin receptor signaling pathway +thrombin receptor signaling pathway +biological_processcellular processsingle-organism cellular processcell communicationsignal transductionsphingolipid mediated signaling pathwaynegative regulation of sphingolipid mediated signaling pathwaypositive regulation of sphingolipid mediated signaling pathwayregulation of sphingolipid mediated signaling pathway +sphingosine-1-phosphate signaling pathway [GO:0003376] (6 genes, 6 annotations)regulation of apoptosis by sphingosine-1-phosphate signaling pathwayregulation of inflammatory response by sphingosine-1-phosphate signaling pathwaybiological_processcellular processsingle-organism cellular processcellular response to stimulussignal transductioncell surface receptor signaling pathwayG-protein coupled receptor signaling pathwayadrenergic receptor signaling pathway +angiotensin-mediated signaling pathway +apelin receptor signaling pathwaybombesin receptor signaling pathwaycannabinoid signaling pathway +complement component C5a signaling pathwaydimeric G-protein coupled receptor signaling pathway +dopamine receptor signaling pathway +endothelin receptor signaling pathway +epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathwayfollicle-stimulating hormone signaling pathwayG-protein coupled acetylcholine receptor signaling pathway +G-protein coupled glutamate receptor signaling pathway +G-protein coupled purinergic receptor signaling pathway +G-protein coupled receptor signaling in absence of ligandG-protein coupled receptor signaling pathway involved in heart process +G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger +G-protein coupled receptor signaling pathway, coupled to S1P second messengergamma-aminobutyric acid signaling pathwayheterotrimeric G-protein complex cycleluteinizing hormone signaling pathway +negative regulation of G-protein coupled receptor protein signaling pathway +neuropeptide signaling pathwayoctopamine or tyramine signaling pathway +opioid receptor signaling pathway +pheromone-dependent signal transduction involved in conjugation with cellular fusion +phospholipase C-activating G-protein coupled receptor signaling pathway +phospholipase C-inhibiting G-protein coupled receptor signaling pathwayphospholipase D-activating G-protein coupled receptor signaling pathwaypositive regulation of G-protein coupled receptor protein signaling pathway +protein kinase C-activating G-protein coupled receptor signaling pathwayregulation of G-protein coupled receptor protein signaling pathway +rhodopsin mediated signaling pathway +serotonin receptor signaling pathway +signal transduction involved in conjugation with mutual genetic exchangesomatostatin receptor signaling pathway +sphingosine-1-phosphate signaling pathway [GO:0003376] (6 genes, 6 annotations)regulation of apoptosis by sphingosine-1-phosphate signaling pathwayregulation of inflammatory response by sphingosine-1-phosphate signaling pathwaytachykinin receptor signaling pathway +thrombin receptor signaling pathway +biological_processcellular processsingle-organism cellular processcellular response to stimulussignal transductionsphingolipid mediated signaling pathwaynegative regulation of sphingolipid mediated signaling pathwaypositive regulation of sphingolipid mediated signaling pathwayregulation of sphingolipid mediated signaling pathway +sphingosine-1-phosphate signaling pathway [GO:0003376] (6 genes, 6 annotations)regulation of apoptosis by sphingosine-1-phosphate signaling pathwayregulation of inflammatory response by sphingosine-1-phosphate signaling pathwaybiological_processregulation of biological processregulation of cellular processsignal transductioncell surface receptor signaling pathwayG-protein coupled receptor signaling pathwayadrenergic receptor signaling pathway +angiotensin-mediated signaling pathway +apelin receptor signaling pathwaybombesin receptor signaling pathwaycannabinoid signaling pathway +complement component C5a signaling pathwaydimeric G-protein coupled receptor signaling pathway +dopamine receptor signaling pathway +endothelin receptor signaling pathway +epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathwayfollicle-stimulating hormone signaling pathwayG-protein coupled acetylcholine receptor signaling pathway +G-protein coupled glutamate receptor signaling pathway +G-protein coupled purinergic receptor signaling pathway +G-protein coupled receptor signaling in absence of ligandG-protein coupled receptor signaling pathway involved in heart process +G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger +G-protein coupled receptor signaling pathway, coupled to S1P second messengergamma-aminobutyric acid signaling pathwayheterotrimeric G-protein complex cycleluteinizing hormone signaling pathway +negative regulation of G-protein coupled receptor protein signaling pathway +neuropeptide signaling pathwayoctopamine or tyramine signaling pathway +opioid receptor signaling pathway +pheromone-dependent signal transduction involved in conjugation with cellular fusion +phospholipase C-activating G-protein coupled receptor signaling pathway +phospholipase C-inhibiting G-protein coupled receptor signaling pathwayphospholipase D-activating G-protein coupled receptor signaling pathwaypositive regulation of G-protein coupled receptor protein signaling pathway +protein kinase C-activating G-protein coupled receptor signaling pathwayregulation of G-protein coupled receptor protein signaling pathway +rhodopsin mediated signaling pathway +serotonin receptor signaling pathway +signal transduction involved in conjugation with mutual genetic exchangesomatostatin receptor signaling pathway +sphingosine-1-phosphate signaling pathway [GO:0003376] (6 genes, 6 annotations)regulation of apoptosis by sphingosine-1-phosphate signaling pathwayregulation of inflammatory response by sphingosine-1-phosphate signaling pathwaytachykinin receptor signaling pathway +thrombin receptor signaling pathway +biological_processregulation of biological processregulation of cellular processsignal transductionsphingolipid mediated signaling pathwaynegative regulation of sphingolipid mediated signaling pathwaypositive regulation of sphingolipid mediated signaling pathwayregulation of sphingolipid mediated signaling pathway +sphingosine-1-phosphate signaling pathway [GO:0003376] (6 genes, 6 annotations)regulation of apoptosis by sphingosine-1-phosphate signaling pathwayregulation of inflammatory response by sphingosine-1-phosphate signaling pathwaybiological_processresponse to stimuluscellular response to stimulussignal transductioncell surface receptor signaling pathwayG-protein coupled receptor signaling pathwayadrenergic receptor signaling pathway +angiotensin-mediated signaling pathway +apelin receptor signaling pathwaybombesin receptor signaling pathwaycannabinoid signaling pathway +complement component C5a signaling pathwaydimeric G-protein coupled receptor signaling pathway +dopamine receptor signaling pathway +endothelin receptor signaling pathway +epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathwayfollicle-stimulating hormone signaling pathwayG-protein coupled acetylcholine receptor signaling pathway +G-protein coupled glutamate receptor signaling pathway +G-protein coupled purinergic receptor signaling pathway +G-protein coupled receptor signaling in absence of ligandG-protein coupled receptor signaling pathway involved in heart process +G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger +G-protein coupled receptor signaling pathway, coupled to S1P second messengergamma-aminobutyric acid signaling pathwayheterotrimeric G-protein complex cycleluteinizing hormone signaling pathway +negative regulation of G-protein coupled receptor protein signaling pathway +neuropeptide signaling pathwayoctopamine or tyramine signaling pathway +opioid receptor signaling pathway +pheromone-dependent signal transduction involved in conjugation with cellular fusion +phospholipase C-activating G-protein coupled receptor signaling pathway +phospholipase C-inhibiting G-protein coupled receptor signaling pathwayphospholipase D-activating G-protein coupled receptor signaling pathwaypositive regulation of G-protein coupled receptor protein signaling pathway +protein kinase C-activating G-protein coupled receptor signaling pathwayregulation of G-protein coupled receptor protein signaling pathway +rhodopsin mediated signaling pathway +serotonin receptor signaling pathway +signal transduction involved in conjugation with mutual genetic exchangesomatostatin receptor signaling pathway +sphingosine-1-phosphate signaling pathway [GO:0003376] (6 genes, 6 annotations)regulation of apoptosis by sphingosine-1-phosphate signaling pathwayregulation of inflammatory response by sphingosine-1-phosphate signaling pathwaytachykinin receptor signaling pathway +thrombin receptor signaling pathway +biological_processresponse to stimuluscellular response to stimulussignal transductionsphingolipid mediated signaling pathwaynegative regulation of sphingolipid mediated signaling pathwaypositive regulation of sphingolipid mediated signaling pathwayregulation of sphingolipid mediated signaling pathway +sphingosine-1-phosphate signaling pathway [GO:0003376] (6 genes, 6 annotations)regulation of apoptosis by sphingosine-1-phosphate signaling pathwayregulation of inflammatory response by sphingosine-1-phosphate signaling pathwaybiological_processsignalingsingle organism signalingsignal transductioncell surface receptor signaling pathwayG-protein coupled receptor signaling pathwayadrenergic receptor signaling pathway +angiotensin-mediated signaling pathway +apelin receptor signaling pathwaybombesin receptor signaling pathwaycannabinoid signaling pathway +complement component C5a signaling pathwaydimeric G-protein coupled receptor signaling pathway +dopamine receptor signaling pathway +endothelin receptor signaling pathway +epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathwayfollicle-stimulating hormone signaling pathwayG-protein coupled acetylcholine receptor signaling pathway +G-protein coupled glutamate receptor signaling pathway +G-protein coupled purinergic receptor signaling pathway +G-protein coupled receptor signaling in absence of ligandG-protein coupled receptor signaling pathway involved in heart process +G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger +G-protein coupled receptor signaling pathway, coupled to S1P second messengergamma-aminobutyric acid signaling pathwayheterotrimeric G-protein complex cycleluteinizing hormone signaling pathway +negative regulation of G-protein coupled receptor protein signaling pathway +neuropeptide signaling pathwayoctopamine or tyramine signaling pathway +opioid receptor signaling pathway +pheromone-dependent signal transduction involved in conjugation with cellular fusion +phospholipase C-activating G-protein coupled receptor signaling pathway +phospholipase C-inhibiting G-protein coupled receptor signaling pathwayphospholipase D-activating G-protein coupled receptor signaling pathwaypositive regulation of G-protein coupled receptor protein signaling pathway +protein kinase C-activating G-protein coupled receptor signaling pathwayregulation of G-protein coupled receptor protein signaling pathway +rhodopsin mediated signaling pathway +serotonin receptor signaling pathway +signal transduction involved in conjugation with mutual genetic exchangesomatostatin receptor signaling pathway +sphingosine-1-phosphate signaling pathway [GO:0003376] (6 genes, 6 annotations)regulation of apoptosis by sphingosine-1-phosphate signaling pathwayregulation of inflammatory response by sphingosine-1-phosphate signaling pathwaytachykinin receptor signaling pathway +thrombin receptor signaling pathway +biological_processsignalingsingle organism signalingsignal transductionsphingolipid mediated signaling pathwaynegative regulation of sphingolipid mediated signaling pathwaypositive regulation of sphingolipid mediated signaling pathwayregulation of sphingolipid mediated signaling pathway +sphingosine-1-phosphate signaling pathway [GO:0003376] (6 genes, 6 annotations)regulation of apoptosis by sphingosine-1-phosphate signaling pathwayregulation of inflammatory response by sphingosine-1-phosphate signaling pathwaybiological_processsingle-organism processsingle organism signalingsignal transductioncell surface receptor signaling pathwayG-protein coupled receptor signaling pathwayadrenergic receptor signaling pathway +angiotensin-mediated signaling pathway +apelin receptor signaling pathwaybombesin receptor signaling pathwaycannabinoid signaling pathway +complement component C5a signaling pathwaydimeric G-protein coupled receptor signaling pathway +dopamine receptor signaling pathway +endothelin receptor signaling pathway +epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathwayfollicle-stimulating hormone signaling pathwayG-protein coupled acetylcholine receptor signaling pathway +G-protein coupled glutamate receptor signaling pathway +G-protein coupled purinergic receptor signaling pathway +G-protein coupled receptor signaling in absence of ligandG-protein coupled receptor signaling pathway involved in heart process +G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger +G-protein coupled receptor signaling pathway, coupled to S1P second messengergamma-aminobutyric acid signaling pathwayheterotrimeric G-protein complex cycleluteinizing hormone signaling pathway +negative regulation of G-protein coupled receptor protein signaling pathway +neuropeptide signaling pathwayoctopamine or tyramine signaling pathway +opioid receptor signaling pathway +pheromone-dependent signal transduction involved in conjugation with cellular fusion +phospholipase C-activating G-protein coupled receptor signaling pathway +phospholipase C-inhibiting G-protein coupled receptor signaling pathwayphospholipase D-activating G-protein coupled receptor signaling pathwaypositive regulation of G-protein coupled receptor protein signaling pathway +protein kinase C-activating G-protein coupled receptor signaling pathwayregulation of G-protein coupled receptor protein signaling pathway +rhodopsin mediated signaling pathway +serotonin receptor signaling pathway +signal transduction involved in conjugation with mutual genetic exchangesomatostatin receptor signaling pathway +sphingosine-1-phosphate signaling pathway [GO:0003376] (6 genes, 6 annotations)regulation of apoptosis by sphingosine-1-phosphate signaling pathwayregulation of inflammatory response by sphingosine-1-phosphate signaling pathwaytachykinin receptor signaling pathway +thrombin receptor signaling pathway +biological_processsingle-organism processsingle organism signalingsignal transductionsphingolipid mediated signaling pathwaynegative regulation of sphingolipid mediated signaling pathwaypositive regulation of sphingolipid mediated signaling pathwayregulation of sphingolipid mediated signaling pathway +sphingosine-1-phosphate signaling pathway [GO:0003376] (6 genes, 6 annotations)regulation of apoptosis by sphingosine-1-phosphate signaling pathwayregulation of inflammatory response by sphingosine-1-phosphate signaling pathwaybiological_processsingle-organism processsingle-organism cellular processcell communicationsignal transductioncell surface receptor signaling pathwayG-protein coupled receptor signaling pathwayadrenergic receptor signaling pathway +angiotensin-mediated signaling pathway +apelin receptor signaling pathwaybombesin receptor signaling pathwaycannabinoid signaling pathway +complement component C5a signaling pathwaydimeric G-protein coupled receptor signaling pathway +dopamine receptor signaling pathway +endothelin receptor signaling pathway +epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathwayfollicle-stimulating hormone signaling pathwayG-protein coupled acetylcholine receptor signaling pathway +G-protein coupled glutamate receptor signaling pathway +G-protein coupled purinergic receptor signaling pathway +G-protein coupled receptor signaling in absence of ligandG-protein coupled receptor signaling pathway involved in heart process +G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger +G-protein coupled receptor signaling pathway, coupled to S1P second messengergamma-aminobutyric acid signaling pathwayheterotrimeric G-protein complex cycleluteinizing hormone signaling pathway +negative regulation of G-protein coupled receptor protein signaling pathway +neuropeptide signaling pathwayoctopamine or tyramine signaling pathway +opioid receptor signaling pathway +pheromone-dependent signal transduction involved in conjugation with cellular fusion +phospholipase C-activating G-protein coupled receptor signaling pathway +phospholipase C-inhibiting G-protein coupled receptor signaling pathwayphospholipase D-activating G-protein coupled receptor signaling pathwaypositive regulation of G-protein coupled receptor protein signaling pathway +protein kinase C-activating G-protein coupled receptor signaling pathwayregulation of G-protein coupled receptor protein signaling pathway +rhodopsin mediated signaling pathway +serotonin receptor signaling pathway +signal transduction involved in conjugation with mutual genetic exchangesomatostatin receptor signaling pathway +sphingosine-1-phosphate signaling pathway [GO:0003376] (6 genes, 6 annotations)regulation of apoptosis by sphingosine-1-phosphate signaling pathwayregulation of inflammatory response by sphingosine-1-phosphate signaling pathwaytachykinin receptor signaling pathway +thrombin receptor signaling pathway +biological_processsingle-organism processsingle-organism cellular processcell communicationsignal transductionsphingolipid mediated signaling pathwaynegative regulation of sphingolipid mediated signaling pathwaypositive regulation of sphingolipid mediated signaling pathwayregulation of sphingolipid mediated signaling pathway +sphingosine-1-phosphate signaling pathway [GO:0003376] (6 genes, 6 annotations)regulation of apoptosis by sphingosine-1-phosphate signaling pathwayregulation of inflammatory response by sphingosine-1-phosphate signaling pathwaybiological_processsingle-organism processsingle-organism cellular processcellular response to stimulussignal transductioncell surface receptor signaling pathwayG-protein coupled receptor signaling pathwayadrenergic receptor signaling pathway +angiotensin-mediated signaling pathway +apelin receptor signaling pathwaybombesin receptor signaling pathwaycannabinoid signaling pathway +complement component C5a signaling pathwaydimeric G-protein coupled receptor signaling pathway +dopamine receptor signaling pathway +endothelin receptor signaling pathway +epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathwayfollicle-stimulating hormone signaling pathwayG-protein coupled acetylcholine receptor signaling pathway +G-protein coupled glutamate receptor signaling pathway +G-protein coupled purinergic receptor signaling pathway +G-protein coupled receptor signaling in absence of ligandG-protein coupled receptor signaling pathway involved in heart process +G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger +G-protein coupled receptor signaling pathway, coupled to S1P second messengergamma-aminobutyric acid signaling pathwayheterotrimeric G-protein complex cycleluteinizing hormone signaling pathway +negative regulation of G-protein coupled receptor protein signaling pathway +neuropeptide signaling pathwayoctopamine or tyramine signaling pathway +opioid receptor signaling pathway +pheromone-dependent signal transduction involved in conjugation with cellular fusion +phospholipase C-activating G-protein coupled receptor signaling pathway +phospholipase C-inhibiting G-protein coupled receptor signaling pathwayphospholipase D-activating G-protein coupled receptor signaling pathwaypositive regulation of G-protein coupled receptor protein signaling pathway +protein kinase C-activating G-protein coupled receptor signaling pathwayregulation of G-protein coupled receptor protein signaling pathway +rhodopsin mediated signaling pathway +serotonin receptor signaling pathway +signal transduction involved in conjugation with mutual genetic exchangesomatostatin receptor signaling pathway +sphingosine-1-phosphate signaling pathway [GO:0003376] (6 genes, 6 annotations)regulation of apoptosis by sphingosine-1-phosphate signaling pathwayregulation of inflammatory response by sphingosine-1-phosphate signaling pathwaytachykinin receptor signaling pathway +thrombin receptor signaling pathway +biological_processsingle-organism processsingle-organism cellular processcellular response to stimulussignal transductionsphingolipid mediated signaling pathwaynegative regulation of sphingolipid mediated signaling pathwaypositive regulation of sphingolipid mediated signaling pathwayregulation of sphingolipid mediated signaling pathway +sphingosine-1-phosphate signaling pathway [GO:0003376] (6 genes, 6 annotations)regulation of apoptosis by sphingosine-1-phosphate signaling pathwayregulation of inflammatory response by sphingosine-1-phosphate signaling pathwayMouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc |
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last database update 05/08/2013 MGI 5.13 |
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