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Gene Ontology Browser
Term Detail
GO term:sphingosine-1-phosphate signaling pathway
Synonym: S1P-activated GPCR signaling pathway
Synonym: S1P-activated G-protein coupled receptor signaling pathway
Synonym: S1P receptor signaling pathway
Synonym: S1P signaling pathway
Synonym: S1P-stimulated signal transduction pathway
Synonym: sphingolipid signaling pathway
Synonym: sphingolipid signalling pathway
Synonym: sphingosine-1-phosphate signal transduction
GO id:GO:0003376
Definition:A series of molecular signals initiated by the sphingolipid sphingosine-1-phosphate (S1P) binding to a receptor on the surface of the cell, and which proceeds with the activated receptor transmitting the signal by promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The pathway ends with regulation of a downstream cellular process, e.g. transcription.
CommentsSphingosine-1-phosphate (S1P) can act both as an extracellular ligand for cell surface G-protein coupled receptors, and as an intracellular second messenger. GO:0003376 describes a pathway where S1P acts as an extracellular ligand. Where S1P acts within the cell to transmit a signal, consider instead 'intracellular signal transduction ; GO:0035556' or 'G-protein signaling, coupled to S1P second messenger (sphingosine kinase activating) ; GO:0001789'.
Number of paths to term: 18

is-adenotes an 'is-a' relationship
part-ofdenotes a 'part-of' relationship
regulatesdenotes a 'regulates' relationship
positively-regulatesdenotes a 'positively-regulates' relationship
negatively-regulatesdenotes a 'negatively-regulates' relationship


Gene_Ontology
        is-abiological_process
                is-abiological regulation
                        is-aregulation of biological process
                                is-aregulation of cellular process
                                        is-asignal transduction
                                                is-acell surface receptor signaling pathway
                                                        is-aG-protein coupled receptor signaling pathway
                                                                is-aadrenergic receptor signaling pathway +
                                                                is-aangiotensin-activated signaling pathway +
                                                                is-aapelin receptor signaling pathway
                                                                is-abombesin receptor signaling pathway
                                                                is-acalcitonin family receptor signaling pathway +
                                                                is-acannabinoid signaling pathway +
                                                                is-acholecystokinin signaling pathway +
                                                                is-acomplement component C5a signaling pathway
                                                                is-adimeric G-protein coupled receptor signaling pathway +
                                                                is-adopamine receptor signaling pathway +
                                                                is-aendothelin receptor signaling pathway +
                                                                is-aepidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway
                                                                is-afollicle-stimulating hormone signaling pathway
                                                                is-aG-protein coupled acetylcholine receptor signaling pathway +
                                                                is-aG-protein coupled glutamate receptor signaling pathway +
                                                                is-aG-protein coupled purinergic receptor signaling pathway +
                                                                is-aG-protein coupled receptor signaling in absence of ligand
                                                                is-aG-protein coupled receptor signaling pathway involved in heart process +
                                                                is-aG-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger +
                                                                is-aG-protein coupled receptor signaling pathway, coupled to S1P second messenger
                                                                is-agamma-aminobutyric acid signaling pathway
                                                                is-agastric inhibitory peptide signaling pathway
                                                                part-ofheterotrimeric G-protein complex cycle
                                                                is-aluteinizing hormone signaling pathway +
                                                                negatively-regulatesnegative regulation of G-protein coupled receptor protein signaling pathway +
                                                                is-aneuropeptide signaling pathway
                                                                is-aoctopamine or tyramine signaling pathway +
                                                                is-aopioid receptor signaling pathway +
                                                                is-apheromone-dependent signal transduction involved in conjugation with cellular fusion +
                                                                is-aphospholipase C-activating G-protein coupled receptor signaling pathway +
                                                                is-aphospholipase C-inhibiting G-protein coupled receptor signaling pathway
                                                                is-aphospholipase D-activating G-protein coupled receptor signaling pathway
                                                                positively-regulatespositive regulation of G-protein coupled receptor protein signaling pathway +
                                                                is-aprotein kinase C-activating G-protein coupled receptor signaling pathway
                                                                regulatesregulation of G-protein coupled receptor protein signaling pathway +
                                                                is-arhodopsin mediated signaling pathway +
                                                                is-aserotonin receptor signaling pathway +
                                                                is-asignal transduction involved in conjugation with mutual genetic exchange
                                                                is-asomatostatin receptor signaling pathway +
                                                                is-asphingosine-1-phosphate signaling pathway [GO:0003376] (3 genes, 4 annotations)
                                                                        is-aregulation of apoptosis by sphingosine-1-phosphate signaling pathway
                                                                        is-aregulation of inflammatory response by sphingosine-1-phosphate signaling pathway
                                                                is-atachykinin receptor signaling pathway +
                                                                is-athrombin receptor signaling pathway +
                                                                is-athromboxane A2 signaling pathway
                                                                is-athyroid-stimulating hormone signaling pathway


Gene_Ontology
        is-abiological_process
                is-abiological regulation
                        is-aregulation of biological process
                                is-aregulation of cellular process
                                        is-asignal transduction
                                                is-asphingolipid mediated signaling pathway
                                                        negatively-regulatesnegative regulation of sphingolipid mediated signaling pathway
                                                        positively-regulatespositive regulation of sphingolipid mediated signaling pathway
                                                        regulatesregulation of sphingolipid mediated signaling pathway +
                                                        is-asphingosine-1-phosphate signaling pathway [GO:0003376] (3 genes, 4 annotations)
                                                                is-aregulation of apoptosis by sphingosine-1-phosphate signaling pathway
                                                                is-aregulation of inflammatory response by sphingosine-1-phosphate signaling pathway


Gene_Ontology
        is-abiological_process
                is-acellular process
                        is-acellular response to stimulus
                                is-asignal transduction
                                        is-acell surface receptor signaling pathway
                                                is-aG-protein coupled receptor signaling pathway
                                                        is-aadrenergic receptor signaling pathway +
                                                        is-aangiotensin-activated signaling pathway +
                                                        is-aapelin receptor signaling pathway
                                                        is-abombesin receptor signaling pathway
                                                        is-acalcitonin family receptor signaling pathway +
                                                        is-acannabinoid signaling pathway +
                                                        is-acholecystokinin signaling pathway +
                                                        is-acomplement component C5a signaling pathway
                                                        is-adimeric G-protein coupled receptor signaling pathway +
                                                        is-adopamine receptor signaling pathway +
                                                        is-aendothelin receptor signaling pathway +
                                                        is-aepidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway
                                                        is-afollicle-stimulating hormone signaling pathway
                                                        is-aG-protein coupled acetylcholine receptor signaling pathway +
                                                        is-aG-protein coupled glutamate receptor signaling pathway +
                                                        is-aG-protein coupled purinergic receptor signaling pathway +
                                                        is-aG-protein coupled receptor signaling in absence of ligand
                                                        is-aG-protein coupled receptor signaling pathway involved in heart process +
                                                        is-aG-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger +
                                                        is-aG-protein coupled receptor signaling pathway, coupled to S1P second messenger
                                                        is-agamma-aminobutyric acid signaling pathway
                                                        is-agastric inhibitory peptide signaling pathway
                                                        part-ofheterotrimeric G-protein complex cycle
                                                        is-aluteinizing hormone signaling pathway +
                                                        negatively-regulatesnegative regulation of G-protein coupled receptor protein signaling pathway +
                                                        is-aneuropeptide signaling pathway
                                                        is-aoctopamine or tyramine signaling pathway +
                                                        is-aopioid receptor signaling pathway +
                                                        is-apheromone-dependent signal transduction involved in conjugation with cellular fusion +
                                                        is-aphospholipase C-activating G-protein coupled receptor signaling pathway +
                                                        is-aphospholipase C-inhibiting G-protein coupled receptor signaling pathway
                                                        is-aphospholipase D-activating G-protein coupled receptor signaling pathway
                                                        positively-regulatespositive regulation of G-protein coupled receptor protein signaling pathway +
                                                        is-aprotein kinase C-activating G-protein coupled receptor signaling pathway
                                                        regulatesregulation of G-protein coupled receptor protein signaling pathway +
                                                        is-arhodopsin mediated signaling pathway +
                                                        is-aserotonin receptor signaling pathway +
                                                        is-asignal transduction involved in conjugation with mutual genetic exchange
                                                        is-asomatostatin receptor signaling pathway +
                                                        is-asphingosine-1-phosphate signaling pathway [GO:0003376] (3 genes, 4 annotations)
                                                                is-aregulation of apoptosis by sphingosine-1-phosphate signaling pathway
                                                                is-aregulation of inflammatory response by sphingosine-1-phosphate signaling pathway
                                                        is-atachykinin receptor signaling pathway +
                                                        is-athrombin receptor signaling pathway +
                                                        is-athromboxane A2 signaling pathway
                                                        is-athyroid-stimulating hormone signaling pathway


Gene_Ontology
        is-abiological_process
                is-acellular process
                        is-acellular response to stimulus
                                is-asignal transduction
                                        is-asphingolipid mediated signaling pathway
                                                negatively-regulatesnegative regulation of sphingolipid mediated signaling pathway
                                                positively-regulatespositive regulation of sphingolipid mediated signaling pathway
                                                regulatesregulation of sphingolipid mediated signaling pathway +
                                                is-asphingosine-1-phosphate signaling pathway [GO:0003376] (3 genes, 4 annotations)
                                                        is-aregulation of apoptosis by sphingosine-1-phosphate signaling pathway
                                                        is-aregulation of inflammatory response by sphingosine-1-phosphate signaling pathway


Gene_Ontology
        is-abiological_process
                is-acellular process
                        regulatesregulation of cellular process
                                is-asignal transduction
                                        is-acell surface receptor signaling pathway
                                                is-aG-protein coupled receptor signaling pathway
                                                        is-aadrenergic receptor signaling pathway +
                                                        is-aangiotensin-activated signaling pathway +
                                                        is-aapelin receptor signaling pathway
                                                        is-abombesin receptor signaling pathway
                                                        is-acalcitonin family receptor signaling pathway +
                                                        is-acannabinoid signaling pathway +
                                                        is-acholecystokinin signaling pathway +
                                                        is-acomplement component C5a signaling pathway
                                                        is-adimeric G-protein coupled receptor signaling pathway +
                                                        is-adopamine receptor signaling pathway +
                                                        is-aendothelin receptor signaling pathway +
                                                        is-aepidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway
                                                        is-afollicle-stimulating hormone signaling pathway
                                                        is-aG-protein coupled acetylcholine receptor signaling pathway +
                                                        is-aG-protein coupled glutamate receptor signaling pathway +
                                                        is-aG-protein coupled purinergic receptor signaling pathway +
                                                        is-aG-protein coupled receptor signaling in absence of ligand
                                                        is-aG-protein coupled receptor signaling pathway involved in heart process +
                                                        is-aG-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger +
                                                        is-aG-protein coupled receptor signaling pathway, coupled to S1P second messenger
                                                        is-agamma-aminobutyric acid signaling pathway
                                                        is-agastric inhibitory peptide signaling pathway
                                                        part-ofheterotrimeric G-protein complex cycle
                                                        is-aluteinizing hormone signaling pathway +
                                                        negatively-regulatesnegative regulation of G-protein coupled receptor protein signaling pathway +
                                                        is-aneuropeptide signaling pathway
                                                        is-aoctopamine or tyramine signaling pathway +
                                                        is-aopioid receptor signaling pathway +
                                                        is-apheromone-dependent signal transduction involved in conjugation with cellular fusion +
                                                        is-aphospholipase C-activating G-protein coupled receptor signaling pathway +
                                                        is-aphospholipase C-inhibiting G-protein coupled receptor signaling pathway
                                                        is-aphospholipase D-activating G-protein coupled receptor signaling pathway
                                                        positively-regulatespositive regulation of G-protein coupled receptor protein signaling pathway +
                                                        is-aprotein kinase C-activating G-protein coupled receptor signaling pathway
                                                        regulatesregulation of G-protein coupled receptor protein signaling pathway +
                                                        is-arhodopsin mediated signaling pathway +
                                                        is-aserotonin receptor signaling pathway +
                                                        is-asignal transduction involved in conjugation with mutual genetic exchange
                                                        is-asomatostatin receptor signaling pathway +
                                                        is-asphingosine-1-phosphate signaling pathway [GO:0003376] (3 genes, 4 annotations)
                                                                is-aregulation of apoptosis by sphingosine-1-phosphate signaling pathway
                                                                is-aregulation of inflammatory response by sphingosine-1-phosphate signaling pathway
                                                        is-atachykinin receptor signaling pathway +
                                                        is-athrombin receptor signaling pathway +
                                                        is-athromboxane A2 signaling pathway
                                                        is-athyroid-stimulating hormone signaling pathway


Gene_Ontology
        is-abiological_process
                is-acellular process
                        regulatesregulation of cellular process
                                is-asignal transduction
                                        is-asphingolipid mediated signaling pathway
                                                negatively-regulatesnegative regulation of sphingolipid mediated signaling pathway
                                                positively-regulatespositive regulation of sphingolipid mediated signaling pathway
                                                regulatesregulation of sphingolipid mediated signaling pathway +
                                                is-asphingosine-1-phosphate signaling pathway [GO:0003376] (3 genes, 4 annotations)
                                                        is-aregulation of apoptosis by sphingosine-1-phosphate signaling pathway
                                                        is-aregulation of inflammatory response by sphingosine-1-phosphate signaling pathway


Gene_Ontology
        is-abiological_process
                is-acellular process
                        is-asingle-organism cellular process
                                is-acell communication
                                        part-ofsignal transduction
                                                is-acell surface receptor signaling pathway
                                                        is-aG-protein coupled receptor signaling pathway
                                                                is-aadrenergic receptor signaling pathway +
                                                                is-aangiotensin-activated signaling pathway +
                                                                is-aapelin receptor signaling pathway
                                                                is-abombesin receptor signaling pathway
                                                                is-acalcitonin family receptor signaling pathway +
                                                                is-acannabinoid signaling pathway +
                                                                is-acholecystokinin signaling pathway +
                                                                is-acomplement component C5a signaling pathway
                                                                is-adimeric G-protein coupled receptor signaling pathway +
                                                                is-adopamine receptor signaling pathway +
                                                                is-aendothelin receptor signaling pathway +
                                                                is-aepidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway
                                                                is-afollicle-stimulating hormone signaling pathway
                                                                is-aG-protein coupled acetylcholine receptor signaling pathway +
                                                                is-aG-protein coupled glutamate receptor signaling pathway +
                                                                is-aG-protein coupled purinergic receptor signaling pathway +
                                                                is-aG-protein coupled receptor signaling in absence of ligand
                                                                is-aG-protein coupled receptor signaling pathway involved in heart process +
                                                                is-aG-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger +
                                                                is-aG-protein coupled receptor signaling pathway, coupled to S1P second messenger
                                                                is-agamma-aminobutyric acid signaling pathway
                                                                is-agastric inhibitory peptide signaling pathway
                                                                part-ofheterotrimeric G-protein complex cycle
                                                                is-aluteinizing hormone signaling pathway +
                                                                negatively-regulatesnegative regulation of G-protein coupled receptor protein signaling pathway +
                                                                is-aneuropeptide signaling pathway
                                                                is-aoctopamine or tyramine signaling pathway +
                                                                is-aopioid receptor signaling pathway +
                                                                is-apheromone-dependent signal transduction involved in conjugation with cellular fusion +
                                                                is-aphospholipase C-activating G-protein coupled receptor signaling pathway +
                                                                is-aphospholipase C-inhibiting G-protein coupled receptor signaling pathway
                                                                is-aphospholipase D-activating G-protein coupled receptor signaling pathway
                                                                positively-regulatespositive regulation of G-protein coupled receptor protein signaling pathway +
                                                                is-aprotein kinase C-activating G-protein coupled receptor signaling pathway
                                                                regulatesregulation of G-protein coupled receptor protein signaling pathway +
                                                                is-arhodopsin mediated signaling pathway +
                                                                is-aserotonin receptor signaling pathway +
                                                                is-asignal transduction involved in conjugation with mutual genetic exchange
                                                                is-asomatostatin receptor signaling pathway +
                                                                is-asphingosine-1-phosphate signaling pathway [GO:0003376] (3 genes, 4 annotations)
                                                                        is-aregulation of apoptosis by sphingosine-1-phosphate signaling pathway
                                                                        is-aregulation of inflammatory response by sphingosine-1-phosphate signaling pathway
                                                                is-atachykinin receptor signaling pathway +
                                                                is-athrombin receptor signaling pathway +
                                                                is-athromboxane A2 signaling pathway
                                                                is-athyroid-stimulating hormone signaling pathway


Gene_Ontology
        is-abiological_process
                is-acellular process
                        is-asingle-organism cellular process
                                is-acell communication
                                        part-ofsignal transduction
                                                is-asphingolipid mediated signaling pathway
                                                        negatively-regulatesnegative regulation of sphingolipid mediated signaling pathway
                                                        positively-regulatespositive regulation of sphingolipid mediated signaling pathway
                                                        regulatesregulation of sphingolipid mediated signaling pathway +
                                                        is-asphingosine-1-phosphate signaling pathway [GO:0003376] (3 genes, 4 annotations)
                                                                is-aregulation of apoptosis by sphingosine-1-phosphate signaling pathway
                                                                is-aregulation of inflammatory response by sphingosine-1-phosphate signaling pathway


Gene_Ontology
        is-abiological_process
                regulatesregulation of biological process
                        is-aregulation of cellular process
                                is-asignal transduction
                                        is-acell surface receptor signaling pathway
                                                is-aG-protein coupled receptor signaling pathway
                                                        is-aadrenergic receptor signaling pathway +
                                                        is-aangiotensin-activated signaling pathway +
                                                        is-aapelin receptor signaling pathway
                                                        is-abombesin receptor signaling pathway
                                                        is-acalcitonin family receptor signaling pathway +
                                                        is-acannabinoid signaling pathway +
                                                        is-acholecystokinin signaling pathway +
                                                        is-acomplement component C5a signaling pathway
                                                        is-adimeric G-protein coupled receptor signaling pathway +
                                                        is-adopamine receptor signaling pathway +
                                                        is-aendothelin receptor signaling pathway +
                                                        is-aepidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway
                                                        is-afollicle-stimulating hormone signaling pathway
                                                        is-aG-protein coupled acetylcholine receptor signaling pathway +
                                                        is-aG-protein coupled glutamate receptor signaling pathway +
                                                        is-aG-protein coupled purinergic receptor signaling pathway +
                                                        is-aG-protein coupled receptor signaling in absence of ligand
                                                        is-aG-protein coupled receptor signaling pathway involved in heart process +
                                                        is-aG-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger +
                                                        is-aG-protein coupled receptor signaling pathway, coupled to S1P second messenger
                                                        is-agamma-aminobutyric acid signaling pathway
                                                        is-agastric inhibitory peptide signaling pathway
                                                        part-ofheterotrimeric G-protein complex cycle
                                                        is-aluteinizing hormone signaling pathway +
                                                        negatively-regulatesnegative regulation of G-protein coupled receptor protein signaling pathway +
                                                        is-aneuropeptide signaling pathway
                                                        is-aoctopamine or tyramine signaling pathway +
                                                        is-aopioid receptor signaling pathway +
                                                        is-apheromone-dependent signal transduction involved in conjugation with cellular fusion +
                                                        is-aphospholipase C-activating G-protein coupled receptor signaling pathway +
                                                        is-aphospholipase C-inhibiting G-protein coupled receptor signaling pathway
                                                        is-aphospholipase D-activating G-protein coupled receptor signaling pathway
                                                        positively-regulatespositive regulation of G-protein coupled receptor protein signaling pathway +
                                                        is-aprotein kinase C-activating G-protein coupled receptor signaling pathway
                                                        regulatesregulation of G-protein coupled receptor protein signaling pathway +
                                                        is-arhodopsin mediated signaling pathway +
                                                        is-aserotonin receptor signaling pathway +
                                                        is-asignal transduction involved in conjugation with mutual genetic exchange
                                                        is-asomatostatin receptor signaling pathway +
                                                        is-asphingosine-1-phosphate signaling pathway [GO:0003376] (3 genes, 4 annotations)
                                                                is-aregulation of apoptosis by sphingosine-1-phosphate signaling pathway
                                                                is-aregulation of inflammatory response by sphingosine-1-phosphate signaling pathway
                                                        is-atachykinin receptor signaling pathway +
                                                        is-athrombin receptor signaling pathway +
                                                        is-athromboxane A2 signaling pathway
                                                        is-athyroid-stimulating hormone signaling pathway


Gene_Ontology
        is-abiological_process
                regulatesregulation of biological process
                        is-aregulation of cellular process
                                is-asignal transduction
                                        is-asphingolipid mediated signaling pathway
                                                negatively-regulatesnegative regulation of sphingolipid mediated signaling pathway
                                                positively-regulatespositive regulation of sphingolipid mediated signaling pathway
                                                regulatesregulation of sphingolipid mediated signaling pathway +
                                                is-asphingosine-1-phosphate signaling pathway [GO:0003376] (3 genes, 4 annotations)
                                                        is-aregulation of apoptosis by sphingosine-1-phosphate signaling pathway
                                                        is-aregulation of inflammatory response by sphingosine-1-phosphate signaling pathway


Gene_Ontology
        is-abiological_process
                is-aresponse to stimulus
                        is-acellular response to stimulus
                                is-asignal transduction
                                        is-acell surface receptor signaling pathway
                                                is-aG-protein coupled receptor signaling pathway
                                                        is-aadrenergic receptor signaling pathway +
                                                        is-aangiotensin-activated signaling pathway +
                                                        is-aapelin receptor signaling pathway
                                                        is-abombesin receptor signaling pathway
                                                        is-acalcitonin family receptor signaling pathway +
                                                        is-acannabinoid signaling pathway +
                                                        is-acholecystokinin signaling pathway +
                                                        is-acomplement component C5a signaling pathway
                                                        is-adimeric G-protein coupled receptor signaling pathway +
                                                        is-adopamine receptor signaling pathway +
                                                        is-aendothelin receptor signaling pathway +
                                                        is-aepidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway
                                                        is-afollicle-stimulating hormone signaling pathway
                                                        is-aG-protein coupled acetylcholine receptor signaling pathway +
                                                        is-aG-protein coupled glutamate receptor signaling pathway +
                                                        is-aG-protein coupled purinergic receptor signaling pathway +
                                                        is-aG-protein coupled receptor signaling in absence of ligand
                                                        is-aG-protein coupled receptor signaling pathway involved in heart process +
                                                        is-aG-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger +
                                                        is-aG-protein coupled receptor signaling pathway, coupled to S1P second messenger
                                                        is-agamma-aminobutyric acid signaling pathway
                                                        is-agastric inhibitory peptide signaling pathway
                                                        part-ofheterotrimeric G-protein complex cycle
                                                        is-aluteinizing hormone signaling pathway +
                                                        negatively-regulatesnegative regulation of G-protein coupled receptor protein signaling pathway +
                                                        is-aneuropeptide signaling pathway
                                                        is-aoctopamine or tyramine signaling pathway +
                                                        is-aopioid receptor signaling pathway +
                                                        is-apheromone-dependent signal transduction involved in conjugation with cellular fusion +
                                                        is-aphospholipase C-activating G-protein coupled receptor signaling pathway +
                                                        is-aphospholipase C-inhibiting G-protein coupled receptor signaling pathway
                                                        is-aphospholipase D-activating G-protein coupled receptor signaling pathway
                                                        positively-regulatespositive regulation of G-protein coupled receptor protein signaling pathway +
                                                        is-aprotein kinase C-activating G-protein coupled receptor signaling pathway
                                                        regulatesregulation of G-protein coupled receptor protein signaling pathway +
                                                        is-arhodopsin mediated signaling pathway +
                                                        is-aserotonin receptor signaling pathway +
                                                        is-asignal transduction involved in conjugation with mutual genetic exchange
                                                        is-asomatostatin receptor signaling pathway +
                                                        is-asphingosine-1-phosphate signaling pathway [GO:0003376] (3 genes, 4 annotations)
                                                                is-aregulation of apoptosis by sphingosine-1-phosphate signaling pathway
                                                                is-aregulation of inflammatory response by sphingosine-1-phosphate signaling pathway
                                                        is-atachykinin receptor signaling pathway +
                                                        is-athrombin receptor signaling pathway +
                                                        is-athromboxane A2 signaling pathway
                                                        is-athyroid-stimulating hormone signaling pathway


Gene_Ontology
        is-abiological_process
                is-aresponse to stimulus
                        is-acellular response to stimulus
                                is-asignal transduction
                                        is-asphingolipid mediated signaling pathway
                                                negatively-regulatesnegative regulation of sphingolipid mediated signaling pathway
                                                positively-regulatespositive regulation of sphingolipid mediated signaling pathway
                                                regulatesregulation of sphingolipid mediated signaling pathway +
                                                is-asphingosine-1-phosphate signaling pathway [GO:0003376] (3 genes, 4 annotations)
                                                        is-aregulation of apoptosis by sphingosine-1-phosphate signaling pathway
                                                        is-aregulation of inflammatory response by sphingosine-1-phosphate signaling pathway


Gene_Ontology
        is-abiological_process
                is-asignaling
                        is-asingle organism signaling
                                part-ofsignal transduction
                                        is-acell surface receptor signaling pathway
                                                is-aG-protein coupled receptor signaling pathway
                                                        is-aadrenergic receptor signaling pathway +
                                                        is-aangiotensin-activated signaling pathway +
                                                        is-aapelin receptor signaling pathway
                                                        is-abombesin receptor signaling pathway
                                                        is-acalcitonin family receptor signaling pathway +
                                                        is-acannabinoid signaling pathway +
                                                        is-acholecystokinin signaling pathway +
                                                        is-acomplement component C5a signaling pathway
                                                        is-adimeric G-protein coupled receptor signaling pathway +
                                                        is-adopamine receptor signaling pathway +
                                                        is-aendothelin receptor signaling pathway +
                                                        is-aepidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway
                                                        is-afollicle-stimulating hormone signaling pathway
                                                        is-aG-protein coupled acetylcholine receptor signaling pathway +
                                                        is-aG-protein coupled glutamate receptor signaling pathway +
                                                        is-aG-protein coupled purinergic receptor signaling pathway +
                                                        is-aG-protein coupled receptor signaling in absence of ligand
                                                        is-aG-protein coupled receptor signaling pathway involved in heart process +
                                                        is-aG-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger +
                                                        is-aG-protein coupled receptor signaling pathway, coupled to S1P second messenger
                                                        is-agamma-aminobutyric acid signaling pathway
                                                        is-agastric inhibitory peptide signaling pathway
                                                        part-ofheterotrimeric G-protein complex cycle
                                                        is-aluteinizing hormone signaling pathway +
                                                        negatively-regulatesnegative regulation of G-protein coupled receptor protein signaling pathway +
                                                        is-aneuropeptide signaling pathway
                                                        is-aoctopamine or tyramine signaling pathway +
                                                        is-aopioid receptor signaling pathway +
                                                        is-apheromone-dependent signal transduction involved in conjugation with cellular fusion +
                                                        is-aphospholipase C-activating G-protein coupled receptor signaling pathway +
                                                        is-aphospholipase C-inhibiting G-protein coupled receptor signaling pathway
                                                        is-aphospholipase D-activating G-protein coupled receptor signaling pathway
                                                        positively-regulatespositive regulation of G-protein coupled receptor protein signaling pathway +
                                                        is-aprotein kinase C-activating G-protein coupled receptor signaling pathway
                                                        regulatesregulation of G-protein coupled receptor protein signaling pathway +
                                                        is-arhodopsin mediated signaling pathway +
                                                        is-aserotonin receptor signaling pathway +
                                                        is-asignal transduction involved in conjugation with mutual genetic exchange
                                                        is-asomatostatin receptor signaling pathway +
                                                        is-asphingosine-1-phosphate signaling pathway [GO:0003376] (3 genes, 4 annotations)
                                                                is-aregulation of apoptosis by sphingosine-1-phosphate signaling pathway
                                                                is-aregulation of inflammatory response by sphingosine-1-phosphate signaling pathway
                                                        is-atachykinin receptor signaling pathway +
                                                        is-athrombin receptor signaling pathway +
                                                        is-athromboxane A2 signaling pathway
                                                        is-athyroid-stimulating hormone signaling pathway


Gene_Ontology
        is-abiological_process
                is-asignaling
                        is-asingle organism signaling
                                part-ofsignal transduction
                                        is-asphingolipid mediated signaling pathway
                                                negatively-regulatesnegative regulation of sphingolipid mediated signaling pathway
                                                positively-regulatespositive regulation of sphingolipid mediated signaling pathway
                                                regulatesregulation of sphingolipid mediated signaling pathway +
                                                is-asphingosine-1-phosphate signaling pathway [GO:0003376] (3 genes, 4 annotations)
                                                        is-aregulation of apoptosis by sphingosine-1-phosphate signaling pathway
                                                        is-aregulation of inflammatory response by sphingosine-1-phosphate signaling pathway


Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle organism signaling
                                part-ofsignal transduction
                                        is-acell surface receptor signaling pathway
                                                is-aG-protein coupled receptor signaling pathway
                                                        is-aadrenergic receptor signaling pathway +
                                                        is-aangiotensin-activated signaling pathway +
                                                        is-aapelin receptor signaling pathway
                                                        is-abombesin receptor signaling pathway
                                                        is-acalcitonin family receptor signaling pathway +
                                                        is-acannabinoid signaling pathway +
                                                        is-acholecystokinin signaling pathway +
                                                        is-acomplement component C5a signaling pathway
                                                        is-adimeric G-protein coupled receptor signaling pathway +
                                                        is-adopamine receptor signaling pathway +
                                                        is-aendothelin receptor signaling pathway +
                                                        is-aepidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway
                                                        is-afollicle-stimulating hormone signaling pathway
                                                        is-aG-protein coupled acetylcholine receptor signaling pathway +
                                                        is-aG-protein coupled glutamate receptor signaling pathway +
                                                        is-aG-protein coupled purinergic receptor signaling pathway +
                                                        is-aG-protein coupled receptor signaling in absence of ligand
                                                        is-aG-protein coupled receptor signaling pathway involved in heart process +
                                                        is-aG-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger +
                                                        is-aG-protein coupled receptor signaling pathway, coupled to S1P second messenger
                                                        is-agamma-aminobutyric acid signaling pathway
                                                        is-agastric inhibitory peptide signaling pathway
                                                        part-ofheterotrimeric G-protein complex cycle
                                                        is-aluteinizing hormone signaling pathway +
                                                        negatively-regulatesnegative regulation of G-protein coupled receptor protein signaling pathway +
                                                        is-aneuropeptide signaling pathway
                                                        is-aoctopamine or tyramine signaling pathway +
                                                        is-aopioid receptor signaling pathway +
                                                        is-apheromone-dependent signal transduction involved in conjugation with cellular fusion +
                                                        is-aphospholipase C-activating G-protein coupled receptor signaling pathway +
                                                        is-aphospholipase C-inhibiting G-protein coupled receptor signaling pathway
                                                        is-aphospholipase D-activating G-protein coupled receptor signaling pathway
                                                        positively-regulatespositive regulation of G-protein coupled receptor protein signaling pathway +
                                                        is-aprotein kinase C-activating G-protein coupled receptor signaling pathway
                                                        regulatesregulation of G-protein coupled receptor protein signaling pathway +
                                                        is-arhodopsin mediated signaling pathway +
                                                        is-aserotonin receptor signaling pathway +
                                                        is-asignal transduction involved in conjugation with mutual genetic exchange
                                                        is-asomatostatin receptor signaling pathway +
                                                        is-asphingosine-1-phosphate signaling pathway [GO:0003376] (3 genes, 4 annotations)
                                                                is-aregulation of apoptosis by sphingosine-1-phosphate signaling pathway
                                                                is-aregulation of inflammatory response by sphingosine-1-phosphate signaling pathway
                                                        is-atachykinin receptor signaling pathway +
                                                        is-athrombin receptor signaling pathway +
                                                        is-athromboxane A2 signaling pathway
                                                        is-athyroid-stimulating hormone signaling pathway


Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle organism signaling
                                part-ofsignal transduction
                                        is-asphingolipid mediated signaling pathway
                                                negatively-regulatesnegative regulation of sphingolipid mediated signaling pathway
                                                positively-regulatespositive regulation of sphingolipid mediated signaling pathway
                                                regulatesregulation of sphingolipid mediated signaling pathway +
                                                is-asphingosine-1-phosphate signaling pathway [GO:0003376] (3 genes, 4 annotations)
                                                        is-aregulation of apoptosis by sphingosine-1-phosphate signaling pathway
                                                        is-aregulation of inflammatory response by sphingosine-1-phosphate signaling pathway


Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle-organism cellular process
                                is-acell communication
                                        part-ofsignal transduction
                                                is-acell surface receptor signaling pathway
                                                        is-aG-protein coupled receptor signaling pathway
                                                                is-aadrenergic receptor signaling pathway +
                                                                is-aangiotensin-activated signaling pathway +
                                                                is-aapelin receptor signaling pathway
                                                                is-abombesin receptor signaling pathway
                                                                is-acalcitonin family receptor signaling pathway +
                                                                is-acannabinoid signaling pathway +
                                                                is-acholecystokinin signaling pathway +
                                                                is-acomplement component C5a signaling pathway
                                                                is-adimeric G-protein coupled receptor signaling pathway +
                                                                is-adopamine receptor signaling pathway +
                                                                is-aendothelin receptor signaling pathway +
                                                                is-aepidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway
                                                                is-afollicle-stimulating hormone signaling pathway
                                                                is-aG-protein coupled acetylcholine receptor signaling pathway +
                                                                is-aG-protein coupled glutamate receptor signaling pathway +
                                                                is-aG-protein coupled purinergic receptor signaling pathway +
                                                                is-aG-protein coupled receptor signaling in absence of ligand
                                                                is-aG-protein coupled receptor signaling pathway involved in heart process +
                                                                is-aG-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger +
                                                                is-aG-protein coupled receptor signaling pathway, coupled to S1P second messenger
                                                                is-agamma-aminobutyric acid signaling pathway
                                                                is-agastric inhibitory peptide signaling pathway
                                                                part-ofheterotrimeric G-protein complex cycle
                                                                is-aluteinizing hormone signaling pathway +
                                                                negatively-regulatesnegative regulation of G-protein coupled receptor protein signaling pathway +
                                                                is-aneuropeptide signaling pathway
                                                                is-aoctopamine or tyramine signaling pathway +
                                                                is-aopioid receptor signaling pathway +
                                                                is-apheromone-dependent signal transduction involved in conjugation with cellular fusion +
                                                                is-aphospholipase C-activating G-protein coupled receptor signaling pathway +
                                                                is-aphospholipase C-inhibiting G-protein coupled receptor signaling pathway
                                                                is-aphospholipase D-activating G-protein coupled receptor signaling pathway
                                                                positively-regulatespositive regulation of G-protein coupled receptor protein signaling pathway +
                                                                is-aprotein kinase C-activating G-protein coupled receptor signaling pathway
                                                                regulatesregulation of G-protein coupled receptor protein signaling pathway +
                                                                is-arhodopsin mediated signaling pathway +
                                                                is-aserotonin receptor signaling pathway +
                                                                is-asignal transduction involved in conjugation with mutual genetic exchange
                                                                is-asomatostatin receptor signaling pathway +
                                                                is-asphingosine-1-phosphate signaling pathway [GO:0003376] (3 genes, 4 annotations)
                                                                        is-aregulation of apoptosis by sphingosine-1-phosphate signaling pathway
                                                                        is-aregulation of inflammatory response by sphingosine-1-phosphate signaling pathway
                                                                is-atachykinin receptor signaling pathway +
                                                                is-athrombin receptor signaling pathway +
                                                                is-athromboxane A2 signaling pathway
                                                                is-athyroid-stimulating hormone signaling pathway


Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle-organism cellular process
                                is-acell communication
                                        part-ofsignal transduction
                                                is-asphingolipid mediated signaling pathway
                                                        negatively-regulatesnegative regulation of sphingolipid mediated signaling pathway
                                                        positively-regulatespositive regulation of sphingolipid mediated signaling pathway
                                                        regulatesregulation of sphingolipid mediated signaling pathway +
                                                        is-asphingosine-1-phosphate signaling pathway [GO:0003376] (3 genes, 4 annotations)
                                                                is-aregulation of apoptosis by sphingosine-1-phosphate signaling pathway
                                                                is-aregulation of inflammatory response by sphingosine-1-phosphate signaling pathway


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory