Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes PICALM
  • Mouse genes Picalm
  • Rat genes Picalm
  • Zfish genes picalma,picalmb
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Picalm

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005545	1-phosphatidylinositol binding	Picalm	IDA		Rat	PMID:11161218|RGD:8554293
Molecular Function	GO:0045296	cadherin binding	PICALM	HDA		Human	PMID:25468996
Molecular Function	GO:0030276	clathrin binding	PICALM	IDA		Human	PMID:10436022
Molecular Function	GO:0030276	clathrin binding	PICALM	IDA		Human	PMID:16262731
Molecular Function	GO:0030276	clathrin binding	Picalm	IDA		Rat	PMID:11161218|RGD:8554293
Molecular Function	GO:0032050	clathrin heavy chain binding	PICALM	IDA		Human	PMID:10436022
Molecular Function	GO:0042802	identical protein binding	Picalm	IPI	UniProtKB:O55012	Rat	PMID:22118466|RGD:8553997
Molecular Function	GO:0050750	low-density lipoprotein particle receptor binding	PICALM	IPI	UniProtKB:Q07954	Human	PMID:26005850
Molecular Function	GO:0005546	phosphatidylinositol-4,5-bisphosphate binding	Picalm	IMP		Rat	PMID:25898166|RGD:13210546
Molecular Function	GO:0005515	protein binding	PICALM	IPI	UniProtKB:O95782	Human	PMID:16262731
Molecular Function	GO:0005515	protein binding	PICALM	IPI	UniProtKB:Q9BSJ6	Human	PMID:16491119
Molecular Function	GO:0005515	protein binding	PICALM	IPI	UniProtKB:P63027	Human	PMID:22118466
Molecular Function	GO:0005515	protein binding	PICALM	IPI	UniProtKB:Q15836	Human	PMID:22118466
Molecular Function	GO:0005515	protein binding	PICALM	IPI	UniProtKB:Q9BV40	Human	PMID:22118466
Molecular Function	GO:0005515	protein binding	PICALM	IPI	UniProtKB:Q14192	Human	PMID:22829078
Molecular Function	GO:0005515	protein binding	PICALM	IPI	UniProtKB:Q96EB6	Human	PMID:23382074
Molecular Function	GO:0005515	protein binding	PICALM	IPI	UniProtKB:P42566	Human	PMID:26496610
Molecular Function	GO:0005515	protein binding	PICALM	IPI	UniProtKB:P42566	Human	PMID:35044719
Molecular Function	GO:0005515	protein binding	Picalm	IPI	UniProtKB:O70404	Rat	PMID:22118466|RGD:8553997
Molecular Function	GO:0005515	protein binding	Picalm	IPI	UniProtKB:P63027	Rat	PMID:22118466|RGD:8553997
Molecular Function	GO:0005515	protein binding	Picalm	IPI	UniProtKB:Q15836	Rat	PMID:22118466|RGD:8553997
Molecular Function	GO:0017124	SH3 domain binding	Picalm	IDA		Rat	PMID:10926122|RGD:1600757
Molecular Function	GO:0031267	small GTPase binding	PICALM	IPI	UniProtKB:P20339|UniProtKB:Q15907	Human	PMID:26005850
Molecular Function	GO:0000149	SNARE binding	PICALM	IDA		Human	PMID:22118466
Molecular Function	GO:0000149	SNARE binding	Picalm	IPI	RGD:3949	Rat	PMID:21808019|RGD:13506237
Molecular Function	GO:0048156	tau protein binding	PICALM	IPI	UniProtKB:P10636	Human	PMID:23589030
Cellular Component	GO:0009986	cell surface	PICALM	IDA		Human	PMID:26005850
Cellular Component	GO:0030132	clathrin coat of coated pit	PICALM	IDA		Human	PMID:10436022
Cellular Component	GO:0030132	clathrin coat of coated pit	PICALM	IDA		Human	PMID:16262731
Cellular Component	GO:0005905	clathrin-coated pit	PICALM	IDA		Human	PMID:10436022
Cellular Component	GO:0005905	clathrin-coated pit	PICALM	IMP		Human	PMID:25898166
Cellular Component	GO:0005905	clathrin-coated pit	Picalm	IDA		Mouse	MGI:MGI:2667577|PMID:12832620
Cellular Component	GO:0030136	clathrin-coated vesicle	PICALM	IMP		Human	PMID:25898166
Cellular Component	GO:0030136	clathrin-coated vesicle	Picalm	IDA		Rat	PMID:11190274|RGD:1600754
Cellular Component	GO:0030136	clathrin-coated vesicle	Picalm	IDA		Rat	PMID:17640037|RGD:8554206
Cellular Component	GO:0030136	clathrin-coated vesicle	Picalm	IDA		Rat	PMID:18842885|RGD:8554167
Cellular Component	GO:0005769	early endosome	PICALM	IDA		Human	PMID:26005850
Cellular Component	GO:0005768	endosome	Picalm	IDA		Rat	PMID:18842885|RGD:8554167
Cellular Component	GO:0070381	endosome to plasma membrane transport vesicle	PICALM	IDA		Human	PMID:26005850
Cellular Component	GO:0098894	extrinsic component of presynaptic endocytic zone membrane	Picalm	IDA		Rat	PMID:15558718|RGD:1600759
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	PICALM	IDA		Human	GO_REF:0000052
Cellular Component	GO:0016020	membrane	PICALM	HDA		Human	PMID:19946888
Cellular Component	GO:0016020	membrane	Picalm	IMP		Rat	PMID:25898166|RGD:13210546
Cellular Component	GO:0097418	neurofibrillary tangle	PICALM	IMP		Human	PMID:23589030
Cellular Component	GO:0043005	neuron projection	Picalm	IDA		Rat	PMID:18842885|RGD:8554167
Cellular Component	GO:0043025	neuronal cell body	PICALM	IDA		Human	PMID:23589030
Cellular Component	GO:0043025	neuronal cell body	Picalm	IDA		Rat	PMID:18842885|RGD:8554167
Cellular Component	GO:0005634	nucleus	PICALM	IDA		Human	PMID:16491119
Cellular Component	GO:0098688	parallel fiber to Purkinje cell synapse	Picalm	IDA		Rat	PMID:15558718|RGD:1600759
Cellular Component	GO:0048471	perinuclear region of cytoplasm	Picalm	IDA		Mouse	MGI:MGI:4410429|PMID:18182011
Cellular Component	GO:0005886	plasma membrane	PICALM	IDA		Human	PMID:16262731
Cellular Component	GO:0005886	plasma membrane	Picalm	IDA		Rat	PMID:16625367|RGD:1600758
Cellular Component	GO:0005886	plasma membrane	Picalm	IDA		Rat	PMID:18842885|RGD:8554167
Cellular Component	GO:0098794	postsynapse	Picalm	IDA		Rat	PMID:15558718|RGD:1600759
Cellular Component	GO:0014069	postsynaptic density	Picalm	IDA		Rat	PMID:17640037|RGD:8554206
Cellular Component	GO:0045211	postsynaptic membrane	Picalm	IDA		Rat	PMID:15558718|RGD:1600759
Cellular Component	GO:0045211	postsynaptic membrane	Picalm	IDA		Rat	PMID:17640037|RGD:8554206
Cellular Component	GO:0042734	presynaptic membrane	Picalm	IDA		Rat	PMID:15558718|RGD:1600759
Cellular Component	GO:0042734	presynaptic membrane	Picalm	IDA		Rat	PMID:17640037|RGD:8554206
Cellular Component	GO:0098685	Schaffer collateral - CA1 synapse	Picalm	IDA		Rat	PMID:15558718|RGD:1600759
Cellular Component	GO:0045202	synapse	Picalm	IDA		Rat	PMID:15558718|RGD:1600759
Cellular Component	GO:0008021	synaptic vesicle	Picalm	IDA		Rat	PMID:17640037|RGD:8554206
Cellular Component	GO:0031982	vesicle	Picalm	IDA		Mouse	MGI:MGI:5432454|PMID:22539346
Biological Process	GO:0150093	amyloid-beta clearance by transcytosis	PICALM	IGI	UniProtKB:Q07954	Human	PMID:26005850
Biological Process	GO:0150093	amyloid-beta clearance by transcytosis	Picalm	IMP		Mouse	MGI:MGI:5637941|PMID:26005850
Biological Process	GO:0150093	amyloid-beta clearance by transcytosis	Picalm	IGI	UniProtKB:P05067:PRO_0000000092	Mouse	MGI:MGI:5637941|PMID:26005850
Biological Process	GO:0007409	axonogenesis	Picalm	IMP		Mouse	MGI:MGI:4418607|PMID:18842885
Biological Process	GO:0007409	axonogenesis	Picalm	IMP		Rat	PMID:18842885|RGD:8554167
Biological Process	GO:0048268	clathrin coat assembly	PICALM	IMP		Human	PMID:16262731
Biological Process	GO:0048268	clathrin coat assembly	PICALM	IDA		Human	PMID:16262731
Biological Process	GO:0048268	clathrin coat assembly	Picalm	IDA		Rat	PMID:11190274|RGD:1600754
Biological Process	GO:0072583	clathrin-dependent endocytosis	PICALM	IMP		Human	PMID:22952941
Biological Process	GO:0072583	clathrin-dependent endocytosis	PICALM	IMP		Human	PMID:24577224
Biological Process	GO:0072583	clathrin-dependent endocytosis	PICALM	IMP		Human	PMID:26005850
Biological Process	GO:0072583	clathrin-dependent endocytosis	Picalm	IMP		Mouse	MGI:MGI:5432454|PMID:22539346
Biological Process	GO:0048813	dendrite morphogenesis	Picalm	IMP		Mouse	MGI:MGI:4418607|PMID:18842885
Biological Process	GO:0048813	dendrite morphogenesis	Picalm	IMP		Rat	PMID:18842885|RGD:8554167
Biological Process	GO:0006897	endocytosis	PICALM	IDA		Human	PMID:22118466
Biological Process	GO:0016197	endosomal transport	PICALM	IMP		Human	PMID:16262731
Biological Process	GO:0030097	hemopoiesis	Picalm	IMP		Mouse	MGI:MGI:2667577|PMID:12832620
Biological Process	GO:0006879	intracellular iron ion homeostasis	PICALM	IMP		Human	PMID:22952941
Biological Process	GO:0007611	learning or memory	Picalm	IGI	UniProtKB:P05067:PRO_0000000092	Mouse	MGI:MGI:5637941|PMID:26005850
Biological Process	GO:0097753	membrane bending	PICALM	IMP		Human	PMID:25898166
Biological Process	GO:0060586	multicellular organismal-level iron ion homeostasis	PICALM	IMP		Human	PMID:22952941
Biological Process	GO:0010629	negative regulation of gene expression	PICALM	IMP		Human	PMID:22952941
Biological Process	GO:1902963	negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process	Picalm	IMP		Mouse	MGI:MGI:5432454|PMID:22539346
Biological Process	GO:2000009	negative regulation of protein localization to cell surface	PICALM	IMP		Human	PMID:21221849
Biological Process	GO:1903077	negative regulation of protein localization to plasma membrane	PICALM	IMP		Human	PMID:21221849
Biological Process	GO:0048261	negative regulation of receptor-mediated endocytosis	PICALM	IDA		Human	PMID:10436022
Biological Process	GO:1902004	positive regulation of amyloid-beta formation	PICALM	IMP		Human	PMID:24577224
Biological Process	GO:1902004	positive regulation of amyloid-beta formation	Picalm	IMP		Mouse	MGI:MGI:5432454|PMID:22539346
Biological Process	GO:1902004	positive regulation of amyloid-beta formation	Picalm	IMP		Mouse	MGI:MGI:5560380|PMID:24577224
Biological Process	GO:1902961	positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process	Picalm	IMP		Mouse	MGI:MGI:5432454|PMID:22539346
Biological Process	GO:0050772	positive regulation of axonogenesis	Picalm	IMP		Rat	PMID:18842885|RGD:8554167
Biological Process	GO:1903861	positive regulation of dendrite extension	Picalm	IMP		Rat	PMID:18842885|RGD:8554167
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	PICALM	IDA		Human	PMID:11425879
Biological Process	GO:0043547	positive regulation of GTPase activity	PICALM	IMP		Human	PMID:26005850
Biological Process	GO:1901216	positive regulation of neuron death	PICALM	IMP		Human	PMID:23589030
Biological Process	GO:2000809	positive regulation of synaptic vesicle clustering	Picalm	IMP		Rat	PMID:22851330|RGD:13506174
Biological Process	GO:1900244	positive regulation of synaptic vesicle endocytosis	Picalm	IMP		Rat	PMID:21808019|RGD:13506237
Biological Process	GO:0031623	receptor internalization	PICALM	IMP		Human	PMID:14985334
Biological Process	GO:0031623	receptor internalization	PICALM	IMP		Human	PMID:25898166
Biological Process	GO:0006898	receptor-mediated endocytosis	PICALM	IDA		Human	PMID:10436022
Biological Process	GO:0006898	receptor-mediated endocytosis	Picalm	IDA		Mouse	MGI:MGI:2667577|PMID:12832620
Biological Process	GO:1902959	regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process	PICALM	IMP		Human	PMID:24577224
Biological Process	GO:0030100	regulation of endocytosis	PICALM	IMP		Human	PMID:18182011
Biological Process	GO:0030100	regulation of endocytosis	Picalm	IMP		Rat	PMID:18842885|RGD:8554167
Biological Process	GO:0032880	regulation of protein localization	PICALM	IDA		Human	PMID:10436022
Biological Process	GO:0051223	regulation of protein transport	Picalm	IMP		Rat	PMID:18842885|RGD:8554167
Biological Process	GO:1900242	regulation of synaptic vesicle endocytosis	Picalm	IMP		Rat	PMID:18842885|RGD:8554167
Biological Process	GO:1902803	regulation of synaptic vesicle transport	Picalm	IMP		Rat	PMID:18842885|RGD:8554167
Biological Process	GO:2000331	regulation of terminal button organization	Picalm	IMP		Rat	PMID:22851330|RGD:13506174
Biological Process	GO:0097494	regulation of vesicle size	PICALM	IMP		Human	PMID:25898166
Biological Process	GO:0048488	synaptic vesicle endocytosis	Picalm	IDA		Rat	PMID:21808019|RGD:13506237
Biological Process	GO:0048488	synaptic vesicle endocytosis	Picalm	IMP		Rat	PMID:21808019|RGD:13506237
Biological Process	GO:0016188	synaptic vesicle maturation	Picalm	IMP		Mouse	MGI:MGI:5559661|PMID:22851330
Biological Process	GO:0006900	vesicle budding from membrane	PICALM	IMP		Human	PMID:25898166
Biological Process	GO:0035459	vesicle cargo loading	PICALM	IMP		Human	PMID:24577224
Biological Process	GO:0035459	vesicle cargo loading	Picalm	IMP		Mouse	MGI:MGI:5432454|PMID:22539346
Biological Process	GO:0016192	vesicle-mediated transport	Picalm	IMP		Rat	PMID:18842885|RGD:8554167

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern