About   Help   FAQ
Gene Ontology Browser
Term Detail
GO term:receptor-mediated endocytosis
Synonym: receptor mediated endocytosis
GO id:GO:0006898
Definition:An endocytosis process in which cell surface receptors ensure specificity of transport. A specific receptor on the cell surface binds tightly to the extracellular macromolecule (the ligand) that it recognizes; the plasma-membrane region containing the receptor-ligand complex then undergoes endocytosis, forming a transport vesicle containing the receptor-ligand complex and excluding most other plasma-membrane proteins. Receptor-mediated endocytosis generally occurs via clathrin-coated pits and vesicles.
Number of paths to term: 1

is-adenotes an 'is-a' relationship
part-ofdenotes a 'part-of' relationship
regulatesdenotes a 'regulates' relationship
positively-regulatesdenotes a 'positively-regulates' relationship
negatively-regulatesdenotes a 'negatively-regulates' relationship

                        is-aestablishment of localization
                                        is-avesicle-mediated transport
                                                        is-acaveolin-mediated endocytosis +
                                                        is-aendocytosis involved in viral entry into host cell +
                                                        negatively-regulatesnegative regulation of endocytosis +
                                                        is-aphagocytosis +
                                                        is-apinocytosis +
                                                        positively-regulatespositive regulation of endocytosis +
                                                        is-areceptor-mediated endocytosis [GO:0006898] (194 genes, 268 annotations)
                                                                is-aclathrin-dependent endocytosis +
                                                                negatively-regulatesnegative regulation of receptor-mediated endocytosis +
                                                                positively-regulatespositive regulation of receptor-mediated endocytosis +
                                                                is-areceptor internalization +
                                                                is-areceptor-mediated endocytosis involved in cholesterol transport +
                                                                is-areceptor-mediated endocytosis of virus by host cell +
                                                                regulatesregulation of receptor-mediated endocytosis +
                                                        regulatesregulation of endocytosis +
                                                        regulatesregulation of endocytosis by exocyst localization
                                                        is-asperm entry
                                                        is-aubiquitin-dependent endocytosis +
                                                        part-ofvesicle scission involved in endocytosis +

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
MGI 6.08
The Jackson Laboratory