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Picalm
Gene Detail
Symbol

Name
ID
Picalm
phosphatidylinositol binding clathrin assembly protein
MGI:2385902
Synonyms
fit1, fit-1, MGC:19382, MGC:36413, MGC:36616
Feature Type
protein coding gene
Genetic Map
Chromosome 7
50.47 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr7:90130232-90209447 bp, + strand
From Ensembl annotation of GRCm38

  79216 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:111783  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: PICALM
Gene Tree: Picalm

Human
homologs
PICALM, phosphatidylinositol binding clathrin assembly protein
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 8301
neXtProt AC: NX_Q13492

Human Synonyms: CALM, CLTH, LAP

Human Chr (Location): 11q14; chr11:85957171-86069881 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(35) : Chemically induced (ENU)(5) Gene trapped(26) Targeted(4)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for different ENU-induced mutations or knock-out alleles are small, runted and display anemia of variable severity.
 
Mutations Annotated to Human Diseases (1)    Phenotype Images(1)
Interactions
Picalm interacts with 404 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (66 annotations)
Process axonogenesis, cargo loading into vesicle, ...
Component AP-2 adaptor complex, clathrin-coated vesicle, ...
Function 1-phosphatidylinositol binding, clathrin adaptor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (2)    Tissues (1)    Tissue x Stage Matrix (view)
Assay TypeResults
RT-PCR 2
cDNA source data(12)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase picalm.1, picalm.2 ; ZFIN picalma, picalmb    NEW 
Molecular
reagents
All nucleic(18) Genomic(2) cDNA(13) Primer pair(1) Other(2)
Microarray probesets(4)
Other database
links
Ensembl Gene Model ENSMUSG00000039361 (Evidence)
Entrez Gene 233489 (Evidence)
DFCI TC1590729, TC1596192, TC1588708, TC1594219, TC1574607, TC1627680
DoTS DT.101409122, DT.97338241, DT.101409127, DT.97338246
NIA Mouse Gene Index U352956, U008359
Consensus CDS Project CCDS52307.1
International Mouse Phenotyping Consortium Status Picalm
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000039361 Ensembl Gene Model | MGI Sequence Detail 79216 C57BL/6J ±  kb
transcript ENSMUST00000049537 Ensembl | MGI Sequence Detail 4174 Not Applicable 
polypeptide ENSMUSP00000051092 Ensembl | MGI Sequence Detail 660 Not Applicable 

For the selected sequences
All sequences(78) RefSeq(36) UniProt(3)
Polymorphisms
SNPs within 2kb(386 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011417 AP180 N-terminal homology (ANTH) domain
InterPro IPR014712 Clathrin adaptor, phosphoinositide-binding, GAT-like
InterPro IPR008942 ENTH/VHS
InterPro IPR013809 Epsin-like, N-terminal
Protein Ontology PR:000029674 phosphatidylinositol-binding clathrin assembly protein
References
(Earliest) J:10283 Rinchik EM, et al., A strategy for fine-structure functional analysis of a 6- to 11-centimorgan region of mouse chromosome 7 by high-efficiency mutagenesis. Proc Natl Acad Sci U S A. 1990 Feb;87(3):896-900
(Latest) J:221101 Zhao Z, et al., Central role for PICALM in amyloid-beta blood-brain barrier transcytosis and clearance. Nat Neurosci. 2015 May 25;
All references(56)
Other
accession IDs
MGD-MRK-9805, MGD-MRK-9806, MGI:95538

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory