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Picalm
Gene Detail
 Symbol
Name
ID
Picalm
phosphatidylinositol binding clathrin assembly protein
MGI:2385902
Synonyms fit1, fit-1, MGC:19382, MGC:36413, MGC:36616
Feature Type protein coding gene
Genetic Map
Chromosome 7
50.47 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr7:90130232-90209447 bp, + strand
From NCBI annotation of GRCm38

  79216 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:111783  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Picalm

Human
homologs
Human Homolog PICALM, phosphatidylinositol binding clathrin assembly protein
NCBI Gene ID 8301
neXtProt AC  NX_Q13492
Human Synonyms  CALM, CLTH, LAP
Human Chr (Location)  11q14; chr11:85957171-86069881 (-)  GRCh38
Alleles
and
phenotypes
All alleles(33) : Chemically induced (ENU)(5) Gene trapped(26) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for different ENU-induced mutations or knock-out alleles are small, runted and display anemia of variable severity.
 
Phenotype Images(1)
Gene Ontology
(GO)
classifications
All GO classifications: (60 annotations)
Process axonogenesis, cargo loading into vesicle, ...
Component AP-2 adaptor complex, clathrin coat, ...
Function 1-phosphatidylinositol binding, clathrin adaptor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (2)    Tissues (1)   
Theiler Stages: 26
Assay TypeResults
RT-PCR 2
cDNA source data(11)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(17) Genomic(2) cDNA(12) Primer pair(1) Other(2)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000039361 (Evidence)
Entrez Gene233489 (Evidence)
DFCITC1574607, TC1588708, TC1590729, TC1594219, TC1596192, TC1627680
DoTSDT.101409122, DT.101409127, DT.97338241, DT.97338246
NIA Mouse Gene IndexU008359, U352956
Consensus CDS ProjectCCDS52307.1
International Mouse Knockout Project StatusPicalm
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 233489 NCBI Gene Model | MGI Sequence Detail 79216 C57BL/6J ±  kb
transcript NM_146194 RefSeq | MGI Sequence Detail 4174 Not Specified 
polypeptide Q7M6Y3 UniProt | EBI | MGI Sequence Detail 660 Not Applicable 

For the selected sequences
All sequences(77) RefSeq(36) UniProt(3)
Polymorphisms SNPs within 2kb(386 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011417 AP180 N-terminal homology (ANTH) domain
InterPro IPR014712 Clathrin adaptor, phosphoinositide-binding, GAT-like
InterPro IPR008942 ENTH/VHS
InterPro IPR013809 Epsin-like, N-terminal
Protein Ontology PR:000029674 phosphatidylinositol-binding clathrin assembly protein
Graphical View of Protein Domain Structure
References (Earliest) J:10283 Rinchik EM, et al., A strategy for fine-structure functional analysis of a 6- to 11-centimorgan region of mouse chromosome 7 by high-efficiency mutagenesis. Proc Natl Acad Sci U S A. 1990 Feb;87(3):896-900
(Latest) J:207966 Kanatsu K, et al., Decreased CALM expression reduces Abeta42 to total Abeta ratio through clathrin-mediated endocytosis of gamma-secretase. Nat Commun. 2014;5:3386
All references(55)
Other
accession IDs
MGD-MRK-9805, MGD-MRK-9806, MGI:95538

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory