Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes NPAS4
  • Mouse genes Npas4
  • Rat genes Npas4
  • Zfish genes npas4a,npas4b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Npas4

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	NPAS4	IDA		Human	PMID:14701734
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	NPAS4	IDA		Human	PMID:24465693
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	Npas4	IMP		Mouse	MGI:MGI:5602898|PMID:24855953
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	Npas4	IMP		Mouse	MGI:MGI:3826741|PMID:18815592
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	Npas4	IMP		Mouse	MGI:MGI:5301011|PMID:22194569
Molecular Function	GO:0005515	protein binding	NPAS4	IPI	UniProtKB:Q9HBZ2	Human	PMID:24465693
Molecular Function	GO:0005515	protein binding	Npas4	IPI	PR:Q61324	Mouse	PMID:14701734
Molecular Function	GO:0005515	protein binding	Npas4	IPI	PR:Q61324	Mouse	PMID:27782878
Molecular Function	GO:0046982	protein heterodimerization activity	NPAS4	IDA		Human	PMID:24465693
Molecular Function	GO:0046982	protein heterodimerization activity	Npas4	IDA		Mouse	MGI:MGI:5824181|PMID:27782878
Molecular Function	GO:0044877	protein-containing complex binding	Npas4	IDA		Rat	PMID:14701734|RGD:1304280
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	NPAS4	IDA		Human	PMID:14701734
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Npas4	IDA		Mouse	MGI:MGI:5301011|PMID:22194569
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Npas4	IDA		Mouse	PMID:14701734
Molecular Function	GO:0000977	RNA polymerase II transcription regulatory region sequence-specific DNA binding	Npas4	IDA		Mouse	PMID:24201284
Cellular Component	GO:0005634	nucleus	Npas4	IDA		Mouse	PMID:24201284
Cellular Component	GO:0005634	nucleus	Npas4	IDA		Mouse	PMID:15363889
Cellular Component	GO:0005667	transcription regulator complex	Npas4	IDA		Mouse	PMID:14701734
Biological Process	GO:0001568	blood vessel development	npas4a	IGI	ZFIN:ZDB-MRPHLNO-170517-1,ZFIN:ZDB-MRPHLNO-170517-2	Zfish	PMID:28082451
Biological Process	GO:0001568	blood vessel development	npas4b	IGI	ZFIN:ZDB-MRPHLNO-170517-1,ZFIN:ZDB-MRPHLNO-170517-2	Zfish	PMID:28082451
Biological Process	GO:0071229	cellular response to acid chemical	Npas4	IMP	MGI:MGI:3828100	Mouse	PMID:24201284
Biological Process	GO:0071386	cellular response to corticosterone stimulus	Npas4	IDA		Mouse	PMID:20626564
Biological Process	GO:0033554	cellular response to stress	Npas4	IDA		Mouse	PMID:20626564
Biological Process	GO:0060079	excitatory postsynaptic potential	Npas4	IMP		Mouse	MGI:MGI:5602898|PMID:24855953
Biological Process	GO:0030900	forebrain development	npas4a	IMP	ZFIN:ZDB-MRPHLNO-150225-1	Zfish	PMID:25538572
Biological Process	GO:0060080	inhibitory postsynaptic potential	Npas4	IMP		Mouse	MGI:MGI:3826741|PMID:18815592
Biological Process	GO:0060080	inhibitory postsynaptic potential	Npas4	IMP		Mouse	MGI:MGI:5602898|PMID:24855953
Biological Process	GO:0060080	inhibitory postsynaptic potential	Npas4	IMP	MGI:MGI:3828100	Mouse	PMID:24201284
Biological Process	GO:1904862	inhibitory synapse assembly	Npas4	IMP		Mouse	MGI:MGI:3826741|PMID:18815592
Biological Process	GO:0007612	learning	Npas4	IMP		Mouse	MGI:MGI:5301011|PMID:22194569
Biological Process	GO:0007616	long-term memory	Npas4	IMP		Mouse	MGI:MGI:5301011|PMID:22194569
Biological Process	GO:0007616	long-term memory	Npas4	IMP		Mouse	MGI:MGI:5464058|PMID:23029555
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Npas4	IMP		Mouse	MGI:MGI:3826741|PMID:18815592
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Npas4	IMP		Mouse	MGI:MGI:5301011|PMID:22194569
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Npas4	IDA		Mouse	PMID:15363889
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	NPAS4	IDA		Human	PMID:14701734
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	NPAS4	IDA		Human	PMID:24465693
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Npas4	IMP		Mouse	MGI:MGI:5602898|PMID:24855953
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Npas4	IMP		Mouse	MGI:MGI:3826741|PMID:18815592
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Npas4	IMP		Mouse	MGI:MGI:5301011|PMID:22194569
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Npas4	IDA		Mouse	PMID:14701734
Biological Process	GO:0048167	regulation of synaptic plasticity	Npas4	IMP		Mouse	MGI:MGI:3826741|PMID:18815592
Biological Process	GO:0032228	regulation of synaptic transmission, GABAergic	Npas4	IMP		Mouse	MGI:MGI:3826741|PMID:18815592
Biological Process	GO:0007614	short-term memory	Npas4	IMP		Mouse	MGI:MGI:5301011|PMID:22194569
Biological Process	GO:0035176	social behavior	Npas4	IMP		Mouse	MGI:MGI:5464058|PMID:23029555

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern