About   Help   FAQ
Npas4 Gene Detail
Summary
  • Symbol
    Npas4
  • Name
    neuronal PAS domain protein 4
  • Synonyms
    LE-PAS, Npas4, Nxf
  • Feature Type
    protein coding gene
  • IDs
    MGI:2664186
    NCBI Gene: 225872
Location & Maps
more
  • Sequence Map
    Chr19:4984355-4989971 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      5617 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    NPAS4, neuronal PAS domain protein 4
  • Vertebrate Orthologs
    12
  • Human Ortholog
    NPAS4, neuronal PAS domain protein 4
    Orthology source: HGNC, HomoloGene
  • Synonyms
    bHLHe79, Le-PAS, NXF, PASD10
  • Links
    NCBI Gene ID: 266743
    neXtProt AC: NX_Q8IUM7

  • Chr Location
    11q13; chr11:66421004-66426706 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 15333
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;3 zebrafish
  • HCOP
    human homology predictions: NPAS4
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    14 phenotypes from 3 alleles in 2 genetic backgrounds
    2 images
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit hyperactivity, seizures and premature death.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000045903 Ensembl Gene Model | MGI Sequence Detail 5617 C57BL/6J ±  kb
transcript ENSMUST00000056129 Ensembl | MGI Sequence Detail 3277 Not Applicable  
polypeptide ENSMUSP00000062992 Ensembl | MGI Sequence Detail 802 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    25 from dbSNP Build 137
Protein
Information
less
  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000011352 neuronal PAS domain-containing protein 4
  • InterPro Domains
    IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
    IPR000014 PAS domain
    IPR013655 PAS fold-3
Molecular
Reagents
less
  • All nucleic 15
    cDNA 13
    Primer pair 2

    Microarray probesets 2
References
more
  • Summaries
    All 38
    Developmental Gene Expression 4
    Gene Ontology 9
    Phenotypes 10
  • Earliest
    J:80366 Ooe N, et al., Identification of a novel basic helix-loop-helix-PAS factor, NXF, reveals a Sim2 competitive, positive regulatory role in dendritic-cytoskeleton modulator drebrin gene expression. Mol Cell Biol. 2004 Jan;24(2):608-16
  • Latest
    J:223967 Jaehne EJ, et al., Effects of Npas4 deficiency on anxiety, depression-like, cognition and sociability behaviour. Behav Brain Res. 2015 Mar 15;281:276-82

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
02/02/2016
MGI 6.02
The Jackson Laboratory