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Npas4 Gene Detail
Summary
  • Symbol
    Npas4
  • Name
    neuronal PAS domain protein 4
  • Synonyms
    LE-PAS, Npas4, Nxf
  • Feature Type
    protein coding gene
  • IDs
    MGI:2664186
    NCBI Gene: 225872
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:4984355-4989971 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 19, 4.20 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    85 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2664186
protein coding gene Chr19:4984353-5001929 (-)
129S1/SvImJ MGP_129S1SvImJ_G0024684
protein coding gene Chr19:1905644-1911260 (-)
A/J MGP_AJ_G0024650
protein coding gene Chr19:1803281-1808897 (-)
AKR/J MGP_AKRJ_G0024623
protein coding gene Chr19:1856531-1862147 (-)
BALB/cJ MGP_BALBcJ_G0024650
protein coding gene Chr19:1797749-1803365 (-)
C3H/HeJ MGP_C3HHeJ_G0024418
protein coding gene Chr19:1857650-1863266 (-)
C57BL/6NJ MGP_C57BL6NJ_G0025097
protein coding gene Chr19:1961599-1967215 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022527
protein coding gene Chr19:1732889-1738490 (-)
CAST/EiJ MGP_CASTEiJ_G0023890
protein coding gene Chr19:1886176-1891792 (-)
CBA/J MGP_CBAJ_G0024389
protein coding gene Chr19:2043964-2049580 (-)
DBA/2J MGP_DBA2J_G0024517
protein coding gene Chr19:1792439-1798055 (-)
FVB/NJ MGP_FVBNJ_G0024484
protein coding gene Chr19:1793435-1799051 (-)
LP/J MGP_LPJ_G0024603
protein coding gene Chr19:1901435-1907051 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0024514
protein coding gene Chr19:1929161-1934777 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0025145
protein coding gene Chr19:1853151-1858767 (-)
PWK/PhJ MGP_PWKPhJ_G0023636
protein coding gene Chr19:1828567-1834183 (-)
SPRET/EiJ MGP_SPRETEiJ_G0023441
protein coding gene Chr19:1843776-1849397 (-)
WSB/EiJ MGP_WSBEiJ_G0023952
protein coding gene Chr19:1865064-1870680 (-)



Homology
more
  • Human Ortholog
    NPAS4, neuronal PAS domain protein 4
  • Vertebrate Orthologs
    12
  • Human Ortholog
    NPAS4, neuronal PAS domain protein 4
    Orthology source: HomoloGene, HGNC
  • Synonyms
    bHLHe79, Le-PAS, NXF, PASD10
  • Links
    NCBI Gene ID: 266743
    neXtProt AC: NX_Q8IUM7
    UniProt: Q8IUM7

  • Chr Location
    11q13.2; chr11:66409158-66426707 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 15333
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;3 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: NPAS4
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    14 phenotypes from 3 alleles in 3 genetic backgrounds
    2 images
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit hyperactivity, seizures and premature death.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000045903 Ensembl Gene Model | MGI Sequence Detail 5617 C57BL/6J ±  kb
transcript ENSMUST00000056129 Ensembl | MGI Sequence Detail 3277 Not Applicable  
polypeptide ENSMUSP00000062992 Ensembl | MGI Sequence Detail 802 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 16
    cDNA 14
    Primer pair 2

    Microarray probesets 2
References
more
  • Summaries
    All 50
    Developmental Gene Expression 5
    Gene Ontology 15
    Phenotypes 16
  • Earliest
    J:80366 Ooe N, et al., Identification of a novel basic helix-loop-helix-PAS factor, NXF, reveals a Sim2 competitive, positive regulatory role in dendritic-cytoskeleton modulator drebrin gene expression. Mol Cell Biol. 2004 Jan;24(2):608-16
  • Latest
    J:260770 Weng FJ, et al., Npas4 Is a Critical Regulator of Learning-Induced Plasticity at Mossy Fiber-CA3 Synapses during Contextual Memory Formation. Neuron. 2018 Mar 7;97(5):1137-1152.e5

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory