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Npas4
Gene Detail
 Symbol
Name
ID
Npas4
neuronal PAS domain protein 4
MGI:2664186
Synonyms LE-PAS, Npas4, Nxf
Feature Type protein coding gene
Genetic Map
Chromosome 19
4.20 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr19:4984355-4989971 bp, - strand
From NCBI annotation of GRCm38

  5617 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:15333  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 3 zebrafish

Gene Tree: Npas4

Human
homologs
Human Homolog NPAS4, neuronal PAS domain protein 4
NCBI Gene ID 266743
neXtProt AC  NX_Q8IUM7
Human Synonyms  bHLHe79, Le-PAS, NXF, PASD10
Human Chr (Location)  11q13; chr11:66421004-66426706 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Targeted(7)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele exhibit hyperactivity, seizures and premature death.
 
Phenotype Images(2)
Interactions
Npas4 interacts with 182 markers (Mir1a-1, Mir1a-2, Mir9-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (12 annotations)
Process positive regulation of transcription, DNA-templated, positive regulation of transcription from RNA polymerase II promoter, ...
Component nucleus, transcription factor complex
Function DNA binding, protein dimerization activity, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (123)    Tissues (102)    Images (9)
Theiler Stages: 10, 17, 18, 21, 23, 25, 26, 27, 28
Assay TypeResults
RNA in situ 118
RT-PCR 5
cDNA source data(12)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(14) cDNA(12) Primer pair(2)
Microarray probesets(2)
Other database
links
Ensembl Gene ModelENSMUSG00000045903 (Evidence)
Entrez Gene225872 (Evidence)
UniGene287867
DFCITC1587983, TC1602535
DoTSDT.103545782, DT.110862869, DT.91328235, DT.97336878
NIA Mouse Gene IndexU040839
Consensus CDS ProjectCCDS29445.1
International Mouse Knockout Project StatusNpas4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 225872 NCBI Gene Model | MGI Sequence Detail 5617 C57BL/6J ±  kb
transcript NM_153553 RefSeq | MGI Sequence Detail 3292 Swiss Webster 
polypeptide Q8BGD7 UniProt | EBI | MGI Sequence Detail 802 Not Applicable 

For the selected sequences
All sequences(26) RefSeq(6) UniProt(2)
Polymorphisms SNPs within 2kb(25 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
InterPro IPR000014 PAS domain
InterPro IPR013655 PAS fold-3
Protein Ontology PR:000011352 neuronal PAS domain-containing protein 4
Graphical View of Protein Domain Structure
References (Earliest) J:80366 Ooe N, et al., Identification of a novel basic helix-loop-helix-PAS factor, NXF, reveals a Sim2 competitive, positive regulatory role in dendritic-cytoskeleton modulator drebrin gene expression. Mol Cell Biol. 2004 Jan;24(2):608-16
(Latest) J:210031 Bersten DC, et al., Regulation of the neuronal transcription factor NPAS4 by REST and microRNAs. Biochim Biophys Acta. 2014 Jan;1839(1):13-24
All references(39)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory