Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes NKX2-2
  • Mouse genes Nkx2-2
  • Rat genes Nkx2-2
  • Zfish genes nkx2.2a,nkx2.2b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Nkx2-2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0000987	cis-regulatory region sequence-specific DNA binding	Nkx2-2	IDA		Mouse	MGI:MGI:4420345|PMID:19759004
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	Nkx2-2	IDA		Mouse	MGI:MGI:4420345|PMID:19759004
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	Nkx2-2	IDA		Mouse	MGI:MGI:3037232|PMID:14701942
Molecular Function	GO:0003700	DNA-binding transcription factor activity	Nkx2-2	IDA		Mouse	PMID:14573534
Molecular Function	GO:0003700	DNA-binding transcription factor activity	Nkx2-2	IDA		Mouse	PMID:14701942
Molecular Function	GO:0005515	protein binding	NKX2-2	IPI	UniProtKB:Q5VTB9	Human	PMID:30177510
Molecular Function	GO:0005515	protein binding	Nkx2-2	IPI	PR:Q08122	Mouse	PMID:17202186
Molecular Function	GO:0005515	protein binding	Nkx2-2	IPI	PR:Q9EQW6	Mouse	PMID:14573534
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Nkx2-2	IDA		Mouse	MGI:MGI:3037232|PMID:14701942
Molecular Function	GO:0043565	sequence-specific DNA binding	Nkx2-2	IDA		Mouse	PMID:14701942
Molecular Function	GO:0008134	transcription factor binding	Nkx2-2	IPI	PR:Q61169	Mouse	PMID:16887115
Cellular Component	GO:0005622	intracellular anatomical structure	Nkx2-2	IDA		Mouse	PMID:15793245
Cellular Component	GO:0005634	nucleus	Nkx2-2	IDA		Mouse	PMID:16306355
Cellular Component	GO:0005634	nucleus	Nkx2-2	IDA		Mouse	PMID:9230312
Cellular Component	GO:0005634	nucleus	Nkx2-2	IDA		Mouse	PMID:14573534
Cellular Component	GO:0005634	nucleus	Nkx2-2	IDA		Mouse	PMID:18076286
Cellular Component	GO:0005634	nucleus	Nkx2-2	IDA		Rat	PMID:18535770|RGD:2306246
Biological Process	GO:0048708	astrocyte differentiation	Nkx2-2	IMP	MGI:MGI:1932100	Mouse	PMID:19258013
Biological Process	GO:0048468	cell development	Nkx2-2	IMP	MGI:MGI:1932100	Mouse	PMID:11526078
Biological Process	GO:0030154	cell differentiation	Nkx2-2	IMP	MGI:MGI:1932100	Mouse	PMID:14970313
Biological Process	GO:0048565	digestive tract development	Nkx2-2	IMP	MGI:MGI:1932100	Mouse	PMID:18987169
Biological Process	GO:0031018	endocrine pancreas development	Nkx2-2	IMP	MGI:MGI:1932100	Mouse	PMID:9584121
Biological Process	GO:0031018	endocrine pancreas development	nkx2.2a	IMP	ZFIN:ZDB-MRPHLNO-070622-2,ZFIN:ZDB-MRPHLNO-070622-3	Zfish	PMID:17335795
Biological Process	GO:0031018	endocrine pancreas development	nkx2.2a	IMP	ZFIN:ZDB-MRPHLNO-100414-12	Zfish	PMID:19759004
Biological Process	GO:0031018	endocrine pancreas development	nkx2.2a	IMP	ZFIN:ZDB-MRPHLNO-070622-3	Zfish	PMID:21750032
Biological Process	GO:0033504	floor plate development	nkx2.2a	IMP	ZFIN:ZDB-MRPHLNO-080321-2	Zfish	PMID:18176560
Biological Process	GO:0021508	floor plate formation	nkx2.2b	IMP	ZFIN:ZDB-MRPHLNO-070305-2	Zfish	PMID:17045256
Biological Process	GO:0021508	floor plate formation	nkx2.2a	IMP	ZFIN:ZDB-MRPHLNO-070305-1	Zfish	PMID:17045256
Biological Process	GO:0008347	glial cell migration	nkx2.2a	IMP	ZFIN:ZDB-MRPHLNO-080321-2	Zfish	PMID:18176560
Biological Process	GO:0008045	motor neuron axon guidance	nkx2.2a	IMP	ZFIN:ZDB-MRPHLNO-080321-2	Zfish	PMID:18176560
Biological Process	GO:0045665	negative regulation of neuron differentiation	Nkx2-2	IDA		Mouse	PMID:10830170
Biological Process	GO:0045665	negative regulation of neuron differentiation	Nkx2-2	IMP	MGI:MGI:1932100	Mouse	PMID:10217145
Biological Process	GO:0007399	nervous system development	Nkx2-2	IDA		Mouse	PMID:14573534
Biological Process	GO:0061101	neuroendocrine cell differentiation	Nkx2-2	IMP	MGI:MGI:1932100	Mouse	PMID:18987169
Biological Process	GO:0030182	neuron differentiation	Nkx2-2	IDA		Mouse	PMID:10830170
Biological Process	GO:0030182	neuron differentiation	Nkx2-2	IMP	MGI:MGI:1932100	Mouse	PMID:10217145
Biological Process	GO:0048665	neuron fate specification	Nkx2-2	IGI	MGI:MGI:97451	Mouse	PMID:16339193
Biological Process	GO:0048665	neuron fate specification	Nkx2-2	IMP	MGI:MGI:1932100	Mouse	PMID:19592574
Biological Process	GO:0014003	oligodendrocyte development	Nkx2-2	IMP	MGI:MGI:1932100	Mouse	PMID:11526078
Biological Process	GO:0048709	oligodendrocyte differentiation	Nkx2-2	IGI	MGI:MGI:1355331	Mouse	PMID:11566099
Biological Process	GO:0021554	optic nerve development	Nkx2-2	IEP		Rat	PMID:15048854|RGD:2306244
Biological Process	GO:0003326	pancreatic A cell fate commitment	Nkx2-2	IGI	MGI:MGI:1339708	Mouse	PMID:17988662
Biological Process	GO:0003326	pancreatic A cell fate commitment	Nkx2-2	IMP	MGI:MGI:1932100	Mouse	PMID:17202186
Biological Process	GO:0003329	pancreatic PP cell fate commitment	Nkx2-2	IGI	MGI:MGI:1339708	Mouse	PMID:17988662
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	nkx2.2a	IDA		Zfish	PMID:19759004|ZFIN:ZDB-PUB-090921-20
Biological Process	GO:0030858	positive regulation of epithelial cell differentiation	Nkx2-2	IMP	MGI:MGI:1932100	Mouse	PMID:14729487
Biological Process	GO:0010628	positive regulation of gene expression	Nkx2-2	IDA		Mouse	PMID:24101522
Biological Process	GO:0045666	positive regulation of neuron differentiation	Nkx2-2	IMP	MGI:MGI:1932100	Mouse	PMID:10217145
Biological Process	GO:0045666	positive regulation of neuron differentiation	Nkx2-2	IDA		Mouse	PMID:10830170
Biological Process	GO:0048714	positive regulation of oligodendrocyte differentiation	Nkx2-2	IGI	MGI:MGI:1355331	Mouse	PMID:11566099
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Nkx2-2	IDA		Mouse	PMID:14701942
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Nkx2-2	IDA		Mouse	PMID:11526078
Biological Process	GO:0006355	regulation of DNA-templated transcription	Nkx2-2	IDA		Mouse	PMID:14573534
Biological Process	GO:0009749	response to glucose	Nkx2-2	IEP		Rat	PMID:19134185|RGD:2306238
Biological Process	GO:0014070	response to organic cyclic compound	Nkx2-2	IEP		Rat	PMID:14568228|RGD:2306245
Biological Process	GO:0032570	response to progesterone	Nkx2-2	IEP		Rat	PMID:19053058|RGD:2306239
Biological Process	GO:0014044	Schwann cell development	nkx2.2a	IMP	ZFIN:ZDB-MRPHLNO-080321-2	Zfish	PMID:18176560
Biological Process	GO:0007224	smoothened signaling pathway	Nkx2-2	IDA		Mouse	PMID:18590716
Biological Process	GO:0021522	spinal cord motor neuron differentiation	Nkx2-2	IMP	MGI:MGI:1932100	Mouse	PMID:10217145
Biological Process	GO:0021529	spinal cord oligodendrocyte cell differentiation	Nkx2-2	IGI	MGI:MGI:96919	Mouse	PMID:18287202
Biological Process	GO:0021529	spinal cord oligodendrocyte cell differentiation	Nkx2-2	IMP	MGI:MGI:1932100	Mouse	PMID:11526078
Biological Process	GO:0021529	spinal cord oligodendrocyte cell differentiation	nkx2.2a	IMP	ZFIN:ZDB-MRPHLNO-080321-2	Zfish	PMID:19737431
Biological Process	GO:0021530	spinal cord oligodendrocyte cell fate specification	Nkx2-2	IDA		Mouse	PMID:18287202
Biological Process	GO:0021530	spinal cord oligodendrocyte cell fate specification	nkx2.2a	IMP	ZFIN:ZDB-MRPHLNO-080321-2	Zfish	PMID:19737431
Biological Process	GO:0003323	type B pancreatic cell development	Nkx2-2	IDA		Mouse	PMID:17456846
Biological Process	GO:0003323	type B pancreatic cell development	Nkx2-2	IMP	MGI:MGI:1932100	Mouse	PMID:17202186
Biological Process	GO:0003309	type B pancreatic cell differentiation	Nkx2-2	IMP	MGI:MGI:1932100	Mouse	PMID:14729487
Biological Process	GO:0003327	type B pancreatic cell fate commitment	Nkx2-2	IMP	MGI:MGI:1932100	Mouse	PMID:17988662
Biological Process	GO:0003327	type B pancreatic cell fate commitment	Nkx2-2	IMP	MGI:MGI:1932100	Mouse	PMID:17202186
Biological Process	GO:0021514	ventral spinal cord interneuron differentiation	nkx2.2b	IGI	ZFIN:ZDB-MRPHLNO-080321-2,ZFIN:ZDB-MRPHLNO-100811-3,ZFIN:ZDB-MRPHLNO-100901-1	Zfish	PMID:20610488
Biological Process	GO:0021514	ventral spinal cord interneuron differentiation	nkx2.2b	IGI	ZFIN:ZDB-MRPHLNO-100811-3,ZFIN:ZDB-MRPHLNO-100901-1	Zfish	PMID:20610488
Biological Process	GO:0021514	ventral spinal cord interneuron differentiation	nkx2.2a	IGI	ZFIN:ZDB-MRPHLNO-080321-2,ZFIN:ZDB-MRPHLNO-100811-3,ZFIN:ZDB-MRPHLNO-100901-1	Zfish	PMID:20610488
Biological Process	GO:0021514	ventral spinal cord interneuron differentiation	nkx2.2a	IGI	ZFIN:ZDB-MRPHLNO-080321-2,ZFIN:ZDB-MRPHLNO-100811-3	Zfish	PMID:20610488
Biological Process	GO:0060580	ventral spinal cord interneuron fate determination	Nkx2-2	IMP	MGI:MGI:1932100	Mouse	PMID:10217145

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern