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Nkx2-2
Gene Detail
Symbol

Name
ID
Nkx2-2
NK2 homeobox 2
MGI:97347
Synonyms
Nkx-2.2, Nkx2.2, tinman
Feature Type
protein coding gene
Genetic Map
Chromosome 2
72.63 cM, cytoband H
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr2:147177546-147194243 bp, - strand
From VEGA annotation of GRCm38

  16698 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1879  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Nkx2-2

Human
homologs
Human Homolog NKX2-2, NK2 homeobox 2
NCBI Gene ID 4821
neXtProt AC  NX_O95096
Human Synonyms  NKX2.2, NKX2B
Human Chr (Location)  20p11.22; chr20:21511010-21514026 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Targeted(8)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mutants die within a few days of birth with severe hyperglycemia due to arrested differentiation of pancreatic beta cells. Mutant embryos exhibit retarded oligodendrocyte differentiation and a virtual loss of serotonergic neurons at the r2 level of the hindbrain.
 
Interactions
Nkx2-2 interacts with 136 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (47 annotations)
Process astrocyte differentiation, cell development, ...
Component intracellular, nucleus
Function chromatin binding, core promoter proximal region DNA binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (344 records)
Data Summary: Results (479)    Tissues (194)    Images (217)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 83
RNA in situ 323
Northern blot 11
RT-PCR 53
RNase protection 9
cDNA source data(17)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(43) Genomic(6) cDNA(20) Primer pair(7) Other(10)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000045623 (Evidence)
Ensembl Gene ModelENSMUSG00000027434 (Evidence)
Entrez Gene18088 (Evidence)
UniGene330639
DFCITC1586353, TC1595081
DoTSDT.527886, DT.91304220, DT.91444122
NIA Mouse Gene IndexU023457
Consensus CDS ProjectCCDS16834.1, CCDS38259.1
International Mouse Knockout Project StatusNkx2-2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000045623 VEGA Gene Model | MGI Sequence Detail 16698 C57BL/6J ±  kb
transcript OTTMUST00000037293 VEGA | MGI Sequence Detail 2120 Not Applicable 
polypeptide OTTMUSP00000016704 VEGA | MGI Sequence Detail 273 Not Applicable 

For the selected sequences
All sequences(47) RefSeq(10) UniProt(7)
Polymorphisms
SNPs within 2kb(158 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017970 Homeobox, conserved site
InterPro IPR001356 Homeodomain
InterPro IPR009057 Homeodomain-like
InterPro IPR020479 Homeodomain, metazoa
Protein Ontology PR:000011242 homeobox protein Nkx-2.2
References
(Earliest) J:2959 Price M, et al., Regional expression of the homeobox gene Nkx-2.2 in the developing mammalian forebrain. Neuron. 1992 Feb;8(2):241-55
(Latest) J:213871 Li X, et al., Sp8 plays a supplementary role to Pax6 in establishing the pMN/p3 domain boundary in the spinal cord. Development. 2014 Jul;141(14):2875-84
All references(395)
Other
accession IDs
MGD-MRK-12889

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/21/2014
MGI 5.20
The Jackson Laboratory