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Nkx2-2
Gene Detail
Symbol

Name
ID
Nkx2-2
NK2 homeobox 2
MGI:97347
Synonyms
Nkx-2.2, Nkx2.2, tinman
Feature Type
protein coding gene
Genetic Map
Chromosome 2
72.63 cM, cytoband H
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr2:147177546-147194243 bp, - strand
From VEGA annotation of GRCm38

  16698 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1879  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: NKX2-2
Gene Tree: Nkx2-2

Human
homologs
NKX2-2, NK2 homeobox 2
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 4821
neXtProt AC: NX_O95096

Human Synonyms: NKX2.2, NKX2B

Human Chr (Location): 20p11.22; chr20:21499260-21514026 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Targeted(8)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygous null mutants die within a few days of birth with severe hyperglycemia due to arrested differentiation of pancreatic beta cells. Mutant embryos exhibit retarded oligodendrocyte differentiation and a virtual loss of serotonergic neurons at the r2 level of the hindbrain.
 
Interactions
Nkx2-2 interacts with 135 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (50 annotations)
Process astrocyte differentiation, cell development, ...
Component intracellular, nucleus
Function chromatin binding, core promoter proximal region DNA binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (368 records)
Data Summary: Results (481)    Tissues (194)    Images (219)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 85
RNA in situ 323
Northern blot 11
RT-PCR 53
RNase protection 9
cDNA source data(17)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: GEISHA NKX2-2 ; Xenbase nkx2-2 ; ZFIN nkx2.2a, nkx2.2b    NEW 
Molecular
reagents
All nucleic(43) Genomic(6) cDNA(20) Primer pair(7) Other(10)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000045623 (Evidence)
Ensembl Gene Model ENSMUSG00000027434 (Evidence)
Entrez Gene 18088 (Evidence)
UniGene 330639
DFCI TC1586353, TC1595081
DoTS DT.527886, DT.91304220, DT.91444122
NIA Mouse Gene Index U023457
Consensus CDS Project CCDS16834.1, CCDS38259.1
International Mouse Phenotyping Consortium Status Nkx2-2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000045623 VEGA Gene Model | MGI Sequence Detail 16698 C57BL/6J ±  kb
transcript OTTMUST00000037293 VEGA | MGI Sequence Detail 2120 Not Applicable 
polypeptide OTTMUSP00000016704 VEGA | MGI Sequence Detail 273 Not Applicable 

For the selected sequences
All sequences(46) RefSeq(12) UniProt(4)
Polymorphisms
SNPs within 2kb(158 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017970 Homeobox, conserved site
InterPro IPR001356 Homeodomain
InterPro IPR009057 Homeodomain-like
InterPro IPR020479 Homeodomain, metazoa
Protein Ontology PR:000011242 homeobox protein Nkx-2.2
References
(Earliest) J:2959 Price M, et al., Regional expression of the homeobox gene Nkx-2.2 in the developing mammalian forebrain. Neuron. 1992 Feb;8(2):241-55
(Latest) J:221787 Arbeille E, et al., Cerebrospinal fluid-derived Semaphorin3B orients neuroepithelial cell divisions in the apicobasal axis. Nat Commun. 2015;6:6366
All references(418)
Other
accession IDs
MGD-MRK-12889

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/28/2015
MGI 5.22
The Jackson Laboratory