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Nkx2-2 Gene Detail
Summary
  • Symbol
    Nkx2-2
  • Name
    NK2 homeobox 2
  • Synonyms
    Nkx-2.2, Nkx2.2, tinman
  • Feature Type
    protein coding gene
  • IDs
    MGI:97347
    NCBI Gene: 18088
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:147019466-147036163 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 2, 72.63 cM, cytoband H
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    158 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97347
protein coding gene Chr2:146967909-147037270 (-)
129S1/SvImJ MGP_129S1SvImJ_G0026603
protein coding gene Chr2:151438933-151462446 (-)
A/J MGP_AJ_G0026567
protein coding gene Chr2:145284805-145301951 (-)
AKR/J MGP_AKRJ_G0026541
protein coding gene Chr2:149542048-149558265 (-)
BALB/cJ MGP_BALBcJ_G0026579
protein coding gene Chr2:145721370-145738122 (-)
C3H/HeJ MGP_C3HHeJ_G0026322
protein coding gene Chr2:149985461-150002724 (-)
C57BL/6NJ MGP_C57BL6NJ_G0027024
protein coding gene Chr2:155871141-155891864 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024402
protein coding gene Chr2:139347513-139363914 (-)
CAST/EiJ MGP_CASTEiJ_G0025783
protein coding gene Chr2:150336409-150370133 (-)
CBA/J MGP_CBAJ_G0026302
protein coding gene Chr2:161557486-161584446 (-)
DBA/2J MGP_DBA2J_G0026436
protein coding gene Chr2:144558960-144577504 (-)
FVB/NJ MGP_FVBNJ_G0026400
protein coding gene Chr2:143089987-143109396 (-)
LP/J MGP_LPJ_G0026540
protein coding gene Chr2:151573214-151594761 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0026420
protein coding gene Chr2:165696292-165715002 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0027079
protein coding gene Chr2:149486237-149503738 (-)
PWK/PhJ MGP_PWKPhJ_G0025519
protein coding gene Chr2:144233949-144265707 (-)
SPRET/EiJ MGP_SPRETEiJ_G0025320
protein coding gene Chr2:148444277-148485912 (-)
WSB/EiJ MGP_WSBEiJ_G0025857
protein coding gene Chr2:150435488-150452448 (-)



Homology
more
  • Human Ortholog
    NKX2-2, NK2 homeobox 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NKX2-2, NK2 homeobox 2
  • Synonyms
    NKX2.2, NKX2B
  • Links
    NCBI Gene ID: 4821
    neXtProt AC: NX_O95096
    UniProt: O95096

  • Chr Location
    20p11.22; chr20:21511017-21522689 (-)  GRCh38

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    33 phenotypes from 5 alleles in 5 genetic backgrounds
    9 phenotypes from multigenic genotypes
    71 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mutants die within a few days of birth with severe hyperglycemia due to arrested differentiation of pancreatic beta cells. Mutant embryos exhibit retarded oligodendrocyte differentiation and a virtual loss of serotonergic neurons at the r2 level of the hindbrain.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000027434 Ensembl Gene Model | MGI Sequence Detail 16698 C57BL/6J ±  kb
    transcript ENSMUST00000067075 Ensembl | MGI Sequence Detail 2120 Not Applicable  
    polypeptide ENSMUSP00000069666 Ensembl | MGI Sequence Detail 273 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 60
      Genomic 7
      cDNA 23
      Primer pair 10
      Other 20

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-12889
    References
    more
    • Summaries
      All 596
      Developmental Gene Expression 534
      Gene Ontology 28
      Phenotypes 71
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:345248 Tran HN, et al., Dbx1 is a dorsal midbrain-specific determinant of GABAergic neuron fate and regulates differentiation of the dorsal midbrain into the inferior and superior colliculi. Front Cell Dev Biol. 2024;12:1336308

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    03/12/2024
    MGI 6.23
    The Jackson Laboratory