Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Lrp6

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes LRP6
- Mouse genes Lrp6
- Rat genes Lrp6
- Zfish genes lrp6
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Lrp6

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0034185	apolipoprotein binding	Lrp6	IPI	PR:E9Q414	Mouse	PMID:18948618
Molecular Function	GO:0071936	coreceptor activity involved in Wnt signaling pathway	LRP6	IDA		Human	PMID:11029007
Molecular Function	GO:0005109	frizzled binding	LRP6	IPI	UniProtKB:Q61091	Human	PMID:11029007
Molecular Function	GO:0042802	identical protein binding	LRP6	IPI	UniProtKB:O75581	Human	PMID:12897152
Molecular Function	GO:0042802	identical protein binding	LRP6	IPI	UniProtKB:O75581	Human	PMID:21984209
Molecular Function	GO:0019210	kinase inhibitor activity	LRP6	IMP		Human	PMID:16365045
Molecular Function	GO:0005041	low-density lipoprotein particle receptor activity	LRP6	IDA		Human	PMID:16263759
Molecular Function	GO:0005515	protein binding	LRP6	IPI	UniProtKB:P04426	Human	PMID:11029007
Molecular Function	GO:0005515	protein binding	LRP6	IPI	UniProtKB:Q61091	Human	PMID:11029007
Molecular Function	GO:0005515	protein binding	LRP6	IPI	UniProtKB:O57464	Human	PMID:11357136
Molecular Function	GO:0005515	protein binding	LRP6	IPI	UniProtKB:Q9QYZ8	Human	PMID:11357136
Molecular Function	GO:0005515	protein binding	LRP6	IPI	UniProtKB:O94907	Human	PMID:11433302
Molecular Function	GO:0005515	protein binding	LRP6	IPI	UniProtKB:O94907	Human	PMID:11448771
Molecular Function	GO:0005515	protein binding	LRP6	IPI	UniProtKB:P04426	Human	PMID:11448771
Molecular Function	GO:0005515	protein binding	LRP6	IPI	UniProtKB:Q61091	Human	PMID:11448771
Molecular Function	GO:0005515	protein binding	LRP6	IPI	UniProtKB:O35625	Human	PMID:12897152
Molecular Function	GO:0005515	protein binding	LRP6	IPI	UniProtKB:P27467	Human	PMID:12897152
Molecular Function	GO:0005515	protein binding	LRP6	IPI	UniProtKB:Q61091	Human	PMID:15908424
Molecular Function	GO:0005515	protein binding	LRP6	IPI	UniProtKB:Q9BQB4	Human	PMID:15908424
Molecular Function	GO:0005515	protein binding	LRP6	IPI	UniProtKB:P49840	Human	PMID:16365045
Molecular Function	GO:0005515	protein binding	LRP6	IPI	UniProtKB:P49841	Human	PMID:16365045
Molecular Function	GO:0005515	protein binding	LRP6	IPI	UniProtKB:Q9H6X2	Human	PMID:16564009
Molecular Function	GO:0005515	protein binding	LRP6	IPI	UniProtKB:D3ZHV2	Human	PMID:16815997
Molecular Function	GO:0005515	protein binding	LRP6	IPI	UniProtKB:O70239	Human	PMID:16890161
Molecular Function	GO:0005515	protein binding	LRP6	IPI	UniProtKB:P49841	Human	PMID:16890161
Molecular Function	GO:0005515	protein binding	LRP6	IPI	UniProtKB:Q03135	Human	PMID:16890161
Molecular Function	GO:0005515	protein binding	LRP6	IPI	UniProtKB:Q9ERE7	Human	PMID:16989816
Molecular Function	GO:0005515	protein binding	LRP6	IPI	UniProtKB:Q96MU8	Human	PMID:17804805
Molecular Function	GO:0005515	protein binding	LRP6	IPI	UniProtKB:P27467	Human	PMID:18528331
Molecular Function	GO:0005515	protein binding	LRP6	IPI	UniProtKB:P47879	Human	PMID:18528331
Molecular Function	GO:0005515	protein binding	LRP6	IPI	UniProtKB:Q9WV60	Human	PMID:18721193
Molecular Function	GO:0005515	protein binding	LRP6	IPI	UniProtKB:Q6IMN6	Human	PMID:18762581
Molecular Function	GO:0005515	protein binding	LRP6	IPI	UniProtKB:O35625	Human	PMID:19107203
Molecular Function	GO:0005515	protein binding	LRP6	IPI	UniProtKB:Q9WV60	Human	PMID:19107203
Molecular Function	GO:0005515	protein binding	LRP6	IPI	UniProtKB:Q8ND76	Human	PMID:20059949
Molecular Function	GO:0005515	protein binding	LRP6	IPI	UniProtKB:O94907	Human	PMID:20093360
Molecular Function	GO:0005515	protein binding	LRP6	IPI	UniProtKB:O75787	Human	PMID:20093472
Molecular Function	GO:0005515	protein binding	LRP6	IPI	UniProtKB:P09619	Human	PMID:21245321
Molecular Function	GO:0005515	protein binding	LRP6	IPI	UniProtKB:O70239	Human	PMID:21304492
Molecular Function	GO:0005515	protein binding	LRP6	IPI	UniProtKB:Q5JTC6	Human	PMID:21304492
Molecular Function	GO:0005515	protein binding	LRP6	IPI	UniProtKB:Q9Y4X0	Human	PMID:21304492
Molecular Function	GO:0005515	protein binding	LRP6	IPI	UniProtKB:Q9BQB4	Human	PMID:21471202
Molecular Function	GO:0005515	protein binding	LRP6	IPI	UniProtKB:O94907	Human	PMID:21944579
Molecular Function	GO:0005515	protein binding	LRP6	IPI	UniProtKB:P56704	Human	PMID:21944579
Molecular Function	GO:0005515	protein binding	LRP6	IPI	UniProtKB:Q9BQB4	Human	PMID:21944579
Molecular Function	GO:0005515	protein binding	LRP6	IPI	UniProtKB:O94907	Human	PMID:21984209
Molecular Function	GO:0005515	protein binding	LRP6	IPI	UniProtKB:P98082	Human	PMID:22491013
Molecular Function	GO:0005515	protein binding	LRP6	IPI	UniProtKB:Q9ULT6	Human	PMID:22575959
Molecular Function	GO:0005515	protein binding	LRP6	IPI	UniProtKB:P56704	Human	PMID:22726442
Molecular Function	GO:0005515	protein binding	LRP6	IPI	UniProtKB:Q5S007	Human	PMID:22899650
Molecular Function	GO:0005515	protein binding	LRP6	IPI	UniProtKB:P27467	Human	PMID:23791946
Molecular Function	GO:0005515	protein binding	LRP6	IPI	UniProtKB:O15169-2	Human	PMID:23892894
Molecular Function	GO:0005515	protein binding	LRP6	IPI	UniProtKB:Q66IA6	Human	PMID:23987510
Molecular Function	GO:0005515	protein binding	LRP6	IPI	UniProtKB:Q5S007	Human	PMID:27013965
Molecular Function	GO:0005515	protein binding	LRP6	IPI	UniProtKB:O94907	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	LRP6	IPI	UniProtKB:Q9BQB4	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	LRP6	IPI	UniProtKB:P49840	Human	PMID:30824926
Molecular Function	GO:0005515	protein binding	LRP6	IPI	UniProtKB:Q6UX01	Human	PMID:31073040
Molecular Function	GO:0005515	protein binding	LRP6	IPI	UniProtKB:Q9UBR5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	Lrp6	IPI	UniProtKB:Q9D1E5	Mouse	MGI:MGI:6303730\|PMID:31073040
Molecular Function	GO:0005515	protein binding	Lrp6	IPI	UniProtKB:P21741	Mouse	MGI:MGI:6294380\|PMID:12573468
Molecular Function	GO:0005515	protein binding	Lrp6	IPI	UniProtKB:Q6PAL1	Mouse	MGI:MGI:4410394\|PMID:19857465
Molecular Function	GO:0005515	protein binding	Lrp6	IPI	UniProtKB:P05556\|UniProtKB:P23229\|UniProtKB:P23229,UniProtKB:Q62656\|UniProtKB:Q62656	Mouse	MGI:MGI:6294160\|PMID:15466886
Molecular Function	GO:0005515	protein binding	Lrp6	IPI	UniProtKB:Q60760	Mouse	MGI:MGI:4821069\|PMID:17376403
Molecular Function	GO:0005515	protein binding	Lrp6	IPI	UniProtKB:O15118	Mouse	PMID:18948618
Molecular Function	GO:0005515	protein binding	Lrp6	IPI	PR:Q9ERE7	Mouse	PMID:18505367
Molecular Function	GO:0005515	protein binding	Lrp6	IPI	PR:P22725	Mouse	PMID:19056682
Molecular Function	GO:0005515	protein binding	Lrp6	IPI	PR:Q9QXZ0	Mouse	PMID:16815997
Molecular Function	GO:0005515	protein binding	Lrp6	IPI	PR:O54908	Mouse	PMID:16126904
Molecular Function	GO:0005515	protein binding	Lrp6	IPI	PR:P15116	Mouse	PMID:19075000
Molecular Function	GO:0005515	protein binding	Lrp6	IPI	PR:P04426	Mouse	PMID:16126904
Molecular Function	GO:0042803	protein homodimerization activity	LRP6	IPI	UniProtKB:O75581	Human	PMID:12897152
Molecular Function	GO:0005102	signaling receptor binding	LRP6	IPI	UniProtKB:Q9UP38	Human	PMID:14739301
Molecular Function	GO:0019534	toxin transmembrane transporter activity	LRP6	IMP		Human	PMID:16564009
Molecular Function	GO:0019534	toxin transmembrane transporter activity	Lrp6	IMP		Mouse	MGI:MGI:4839448\|PMID:16564009
Molecular Function	GO:0017147	Wnt-protein binding	LRP6	IPI	UniProtKB:P04426	Human	PMID:11029007
Molecular Function	GO:0017147	Wnt-protein binding	LRP6	IPI	UniProtKB:P27467	Human	PMID:12897152
Molecular Function	GO:0017147	Wnt-protein binding	LRP6	IPI	UniProtKB:O35468	Human	PMID:20093360
Molecular Function	GO:0017147	Wnt-protein binding	LRP6	IPI	UniProtKB:P56704	Human	PMID:20093360
Molecular Function	GO:0017147	Wnt-protein binding	Lrp6	IPI	PR:P27467	Mouse	PMID:18606138
Cellular Component	GO:0005901	caveola	LRP6	IDA		Human	PMID:16890161
Cellular Component	GO:0005901	caveola	LRP6	IDA		Human	PMID:17569865
Cellular Component	GO:0009986	cell surface	LRP6	IDA		Human	PMID:12897152
Cellular Component	GO:0031410	cytoplasmic vesicle	LRP6	IDA		Human	PMID:16890161
Cellular Component	GO:0031410	cytoplasmic vesicle	LRP6	IDA		Human	PMID:20093472
Cellular Component	GO:0005769	early endosome	LRP6	IDA		Human	PMID:16890161
Cellular Component	GO:0005769	early endosome	Lrp6	IDA		Mouse	PMID:18948618
Cellular Component	GO:0005794	Golgi apparatus	LRP6	IDA		Human	PMID:16890161
Cellular Component	GO:0016020	membrane	Lrp6	IDA		Mouse	PMID:16126904
Cellular Component	GO:0043025	neuronal cell body	Lrp6	IDA		Rat	PMID:20404321\|RGD:4110125
Cellular Component	GO:0005886	plasma membrane	LRP6	IDA		Human	PMID:16263759
Cellular Component	GO:0005886	plasma membrane	LRP6	IDA		Human	PMID:16890161
Cellular Component	GO:0005886	plasma membrane	LRP6	IDA		Human	PMID:17569865
Cellular Component	GO:0005886	plasma membrane	Lrp6	IDA		Mouse	PMID:18505367
Cellular Component	GO:0005886	plasma membrane	Lrp6	IDA		Mouse	PMID:18948618
Cellular Component	GO:0045202	synapse	Lrp6	IDA		Rat	PMID:20404321\|RGD:4110125
Cellular Component	GO:1990909	Wnt signalosome	LRP6	IDA		Human	PMID:22899650
Cellular Component	GO:1990851	Wnt-Frizzled-LRP5/6 complex	LRP6	IPI	UniProtKB:Q61091	Human	PMID:11029007
Cellular Component	GO:1990851	Wnt-Frizzled-LRP5/6 complex	LRP6	IPI	UniProtKB:Q61091	Human	PMID:11448771
Cellular Component	GO:1990851	Wnt-Frizzled-LRP5/6 complex	LRP6	IDA		Human	PMID:20093360
Biological Process	GO:0009952	anterior/posterior pattern specification	Lrp6	IMP	MGI:MGI:2156191	Mouse	PMID:19795512
Biological Process	GO:0009952	anterior/posterior pattern specification	Lrp6	IMP	MGI:MGI:1861309	Mouse	PMID:16126904
Biological Process	GO:0009952	anterior/posterior pattern specification	Lrp6	IGI	MGI:MGI:1278315	Mouse	PMID:15142971
Biological Process	GO:0003401	axis elongation	Lrp6	IMP	MGI:MGI:2156191	Mouse	PMID:19795512
Biological Process	GO:0090245	axis elongation involved in somitogenesis	Lrp6	IGI	MGI:MGI:98956	Mouse	PMID:11029008
Biological Process	GO:0060349	bone morphogenesis	Lrp6	IMP	MGI:MGI:1861309	Mouse	MGI:MGI:61254
Biological Process	GO:0046849	bone remodeling	Lrp6	IGI	MGI:MGI:1278315	Mouse	PMID:15537447
Biological Process	GO:0060444	branching involved in mammary gland duct morphogenesis	Lrp6	IMP	MGI:MGI:2156191	Mouse	PMID:19503830
Biological Process	GO:0060070	canonical Wnt signaling pathway	LRP6	IDA		Human	PMID:16263759
Biological Process	GO:0060070	canonical Wnt signaling pathway	LRP6	IDA		Human	PMID:16543246
Biological Process	GO:0060070	canonical Wnt signaling pathway	LRP6	IMP		Human	PMID:11029007
Biological Process	GO:0060070	canonical Wnt signaling pathway	LRP6	IDA		Human	PMID:11448771
Biological Process	GO:0060070	canonical Wnt signaling pathway	LRP6	IDA		Human	PMID:11742004
Biological Process	GO:0060070	canonical Wnt signaling pathway	LRP6	IDA		Human	PMID:12121999
Biological Process	GO:0060070	canonical Wnt signaling pathway	LRP6	IDA		Human	PMID:14739301
Biological Process	GO:0060070	canonical Wnt signaling pathway	LRP6	IDA		Human	PMID:15271658
Biological Process	GO:0060070	canonical Wnt signaling pathway	LRP6	IDA		Human	PMID:15908424
Biological Process	GO:0060070	canonical Wnt signaling pathway	LRP6	IGI	UniProtKB:O00755,UniProtKB:P02649	Human	PMID:16805831
Biological Process	GO:0060070	canonical Wnt signaling pathway	LRP6	IDA		Human	PMID:17239604
Biological Process	GO:0060070	canonical Wnt signaling pathway	LRP6	IMP		Human	PMID:18215320
Biological Process	GO:0060070	canonical Wnt signaling pathway	LRP6	IDA		Human	PMID:19107203
Biological Process	GO:0060070	canonical Wnt signaling pathway	LRP6	IDA		Human	PMID:20059949
Biological Process	GO:0060070	canonical Wnt signaling pathway	LRP6	IDA		Human	PMID:20093106
Biological Process	GO:0060070	canonical Wnt signaling pathway	LRP6	IMP		Human	PMID:20093472
Biological Process	GO:0060070	canonical Wnt signaling pathway	LRP6	IDA		Human	PMID:20137080
Biological Process	GO:0060070	canonical Wnt signaling pathway	Lrp6	IMP	MGI:MGI:2156191	Mouse	PMID:19795512
Biological Process	GO:0060070	canonical Wnt signaling pathway	Lrp6	IGI	MGI:MGI:1329040	Mouse	PMID:16126904
Biological Process	GO:0060070	canonical Wnt signaling pathway	Lrp6	IMP		Mouse	PMID:15064719
Biological Process	GO:0060070	canonical Wnt signaling pathway	Lrp6	IMP	MGI:MGI:2673982	Mouse	PMID:15469977
Biological Process	GO:0060070	canonical Wnt signaling pathway	Lrp6	IMP	MGI:MGI:2673982	Mouse	PMID:18505367
Biological Process	GO:0060070	canonical Wnt signaling pathway	Lrp6	IGI	MGI:MGI:98956	Mouse	PMID:15143170
Biological Process	GO:0060070	canonical Wnt signaling pathway	Lrp6	IGI	MGI:MGI:98956	Mouse	PMID:11029008
Biological Process	GO:0060070	canonical Wnt signaling pathway	Lrp6	IGI	MGI:MGI:1922667	Mouse	PMID:18256198
Biological Process	GO:0060070	canonical Wnt signaling pathway	Lrp6	IGI	MGI:MGI:98956	Mouse	PMID:19910923
Biological Process	GO:0060070	canonical Wnt signaling pathway	Lrp6	IMP	MGI:MGI:4415718	Mouse	PMID:19700620
Biological Process	GO:0060070	canonical Wnt signaling pathway	Lrp6	IMP		Rat	PMID:18006602\|RGD:4110127
Biological Process	GO:0060070	canonical Wnt signaling pathway	lrp6	IMP		Zfish	ZFIN:ZDB-PUB-130905-3
Biological Process	GO:0061310	canonical Wnt signaling pathway involved in cardiac neural crest cell differentiation involved in heart development	Lrp6	IMP	MGI:MGI:2156191	Mouse	PMID:19705442
Biological Process	GO:0061324	canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation	Lrp6	IMP	MGI:MGI:2156191	Mouse	PMID:19705442
Biological Process	GO:0042074	cell migration involved in gastrulation	Lrp6	IGI	MGI:MGI:1278315	Mouse	PMID:15142971
Biological Process	GO:0098609	cell-cell adhesion	Lrp6	IMP		Rat	PMID:18006602\|RGD:4110127
Biological Process	GO:0071397	cellular response to cholesterol	LRP6	IMP		Human	PMID:16890161
Biological Process	GO:0021587	cerebellum morphogenesis	Lrp6	IMP	MGI:MGI:2156191	Mouse	PMID:11029008
Biological Process	GO:0021795	cerebral cortex cell migration	Lrp6	IMP	MGI:MGI:2156191	Mouse	PMID:16920270
Biological Process	GO:0021987	cerebral cortex development	Lrp6	IMP	MGI:MGI:2156191	Mouse	PMID:16920270
Biological Process	GO:0007268	chemical synaptic transmission	Lrp6	IMP		Rat	PMID:20404321\|RGD:4110125
Biological Process	GO:0060026	convergent extension	Lrp6	IGI	MGI:MGI:98958	Mouse	PMID:19795512
Biological Process	GO:0071542	dopaminergic neuron differentiation	Lrp6	IMP	MGI:MGI:2156191	Mouse	PMID:19795519
Biological Process	GO:0009950	dorsal/ventral axis specification	Lrp6	IMP	MGI:MGI:2156191	Mouse	PMID:18985738
Biological Process	GO:0048596	embryonic camera-type eye morphogenesis	Lrp6	IMP	MGI:MGI:4415718	Mouse	PMID:19653321
Biological Process	GO:0048596	embryonic camera-type eye morphogenesis	Lrp6	IMP	MGI:MGI:2156191	Mouse	PMID:18985738
Biological Process	GO:0042733	embryonic digit morphogenesis	Lrp6	IMP	MGI:MGI:2156191	Mouse	PMID:19795512
Biological Process	GO:0042733	embryonic digit morphogenesis	Lrp6	IGI	MGI:MGI:1278315	Mouse	PMID:15142971
Biological Process	GO:0035115	embryonic forelimb morphogenesis	Lrp6	IGI	MGI:MGI:98961	Mouse	PMID:15880584
Biological Process	GO:0035115	embryonic forelimb morphogenesis	Lrp6	IMP	MGI:MGI:4415718	Mouse	PMID:19653321
Biological Process	GO:0035115	embryonic forelimb morphogenesis	Lrp6	IGI	MGI:MGI:1922667	Mouse	PMID:18256198
Biological Process	GO:0035115	embryonic forelimb morphogenesis	Lrp6	IMP	MGI:MGI:2156191	Mouse	PMID:11029008
Biological Process	GO:0035116	embryonic hindlimb morphogenesis	Lrp6	IGI	MGI:MGI:98961	Mouse	PMID:15880584
Biological Process	GO:0035116	embryonic hindlimb morphogenesis	Lrp6	IMP	MGI:MGI:4415718	Mouse	PMID:19653321
Biological Process	GO:0035116	embryonic hindlimb morphogenesis	Lrp6	IGI	MGI:MGI:1922667	Mouse	PMID:18256198
Biological Process	GO:0030326	embryonic limb morphogenesis	Lrp6	IGI	MGI:MGI:1921749	Mouse	PMID:20359476
Biological Process	GO:0009880	embryonic pattern specification	Lrp6	IMP	MGI:MGI:4415718	Mouse	PMID:19653321
Biological Process	GO:0060059	embryonic retina morphogenesis in camera-type eye	Lrp6	IMP	MGI:MGI:4415718	Mouse	PMID:19653321
Biological Process	GO:0060856	establishment of blood-brain barrier	Lrp6	IMP	MGI:MGI:5299216	Mouse	PMID:25083995
Biological Process	GO:1990963	establishment of blood-retinal barrier	Lrp6	IMP	MGI:MGI:5299216	Mouse	PMID:25083995
Biological Process	GO:0035261	external genitalia morphogenesis	Lrp6	IMP	MGI:MGI:4415718	Mouse	PMID:19653321
Biological Process	GO:0060325	face morphogenesis	Lrp6	IMP	MGI:MGI:2156191	Mouse	PMID:19700620
Biological Process	GO:0060325	face morphogenesis	Lrp6	IMP	MGI:MGI:4415718	Mouse	PMID:19653321
Biological Process	GO:0045444	fat cell differentiation	Lrp6	IMP	MGI:MGI:2156191	Mouse	PMID:17888405
Biological Process	GO:0030900	forebrain development	Lrp6	IMP	MGI:MGI:3043026	Mouse	PMID:15384171
Biological Process	GO:0021872	forebrain generation of neurons	Lrp6	IMP	MGI:MGI:2156191	Mouse	PMID:14715945
Biological Process	GO:0021861	forebrain radial glial cell differentiation	Lrp6	IGI	MGI:MGI:96770	Mouse	PMID:14715945
Biological Process	GO:0021943	formation of radial glial scaffolds	Lrp6	IGI	MGI:MGI:96770	Mouse	PMID:14715945
Biological Process	GO:0001702	gastrulation with mouth forming second	Lrp6	IGI	MGI:MGI:1278315	Mouse	PMID:15142971
Biological Process	GO:0048699	generation of neurons	Lrp6	IMP	MGI:MGI:2156191	Mouse	PMID:15342729
Biological Process	GO:0001947	heart looping	Lrp6	IGI	MGI:MGI:98958	Mouse	PMID:19795512
Biological Process	GO:0035108	limb morphogenesis	Lrp6	IGI	MGI:MGI:1278315	Mouse	PMID:15537447
Biological Process	GO:0035108	limb morphogenesis	Lrp6	IMP	MGI:MGI:2673982	Mouse	PMID:15469977
Biological Process	GO:0060603	mammary gland duct morphogenesis	Lrp6	IGI	MGI:MGI:1278315	Mouse	PMID:19503830
Biological Process	GO:0060596	mammary placode formation	Lrp6	IMP	MGI:MGI:2156191	Mouse	PMID:19503830
Biological Process	GO:0010463	mesenchymal cell proliferation	Lrp6	IMP	MGI:MGI:4415718	Mouse	PMID:19700620
Biological Process	GO:0008078	mesodermal cell migration	Lrp6	IGI	MGI:MGI:1278315	Mouse	PMID:15142971
Biological Process	GO:0030901	midbrain development	Lrp6	IMP	MGI:MGI:2156191	Mouse	PMID:11029008
Biological Process	GO:0030917	midbrain-hindbrain boundary development	Lrp6	IMP	MGI:MGI:2156191	Mouse	PMID:11029008
Biological Process	GO:0030917	midbrain-hindbrain boundary development	Lrp6	IMP	MGI:MGI:2156191	Mouse	PMID:19795512
Biological Process	GO:0002009	morphogenesis of an epithelium	Lrp6	IMP	MGI:MGI:1861309	Mouse	MGI:MGI:61211
Biological Process	GO:0050680	negative regulation of epithelial cell proliferation	Lrp6	IMP	MGI:MGI:4415718	Mouse	PMID:19700620
Biological Process	GO:0045599	negative regulation of fat cell differentiation	Lrp6	IMP	MGI:MGI:2156191	Mouse	PMID:17888405
Biological Process	GO:2000051	negative regulation of non-canonical Wnt signaling pathway	Lrp6	IGI	MGI:MGI:98958	Mouse	PMID:19056682
Biological Process	GO:2000151	negative regulation of planar cell polarity pathway involved in cardiac muscle tissue morphogenesis	Lrp6	IGI	MGI:MGI:98958	Mouse	PMID:19056682
Biological Process	GO:2000162	negative regulation of planar cell polarity pathway involved in cardiac right atrium morphogenesis	Lrp6	IGI	MGI:MGI:98958	Mouse	PMID:19056682
Biological Process	GO:2000168	negative regulation of planar cell polarity pathway involved in neural tube closure	Lrp6	IGI	MGI:MGI:98958	Mouse	PMID:19056682
Biological Process	GO:2000164	negative regulation of planar cell polarity pathway involved in outflow tract morphogenesis	Lrp6	IGI	MGI:MGI:98958	Mouse	PMID:19056682
Biological Process	GO:2000166	negative regulation of planar cell polarity pathway involved in pericardium morphogenesis	Lrp6	IGI	MGI:MGI:98958	Mouse	PMID:19056682
Biological Process	GO:2000149	negative regulation of planar cell polarity pathway involved in ventricular septum morphogenesis	Lrp6	IGI	MGI:MGI:98958	Mouse	PMID:19056682
Biological Process	GO:0006469	negative regulation of protein kinase activity	LRP6	IMP		Human	PMID:16365045
Biological Process	GO:0001933	negative regulation of protein phosphorylation	LRP6	IMP		Human	PMID:16365045
Biological Process	GO:0071901	negative regulation of protein serine/threonine kinase activity	LRP6	IDA		Human	PMID:19107203
Biological Process	GO:0034392	negative regulation of smooth muscle cell apoptotic process	LRP6	IMP		Human	PMID:15271658
Biological Process	GO:0014033	neural crest cell differentiation	LRP6	IDA		Human	PMID:11029007
Biological Process	GO:0014029	neural crest formation	LRP6	IDA		Human	PMID:11029007
Biological Process	GO:0001843	neural tube closure	Lrp6	IMP	MGI:MGI:4415718	Mouse	PMID:19653321
Biological Process	GO:0001843	neural tube closure	Lrp6	IMP	MGI:MGI:2673982	Mouse	PMID:15469977
Biological Process	GO:0001843	neural tube closure	Lrp6	IMP	MGI:MGI:1861309	Mouse	PMID:10545599
Biological Process	GO:0001843	neural tube closure	Lrp6	IGI	MGI:MGI:98958	Mouse	PMID:19795512
Biological Process	GO:0001843	neural tube closure	Lrp6	IMP	MGI:MGI:1861309	Mouse	MGI:MGI:61254
Biological Process	GO:0021915	neural tube development	Lrp6	IGI	MGI:MGI:98958	Mouse	PMID:19795512
Biological Process	GO:0110135	Norrin signaling pathway	Lrp6	IDA		Mouse	MGI:MGI:3621833\|PMID:15035989
Biological Process	GO:0042475	odontogenesis of dentin-containing tooth	Lrp6	IMP	MGI:MGI:1861309	Mouse	MGI:MGI:61254
Biological Process	GO:0042475	odontogenesis of dentin-containing tooth	Lrp6	IMP	MGI:MGI:1861309	Mouse	MGI:MGI:61211
Biological Process	GO:0042475	odontogenesis of dentin-containing tooth	Lrp6	IMP	MGI:MGI:1861309	Mouse	PMID:5893447
Biological Process	GO:0042475	odontogenesis of dentin-containing tooth	Lrp6	IMP	MGI:MGI:1861309	Mouse	PMID:591875
Biological Process	GO:0003344	pericardium morphogenesis	Lrp6	IGI	MGI:MGI:98958	Mouse	PMID:19795512
Biological Process	GO:0061350	planar cell polarity pathway involved in cardiac muscle tissue morphogenesis	Lrp6	IGI	MGI:MGI:98958	Mouse	PMID:19056682
Biological Process	GO:0061349	planar cell polarity pathway involved in cardiac right atrium morphogenesis	Lrp6	IGI	MGI:MGI:98958	Mouse	PMID:19056682
Biological Process	GO:0090179	planar cell polarity pathway involved in neural tube closure	Lrp6	IGI	MGI:MGI:98958	Mouse	PMID:19056682
Biological Process	GO:0061347	planar cell polarity pathway involved in outflow tract morphogenesis	Lrp6	IGI	MGI:MGI:98958	Mouse	PMID:19056682
Biological Process	GO:0061354	planar cell polarity pathway involved in pericardium morphogenesis	Lrp6	IGI	MGI:MGI:98958	Mouse	PMID:19056682
Biological Process	GO:0061348	planar cell polarity pathway involved in ventricular septum morphogenesis	Lrp6	IGI	MGI:MGI:98958	Mouse	PMID:19056682
Biological Process	GO:0043065	positive regulation of apoptotic process	Lrp6	IMP	MGI:MGI:4415718	Mouse	PMID:19700620
Biological Process	GO:0045780	positive regulation of bone resorption	Lrp6	IMP	MGI:MGI:2673982	Mouse	PMID:18505367
Biological Process	GO:0045787	positive regulation of cell cycle	LRP6	IMP		Human	PMID:15271658
Biological Process	GO:0007204	positive regulation of cytosolic calcium ion concentration	Lrp6	IMP		Rat	PMID:20404321\|RGD:4110125
Biological Process	GO:0051091	positive regulation of DNA-binding transcription factor activity	LRP6	IDA		Human	PMID:14739301
Biological Process	GO:0051091	positive regulation of DNA-binding transcription factor activity	Lrp6	IMP		Mouse	MGI:MGI:3621833\|PMID:15035989
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	LRP6	IMP		Human	PMID:18215320
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Lrp6	IDA		Mouse	MGI:MGI:3621833\|PMID:15035989
Biological Process	GO:0002053	positive regulation of mesenchymal cell proliferation	Lrp6	IMP	MGI:MGI:4415718	Mouse	PMID:19700620
Biological Process	GO:0010976	positive regulation of neuron projection development	Lrp6	IGI	UniProtKB:P02649	Mouse	MGI:MGI:5825420\|PMID:23845000
Biological Process	GO:0045778	positive regulation of ossification	Lrp6	IMP	MGI:MGI:2673982	Mouse	PMID:15469977
Biological Process	GO:2000648	positive regulation of stem cell proliferation	Lrp6	IMP	MGI:MGI:4415718	Mouse	PMID:19700620
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	LRP6	IDA		Human	PMID:12857724
Biological Process	GO:0036342	post-anal tail morphogenesis	Lrp6	IMP	MGI:MGI:2156191	Mouse	PMID:19795512
Biological Process	GO:0036342	post-anal tail morphogenesis	Lrp6	IGI	MGI:MGI:98958	Mouse	PMID:19795512
Biological Process	GO:0036342	post-anal tail morphogenesis	Lrp6	IMP	MGI:MGI:4415718	Mouse	PMID:19653321
Biological Process	GO:0090009	primitive streak formation	Lrp6	IGI	MGI:MGI:98958	Mouse	PMID:19795512
Biological Process	GO:0072659	protein localization to plasma membrane	LRP6	IPI	UniProtKB:Q5S007	Human	PMID:22899650
Biological Process	GO:0090118	receptor-mediated endocytosis involved in cholesterol transport	Lrp6	IMP	MGI:MGI:4123883	Mouse	PMID:18948618
Biological Process	GO:0060284	regulation of cell development	Lrp6	IMP	MGI:MGI:2156191	Mouse	PMID:19795519
Biological Process	GO:0006355	regulation of DNA-templated transcription	Lrp6	IMP		Rat	PMID:18006602\|RGD:4110127
Biological Process	GO:0050678	regulation of epithelial cell proliferation	Lrp6	IMP	MGI:MGI:1861309	Mouse	PMID:591875
Biological Process	GO:0051593	response to folic acid	Lrp6	IMP	MGI:MGI:1861309	Mouse	PMID:17050573
Biological Process	GO:0043434	response to peptide hormone	Lrp6	IEP		Rat	PMID:15962290\|RGD:2298726
Biological Process	GO:0043434	response to peptide hormone	Lrp6	IEP		Rat	PMID:18981475\|RGD:4110126
Biological Process	GO:0060042	retina morphogenesis in camera-type eye	Lrp6	IMP	MGI:MGI:2156191	Mouse	PMID:18985738
Biological Process	GO:0060021	roof of mouth development	Lrp6	IMP	MGI:MGI:4415718	Mouse	PMID:19653321
Biological Process	GO:0060021	roof of mouth development	Lrp6	IMP	MGI:MGI:2156191	Mouse	PMID:19700620
Biological Process	GO:0048705	skeletal system morphogenesis	Lrp6	IMP	MGI:MGI:2673982	Mouse	PMID:15469977
Biological Process	GO:0001756	somitogenesis	Lrp6	IGI	MGI:MGI:98958	Mouse	PMID:19795512
Biological Process	GO:0072089	stem cell proliferation	Lrp6	IMP	MGI:MGI:4415718	Mouse	PMID:19700620
Biological Process	GO:0021794	thalamus development	Lrp6	IMP	MGI:MGI:2156191	Mouse	PMID:15342729
Biological Process	GO:0060535	trachea cartilage morphogenesis	Lrp6	IGI	MGI:MGI:1922667	Mouse	PMID:18256198
Biological Process	GO:0016055	Wnt signaling pathway	LRP6	IDA		Human	PMID:11357136
Biological Process	GO:0044332	Wnt signaling pathway involved in dorsal/ventral axis specification	lrp6	IMP		Zfish	ZFIN:ZDB-PUB-130905-3
Biological Process	GO:0021874	Wnt signaling pathway involved in forebrain neuroblast division	Lrp6	IGI	MGI:MGI:96770	Mouse	PMID:14715945
Biological Process	GO:0021874	Wnt signaling pathway involved in forebrain neuroblast division	Lrp6	IMP	MGI:MGI:2156191	Mouse	PMID:16920270
Biological Process	GO:0090244	Wnt signaling pathway involved in somitogenesis	Lrp6	IMP	MGI:MGI:2673982	Mouse	PMID:15469977

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 03/25/2025 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.